91,551 results match your criteria thromboembolic events

Continuum modeling of thrombus formation and growth under different shear rates.

J Biomech 2022 Jan 4;132:110915. Epub 2022 Jan 4.

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address:

Obstruction of blood flow due to thrombosis is a major cause of ischemic stroke, myocardial infarction, and in severe cases, mortality. In particular, in blood wetting medical devices, thrombosis is a common reason for failure. The prediction of thrombosis by understanding signaling pathways using computational models, lead to identify the risk of thrombus formation in blood-contacting devices and design improvements. Read More

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January 2022

Purification and characterization of a novel thermostable anticoagulant protein from medicinal leech Whitmania pigra Whitman.

J Ethnopharmacol 2022 Jan 12:114990. Epub 2022 Jan 12.

Department of Chinese Materia Medica and Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, 212013, PR China. Electronic address:

Ethnopharmacological Relevance: The prevalence of cardiovascular disease (CVD) is increasing worldwide. Despite significant improvements in novel targeted treatment agents, natural products purified from medicinal animals with minimal side effects have attracted much attention. Several native proteins explored from suck-blood leeches, such as non-thermostable hirudin and its variants, revealed potent anticoagulant activity. Read More

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January 2022

Recurrent hematuria and painful necrotic purpura induced by acquired Protein S deficiency associated with monoclonal immunoglobulin.

J Thromb Thrombolysis 2022 Jan 15. Epub 2022 Jan 15.

Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, No 37 Guoxue Alley, District Wuhou, Chengdu, 610041, Sichuan, China.

Protein S deficiency is associated with an increased risk of thromboembolism, which may be caused by hereditary deficiency and several physiological and pathologic conditions, such as pregnancy, contraceptive use, liver diseases, inflammatory disease, and certain viruses infections. However, monoclonal immunoglobulin-mediated Protein S deficiency is rarely reported. Here we described a 49-year-old woman with a history of recurrent painful swelling in both lower extremities due to venous thrombosis for 7 years, accompanied by recurrent gross hematuria and multiple painful necrotic purpuras for 5 years, who was then diagnosed with acquired Protein S deficiency induced by the monoclonal immunoglobulin. Read More

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January 2022

Influence of using recommended radiological criteria on MDCT-angiography diagnosis of single isolated subsegmental pulmonary embolism.

Eur Radiol 2022 Jan 15. Epub 2022 Jan 15.

Servei de Diagnòstic per la Imatge, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Universitat Autònoma de Barcelona, Parc Taulí 1, 08208, Sabadell, Barcelona, Spain.

Objectives: We assessed the rate of false-positive diagnoses of MDCT-pulmonary angiography (MDCT-A) in patients with single isolated subsegmental pulmonary embolism (SISSPE).

Methods: All patients who underwent MDCT-A between 2006 and 2017 for ruling out acute pulmonary embolism (PE) and received an initial diagnosis of SISSPE were included. The MDCT-A of these patients were reviewed retrospectively by four experienced thoracic radiologists, who applied radiological criteria recommended by the American College of Chest Physicians Antithrombotic Guidelines (ACCP 2016) for the diagnosis of SISSPE. Read More

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January 2022

Thromboembolism in children with multisystem inflammatory syndrome: a literature review.

Pediatr Res 2022 Jan 14. Epub 2022 Jan 14.

Division of Hematology, Department of Pediatrics, University of Texas Health Science Center at Houston, 7000 Fannin Street, Houston, TX, 77030, USA.

Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory response observed in children several weeks to months after acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). On review of all published cases of thromboembolism (TE) as a complication of MIS-C, 33 cases of TE were found with incidence ranging from 1.4 to 6. Read More

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January 2022

Crohn's disease in total knee arthroplasty patients correlates with increased rates of 90-day and overall postoperative complications and readmissions.

Knee 2022 Jan 11;34:238-245. Epub 2022 Jan 11.

Department of Orthopaedic Surgery and Rehabilitation Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY, USA. Electronic address:

Background: Joint involvement is a common extraintestinal manifestation of Crohn's Disease (CD) that may require total knee arthroplasty (TKA). There is a paucity of evidence regarding the relationship between CD and postoperative outcomes after TKA surgery. This study seeks to evaluate the impact of CD on 90-day and ≥2-year follow-up postoperative outcomes of TKA patients. Read More

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January 2022

Aspirin Is an Effective Prophylaxis for Venous Thromboembolism in Ambulatory Patients with Femoral Neck Fracture Undergoing Hip Arthroplasty.

J Bone Joint Surg Am 2022 Jan 14. Epub 2022 Jan 14.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Background: Although aspirin has been adopted as an effective and safe prophylaxis against venous thromboembolism (VTE) by the arthroplasty community, the role of aspirin in the prevention of VTE in the setting of arthroplasty for trauma remains insufficiently known. Therefore, the present multicenter study investigated the efficacy of aspirin as VTE prophylaxis for patients with femoral neck fracture undergoing total hip arthroplasty or hemiarthroplasty.

Methods: We reviewed the medical records of 1,141 patients with femoral neck fracture who underwent total hip arthroplasty or hemiarthroplasty from 2008 to 2018 at 3 different institutions. Read More

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January 2022

[Treatment of rheumatoid arthritis and spondylarthritis with biologics].

Christoph Fiehn

Internist (Berl) 2022 Jan 14. Epub 2022 Jan 14.

Rheumatologie Baden-Baden, Tätigkeitsschwerpunkt Klinische Immunologie und Belegarzteinheit Rheumatologie an den ViDia-Kliniken Karlsruhe, Beethovenstr. 2, 76530, Baden-Baden, Deutschland.

Biologics are an integral part of modern strategies for treatment of rheumatoid arthritis (RA) and spondylarthritis (SpA), including psoriatic arthritis (PsA). Biologics are biotechnologically produced proteins that have inhibiting effects on humoral and cellular components of rheumatic inflammation. Substance classes used in rheumatology are tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, IL‑6, IL-12, IL-17 and IL-23 inhibitors effective against cytokines as well as the T lymphocyte activation inhibitor abatacept and the B lymphocyte-depleting rituximab. Read More

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January 2022

Association of Hormonal Contraceptive Use With Adverse Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials and Cohort Studies.

JAMA Netw Open 2022 Jan 4;5(1):e2143730. Epub 2022 Jan 4.

Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City.

Importance: Meta-analyses have reported conflicting data on the safety of hormonal contraception, but the quality of evidence for the associations between hormonal contraceptive use and adverse health outcomes has not been quantified in aggregate.

Objective: To grade the evidence from meta-analyses of randomized clinical trials (RCTs) and cohort studies that assessed the associations between hormonal contraceptive use and adverse health outcomes among women.

Data Sources: MEDLINE, Embase, and the Cochrane Database of Systematic Reviews were searched from database inception to August 2020. Read More

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January 2022

Timing of Resumption of Anticoagulation After Polypectomy and Frequency of Post-procedural Complications: A Post-hoc Analysis.

Dig Dis Sci 2022 Jan 14. Epub 2022 Jan 14.

Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Health Discovery Building, 1601 Trinity Street, Building B, Austin, TX, 78712, USA.

Background: Optimal timing for anticoagulation resumption after polypectomy is unclear. We explored the association between timing of anticoagulation resumption and occurrence of delayed post-polypectomy bleeding (PPB) and thromboembolic (TE) events.

Methods: We performed a post-hoc analysis of patients in an earlier study whose anticoagulants were interrupted for polypectomy. Read More

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January 2022

Role of von Willebrand factor in venous thromboembolic disease.

JVS Vasc Sci 2022 7;3:17-29. Epub 2021 Oct 7.

Division of Cardiovascular Surgery, Queen's University, Kingston Health Sciences Centre, Kingston, Ontario, Canada.

Objective: Evolving evidence of the shared risk factors and pathogenic mechanisms in arterial and venous thrombosis questions of the strict vascular dichotomy of arterial vs venous. The connection between arterial and venous thrombosis has been highlighted by common underlying inflammatory processes, a concept known as thromboinflammatory disease. Using this relationship, we can apply knowledge from arterial disease to better understand and potentially mitigate venous disease. Read More

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October 2021

Evaluation of the Khorana score for prediction of venous thromboembolism in patients with multiple myeloma.

Res Pract Thromb Haemost 2022 Jan 9;6(1):e12634. Epub 2022 Jan 9.

Washington University School of Medicine in St. Louis St. Louis Missouri USA.

Background: Guidelines recommend thromboprophylaxis for patients with multiple myeloma (MM) at high risk for venous thromboembolism (VTE). However, the optimal risk prediction model for VTE in MM remains unclear. Khorana et al developed a VTE risk score (Khorana score) in ambulatory cancer patients receiving chemotherapy. Read More

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January 2022

Serpentine Thrombus in Right Atrium: A Tell-Tale Sign of Venous Thromboembolism.

Cureus 2021 Dec 10;13(12):e20336. Epub 2021 Dec 10.

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be university), Wardha, IND.

Pulmonary embolism is linked with a remarkable rate of mortality, particularly when it is associated with hemodynamic instability, right atrial thrombus and related right ventricular dysfunction. In patients affected with pulmonary embolism, thrombolysis has been documented to be life-saving. The administration of thrombolytic agents ensures early resolution of the thrombus and prevents arrhythmia and cardiogenic shock. Read More

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December 2021

Pulmonary artery sarcoma: An important mimic of pulmonary embolism-Case reports and literature review.

Respirol Case Rep 2022 Feb 9;10(2):e0897. Epub 2022 Jan 9.

Respiratory and Sleep Medicine Department St George Hospital Sydney New South Wales Australia.

Pulmonary artery intimal sarcoma (PAIS) is a rare malignancy which closely mimics acute or chronic pulmonary thromboembolism. There are clinical and radiological characteristics which may raise suspicion of this important differential diagnosis. These include disproportionately low d-dimer, troponin T or NT-proBNP, as well as characteristic findings on CT pulmonary angiography such as the 'wall eclipsing sign' and an non-dependent position of filling defects in the large arteries. Read More

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February 2022

Assessment of knowledge and practice of venous thromboembolism (VTE) prophylaxis after cesarean section among gynecologists and obstetricians in Al-Najaf hospitals.

J Med Life 2021 Sep-Oct;14(5):690-694

Faculty of Dentistry, University of Kufa, Al Najaf, Iraq.

Venous Thromboembolism (VTE) is associated with high morbidity and mortality rates after cesarean sections. VTE is likely four-time greater following cesarean section than normal vaginal delivery. Despite a large number of published studies and the availability of well-evidenced guideline recommendations for VTE prevention, it is evident that these guidelines are poorly implemented with suboptimal use of a prophylactic thrombotic agent. Read More

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Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium.

Nat Rev Cardiol 2022 Jan 13. Epub 2022 Jan 13.

Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and thromboembolic events, owing to excessive inflammation, endothelial cell activation and injury, platelet activation and hypercoagulability. Patients with COVID-19 have a prothrombotic or thrombophilic state, with elevations in the levels of several biomarkers of thrombosis, which are associated with disease severity and prognosis. Although some biomarkers of COVID-19-associated coagulopathy, including high levels of fibrinogen and D-dimer, were recognized early during the pandemic, many new biomarkers of thrombotic risk in COVID-19 have emerged. Read More

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January 2022

Development and validation of a prediction model to estimate risk of acute pulmonary embolism in deep vein thrombosis patients.

Sci Rep 2022 Jan 13;12(1):649. Epub 2022 Jan 13.

Department of Peripheral Vascular Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, Yanta West Road, Xi'an, 710061, Shaanxi, China.

Venous thromboembolism (VTE), clinically presenting as deep vein thrombosis (DVT) or pulmonary embolism (PE). Not all DVT patients carry the same risk of developing acute pulmonary embolism (APE). To develop and validate a prediction model to estimate risk of APE in DVT patients combined with past medical history, clinical symptoms, physical signs, and the sign of the electrocardiogram. Read More

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January 2022

Coagulome and the tumor microenvironment: an actionable interplay.

Trends Cancer 2022 Jan 10. Epub 2022 Jan 10.

Laboratoire de Biochimie, Centre de Biologie Humaine, CHU Sud, Amiens, France; UR7516 'CHIMERE', Université de Picardie Jules Verne, Amiens, France.

Human tumors often trigger a hypercoagulable state that promotes hemostatic complications, including venous thromboembolism. The recent application of systems biology to the study of the coagulome highlighted its link to shaping the tumor microenvironment (TME), both within and outside of the vascular space. Addressing this link provides the opportunity to revisit the significance of biomarkers of hemostasis and assess the communication between vasculature and tumor parenchyma, an important topic considering the advent of immune checkpoint inhibitors and vascular normalization strategies. Read More

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January 2022

Successful Secondary Endovascular Intervention in Pediatric Patients with Venous Thromboembolic Events.

Hamostaseologie 2022 Jan 13. Epub 2022 Jan 13.

Department of Congenital Heart Defects and Pediatric Cardiology, Faculty of Medicine, University Heart Center Freiburg - Bad Krozingen, University of Freiburg, Freiburg im Breisgau, Germany.

Background:  In the past, pediatric patients with venous thromboembolic events (VTE) were treated with low-molecular-weight heparin (LMWH) which was successful in around 70% of the cases. However, anticoagulation alone might not restore patency in all patients, and advanced therapeutic options to prevent postthrombotic syndrome are needed. During recent years, endovascular interventions have become a treatment option for pediatric patients with persistent thrombotic occlusion, not only in life- or limb-threatening VTE. Read More

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January 2022

Clinical and genetic features of Chinese pediatric patients with severe congenital protein C deficiency who first presented with purpura fulminans: A case series study and literature review.

Thromb Res 2022 Jan 3;210:70-77. Epub 2022 Jan 3.

Department of Hematology and Oncology, Children's Hospital of Chongqing Medical University, Chongqing, China; National Clinical Research Center for Child Health and Disorders, Chongqing, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China; Chongqing Key Laboratory of Pediatrics, Chongqing, China. Electronic address:

Introduction: Purpura fulminans (PF) is a hematological emergency that can be caused by severe congenital protein C (PC) deficiency. It has been rarely reported in the Chinese population. We aimed to characterize the clinical and genetic features of Chinese pediatric patients with severe congenital PC deficiency who first presented with PF. Read More

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January 2022

Aspirin Administered for Venous Thromboembolism Prophylaxis May Protect Against Stiffness Following Total Knee Arthroplasty.

J Arthroplasty 2022 Jan 10. Epub 2022 Jan 10.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA. Electronic address:

Background: Aspirin has become the main agent for venous thromboembolism (VTE) prophylaxis following total knee arthroplasty (TKA). This study assesed whether aspirin is associated with less knee stiffness compared to warfarin and other chemoprophylaxis agents.

Methods: This was a retrospective review of all primary and revision TKA performed between January 2009 and October 2020 at a high volume institution. Read More

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January 2022

Short stay laparoscopic hysterectomy: An evaluation of feasibility and patient satisfaction.

Facts Views Vis Obgyn 2021 Dec;13(4):377-385

Background: Short-stay total laparoscopic hysterectomy (TLH) could lead to reduced hospital costs and decrease complications associated with hospitalisation such as hospital acquired-infection and venous thromboembolism.

Objective: To evaluate the feasibility, safety and patient satisfaction of a novel short 'less than 23-hour' stay TLH protocol.

Material And Methods: Prospective cohort study, at Birmingham Women's Hospital, United Kingdom including eligible women undergoing TLH for benign indications or early stage cervical/endometrial cancer. Read More

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December 2021

Digoxin use and clinical outcomes in elderly Chinese patients with atrial fibrillation: a report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry.

Europace 2022 Jan 13. Epub 2022 Jan 13.

Department of Pulmonary Vessel and Thrombotic Disease, Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100142, China.

Aims: Prior studies have reported conflicting results on digoxin's impact on clinical outcomes and quality of life, and there are limited data from Asia. The aim of this study is to evaluate the use of digoxin and its impact on clinical outcomes and quality of life in a high-risk cohort of elderly Chinese atrial fibrillation (AF) patients.

Methods And Results: The Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry is a prospective, multicentre nationwide study conducted from October 2014 to December 2018. Read More

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January 2022

Central Retinal Vein Occlusion Following BNT162b2 (Pfizer-BioNTech) COVID-19 Messenger RNA Vaccine.

Retin Cases Brief Rep 2021 Dec 1. Epub 2021 Dec 1.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.

Purpose: Coronavirus disease 2019 (COVID-19) has had a wide-ranging public health impact, contributing to at least 5 million deaths globally at the time of this report. Although thromboembolic events following COVID-19 vaccination have been an ongoing concern, only a limited number of ophthalmic manifestations have been reported to date.

Methods: We obtained a detailed history, hypercoagulable workup, best-corrected visual acuity (BCVA), Humphrey visual field (HVF), dilated fundus exam (DFE), and multimodal imaging including optical coherence tomography (OCT), fundus fluorescein angiography (FFA), and fundus photography. Read More

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December 2021

Cancer Chemotherapy-Induced Sinus Bradycardia: A Narrative Review of a Forgotten Adverse Effect of Cardiotoxicity.

Drug Saf 2022 Jan 13. Epub 2022 Jan 13.

Department of Pharmacology, School of Medicine, Universidad Complutense, Institute of Health Gregorio Marañón, CIBERCV, 28040, Madrid, Spain.

Cardiotoxicity is a common adverse effect of anticancer drugs (ACDs), including the so-called targeted drugs, and increases morbidity and mortality in patients with cancer. Attention has focused mainly on ACD-induced heart failure, myocardial ischemia, hypertension, thromboembolism, QT prolongation, and tachyarrhythmias. Yet, although an increasing number of ACDs can produce sinus bradycardia (SB), this proarrhythmic effect remains an underappreciated complication, probably because of its low incidence and severity since most patients are asymptomatic. Read More

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January 2022

A Case of Complex Pulmonary Hypertension: the Importance of Diagnostic Investigation.

Clin Med Insights Circ Respir Pulm Med 2022 8;16:11795484211073292. Epub 2022 Jan 8.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran - Hasan Sadikin General Hospital, Bandung, Indonesia.

Pulmonary hypertension (PH) encompasses several heterogeneous groups of multiple diseases characterized by abnormal pulmonary arterial blood pressure elevation. Unrepaired atrial septal defect (ASD) may be associated with pulmonary arterial hypertension (PAH), indicating pulmonary vascular remodeling. Furthermore, unrepaired ASD could also be associated with other conditions, such as left heart disease or thromboembolism, contributing to the disease progression. Read More

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January 2022

Antithrombotic therapy for secondary prevention of unprovoked venous thromboembolism: a systematic review and network meta-analysis of randomized controlled trials.

Ann Med 2022 Dec;54(1):253-261

Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Extended antithrombotic treatment is recommended for secondary prevention of unprovoked venous thromboembolism (VTE), however, there is no consensus on which antithrombotic strategy is preferable.

Aim: To compare the efficacy and safety of different antithrombotic strategies for secondary prevention unprovoked VTE.

Methods: Cochrane Central Register of Controlled Trials, Embase, and MEDLINE were systematically searched from inception to 22 July 2020 for randomized controlled trials (RCTs) that compared the efficacy and/or safety of extended antithrombotic strategies including aspirin, warfarin and direct oral anticoagulants (DOACs) for secondary prevention of unprovoked VTE. Read More

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December 2022

Validation and characterization of venous thromboembolism diagnoses in the Swedish National Patient Register among patients with rheumatoid arthritis.

Scand J Rheumatol 2022 Jan 13:1-7. Epub 2022 Jan 13.

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Objective: To assess the validity of venous thromboembolism (VTE) diagnoses registered in the Swedish National Patient Register (NPR) in patients with rheumatoid arthritis (RA).

Method: We performed a validation study using manual chart reviews to validate ICD-10 codes for VTE from the NPR. We took a random sample of 269 VTE events registered at hospitals in Region Stockholm from 2009 to 2018 in patients with RA. Read More

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January 2022

Factor XI as a target for preventing venous thromboembolism.

David Gailani

J Thromb Haemost 2022 Jan 12. Epub 2022 Jan 12.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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January 2022