30,920 results match your criteria thrombolysis


Re: Tenecteplase for thrombolysis in stroke patients: Systematic review with meta-analysis.

Am J Emerg Med 2021 Jun 1. Epub 2021 Jun 1.

Division of Stroke Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States of America. Electronic address:

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Ultrastructural Analysis of Volumetric Histotripsy Bio-effects in Large Human Hematomas.

Ultrasound Med Biol 2021 Jun 8. Epub 2021 Jun 8.

Laboratory for Industrial and Medical Ultrasound, Physics Faculty, M. V. Lomonosov Moscow State University, Moscow, Russian Federation; Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA.

Large-volume soft tissue hematomas are a serious clinical problem, which, if untreated, can have severe consequences. Current treatments are associated with significant pain and discomfort. It has been reported that in an in vitro bovine hematoma model, pulsed high-intensity focused ultrasound (HIFU) ablation, termed histotripsy, can be used to rapidly and non-invasively liquefy the hematoma through localized bubble activity, enabling fine-needle aspiration. Read More

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In-Hospital Acute Ischemic Stroke is Associated with Worse Outcome: Experience of a Single Center in Santiago Chile.

J Stroke Cerebrovasc Dis 2021 Jun 8;30(8):105894. Epub 2021 Jun 8.

Unidad de Neurología Vascular, Servicio de Neurología, Departamento de Neurología y Psiquiatría, Clínica Alemana de Santiago, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Chile; Unidad de Neurología Vascular, Servicio de Neurología, Departamento de Neurología y Psiquiatría y Departamento de Paciente Critico, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.

Objectives: In-hospital acute ischemic stroke (HIS) accounts for 2-17% of all acute ischemic strokes (AIS) seen in hospital and they have worse prognosis. In this study we aimed to identify the frequency of HIS and their characteristics in our center.

Materials And Methods: Retrospective analysis of a prospective register of patients with AIS seen at Clínica Alemana de Santiago, between January 2017 and January 2019. Read More

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Thrombolysis for COVID-19-associated bioprosthetic mitral valve thrombosis with shock.

Eur Heart J 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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In-hospital mortality among consecutive patients with ST-Elevation myocardial infarction in modern primary percutaneous intervention era ~ Insights from 15-year data of single-center hospital-based registry ~.

PLoS One 2021 11;16(6):e0252503. Epub 2021 Jun 11.

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: To clarify the association of detailed angiographic findings with in-hospital outcome after primary percutaneous coronary intervention (p-PCI) for ST-elevation myocardial infarction (STEMI) in Japan.

Background: Data regarding the association of detailed angiographic findings with in-hospital outcome after STEMI are limited in the p-PCI era.

Methods: Between January-2004 and December-2018, 1735 patients with STEMI (mean age, 68. Read More

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Glycoprotein IIb/IIIa inhibitors use in the setting of primary percutaneous coronary intervention for ST elevation myocardial infarction in patients pre-treated with newer P2Y12 inhibitors.

Clin Cardiol 2021 Jun 11. Epub 2021 Jun 11.

CHU de Caen Normandie, Service de Cardiologie, Caen, France.

Objectives: We sought to investigate the safety and potential benefit of administrating glycoprotein IIb-IIIa inhibitors (GPIs) on top of more potent P2Y12 inhibitors.

Background: A number of clinical trials, performed at a time when pretreatment and potent platelet inhibition was not part of routine clinical practice, have documented clinical benefits of GPI in ST-segment elevation myocardial infarction (STEMI) patients at the cost of a higher risk of bleeding.

Methods: We used the data of a prospective, ongoing registry of patients admitted for STEMI in our center. Read More

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Free-floating thrombus of the aorta: 3 case reports.

Surg Case Rep 2021 Jun 10;7(1):141. Epub 2021 Jun 10.

Department of Cardiovascular Surgery, Hiratsuka City Hospital, 1-19-1 Minamihara, Hiratsuka City, Kanagawa, 254-0065, Japan.

Background: Idiopathic free-floating thrombus (FFT) of the aorta is a rare occurrence, but it can lead to catastrophic consequences. The initial symptoms are typically cerebral or peripheral embolisms. Surgical thrombectomy and thrombolysis are two primary treatments for FFT. Read More

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Acute submassive pulmonary embolism after SARS-CoV-2 infection: a case report of reinfection or prolonged hypercoagulable state.

Eur Heart J Case Rep 2021 Mar 24;5(3):ytab103. Epub 2021 Mar 24.

Department of Cardiology, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153, USA.

Background: Coronavirus disease 19 (COVID-19) reinfection has been a topic of discussion with data still emerging. Viral antibodies are known to develop upon initial infection; however, it is unclear the amount of protection this confers against reinfection. Additionally, COVID-19-associated coagulopathy (CAC) is a well-documented phenomenon; however, there are no high-quality studies to support the treatment of outpatients beyond standard indications of venous thromboembolism (VTE) prophylaxis. Read More

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Stroke care and case fatality in people with and without schizophrenia: a retrospective cohort study.

BMJ Open 2021 Jun 10;11(6):e044766. Epub 2021 Jun 10.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Background: Schizophrenia is associated with an increased risk of death following stroke; however, the magnitude and underlying reasons for this are not well understood.

Objective: To determine the association between schizophrenia and stroke case fatality, adjusting for baseline characteristics, stroke severity and processes of care.

Design: Retrospective cohort study used linked clinical and administrative databases. Read More

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Obesity in acute ischaemic stroke patients treated with intravenous thrombolysis therapy.

Neurol Res 2021 Jun 10:1-8. Epub 2021 Jun 10.

The Departments of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University.

: This article aimed to analyze the relationship between obesity and the efficacy of acute ischaemic stroke patients treated with IVT.: Stroke causes morbidity and mortality in large numbers of individuals annually. Intravenous thrombolysis (IVT)with recombinant tissue plasminogen activator (r-tPA) is currently the only approved by the FDA for treatment of acute ischaemic stroke. Read More

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Successful treatment of acute spleno-porto-mesenteric vein thrombosis after ChAdOx1 nCoV-19 vaccine. A case report.

J Crit Care 2021 Jun 4;65:72-75. Epub 2021 Jun 4.

SC Anestesia e Rianimazione II, Ospedale San Carlo Borromeo, ASST Santi Paolo e Carlo - Polo Universitario, Milano, Italy.

Several cases of deep venous thrombosis in people who had recently received Vaxzevria (previously known as COVID-19 Vaccine AstraZeneca) have recently been reported, mainly presenting as cerebral vein/cerebral venous sinus thrombosis. This syndrome has been termed "vaccine-induced immune thrombotic thrombocytopenia (VITT)". Acute spleno-porto-mesenteric vein thrombosis is an uncommon but serious condition with potential sequelae, such as small-bowel gangrene and end-stage liver failure. Read More

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Interaction between thrombin potential and age on early clinical outcome in patients hospitalized for COVID-19.

J Thromb Thrombolysis 2021 Jun 10. Epub 2021 Jun 10.

Dipartimento Di Medicina Traslazionale, Università del Piemonte Orientale, Azienda Ospedaliero-Universitaria Maggiore Della Carità, Via Solaroli 17, 28100, Novara, NO, Italy.

Patients with Coronavirus Disease-2019 (COVID-19) have haemostatic dysfunction and are at higher risk of thrombotic complications. Although age is a major risk factor for outcome impairment in COVID-19, its impact on coagulative patterns here is still unclear. We investigated the association of Endogenous Thrombin Potential (ETP) with thrombotic and haemorrhagic events according to different ages in patients admitted for COVID-19. Read More

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Systolic blood pressure variability following endovascular thrombectomy and clinical outcome in acute ischemic stroke: A meta-analysis.

Acta Neurol Scand 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA.

Blood pressure variability (BPV) has been linked with the outcome of acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). However, the association of the stroke outcome with specific short-term BPV parameters is unclear. We did a systematic literature search for studies published from January 2010 to September 2020. Read More

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Successful Intravenous Thrombolysis and Endovascular Treatment for Acute Ischemic Stroke in a Patient Pretreated with Ticagrelor: A Case Report and Literature Review.

Clin Drug Investig 2021 Jun 9. Epub 2021 Jun 9.

Neurology Unit and Stroke Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124, Bari, Italy.

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An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke.

Sci Transl Med 2021 Jun;13(597)

Translational Research Institute of Brain and Brain-Like Intelligence and Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Tongji University School of Medicine, Shanghai 200434, China.

Studies have failed to translate more than 1000 experimental treatments from bench to bedside, leaving stroke as the second leading cause of death in the world. Thrombolysis within 4.5 hours is the recommended therapy for stroke and cannot be performed until neuroimaging is used to distinguish ischemic stroke from hemorrhagic stroke. Read More

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Low dose statins improve prognosis of ischemic stroke patients with intravenous thrombolysis.

BMC Neurol 2021 Jun 9;21(1):220. Epub 2021 Jun 9.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Background: For acute ischaemic stroke patients, it is uncertain whether intravenous thrombolysis combined with statins might increase the therapeutic effect. Additionally, using high-intensity statins after thrombolysis may increase the risk of bleeding in patients. Asian stroke patients often take low-dose statins. Read More

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Demographic Disparities in Proximity to Certified Stroke Care in the United States.

Stroke 2021 Jun 10:STROKEAHA121034493. Epub 2021 Jun 10.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO. (T.B., A.P.K.).

Background And Purpose: Demographic disparities in proximity to stroke care influence time to treatment and clinical outcome but remain understudied at the national level. This study quantifies the relationship between distance to the nearest certified stroke hospital and census-derived demographics.

Methods: This cross-sectional study included population data by census tract from the United States Census Bureau's 2014-2018 American Community Survey, stroke hospitals certified by a state or national body and providing intravenous thrombolysis, and geographic data from a public mapping service. Read More

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The risk factors of early hemorrhage after emergency intravenous thrombolysis in patients with acute ischemic stroke.

Ann Palliat Med 2021 May;10(5):5706-5713

Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, China.

Background: At present, the treatment of acute ischaemic stroke (AIS) by aticepase (rt-PA) in emergency veins has become the main treatment mode in hospital, but the research on early hemorrhage complications in patients with emergency thrombolysis is rarely reported. This research aims to study the earlier warning index of early hemorrhage complications in patients with emergency thrombolysis.

Methods: A retrospective analysis was performed on the clinical data of rt-PA intravenous thrombolysis-treated AIS patients in the advanced stroke center of the emergency department of a tertiary grade hospital from January 2018 to May 2020. Read More

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Efficacy and safety of integrated traditional Chinese medicine and standard Western medicine for patients with acute coronary syndrome: protocol for a systematic review and meta-analysis.

Ann Palliat Med 2021 May;10(5):5763-5766

Hunan University of Chinese Medicine, Changsha, China.

Background: Acute coronary syndrome (ACS), which usually results from the buildup of fatty deposits (plaques) in and on the walls of coronary arteries, remains a major cause of morbidity and mortality worldwide. In the present systematic review, we aim to evaluate the efficacy and safety of adding traditional Chinese medicine (TCM) to standard western medicine to treat patients with ACS.

Methods: A systematic search was carried out in the China National Knowledge Infrastructure (CNKI; Chinese), the Chinese Biomedical Literature Disk Database CBMdisc (Chinese), Wanfang Data (Chinese), PubMed, Embase, and Web of Science for relevant papers up to January 20, 2021. Read More

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Anesthetic Considerations for Endovascular Neurologic, Vascular, and Cardiac Procedures.

Adv Anesth 2020 Dec 18;38:63-95. Epub 2020 Sep 18.

Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22908, USA. Electronic address:

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December 2020

[Thrombolysis with Tenecteplase in a stroke with a long time window after onset of symptoms. Report of one case].

Rev Med Chil 2021 Jan;149(1):128-131

Facultad de Medicina Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.

We report a 78-year-old man with a basal Rankin score of 2 points, last seen 10 hours before in good conditions, who arrived at the emergency department with left hemiparesis, hypoesthesia, and spacial neglect. Neuroimaging was compatible with stroke in the territory of the right middle cerebral artery. Due to the evolution time of the stroke, usual thrombolysis was contraindicated. Read More

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January 2021

Shape anisotropic magnetic thrombolytic actuators: synthesis and systematic behavior study.

J Mater Chem B 2021 Jun 9. Epub 2021 Jun 9.

International Institute "Solution Chemistry of Advanced Materials and Technology", ITMO University, St. Petersburg 197101, Russia.

Thrombosis-related diseases are undoubtedly the deadliest disorders. During the last decades, numerous attempts were made to reduce the overall death rate and severe complications caused by treatment delays. Significant progress has been made in the development of nanostructured thrombolytics, especially magnetically controlled. Read More

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Thrombectomy for ischemic stroke with large vessel occlusion and concomitant subarachnoid hemorrhage.

J Thromb Thrombolysis 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology and Stroke Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

To report our experience in treating one patient with nontraumatic subarachnoid hemorrhage (SAH) and concurrent acute ischemic stroke (AIS) due to large vessels occlusion (LVO). A man in his 50 s presented with acute right hemiparesis and aphasia. Brain CT showed a SAH in the left central sulcus; CT-angiography revealed a tandem occlusion of the left internal carotid artery and homolateral middle cerebral artery. Read More

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Prothrombinase: the paradigm for membrane bound enzyme complexes; a memoir.

Authors:
Kenneth G Mann

J Thromb Thrombolysis 2021 Jun 8. Epub 2021 Jun 8.

Professor Emeritus, College of Medicine, University of Vermont, Burlington, VT, USA.

This review is a brief summary of the history of the development of the Prothrombinase complex paradigm and its incorporation into the "extrinsic pathway". It summarizes my laboratory's research from 1968 to 2012 and identifies many of the key players in these efforts. Read More

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Massive Pulmonary Embolism and Deep Vein Thrombosis in COVID-19 Pneumonia: Two Case Reports.

Cureus 2021 May 4;13(5):e14833. Epub 2021 May 4.

Diagnostic Radiology, St. Joseph Mercy Oakland Hospital, Pontiac, USA.

Coronavirus disease 2019 (COVID-19) is known to cause a severe acute respiratory syndrome with increased morbidity and mortality due to multiorgan involvement. COVID-19 is associated with an increased risk of venous thromboembolism (VTE), ranging from asymptomatic to potentially fatal presentations. Predictors of VTE in COVID-19 are not fully defined, and the role of anticoagulation in these patients is debatable. Read More

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Clinical profile and management of patients with acute pulmonary thromboembolism - a single centre, large observational study from India.

Pulm Circ 2021 Jan-Mar;11(1):2045894021992678. Epub 2021 Feb 16.

Department of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, India.

Acute pulmonary thromboembolism is associated with high mortality, similar to that of myocardial infarction and stroke. We studied the clinical presentation and management of pulmonary thromboembolism in the Indian population. An analysis of 140 patients who presented with acute pulmonary thromboembolism at a large volume center in India from June 2015 through December 2018 was performed. Read More

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February 2021

Pulmonary artery thromboembolism in a critically ill neonate successfully treated using thrombolytic therapy.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):215-219. Epub 2021 Feb 16.

Division of Pediatric Cardiology, Columbia University Medical Center, Morgan Stanley Children's Hospital of New York-Presbyterian, New York, NY, USA.

Pulmonary artery thromboembolism is a common and treatable cause of adult pulmonary hypertension. Although rare in children, if undiagnosed, it can result in significant morbidity and mortality. We report a case of a cyanotic neonate found to have bilateral pulmonary arterial thrombi who successfully underwent thrombolysis using tissue plasminogen activator with prompt resolution of right ventricular hypertension. Read More

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February 2021

Catheter-directed thrombolysis for in situ pulmonary artery thrombosis in children.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):211-214. Epub 2021 May 3.

Department of Pediatric Cardiac Critical Care Medicine, Sheba Medical Center, The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.

pulmonary artery thrombosis (ISPAT) is a unique form of pulmonary embolism characterized by local formation of thrombus in the pulmonary arteries. We present here a baby with hypoplastic left heart syndrome who developed ISPAT after Glenn surgery. The patient underwent catheter-directed thrombolysis, followed by systemic anticoagulation with excellent results. Read More

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Clinical imaging factors of excellent outcome after thrombolysis in large-vessel stroke: a THRACE subgroup analysis.

Stroke Vasc Neurol 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology-Stroke Unit, CIC-P 1433, INSERMU1116, Université de Lorraine, Nancy Regional University Hospital Center, Nancy, France

Background: For patients with stroke with large-vessel occlusion (LVO), study of factors predicting response to intravenous thrombolysis (IVT) would allow identifying subgroups with high expected gain, and those for whom it could be considered as futile, and even detrimental. From patients included in the Mechanical Thrombectomy After Intravenous Alteplase vs Alteplase Alone After Stroke trial, we investigated clinical-imaging factors associated with optimal response to IVT.

Methods: We included patients receiving IVT alone. Read More

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Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion.

J Stroke 2021 May 31;23(2):244-252. Epub 2021 May 31.

Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Background And Purpose: We aimed to develop a model predicting early recanalization after intravenous tissue plasminogen activator (t-PA) treatment in large-vessel occlusion.

Methods: Using data from two different multicenter prospective cohorts, we determined the factors associated with early recanalization immediately after t-PA in stroke patients with large-vessel occlusion, and developed and validated a prediction model for early recanalization. Clot volume was semiautomatically measured on thin-section computed tomography using software, and the degree of collaterals was determined using the Tan score. Read More

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