3,706 results match your criteria three triterpenes

Differential regulation of triterpene biosynthesis induced by an early failure in cuticle formation in apple.

Hortic Res 2021 Apr 1;8(1):75. Epub 2021 Apr 1.

The New Zealand Institute for Plant and Food Research, Auckland, New Zealand.

Waxy apple cuticles predominantly accumulate ursane-type triterpenes, but the profile shifts with the induction of skin russeting towards lupane-type triterpenes. We previously characterised several key enzymes in the ursane-type and lupane-type triterpene pathways, but this switch in triterpene metabolism associated with loss of cuticle integrity is not fully understood. To analyse the relationship between triterpene biosynthesis and russeting, we used microscopy, RNA-sequencing and metabolite profiling during apple fruit development. Read More

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[Transcriptome analysis of Platycodon grandiflorum at different growth years and discovery of key genes for platycodin biosynthesis].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(6):1386-1392

Chongqing Engineering Research Center for Fine Variety Breeding Techniques of Chinese Materia Medica,Chongqing Sub-center of National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Science,Chongqing Academy of Chinese Materia Medica Chongqing 400065,China.

Platycodon grandiflorum is a medicinal and edible medicinal material. Our study is aimed to explore the differences in the gene expression of P. grandiflorum in different growth years, and the expression rules of key genes in the biosynthesis of the main active substances of P. Read More

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[Qualitative and quantitative analysis on triterpenoids in Ligustri Lucidi Fructus].

Zhongguo Zhong Yao Za Zhi 2021 Mar;46(5):1168-1178

National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.

Triterpenoids are one of the most active constituents in Ligustri Lucidi Fructus, but only oleanolic acid has been mostly studied. In recent years, a growing number of studies have shown that other triterpenes from Ligustri Lucidi Fructus also have various biological activities, so it is necessary to build up a detailed profile of the triterpenoids in Ligustri Lucidi Fructus. The chromatographic separation was performed on a C_(18) column(4. Read More

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Azadirachtin directly or indirectly affects the abundance of intestinal flora of Spodoptera litura and the energy conversion of intestinal contents mediates the energy balance of intestine-brain axis, and along with decreased expression CREB in the brain neurons.

Pestic Biochem Physiol 2021 Mar 23;173:104778. Epub 2021 Jan 23.

Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Azadirachtin is a good growth inhibitor for Lepidopteran larvae, but its effect on the brain neurons, intestinal flora and intestinal contents caused by the growth inhibition mechanism has not been reported yet. This study explored the mechanism of azadirachtin on the growth and development of Spodoptera litura larvae and brain neurons through three aspects: intestinal pathology observation, intestinal flora sequencing, and intestinal content analysis. The results showed that the treatment of azadirachtin led to the pathological changes in the structure of the midgut and the goblet cells in the intestinal wall cells to undergo apoptosis. Read More

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Plasma and intracerebral pharmacokinetics and pharmacodynamics modeling for the acetylcholine releasing effect of ginsenoside Rg1 in mPFC of A model rats.

J Asian Nat Prod Res 2021 Mar 26;23(3):294-306. Epub 2021 Mar 26.

Clinical Trial Center, Beijing hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Ginsenoside Rg1 is a major bioactive component of ginseng. Limited information is available regarding Rg1 concentrations in the central neural system and the corresponding relationship of plasma/intracerebral concentrations, and intracerebral effects of Rg1. Awake Aβ model rats received a single subcutaneous administration of Rg1. Read More

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Oleanane-type saponins and prosapogenins from Albizia julibrissin and their cytotoxic activities.

Phytochemistry 2021 May 23;185:112674. Epub 2021 Mar 23.

State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China. Electronic address:

Two undescribed oleanane-type saponins, julibrosides K-L, along with three undescribed oleanane-type prosapogenins, julibrosides M-O, were isolated from the stem bark of Albizia julibrissin Durazz. and the mild alkaline hydrolysate of the total saponin, respectively. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, TOCSY, HSQC, HMBC, and HSQC-TOCSY) and mass spectrometry. Read More

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Broad-spectrum pharmacological activity of Australian propolis and metabolomic-driven identification of marker metabolites of propolis samples from three continents.

Food Funct 2021 Mar 8;12(6):2498-2519. Epub 2021 Mar 8.

NICM Health Research Institute, Western Sydney University, Penrith, NSW, Australia.

Propolis is a by-product of honeybee farming known for its broad therapeutic benefits around the world and is extensively used in the health food and beverage industry. Despite Australia being one of the world's megadiverse countries with rich flora and fauna, Australian propolis samples have not been explored adequately with most in vitro and in vivo studies centred on their Brazilian and Chinese counterparts. In view of this, our study was designed to investigate the chemical composition and anti-proliferative, antibacterial, antifungal, anti-inflammatory and antioxidant properties of Australian propolis (AP-1) extract to draw a comparison with Brazilian (BP-1) and Chinese propolis (CP-1) extracts. Read More

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Two Triterpene Synthases from Imperata cylindrica Catalyzing the Formation of a Pair of Diastereoisomers through Boat or Chair Cyclization.

Chembiochem 2021 Mar 4. Epub 2021 Mar 4.

School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki, Kanagawa, 214-8571, Japan.

Imperata cylindrica is known to produce a pair of triterpenes, isoarborinol and fernenol, that exhibit identical planar structures but possess opposite stereochemistry at six of the nine chiral centers. These differences arise from a boat or a chair cyclization of the B-ring of the substrate. Herein, we report the characterization of three OSC genes from I. Read More

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Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae).

Fitoterapia 2021 Feb 28;151:104869. Epub 2021 Feb 28.

Faculty of Science, Department of Organic Chemistry, University of Yaoundé 1, Yaoundé, Cameroon.

The phytochemical study of leaves of Funtumia elastica led to the isolation of three undescribed ursane derivatives, funtumic acids A, B and C (1-3), as well as one steroidal alkaloid, elasticine (4) and five other known compounds (5-9). Their structures were elucidated on the basis of NMR, MS, IR, UV spectroscopic data as well as by comparison with the literature. The compound 5-hydroxypyridine-3-carboxamide (9) was isolated for the first time from the Apocynaceae family. Read More

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February 2021

Chemical constituents of radix Actinidia chinensis planch by UPLC-QTOF-MS.

Biomed Chromatogr 2021 Feb 25:e5103. Epub 2021 Feb 25.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.

Radix Actinidia decoction and its prescriptions are used to treat tumors and other diseases. Although some chemical components have been isolated from Radix Actinidia, systematic analysis of its chemical components has not been reported, which hinders the basic research on its effective substances and its quality control. In this work, a UPLC-QTOF-MS method was employed to profile and characterize the chemical constituents of water extracts from Radix Actinidia Chinensis Planch (RACP). Read More

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February 2021

From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities.

Antioxidants (Basel) 2021 Jan 30;10(2). Epub 2021 Jan 30.

Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), Carrer Doctor Aiguader 88, 08003 Barcelona, Spain.

Our aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination, at nutritional (Ps: 0. Read More

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January 2021

Anti-Cancer Effects of Glaucarubinone in the Hepatocellular Carcinoma Cell Line Huh7 via Regulation of the Epithelial-To-Mesenchymal Transition-Associated Transcription Factor Twist1.

Int J Mol Sci 2021 Feb 8;22(4). Epub 2021 Feb 8.

Laboratory of Molecular and Pharmacological Cell Biology, College of Pharmacy, Chung-Ang University, Seoul 06974, Korea.

Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a leading cause of cancer-related deaths. As HCC has a high mortality rate and its incidence is increasing worldwide, understanding and treating HCC are crucial for resolving major public health concerns. In the present study, wound healing screening assays were performed using natural product libraries to identify natural chemicals that can inhibit cancer cell migration. Read More

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February 2021

Dammarane-type triterpenoid saponins from Salvia russellii Benth.

Phytochemistry 2021 Apr 29;184:112653. Epub 2021 Jan 29.

Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, 71348-53734, Iran. Electronic address:

Three undescribed dammarane-type saponins, russelliinosides A-C, together with a common sterol (β-sitosterol), an abietane diterpenoid (18-hydroxyferruginol), two oleane triterpenoids (daturaolone and oleanolic acid), an ursane triterpenoid (ursolic acid) as well as three 5-hydroxyflavones (cirsimaritin, eupatorin, and salvigenin) were isolated from a dichloromethane extract of the aerial parts of Salvia russellii Benth. The chemical structures of the aforementioned compounds were characterized, using detailed spectroscopic analyses, including high-resolution mass spectrometry and 1D and 2D NMR (H-H COSY, TOCSY, HSQC, HMBC and NOESY) spectroscopy as well as physicochemical properties. Cytotoxic effects of S. Read More

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Limonoid biosynthesis 3: Functional characterization of crucial genes involved in neem limonoid biosynthesis.

Phytochemistry 2021 Apr 29;184:112669. Epub 2021 Jan 29.

Chemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India; CSIR-Institute of Genomics and Integrative Biology, Mall Road, New Delhi, 110007, India. Electronic address:

Neem (Azadirachta indica L.) is well known for its medicinal, agricultural, and pesticidal applications since ages. The secondary metabolites, limonoids, confer these biological properties, wherein over 150 different limonoids have been reported from neem. Read More

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Pentacyclic triterpenes with nitric oxide inhibitory activity from Potentilla chinensis.

Bioorg Chem 2021 Mar 21;108:104659. Epub 2021 Jan 21.

College of Pharmacy, Chungbuk National University, Cheongju 28610, South Korea. Electronic address:

Three new ursane-type triterpenes (1-3) and twenty-one known triterpenoids (4-24) were isolated from the methanolic extract of the whole plants of Potentilla chinensis. Their structures were elucidated by extensive spectroscopic analysis of 1D and 2D NMR (HSQC, HMBC, COSY and ROESY) and HRESIMS data. The bioassay screening revealed the inhibitory effects on nitric oxide production of compounds 2, 5, 7, 9, 10, and 13-24 in LPS-induced RAW264. Read More

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Suppressive Effect of Two Cucurbitane-Type Triterpenoids from on -Induced Inflammatory Responses in Human THP-1 Monocytic Cell and Mouse Models.

Molecules 2021 Jan 22;26(3). Epub 2021 Jan 22.

Department of Human Development and Family Studies, National Taiwan Normal University, Taipei 106, Taiwan.

(formerly ) is one of the major bacterial species responsible for acne vulgaris. Numerous bioactive compounds from Linn. var. Read More

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January 2021

Exploration for the real causative agents of licorice-induced pseudoaldosteronism.

Toshiaki Makino

J Nat Med 2021 Mar 22;75(2):275-283. Epub 2021 Jan 22.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.

I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver to 3-monoglucuronyl-glycyrrhetinic acid (3MGA). In normal condition, 3MGA is excreted into bile via a multidrug resistance-related protein (Mrp) 2, therefore, 3MGA does not appear in blood circulation. Read More

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Triterpenoids and Other Non-Polar Compounds in Leaves of Wild and Cultivated Species.

Plants (Basel) 2021 Jan 5;10(1). Epub 2021 Jan 5.

Department of Analytical Chemistry and Physical Chemistry, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria.

The purpose of the current study was to identify and quantify triterpenoids and other non-polar compounds in the leaves of three high bush blueberry cultivars ( L. var. Bluegold, var. Read More

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January 2021

Sterols and Triterpenes from Growing in Saudi Arabia and Their Cytotoxic Activity.

Plants (Basel) 2021 Jan 8;10(1). Epub 2021 Jan 8.

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

A new lupane caffeoyl ester, lup-20(29)-ene 3β-caffeate-30-al (), and a new oleanane-type triterpene, 3-hydroxyolean-13(18)-en-12-one (), were isolated from the aerial parts of (Forssk), along with ten known triterpenes, including seven lupane-type lupeol (), 30-nor-lup-3-ol-20-one (), ∆-lupenone (), lup-20(29)-en-3,30-diol (), lupeol caffeate (), 30-hydroxy lup-20(29)-ene 3-caffeate (), and betunaldehyde (); three oleanane-type compounds were also identified, comprising -amyrone (), -amyrin (), and 11-oxo--amyrin (); together with six sterols, comprising -sitosterol (), stigmasterol (), 7-hydroxy--sitosterol (), 7-hydroxy-stigmasterol (), 7-keto--sitosterol (), and 7-keto-stigmasterol (). Their structures were elucidated using a variety of spectroscopic techniques, including 1D (H, C, and DEPT-135 C) and 2D (H-H COSY, H-C HSQC, and H-C HMBC) nuclear magnetic resonance (NMR) and accurate mass spectroscopy. Subsequently, the different plant extracts and some of the isolated compounds (, and ) were investigated for their possible cytotoxic activity in comparison to cisplatin against a wide array of aggressive cancer cell lines, such as colorectal cancer (HCT-116), hepatocellular carcinoma (HepG-2), and prostate cancer (PC-3) cell lines. Read More

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January 2021

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.

EBioMedicine 2021 Jan 7;63:103197. Epub 2021 Jan 7.

Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark. Electronic address:

Background: SARS-CoV-2 has caused a global pandemic, infecting millions of people. A safe, effective vaccine is urgently needed and remains a global health priority. Subunit vaccines are used successfully against other viruses when administered in the presence of an effective adjuvant. Read More

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January 2021

Vochysia tucanorum Mart. butanol fraction presents antitumoral activity in vivo and prevents the installation of cachexia in solid Ehrlich tumor model.

BMC Complement Med Ther 2021 Jan 7;21(1):20. Epub 2021 Jan 7.

Laboratory of Endocrine Pancreas Physiology, Faculty of Science, Department of Physical Education, São Paulo State University, Av. Eng. Luiz Edmundo Carrijo Coube 14-01, Bauru, São Paulo, Postal Code: 17033-360, Brazil.

Background: Cancer is a multifactorial disease caused by uncontrolled proliferation of cells. About 50-80% of cancer patients develop cachexia, a complex metabolic syndrome associated with an increase of mortality and morbidity. However, there are no effective therapies in medical clinic for cancer cachexia. Read More

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January 2021

Twelve undescribed derivatives of ganoderic acid isolated from Ganoderma luteomarginatum and their cytotoxicity against three human cancer cell lines.

Phytochemistry 2021 Mar 29;183:112617. Epub 2020 Dec 29.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:

Lanostane triterpenoids are thought to be the main underlying preclinical antitumor secondary metabolites of the genus Ganoderma. To further explore the potential cytotoxic triterpenoids from Ganoderma luteomarginatum, the ethyl acetate soluble fraction of 95% ethanolic extract was systematically studied. Twelve previously undescribed lanostane-type triterpene acids were isolated from the fruiting bodies of G. Read More

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Variations in Triterpenoid Deposition in Cuticular Waxes during Development and Maturation of Selected Fruits of Rosaceae Family.

Int J Mol Sci 2020 Dec 21;21(24). Epub 2020 Dec 21.

Department of Plant Biochemistry, Institute of Biochemistry, Faculty of Biology, University of Warsaw, 1 Miecznikowa Street, 02-096 Warsaw, Poland.

The process of fruit ripening involves many chemical changes occurring not only in the mesocarp but also in the epicarp, including changes in the triterpenoid content of fruit cuticular waxes that can modify the susceptibility to pathogens and mechanical properties of the fruit surface. The aim of the study was the determination of the ripening-related changes in the triterpenoid content of fruit cuticular waxes of three plant species from the Rosaceae family, including rugosa rose (), black chokeberry ( var. "Galicjanka") and apple ( var. Read More

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December 2020

Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking.

J Enzyme Inhib Med Chem 2021 Dec;36(1):154-162

Departamento de Física and Soft Matter Research Center, SMAT-C, Universidad de Santiago, Santiago, Chile.

Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes , , , and we determined that and inhibit β-aggregation through thioflavine T rather than . Since compound was most active, we determined the interaction between α-synuclein and at 50 µM (Kd) through microscale thermophoresis. Read More

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December 2021

Targeting Sirtuin 1 signaling pathway by ginsenosides.

J Ethnopharmacol 2021 Mar 1;268:113657. Epub 2020 Dec 1.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China; Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China; Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China. Electronic address:

Ethnopharmacological Relevance: Ginseng is a kind of traditional Chinese herbal medicine, known as "king of herbs" and widely used in China, South Korea, and other Asian countries. Ginsenosides are one of active components of Panax ginseng Meyer, which have many pharmacological effects, such as enhancing memory, improving immunity and cardiovascular system, delaying aging, and preventing cancer.

Aims Of The Review: This review aims to summarize the recent findings for ginsenosides targeting Sirtuin 1 (SIRT1) signaling pathway for the prevention and treatment of a series of diseases. Read More

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Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism.

Environ Toxicol 2021 Apr 4;36(4):628-641. Epub 2020 Dec 4.

Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Nimbolide is a tetranortriterpenoid derived from the leaves and flowers of Azadirachta indica (Neem). It exhibits anticancer activity against a variety of cancers by modulating various crucial features, including cell proliferation, apoptosis, and invasion and metastasis. More importantly, the cytotoxic effect of nimbolide has also been observed against T cell lymphoma, but the underlying mechanisms are still unexplored. Read More

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Compositional, structural and functional cuticle analysis of Prunus laurocerasus L. sheds light on cuticular barrier plasticity.

Plant Physiol Biochem 2021 Jan 24;158:434-445. Epub 2020 Nov 24.

University of Würzburg, Julius-von-Sachs-Institute for Biosciences, D-97082, Würzburg, Germany. Electronic address:

Barrier properties of the hydrophobic plant cuticle depend on its physicochemical composition. The cuticular compounds vary considerably among plant species but also among organs and tissues of the same plant and throughout developmental stages. As yet, these intraspecific modifications at the cuticular wax and cutin level are only rarely examined. Read More

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January 2021

22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling.

J Ethnopharmacol 2021 Mar 21;267:113605. Epub 2020 Nov 21.

Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, 69080-900, Brazil. Electronic address:

Ethnopharmacological Relevance: 22β-hydroxytingenone (22-HTG) is a quinonemethide triterpene isolated from Salacia impressifolia (Miers) A. C. Smith (family Celastraceae), which has been used in traditional medicine to treat a variety of diseases, including dengue, renal infections, rheumatism and cancer. Read More

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Identification of triterpenes and functional characterization of oxidosqualene cyclases involved in triterpene biosynthesis in lettuce (Lactuca sativa).

Plant Sci 2020 Dec 3;301:110656. Epub 2020 Sep 3.

Division of Forest Sciences, College of Forest and Environmental Sciences, Kangwon National University, Chuncheon 200-701, Republic of Korea. Electronic address:

Lettuce (Lactuca sativa) is a member of the family Asteraceae and is most often used for green salads. Triterpenes are the largest class of natural compounds in plants and have beneficial health effects. Here, we identified various triterpene esters (taraxasterol acetates, ψ-taraxasterol acetates, taraxerol acetates, lupeol acetates, α-amyrin acetates, β-amyrin acetates, and germanicol acetate) and free triterpenes (α-amyrin, β-amyrin, taraxerol, and taraxasterol) in both the leaves and roots of lettuce. Read More

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December 2020

Evaluation of Botanicals for Management of Piercing-Sucking Pests and the Effect on Beneficial Arthropod Populations in Tea Trees Camellia sinensis (L.) O. Kuntze (Theaceae).

J Insect Sci 2020 Nov;20(6)

College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong, People's Republic of China.

The tea green leafhopper Empoasca onukii Matsuda (Hemiptera: Cicadellidae), the orange spiny whitefly, Aleurocanthus spiniferus (Quaintanca) (Hemiptera: Aleyrodidae), and the green plant bugs Apolygus lucorum Meyer-Dür (Hemiptera: Miridae) are the important piercing-sucking herbivores in tea trees Camellia sinensis (L.) O. Kuntze (Theaceae). Read More

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November 2020