1,897 results match your criteria three-way interaction


Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.

PLoS One 2021 26;16(7):e0254776. Epub 2021 Jul 26.

Institute of Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia, United States of America.

Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships between the impaired white matter and glutamic acid decarboxylase (GAD) polymorphisms. This work explored the two-way and three-way interactions between GAD1a (SNP: rs1978340) and GAD1b (SNP: rs769390) polymorphisms and years of cocaine use (YCU). Read More

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Distinct progression patterns across Parkinson disease clinical subtypes.

Ann Clin Transl Neurol 2021 Jul 26. Epub 2021 Jul 26.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

Objective: To examine specific symptom progression patterns and possible disease staging in Parkinson disease clinical subtypes.

Methods: We recently identified Parkinson disease clinical subtypes based on comprehensive behavioral evaluations, "Motor Only," "Psychiatric & Motor," and "Cognitive & Motor," which differed in dementia and mortality rates. Parkinson disease participants ("Motor Only": n = 61, "Psychiatric & Motor": n = 17, "Cognitive & Motor": n = 70) and controls (n = 55) completed longitudinal, comprehensive motor, cognitive, and psychiatric evaluations (average follow-up = 4. Read More

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A cross-cultural exploratory analysis of pandemic growth: The case of COVID-19.

J Int Bus Stud 2021 Jul 21:1-22. Epub 2021 Jul 21.

Department of Management Programs, College of Business, Florida Atlantic University, Boca Raton, FL 33431 USA.

Although the novel coronavirus that has resulted in more than 3 million deaths and 140 million cases of infection worldwide has wreaked havoc globally, some nations were more successful than others in curbing growth in their number of cases, thereby saving lives. In this research note, we integrate insights from cross-cultural research with inquiry in social psychology and public health literatures to advance a theoretically grounded and culturally derived explanation of cross-national variance in the growth rate of COVID-19. Our multi-level analyses, based on longitudinal time series data from 107 nations, and focused on the first 91 days of this pandemic in different nations, illustrate the direct and interactive effects of culture. Read More

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Intranasal oxytocin, testosterone reactivity, and human competitiveness.

Psychoneuroendocrinology 2021 Jul 9;132:105352. Epub 2021 Jul 9.

Psychology Department, The Hebrew University of Jerusalem, Mount Scopus Campus, Mt. Scopus, Jerusalem 9190501, Israel. Electronic address:

Competitiveness is an essential feature of human social interactions. Despite an extensive body of research on the underlying psychological and cultural factors regulating competitive behavior, the role of biological factors remains poorly understood. Extant research has focused primarily on sex hormones, with equivocal findings. Read More

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Theoretical analysis and finite element simulation of pipeline structure in liquefied soil.

Heliyon 2021 Jul 6;7(7):e07480. Epub 2021 Jul 6.

MOE Key Laboratory of Disaster Forecast and Control in Engineering, School of Mechanics and Construction Engineering, Jinan University, Guangzhou, China.

A mechanical analysis model for the floating of buried pipelines in soil liquefaction areas is established in this paper. In order to improve the inherent defects of the elastic foundation beam method based on the Winkler model and increase the calculation accuracy, the Pasternak model is introduced and the interaction between soil and spring is considered. A mechanical analysis method for buried pipelines in liquefaction zone considering axial load is proposed in present paper. Read More

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Isolation and identification of Arbutus unedo L. fungi endophytes and biological control of Phytophthora cinnamomi in vitro.

Protoplasma 2021 Jul 19. Epub 2021 Jul 19.

Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.

Strawberry tree (Arbutus unedo, Ericaceae) is an evergreen tree with a circum-Mediterranean distribution. It has a great ecological and economic importance as a source of bioactive compounds with industrial applications and for fruit production. This study aims to characterize the fungi microbiome of this forestry species in order to develop biological control strategies in the increasing orchard production area. Read More

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Direct and Stress-Buffering Effects of COVID-19-Related Changes in Exercise Activity on the Well-Being of German Sport Students.

Int J Environ Res Public Health 2021 Jul 2;18(13). Epub 2021 Jul 2.

Institute of Sports and Sports Sciences, Heidelberg University, 69120 Heidelberg, Germany.

Maintaining or initiating exercise activity in the COVID-19 pandemic may act as a buffer against the observed stress-related deterioration in well-being, with emotion regulation (ER) discussed as a possible moderator. Therefore, the present study investigated the interaction between stress, exercise activity (EA), and ER on mood. In an online survey, 366 German sports science students (56% women, = 23. Read More

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Validation of a Motor Competence Assessment Tool for Children and Adolescents (KTK3+) With Normative Values for 6- to 19-Year-Olds.

Front Physiol 2021 23;12:652952. Epub 2021 Jun 23.

Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium.

The use of the short form of the Körperkoordinationstest für Kinder (KTK3) to evaluate children's and adolescents' motor competence (MC) is increasing. When combined with an alternating one-handed catching and throwing ball task, assessing eye-hand coordination (EHC), it has been shown that the different aspects of motor skills are adequately covered in one compact KTK3+ test battery, studied in 6- to 10-year-old children. The present study aimed to validate the KTK3+ test battery and to provide contemporary MC normative values for boys and girls from 6- to 19-year-olds. Read More

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Reduced Emotional Awareness and Distress Concealment: A Pathway to Loneliness for Young Men Seeking Mental Health Care.

Front Psychol 2021 21;12:679639. Epub 2021 Jun 21.

White Rock/South Surrey Mental Health & Substance Use Services, Fraser Health Authority, Surrey, BC, Canada.

: Loneliness, the painful affective state that reflects perceived deficits in social relationships, is a significant health issue requiring further understanding. Individual differences in awareness and disclosure of emotional concerns may contribute to loneliness, and may do so diversely according to gender and age. The present study examined a hypothesized mediation pathway from emotional awareness abilities to loneliness through distress concealment, with moderation by gender and age, in a sample of adults attending outpatient mental health services. Read More

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Unmitigated Surgical Castration in Calves of Different Ages: Electroencephalographic and Neurohormonal Findings.

Animals (Basel) 2021 Jun 15;11(6). Epub 2021 Jun 15.

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.

Castration is a common management procedure employed in North American cattle production and is known to cause a pain response. The present study was designed to investigate the effect of unmitigated surgical castration on the electroencephalography (EEG) responses and plasma substance P (SP) concentrations in calves of different ages under the same experimental conditions. Thirty male Holstein calves in three age categories [<6 weeks (6W); 3 months (3M); 6 months (6M); 10 calves per age group] were used in the study. Read More

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Unilateral, bilateral, and alternating muscle actions elicit similar muscular responses during low load blood flow restriction exercise.

Eur J Appl Physiol 2021 Jun 30. Epub 2021 Jun 30.

Applied Human Health and Physical Function Laboratory, Department of Health, Exercise Science, Recreation and Sports Management, The University of Mississippi, 642 All-American Dr, 211-Turner Center, University, MS, 38677, USA.

Purpose: Compare acute muscular responses to unilateral, bilateral, and alternating blood flow restriction (BFR) exercise.

Methods: Maximal strength was tested on visit one. On visits 2-4, 2-10 days apart, 19 participants completed 4 sets of knee extensions (30% one-repetition maximum) with BFR (40% arterial occlusion pressure) to momentary failure (inability to lift load) using each muscle action (counterbalanced order). Read More

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Steeling or sensitizing? A longitudinal examination of how ongoing accumulation of negative life events affects depressive symptoms in older adults.

J Gerontol B Psychol Sci Soc Sci 2021 Jun 25. Epub 2021 Jun 25.

Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam UMC - Location VU University Medical Center, Amsterdam, The Netherlands.

Objectives: To examine whether: 1) as people age, accumulation of negative events increases ('sensitizing') or decreases ('steeling') the detrimental effects of subsequent events on depressive symptoms, and 2) how particular psychosocial factors are associated with the strength of these steeling or sensitizing effects.

Method: We used data from six measurement waves from 2,069 adults aged 55-84 (M=68.0) at baseline in the Longitudinal Aging Study Amsterdam, the Netherlands. Read More

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Motor dual task with eyes closed improves postural control in patients with functional motor disorders: A posturographic study.

Gait Posture 2021 Jul 11;88:286-291. Epub 2021 Jun 11.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Electronic address:

Background: Functional motor disorders (FMD) are highly disabling neurological conditions in which postural control deficits increase the risk of falls and disability in performing daily living activities. Scattered evidence suggests that such disturbances may depend on abnormal attentional focus and might improve with distraction.

Research Question: How do motor and cognitive dual tasks performed under two different sensory conditions shape postural control in patients with FMD. Read More

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An evolution-based high-fidelity method of epistasis measurement: Theory and application to influenza.

PLoS Pathog 2021 Jun 21;17(6):e1009669. Epub 2021 Jun 21.

Sorbonne Université, Institute de Biologie Paris-Seine, Laboratoire de Biologie Computationelle et Quantitative LCQB, Paris, France.

Linkage effects in a multi-locus population strongly influence its evolution. The models based on the traveling wave approach enable us to predict the average speed of evolution and the statistics of phylogeny. However, predicting statistically the evolution of specific sites and pairs of sites in the multi-locus context remains a mathematical challenge. Read More

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Viewing time and facial trustworthiness perception: Giving it a second thought may not work for older adults.

Psych J 2021 Jun 16. Epub 2021 Jun 16.

School of Psychological and Cognitive Sciences, Peking University, Beijing, China.

Older adults tend to rate unfamiliar faces higher on trustworthiness than do their younger counterparts. Although the saying goes "look before you leap", it is still unknown whether such a strategy could also apply to facial trustworthiness perception, and our understanding of the time course in facial trustworthiness perception also remains unclear. Here, we have argued that a cognitive controlled process suggested by "socioemotional selectivity theory" could potentially lead to such biased trustworthiness perception. Read More

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Overweight and Obesity and Progression of ADPKD.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):908-915. Epub 2021 Jun 11.

University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Background And Objectives: On the basis of earlier observations, we evaluated the association between overweight and obesity and rapid progression of autosomal dominant polycystic kidney disease in participants in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO) 3:4 trial. More importantly, we also determined whether efficacy of tolvaptan was attenuated in individuals with baseline overweight or obesity.

Design, Setting, Participants, & Measurements: A total of 1312 study participants with relatively early-stage autosomal dominant polycystic kidney disease (mean eGFR 78±22 ml/min per 1. Read More

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Variance components of ratings of physician-patient communication: A generalizability theory analysis.

PLoS One 2021 10;16(6):e0252968. Epub 2021 Jun 10.

Department of Research Methods, Freiburg University of Education, Freiburg, Germany.

Background: The ratings of physician-patient communication are an important indicator of the quality of health care delivery and provide guidance for many important decisions in the health care setting and in health research. But there is no gold standard to assess physician-patient communication. Thus, depending on the specific measurement condition, multiple sources of variance may contribute to the total score variance of ratings of physician-patient communication. Read More

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Individual differences in the associations between risk factors for alcohol use disorder and alcohol use-related outcomes.

Psychol Addict Behav 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychiatry.

Background: Family history of alcohol use disorder; AUD (FH +) and impulsivity-related traits are known risk factors for problem drinking that have been investigated in predominately White samples. This cross-sectional study examined whether these risk factors vary by sex in the overall, majority White sample and in a Black subsample.

Method: A model building regression procedure was used to investigate the combined effect of FH + and impulsivity-related traits on alcohol quantity, frequency, and problems by sex (overall sample: = 757, 50% female, 73% White, age = 33. Read More

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Online digital storytelling video on promoting men's intentions to seek counselling for depression: The role of empathy.

Int J Soc Psychiatry 2021 Jun 4:207640211023532. Epub 2021 Jun 4.

Department of Social Welfare, University of California Los Angeles, Los Angeles, CA, USA.

Background: Applying the narrative transportation theory, we sought to test the role of a male-sensitive digital storytelling video as a source to persuade men to develop greater intentions to seek counselling based on their empathic reactions to the storyteller.

Methods: Using a post-test only design, a total of 247 diverse adult men ( = 35.86,  = 12. Read More

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Mistreatment from Multiple Sources: Interaction Effects of Abusive Supervision, Coworker Incivility, and Customer Incivility on Work Outcomes.

Int J Environ Res Public Health 2021 05 18;18(10). Epub 2021 May 18.

College of Business, Chosun University, 309 Pilmundae-ro, Dong-gu, Gwangju 61452, Korea.

Despite the large body of research on workplace mistreatment, surprisingly few studies have examined the interaction effect of multiple interpersonal stressors on employee outcomes. To fill this gap, our research aimed to test the moderating effects of coworker incivility and customer incivility on the relationship between abusive supervision, emotional exhaustion, and job performance. Analyses conducted on 651 South Korean frontline service employees revealed that abusive supervision exerted a significant indirect effect on job performance through emotional exhaustion. Read More

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Effect of Neck Strength on Simulated Head Impacts During Falls in Female Ice Hockey Players.

Int J Exerc Sci 2021 1;14(1):446-461. Epub 2021 Apr 1.

School of Kinesiology, Lakehead University, Thunder Bay, ON, CANADA.

This study examined the effect of isometric cervical strength and impact location of the hockey helmet in mitigating the risk of concussions for two different mechanisms of injury from a fall during head impact simulation testing. Isometric cervical strength was measured on 25 female hockey players to compute and model neck strength on a mechanical neckform. A dual-rail vertical drop system with a helmet mounted on a surrogate headform simulated the mechanisms of injury causing concussions on female ice hockey players. Read More

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Retention and Transmission of Grapevine Leafroll-Associated Virus 3 by .

Front Microbiol 2021 12;12:663948. Epub 2021 May 12.

The New Zealand Institute for Plant and Food Research Limited (PFR), Auckland, New Zealand.

Grapevine leafroll-associated virus 3 (GLRaV-3), an economically significant pathogen of grapevines, is transmitted by , a mealybug commonly found in New Zealand vineyards. To help inform alternative GLRaV-3 control strategies, this study evaluated the three-way interaction between the mealybug, its plant host and the virus. The retention and transmission of GLRaV-3 by after access to non- host plants (and a non-GLRaV-3 host) White clover ( L. Read More

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Self in the Service: Self-Identification Moderates the Association between Perceived Drinking Norms and Own Drinking among Veterans.

Subst Use Misuse 2021 26;56(10):1428-1438. Epub 2021 May 26.

RAND Corporation, Santa Monica, California, USA.

Purpose: Drinking is common among young adult veterans. Previous research has established that veterans' drinking is more strongly associated with veteran versus civilian drinking norms. The present research extends these findings by examining the influence of self-identification both with other veterans and with civilians as moderators of the association between perceived norms and drinking. Read More

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The effects of media narratives about failures and discoveries in science on beliefs about and support for science.

Public Underst Sci 2021 May 17:9636625211012630. Epub 2021 May 17.

University of Pennsylvania, USA.

This study examines the effects of exposure to media narratives about science on perceptions pertaining to the reliability of science, including trust, beliefs, and support for science. In an experiment ( = 4497), participants were randomly assigned to read stories representing ecologically valid media narratives: the honorable quest, counterfeit quest, crisis or broken, and problem explored. Exposure to stories highlighting problems reduced trust in scientists and induced negative beliefs about scientists, with more extensive effects among those exposed to the "crisis/broken" accounts and fewer for those exposed to "counterfeit" and "problem explored" stories. Read More

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Ventral Striatal Activation During Reward Anticipation of Different Reward Probabilities in Adolescents and Adults.

Front Hum Neurosci 2021 20;15:649724. Epub 2021 Apr 20.

Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Adolescence has been linked to an enhanced tolerance of uncertainty and risky behavior and is possibly connected to an increased response toward rewards. However, previous research has produced inconsistent findings. To investigate whether these findings are due to different reward probabilities used in the experimental design, we extended a monetary incentive delay (MID) task by including three different reward probabilities. Read More

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No Relevant Pharmacokinetic Drug-Drug Interaction Between the Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin and Lobeglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, in Healthy Subjects.

Drug Des Devel Ther 2021 28;15:1725-1734. Epub 2021 Apr 28.

Department of Clinical Pharmacology and Therapeutics, Chungbuk National University College of Medicine and Hospital, Cheongju, Republic of Korea.

Purpose: Combination therapy with insulin-independent sodium-glucose cotransporter 2 inhibitors and thiazolidinedione drugs, such as lobeglitazone, has been reported to elicit potential additive efficacy in glycemic control in type 2 diabetes mellitus. This study was conducted to evaluate the pharmacokinetic (PK) drug-drug interactions between empagliflozin and lobeglitazone in healthy subjects.

Subjects And Methods: A randomized, open-label, multiple-dose study was conducted in 30 healthy subjects using a three-treatment, six-sequence, three-way crossover design. Read More

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Effects of Perturbation Velocity, Direction, Background Muscle Activation, and Task Instruction on Long-Latency Responses Measured From Forearm Muscles.

Front Hum Neurosci 2021 16;15:639773. Epub 2021 Apr 16.

Human Robotics Laboratory, Department of Biomedical Engineering, University of Delaware, Newark, DE, United States.

The central nervous system uses feedback processes that occur at multiple time scales to control interactions with the environment. The long-latency response (LLR) is the fastest process that directly involves cortical areas, with a motoneuron response measurable 50 ms following an imposed limb displacement. Several behavioral factors concerning perturbation mechanics and the active role of muscles prior or during the perturbation can modulate the long-latency response amplitude (LLRa) in the upper limbs, but the interactions among many of these factors had not been systematically studied before. Read More

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Quantifying supraspinatus tendon responses to exposures emulative of human physiological levels in an animal model.

J Biomech 2021 06 25;122:110476. Epub 2021 Apr 25.

Department of Kinesiology, University of Waterloo, Waterloo Canada. Electronic address:

Rotator cuff pathology typically originates in the supraspinatus tendon, but uncertainty exists on how combinations of glenohumeral elevation angle and load intensity influence responses of the intact, functional supraspinatus unit. This study exposed the supraspinatus tendon to mechanical loading scenarios emulative of derived muscle force and postural conditions measured in vivo to document its responses. Right shoulders from 48 Sprague-Dawley rats were placed into one of eight testing groups combining glenohumeral elevation angles (0/30/60/75°) and a high or low load intensity for 1500 cycles at 0. Read More

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