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Novel photosensitive dual-anisotropic conductive Janus film endued with magnetic-luminescent properties and derivative 3D structures.

J Colloid Interface Sci 2021 May 26;601:899-914. Epub 2021 May 26.

Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties. Read More

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The impact of school exclusion zone planning guidance on the number and type of food outlets in an English local authority: A longitudinal analysis.

Health Place 2021 Jun 9;70:102600. Epub 2021 Jun 9.

Professor of Public Health Nutrition, Teesside University SHLS Allied Health Professions, Centre for Public Health, UK. Electronic address:

The use of planning policy to manage and create a healthy food environment has become a popular policy tool for local governments in England. To date there has been no evaluation of their short-term impact on the built environment. We assess if planning guidance restricting new fast food outlets within 400 m of a secondary school, influences the food environment in the local authority of Newcastle Upon Tyne, UK. Read More

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Is a cloud-based platform useful for diabetes management in Colombia? The Tidepool experience.

Comput Methods Programs Biomed 2021 May 27;208:106205. Epub 2021 May 27.

Hospital Universitario San Ignacio, Carrera 7 No 40 - 62, Bogotá, Colombia.

Background: There are several medical devices used in Colombia for diabetes management, most of which have an associated telemedicine platform to access the data. In this work, we present the results of a pilot study evaluating the use of the Tidepool telemedicine platform for providing remote diabetes health services in Colombia across multiple devices.

Method: Individuals with Type 1 and Type 2 diabetes using multiple diabetes devices were recruited to evaluate the user experience with Tidepool over three months. Read More

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Clinical and epidemiological features of patients colonized by different types of carbapenemase-producing Enterobacterales.

J Glob Antimicrob Resist 2021 Jun 9. Epub 2021 Jun 9.

Clinical Microbiology Laboratory, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Objectives: To compare the epidemiological and clinical characteristics of hospitalized patients colonized or infected with different types of carbapenemase-producing Enterobacterales (CPE) and to analyze the differences in their outcome.

Methods: A retrospective, comparative study of all patients colonized or infected by KPC-, NDM- or OXA-48 CPE that were hospitalized between 01/01/2018 and 30/06/2019. Microbiological, demographic and clinical data was collected from the patient's computerized files. Read More

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Combining tunable proteolytic sequences and a VEGF-mimetic peptide for the spatiotemporal control of angiogenesis within Elastin-Like Recombinamer scaffolds.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

G.I.R. BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, Edificio LUCIA, Universidad de Valladolid, Paseo Belén 19, 47011 Valladolid, Spain. Electronic address:

One of the main challenges in regenerative medicine is the spatiotemporal control of angiogenesis, which is key for the successful repair of many tissues, and determines the proper integration of the implant through the generation of a functional vascular network. To this end, we have designed a three-dimensional (3D) model consisting of a coaxial binary elastin-like recombinamer (ELR) tubular construct. It displays fast and slow proteolytic hydrogels on its inner and outer part, respectively, both sensitive to the urokinase plasminogen activator protease. Read More

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Evaluation of virucidal activity of fabrics using Feline Coronavirus.

J Virol Methods 2021 Jun 9:114214. Epub 2021 Jun 9.

Department of Veterinary Medicine, University of Bari, Valenzano, Italy.

Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) is an enveloped RNA virus responsible for the 2019 coronavirus disease (COVID-19) that represents a global health threat, causing an ongoing pandemic in many countries and territories. WHO recommendations emphasize the importance of all personal protective equipment (PPE) that can interrupt COVID-19 transmission. The textile industry and scientists are developing hygienic fabrics by the addition of or treatment with various antimicrobial and antiviral compounds. Read More

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Beneficial effect of the methanolic leaf extract of Allium hookeri on stimulating glutathione biosynthesis and preventing impaired glucose metabolism in type 2 diabetes.

Arch Biochem Biophys 2021 Jun 9:108961. Epub 2021 Jun 9.

Chemical Biology Lab, Institute of Advanced Study in Science and Technology (IASST) Paschim Boragaon, Guwahati, 35, India; Assam Down Town University, Panikhaiti, Assam, 781068, India. Electronic address:

Oxidative stress resulting from the depletion of glutathione (GSH) level plays a vital role in generating various degenerative diseases, including type 2 diabetes (T2D). We tested the hypothesis that depleted glutathione levels can be enhanced and the impaired glucose metabolism can be prevented by supplementing Allium hookeri, a herb rich in organosulfur compounds, in a High Fat (HF) diet-induced T2D Male Sprague Dawley rat model. The experimental rats were divided into three groups (n = 6), namely normal diet, high-fat diet, and high-fat diet treated with A. Read More

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Clinico-microbiological description and evaluation of rapid lateral flow immunoassay and PCR for detection of Burkholderia pseudomallei from patients hospitalized with sepsis and pneumonia: A twenty-one months study from Odisha, India.

Acta Trop 2021 Jun 9:105994. Epub 2021 Jun 9.

Department of Community and Family Medicine, AIIMS, Bhubaneswar. Electronic address:

Establishing a diagnosis of melioidosis based on clinical grounds is difficult in hospitalized patients with sepsis or community acquired pneumonia (CAP). We aimed to ascertain the prevalence, clinico-epidemiological and laboratory profile of melioidosis in hospitalized patients with sepsis or CAP, and to evaluate the diagnostic utility of rapid lateral flow immunoassay (LFI) and PCR in comparison with culture. In all patients with sepsis or CAP, blood, sputum/throat swab, and urine sample were subjected to culture along with other samples based on clinical presentation. Read More

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The B-Natural study-The outcome of immune tolerance induction therapy in patients with severe haemophilia B.

Haemophilia 2021 Jun 12. Epub 2021 Jun 12.

Indiana Haemophilia and Thrombosis Centre, Indianapolis, Indiana, USA.

Introduction: Inhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher.

Aim: To evaluate the use and outcome of ITI in patients with HB and inhibitors. Read More

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Safety of Dapagliflozin in Patients with Type 2 Diabetes Mellitus in Saudi Arabia: A Post Authorization Safety Study.

Diabetes Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction: Sodium-glucose co-transporter-2 (SGLT2) inhibitors moderately reduce glucose levels in type-2 diabetes mellitus (T2DM). Some cases of diabetic ketoacidosis (DKA) were reported with SGLT2 inhibitors. However, data on the long-term safety of dapagliflozin in Saudi Arabia are lacking. Read More

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NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease.

Brain 2021 Jun 12. Epub 2021 Jun 12.

Neuropore Therapies, Inc., 10835 Road to the Cure, Suite 230, San Diego, CA 92121 USA.

NPT520-34 is a clinical-stage, small molecule being developed for the treatment of Parkinson's disease and other neurodegenerative disorders. The therapeutic potential of NPT520-34 was first suggested by findings from cell-based assays of alpha-synuclein (ASYN) clearance. As reported here, NPT520-34 was subsequently evaluated for therapeutically relevant actions in a transgenic animal model of Parkinson's disease that overexpresses human ASYN and in an acute lipopolysaccharide (LPS)-challenge model using wild-type mice. Read More

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Impact of socioeconomic status,population mobility and control measures on COVID-10 development in major cities of China.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Feb;50(1):52-60

Yale School of Public Health,Yale University,New Haven 06520,Connecticut,USA.

:To evaluate the impact of socioeconomic status,population mobility,prevention and control measures on the early-stage coronavirus disease 2019 (COVID-19) development in major cities of China. : The rate of daily new confirmed COVID-19 cases in the 51 cities with the largest number of cumulative confirmed cases as of February 19,2020 (except those in Hubei province) were collected and analyzed using the time series cluster analysis. It was then assessed according to three aspects,that is, socioeconomic status,population mobility,and control measures for the pandemic. Read More

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February 2021

Comparison of the analgesic effects of two quadratus lumborum blocks (QLBs), QLB type II vs. QLB type III, in Cesarean Delivery: A randomised study.

Int J Clin Pract 2021 Jun 12:e14513. Epub 2021 Jun 12.

Department of Anaesthesiology and Reanimation, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Background: Quadratus lumborum blocks (QLB) are relatively novel regional anesthesia techniques, and the efficacy of all three types of QLB for postoperative analgesia in cesarean delivery (CD) has been demonstrated in separate studies. The aim of the present study is to compare the analgesic efficacy of the QLB-II and QLB-III blocks performed at the end of surgery in patients undergoing spinal anesthesia for CD.

Methods: We conducted a comparative, blinded, prospective, randomized, efficiency study. Read More

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Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community-Based Cohort.

Mov Disord 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.

Background: Premutation-sized (55-200) CGG repeat expansions in the FMR1 gene cause fragile X-associated tremor/ataxia syndrome (FXTAS). Most studies of premutation carriers utilized reverse ascertainment to identify patients, leading to a selection bias for larger repeats. As shorter CGG premutation repeats are common in the population, understanding their impact on health outcomes has a potentially large public health footprint. Read More

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Quantifying Bone Marrow Fat Fraction and Iron by MRI for Distinguishing Aplastic Anemia from Myelodysplastic Syndromes.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Radiology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Background: Bone marrow of patients with aplastic anemia (AA) is different from that of patients with myelodysplastic syndrome (MDS) and is difficult to identify by blood examination. IDEAL-IQ (iterative decomposition of water and fat with echo asymmetry and least-squares estimation) imaging might be able to quantify fat fraction (FF) and iron content in bone tissues.

Purpose: To determine if IDEAL-IQ measurements of bone marrow FF and iron content can distinguish between patients with AA and MDS. Read More

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Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene.

Sci Rep 2021 Jun 11;11(1):12357. Epub 2021 Jun 11.

Department of Radiobiology and Hygiene Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). Read More

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Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Divisions of Pediatric Gastroenterology Pathology Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA Division of Pediatric Gastroenterology, Inova Children's Hospital, Fairfax, VA, USA Division of Pediatric Gastroenterology, Pediatric Specialists of Virginia, Fairfax, VA, USA.

Objectives: This study aimed to determine whether mRNA expression of oncostatin-M (OSM) and its receptor (OSMR) in initial, pre-treatment intestinal biopsies is predictive of response to tumor necrosis factor antagonists (antiTNF) in a pediatric inflammatory bowel disease (IBD) cohort. Secondary outcomes correlated OSM and OSMR expression with demographic variables; IBD type, extent, phenotype, and severity; laboratory values; and endoscopic findings.

Methods: A retrospective chart review was conducted on 98 pediatric patients. Read More

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What is the burden of heterosexually-acquired HIV due to HSV-2? Global and regional model-based estimates of the proportion and number of HIV infections attributable to HSV-2 infection.

J Acquir Immune Defic Syndr 2021 Jun 9. Epub 2021 Jun 9.

MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London. Department of Respiratory Sciences, University of Leicester. London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal (QC), Canada Bristol Veterinary School, University of Bristol, Bristol, United Kingdom Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Background: Biological and epidemiological evidence suggest that herpes simplex virus type 2 (HSV-2) elevates HIV acquisition and transmission risk. We improved previous estimates of the contribution of HSV-2 to HIV infections by using a dynamic-transmission model.

Setting: WHO regions. Read More

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Association between sleep quality and type 2 diabetes at 20-year follow-up in the Southall and Brent REvisited (SABRE) cohort: a triethnic analysis.

J Epidemiol Community Health 2021 Jun 11. Epub 2021 Jun 11.

MRC Unit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.

Background: The risk of developing type 2 diabetes associated with poor sleep quality is comparable to other lifestyle factors (eg, overweight, physical inactivity). In the UK, these risk factors could not explain the two to three-fold excess risks in South-Asian and African-Caribbean men compared with Europeans. This study investigates (1) the association between mid-life sleep quality and later-life type 2 diabetes risk and (2) the potential modifying effect of ethnicity. Read More

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Severe multisystem pathology, metabolic acidosis, mitochondrial dysfunction, and early death associated with an X-linked variant.

Cold Spring Harb Mol Case Stud 2021 Jun 11;7(3). Epub 2021 Jun 11.

Greenwood Genetic Center, Greenwood, South Carolina 29646, USA.

Variants in the X-linked gene (apoptosis-inducing factor mitochondria-associated 1) are associated with a highly variable clinical presentation that encompasses motor neuropathy, ataxia, encephalopathies, deafness, and cognitive impairment. encodes a mitochondrial flavin adenine dinucleotide (FAD)-dependent nicotinamide adenine dinucleotide (NADH) oxidoreductase, with roles in the regulation of respiratory complex assembly and function, production of reactive oxygen species, and the coordination of a caspase-independent type of apoptosis known as parthanatos. In this report, we describe a missense variant (absent in reference population databases; c. Read More

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Prevalence of leg ulcers in the province of Cuenca: A study in Primary Care.

Enferm Clin (Engl Ed) 2021 Jun 8. Epub 2021 Jun 8.

Centro de Salud de Tarancón, Servicio de Salud de Castilla-La Mancha (SESCAM), Cuenca, Spain.

Objective: To determine the prevalence of leg ulcers, and to describe the affected patients, wounds, and treatment.

Method: Observational, cross-sectional prevalence study. An ad hoc online questionnaire was sent to all nurses attending Primary Care centres of the "Gerencia de Atención Integrada de Cuenca" (Integrated Care Management of Cuenca, Spain). Read More

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The Impact of Vocal Task on Voice Acoustics, Effort and Discomfort Following Submandibular Neuromuscular Electrical Stimulation in Healthy Adults.

J Voice 2021 Jun 8. Epub 2021 Jun 8.

Department of Physical Therapy and Human Movement, Sacred Heart University, Fairfield, Connecticut; College of Health & Wellness, Johnson & Wales University, Providence, RI.

Background: Neuromuscular electrical stimulation (NMES) offers a potential adjuvant to traditional voice therapy for individuals with dysphonia. The type of vocal task to implement in conjunction with electrical stimulation to achieve maximal therapeutic benefit is unknown. The purpose of this study was to elucidate the impact of tasks on voice outcomes. Read More

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Enhanced isomerization of rare sugars by ribose-5-phosphate isomerase A from Ochrobactrum sp. CSL1.

Enzyme Microb Technol 2021 Aug 26;148:109789. Epub 2021 Mar 26.

School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, 215009, PR China. Electronic address:

Ribose-5-phosphate isomerase A (RpiA) is of great importance in biochemistry research, however its application in biotechnology has not been fully explored. In this study the activity of RpiA from Ochrobactrum sp. CSL1 (OsRpiA) towards D-allose was engineered based on sequential and structural analyses. Read More

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia.

BMC Pediatr 2021 Jun 11;21(1):275. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia. Read More

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State-level trends in sudden unexpected infant death and immunization in the United States: an ecological study.

BMC Pediatr 2021 Jun 11;21(1):274. Epub 2021 Jun 11.

Institute for Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Background: Sudden unexpected infant death (SUID) continues to be a major contributor to infant mortality in the United States. The objective was to analyze time trends in SUID and their association with immunization coverage.

Methods: The number of deaths and live births per year and per state (1992-2015) was obtained from the Centers for Disease Control and Prevention (CDC). Read More

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Is therapeutic inertia present in hyperglycaemia, hypertension and hypercholesterolaemia management among adults with type 2 diabetes in three health clinics in Malaysia? a retrospective cohort study.

BMC Fam Pract 2021 Jun 11;22(1):111. Epub 2021 Jun 11.

Seri Kembangan Health Clinic, Taman Muhibbah, Jalan Besar43300 Seri Kembangan, Selangor, Malaysia.

Background: Good-quality evidence has shown that early glycaemic, blood pressure and LDL-cholesterol control in people with type 2 diabetes (T2D) leads to better outcomes. In spite of that, diseases control have been inadequate globally, and therapeutic inertia could be one of the main cause. Evidence on therapeutic inertia has been lacking at primary care setting. Read More

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Ultralow lattice thermal conductivity and dramatically enhanced thermoelectric properties of monolayer InSe induced by an external electric field.

Phys Chem Chem Phys 2021 Jun 12. Epub 2021 Jun 12.

Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, School of Energy and Power Engineering, Dalian University of Technology, Dalian 116024, China.

With the ability to alter the inherent interatomic electrostatic interactions, modulating external electric field strength is a promising approach to tune the phonon transport behavior and enhance the thermoelectric performance of two-dimensional (2D) materials. Here, by applying an electric field (Ez = 0.1 V Å-1), it is predicted that an ultralow value of the lattice thermal conductivity (0. Read More

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Use of available crop by-products as alternative bedding materials to wheat straw for rearing broilers.

Animal 2021 Jun 8;15(7):100260. Epub 2021 Jun 8.

Poultry Production Department, Agriculture College, Damietta University, Damietta 34517, Egypt.

The provision of suitable bedding for rearing broilers is an ongoing challenge for poultry producers. The aim of the present study was to evaluate the effect of using different types of crop residues as alternative bedding materials to wheat straw on growth performance, carcass traits, health, and welfare of broilers; moreover, the effects on the bedding and air quality were analyzed. We randomly assigned 180 1-day-old chickens (Cobb 500) across six bedding groups (three replicates of 10 birds each). Read More

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Mechanical property characterization of partially crystalline Poly-Ether-Ether-Ketone.

J Mech Behav Biomed Mater 2021 Jun 1;121:104600. Epub 2021 Jun 1.

CAS Key Laboratory for Mechanical Behavior and Design of Materials, Department of Modern Mechanics. University of Science and Technology of China, Hefei, Anhui, 230027, China.

The present study investigates the mechanical properties of partially crystalline Poly-Ether-Ether-Ketone between the glass transition and the cold crystallization. Biaxial tension, uniaxial tension, and DMA experiments were conducted to investigate the influence of temperature-induced crystallization on mechanical properties, and three stiffening behaviors are observed. Firstly, a 'U' type mechanical property is observed for all three experiments with first softening and then significant stiffening behavior with increasing temperature. Read More

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Gross alpha activity in urban sediments as an important indicator of urban environmental processes on the example of three Russian cities.

J Environ Manage 2021 Jun 8;294:113011. Epub 2021 Jun 8.

Zavaritsky Institute of Geology and Geochemistry UB RAS, 15 Akademika Vonsovskogo Str., Ekaterinburg, 620016, Russia.

The protection of the urban environment from radioactive wastes (including technologically enhanced natural radionuclides) and potentially harmful elements have recently become very critical. Thus, the present study aimed to assess the radioactive levels in low-volume samples of dust and fine sand fractions of the urban surface deposited sediments (USDS) collected in three Russian cities. The detection was conducted via CR-39 and LR-115 type II solid-state nuclear track detectors (SSNTDs) have been used to detect gross alpha activity concentrations. Read More

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