3,006,708 results match your criteria three pelvic


Design, synthesis, and biological evaluation of novel bifunctional thyrointegrin antagonists for neuroblastoma.

Bioorg Med Chem 2021 Jun 6;42:116250. Epub 2021 Jun 6.

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, United States. Electronic address:

Receptor-mediated cancer therapy has received much attention in the last few decades. Neuroblastoma and other cancers of the sympathetic nervous system highly express norepinephrine transporter (NET) and cell plasma membrane integrin αvβ3. Dual targeting of the NET and integrin αvβ3 receptors using a Drug-Drug Conjugate (DDC) might provide effective treatment strategy in the fight against neuroblastoma and other neuroendocrine tumors. Read More

View Article and Full-Text PDF

The protective effect of tight-fitting powered air-purifying respirators during chest compressions.

Am J Emerg Med 2021 Jun 7;49:172-177. Epub 2021 Jun 7.

Department of Emergency and Critical Care, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya, Aichi 466-8560, Japan. Electronic address:

Background: Airborne personal protective equipment is required for healthcare workers when performing aerosol-generating procedures on patients with infectious diseases. Chest compressions, one of the main components of cardiopulmonary resuscitation, require intense and dynamic movements of the upper body. We aimed to investigate the protective effect of tight-fitting powered air-purifying respirators (PAPRs) during chest compressions. Read More

View Article and Full-Text PDF

Experiences of nursing students during clinical education in mental health clinics: A phenomenological qualitative study.

Nurse Educ Pract 2021 Jun 4;54:103113. Epub 2021 Jun 4.

Department of Psychiatric Nursing, Health Sciences Faculty, Zonguldak Bülent Ecevit University, Kozlu, Zonguldak, Turkey. Electronic address:

Aim: Nursing students have both positive and negative experiences during clinical education. This study was conducted to identify experiences of nursing students during clinical education in mental health clinics.

Design: This phenomenological qualitative design study was conducted with 4th year undergraduate nursing students from a university in Turkey to identify their experiences specifically in mental health clinics. Read More

View Article and Full-Text PDF

Novel photosensitive dual-anisotropic conductive Janus film endued with magnetic-luminescent properties and derivative 3D structures.

J Colloid Interface Sci 2021 May 26;601:899-914. Epub 2021 May 26.

Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties. Read More

View Article and Full-Text PDF

Seasonal variation in oestrogenic potency and biological effects of wastewater treatment works effluents assessed using ERE-GFP transgenic zebrafish embryo-larvae.

Aquat Toxicol 2021 May 19;237:105864. Epub 2021 May 19.

Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom. Electronic address:

Effluents from wastewater treatment works (WwTW) exhibit both temporal and spatial variation in oestrogenicity, however few studies have attempted to quantify how this variation affects biological responses in fish. Here we used an oestrogen-responsive green fluorescent protein (ERE-GFP) transgenic zebrafish (Danio rerio) to quantify oestrogenic activity and health effects for exposure to three different WwTW effluents. Endpoints measured included survival/hatching rate, GFP induction (measured in target tissues or gfp mRNA induction in whole embryos) and vtg mRNA induction in whole embryos. Read More

View Article and Full-Text PDF

Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.

ESMO Open 2021 Jun 9;6(4):100187. Epub 2021 Jun 9.

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan; Outpatient Treatment Center, National Cancer Center Hospital, Tokyo, Japan. Electronic address:

Background: Precision and matched cancer medicine has the potential to complement the existing biomarker approaches in cancer treatment. However, despite their promising potential, certain negative results have highlighted their limitations in molecular biology-driven treatment strategies. This study aimed to evaluate the clinical benefits of precision therapies. Read More

View Article and Full-Text PDF

Quantitative detection of aflatoxin B using quantum dots-based immunoassay in a recyclable gravity-driven microfluidic chip.

Biosens Bioelectron 2021 Jun 2;190:113394. Epub 2021 Jun 2.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. Electronic address:

To achieve rapid and sensitive detection of aflatoxin B (AFB), we developed a polydimethylsiloxane gravity-driven cyclic microfluidic chip using the two-signal mode strategy. The structural design of the chip, together with the two-wavelength quantum dot ratio fluorescence, effectively eliminates the influence of environmental factors, improves the signal stability, and ensures that the final detection result positively correlates with the target concentration. Moreover, the theoretical analysis performed for the established physical model of the three-dimensional reaction interface inside the chip confirmed the improved reaction rate of immune adsorption in the microfluidic strategy. Read More

View Article and Full-Text PDF

Bioactive compounds and antibacterial activities in crystallized honey liquefied with ultrasound.

Ultrason Sonochem 2021 Jun 4;76:105619. Epub 2021 Jun 4.

Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Av. Rancho Universitario s/n Km.1 C.P. 43760, Tulancingo, Hgo, Mexico. Electronic address:

The effect of ultrasound on the crystal size, phenols, flavonoids, Maillard products and antibacterial activity of crystallized honeys was studied. Three multifloral honeys (M), one monofloral (MO) and one honeydew (HD) honey were used. Ultrasound was performed at 42 kHz for different times (0, 5, 10 and 15 min). Read More

View Article and Full-Text PDF

Insight into the pigmented anthocyanins and the major potential co-pigmented flavonoids in purple-coloured leaf teas.

Food Chem 2021 Jun 3;363:130278. Epub 2021 Jun 3.

Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. Electronic address:

Tea cultivars possessing purple shoots have attracted global interest. In order to gain a better understanding of the major chemical constituents responsible for the purple colouration, we applied widely targeted metabolomics to investigate the pigmented flavonoids of freeze-dried purple-coloured tea leaves (PTLs) in comparison with green-coloured tea leaves (GTLs). Thirty-three anthocyanins were identified, and delphinidin 3-O-galactoside and cyanidin 3-O-galactoside were found to be the most abundant in PTLs. Read More

View Article and Full-Text PDF

Deep sequence modelling for Alzheimer's disease detection using MRI.

Comput Biol Med 2021 Jun 1;134:104537. Epub 2021 Jun 1.

School of Electrical Engineering and Computing, The University of Newcastle, NSW 2308, Australia.

Background: Alzheimer's disease (AD) is one of the deadliest diseases in developed countries. Treatments following early AD detection can significantly delay institutionalisation and extend patients' independence. There has been a growing focus on early AD detection using artificial intelligence. Read More

View Article and Full-Text PDF

Are periodontal diseases associated with sleep duration or sleep quality? A systematic review.

Arch Oral Biol 2021 Jun 6;129:105184. Epub 2021 Jun 6.

Department of Periodontology, School of Dentistry, Federal University of Pelotas, Rua Gonçalves Chaves, 457, Pelotas, RS, 96015-560, Brazil. Electronic address:

Objectives: This study aimed to systematically review the associations between periodontal diseases/tooth loss and sleep duration/quality.

Material And Methods: PubMed, Scopus, and Embase databases were searched (up to May 2021) to identify studies that assessed the association between periodontal diseases or number of teeth with sleep quality and sleep duration. Two researchers independently selected the studies and extracted the data. Read More

View Article and Full-Text PDF

Benzofuranyl-2-imidazoles as imidazoline I receptor ligands for Alzheimer's disease.

Eur J Med Chem 2021 May 20;222:113540. Epub 2021 May 20.

Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028, Barcelona, Spain. Electronic address:

Recent findings unveil the pharmacological modulation of imidazoline I receptors (I-IR) as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we report the chemical characterization, three-dimensional quantitative structure-activity relationship (3D-QSAR) and ADMET in silico of a family of benzofuranyl-2-imidazoles that exhibit affinity against human brain I-IR and most of them have been predicted to be brain permeable. Acute treatment in mice with 2-(2-benzofuranyl)-2-imidazole, known as LSL60101 (garsevil), showed non-warning properties in the ADMET studies and an optimal pharmacokinetic profile. Read More

View Article and Full-Text PDF

An evaluation of StaySafe, a tablet app to improve health risk decision-making among people under community supervision.

J Subst Abuse Treat 2021 May 14;130:108480. Epub 2021 May 14.

Texas Christian University, Institute of Behavioral Research, TCU Box 298740, Fort Worth, TX 76129, USA. Electronic address:

Background: A self-administered tablet app, StaySafe, helps people under community supervision to make better decisions regarding health risk behaviors, especially those linked to HIV, viral hepatitis, and other sexually transmitted infections. The multi-session StaySafe design uses an interactive, analytical schema called WORKIT that guides users through a series of steps, questions, and exercises aimed at promoting critical thinking about health risks associated with substance use and unprotected sex. Repetition of the WORKIT schema is designed to enhance procedural memory that can be rapidly accessed when individuals are faced with making decisions about risky behaviors. Read More

View Article and Full-Text PDF

Drug and sexual HIV-risk behaviors among adolescents and young adults with opioid use disorder.

J Subst Abuse Treat 2021 May 19;130:108477. Epub 2021 May 19.

Friends Research Institute, Inc., 1040 Park Avenue, Suite 103, Baltimore, MD 21201, United States of America.

Opioid use disorder (OUD) among adolescents and young adults (youth) is associated with drug use and sexual HIV-related risk behaviors and opioid overdose. This mixed methods analysis assesses risk behaviors among a sample of 15-21-year-olds (N = 288) who were being treated for OUD in a residential drug treatment program in Baltimore, Maryland. Participants were enrolled in a parent study in which they received either extended-release naltrexone (XR-NTX) or Treatment as Usual (TAU), consisting of outpatient counseling with or without buprenorphine, prior to discharge. Read More

View Article and Full-Text PDF

Do standard classifications still represent European welfare typologies? Novel evidence from studies on health and social care.

Soc Sci Med 2021 May 29;281:114086. Epub 2021 May 29.

Ca' Foscari, University of Venice, Department of Economics, Fondamenta S. Giobbe - Cannaregio 873, 30121, Venezia, Italy. Electronic address:

Due to the profound changes that have characterised welfare systems, the representativeness of standard welfare classifications such as Esping-Andersen's Three Worlds of Welfare (TWW) have been questioned. In response to concerns that welfare services do not share a common rationale across policy areas, new typologies focused on sub-areas of welfare provision have been introduced. Still, there is little evidence on whether such policy-specific typologies are (i) consistent with the standard TWW classifications; and (ii) consistent across policy areas. Read More

View Article and Full-Text PDF

Effect of cohabiting partners on the development of posttraumatic stress symptoms after emergency department visits for stroke and transient ischemic attack.

Soc Sci Med 2021 May 30;281:114088. Epub 2021 May 30.

Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center, New York, NY, USA.

Objective: Partners can be beneficial for patients experiencing stressful health events such as a stroke/transient ischemic attack (TIA). During such events, however, partners may exacerbate early distress. The present study tested whether having a cohabiting partner modified the association between patients' early perceptions of threat (e. Read More

View Article and Full-Text PDF

Temporal transition of racial/ethnic disparities in COVID-19 outcomes in 3108 counties of the United States: Three phases from January to December 2020.

Sci Total Environ 2021 Jun 1;791:148167. Epub 2021 Jun 1.

School of the Environment, Yale University, New Haven, CT, United States of America.

Early studies reported higher risk of COVID-19 outcomes for racial/ethnic minorities in the early phase of the pandemic in the United States. While the initial surge of COVID-19 was concentrated in some areas, COVID-19 became pervasive across the entire continent with high impacts in the northern region and central region in the end of 2020. With this geographical transition, we aim to investigate patterns of these racial/ethnic disparities over time. Read More

View Article and Full-Text PDF

Nanoplastics adsorption and removal efficiency by granular activated carbon used in drinking water treatment process.

Sci Total Environ 2021 Jun 1;791:148175. Epub 2021 Jun 1.

Group of Environmental Physical Chemistry, Department F.-A. Forel for Environmental and Aquatic Sciences, University of Geneva, Uni Carl Vogt, 66, boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland. Electronic address:

In this study Granular Activated Carbon (GAC) used in drinking water treatment processes is evaluated for its capacity to adsorb and remove polystyrene (PS) nanoplastics. Batch experiments are conducted in ultrapure and surface water from Lake Geneva, currently used as drinking water resources. Equilibrium and kinetic studies are conducted to understand adsorption mechanisms and limiting factors. Read More

View Article and Full-Text PDF

Investigating the potential of Sentinel-2 configuration to predict the quality of Mediterranean permanent grasslands in open woodlands.

Sci Total Environ 2021 May 29;791:148101. Epub 2021 May 29.

Department of Forest Engineering, ETSIAM, University of Cordoba, Ctra. Madrid, Km 396, 14071 Córdoba, Spain. Electronic address:

The assessment of pasture quality in permanent grasslands is essential for their conservation and management, as it can contribute to making real-time decisions for livestock management. In this study, we assessed the potential of Sentinel-2 configuration to predict forage quality in high diverse Mediterranean permanent grasslands of open woodlands. We evaluated the performance of Partial Least Squares Regression (PLS) models to predict crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF) and enzyme digestibility of organic matter (EDOM) by using three different reflectance datasets: (i) laboratory measurements of reflectance of dry and ground pasture samples re-sampled to Sentinel-2 configuration (Spec-lab) (ii) field in-situ measurements of grasslands canopy reflectance resampled to Sentinel-2 configuration (Spec-field); (iii) and Bottom Of Atmosphere Sentinel-2 imagery. Read More

View Article and Full-Text PDF

Evaluating scenarios for carbon reduction using different tableware in China.

Sci Total Environ 2021 Jun 5;791:148279. Epub 2021 Jun 5.

School of Urban Planning and Design, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address:

Global consumption of disposable plastic tableware (DPT) is massive because it is durable, light and inexpensive. Using the life cycle assessment method, we found that DPT for per person per meal emitted 597 g of CO and was far more than that of reusable plastic tableware (RPT, 7.00 g), ceramic tableware (9. Read More

View Article and Full-Text PDF

Estimation of municipal solid waste amount based on one-dimension convolutional neural network and long short-term memory with attention mechanism model: A case study of Shanghai.

Sci Total Environ 2021 Jun 9;791:148088. Epub 2021 Jun 9.

The State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, 1515 North Zhongshan Rd. (No. 2), Shanghai 200092, China. Electronic address:

Municipal solid waste (MSW) amount has direct influence on MSW management, policy-decision making, and MSW treatment methods. Machine learning has great potential for prediction, but few studies apply the approaches of deep learning to forecast the quantity of MSW. Therefore, the aim of this study is to evaluate the feasibility and practicability of employing the methods of supervised learning, including Attention, one-dimension Convolutional Neural Network (1D-CNN) and Long Short-Term Memory (LSTM) to predict the MSW Amount in Shanghai. Read More

View Article and Full-Text PDF

Enhancing the retention of phosphorus through bacterial oxidation of iron or sulfide in the eutrophic sediments of Lake Taihu.

Sci Total Environ 2021 May 26;791:148039. Epub 2021 May 26.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

Microbial activity can enhance the sequestration of phosphorus (P) in sediments, but little is known about the mechanisms behind it. In this study, sediment cores were sampled from the most eutrophic Meiliang Bay of Lake Taihu, and three treatments were set up in a laboratory incubation experiment, involving (a) the non-treated sediment cores, (b) inoculation, and (c) sterilization. The dissolved and labile iron (Fe) and P were obtained by high-resolution dialysis and the diffusive gradients in thin films (DGT) technique, respectively. Read More

View Article and Full-Text PDF

Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017.

Environ Int 2021 Jun 9;155:106678. Epub 2021 Jun 9.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

Ten years of nationally representative biomonitoring data collected between 2007 and 2017 are available from the Canadian Health Measures Survey (CHMS). These data establish baseline environmental chemical concentrations in the general population. Here we sought to evaluate temporal trends in environmental chemical exposures in the Canadian population by quantifying changes in biomarker concentrations measured in the first five two-year cycles of the CHMS. Read More

View Article and Full-Text PDF

Co-occurring risk and protective factors and regulatory behavior of infants living in low-income homes.

Infant Behav Dev 2021 Jun 9;64:101598. Epub 2021 Jun 9.

Crane Center for Early Childhood Research and Policy, The Ohio State University, United States.

Early self-regulation is a foundation for lifelong wellness and can be shaped by the interplay among several vital exposures. In this study, we examined the emergence of reliable profiles based upon exposure to risk and protective factors in infancy, determined if sociodemographic resources predict profile membership, and determined if these profiles predict early regulatory behaviors in a sample of infants reared in low-income homes. Data were collected from a sample of primarily Black or White mother-infant dyads living in low-income homes in the Midwest (n = 222) during the infants' first year of life (mean maternal age at enrollment: 26. Read More

View Article and Full-Text PDF

Production of an electro-biological particle electrode (EBPE) from lithium slag and its removal performance to salicylic acid in a three-dimensional electrocatalytic biological coupling reactor (3D-EBCR).

Chemosphere 2021 Jun 2;282:131020. Epub 2021 Jun 2.

School of Civil Engineering and Architecture, University of Jinan, Jinan, 250022, China.

Electro-biological particle electrode (EBPE) prepared by lithium slag was used to remove salicylic acid in a three-dimensional electrocatalytic biological coupling reactor (3D-EBCR). The physical and chemical properties of the EBPE, the removal performance of salicylic acid and the degradation mechanism were studied. Results revealed as follows: (1) the EBPE prepared by lithium slag contained effective catalytic components including FeO, SnO, ZnO, MnO, RbO and TiO, with stable structure and good adsorption performance; (2) the 3D-EBCR with EBPE had strong adaptability to the current intensity in the range of 0. Read More

View Article and Full-Text PDF

Assessing the effect of herbicide diuron on river biofilm: A statistical model.

Chemosphere 2021 Jun 4;282:131104. Epub 2021 Jun 4.

School of Environmental Studies. Jadavpur University. Kolkata, 700032, India. Electronic address:

River biofilm communities are the first ones to be exposed to all toxic discharges received via run off from agricultural fields. Hence, changes in river biofilm community structure and growth pattern are considered as indicator of overall health of lotic ecosystem. Toxicants have effect on biofilm biomass, photosynthetic efficiency and chlorophyll a concentrations. Read More

View Article and Full-Text PDF

Biodegradation of foam plastics by Zophobas atratus larvae (Coleoptera: Tenebrionidae) associated with changes of gut digestive enzymes activities and microbiome.

Chemosphere 2021 May 27;282:131006. Epub 2021 May 27.

Institute for Environmental Genomics, University of Oklahoma, Norman, 73019, USA.

In order to uncover the plastic types that superworm Zophobas atratus can degrade and the underlying changes associated with plastics consumption, three types of plastics including polystyrene (PS), polyethylene (PE) and polyurethane (PU) foam were used as sole feedstock to feed the superworm larvae for 35 days with bran as control. Compared to the control, PS- or PU-fed larvae showed 100% survival rates, the PE-fed and starvation larvae had decreased survival rates of 81.67% and 65%, respectively. Read More

View Article and Full-Text PDF

Impact of time and phosphorus application rate on phosphorus bioavailability and efficiency of secondary fertilizers recovered from municipal wastewater.

Chemosphere 2021 May 28;282:131017. Epub 2021 May 28.

Ghent University, Faculty of Bioscience Engineering, Laboratory of Analytical Chemistry and Applied Ecochemistry (Ecochem), Coupure Links 653, B Block, 6th Floor, 9000, Ghent, Belgium. Electronic address:

Demand for phosphorus (P) resources other than non-renewable P rock has driven the development of several P recovery technologies from municipal wastewater treatment and directed recovery of P into valuable fertilizers (struvite, ash, iron phosphate, etc.). Although the bioavailability of novel secondary P fertilizers has been examined in previous studies, insufficient attention has been paid to defining optimal plant growth duration and monitoring conditions to assess the dynamic changes in P. Read More

View Article and Full-Text PDF

Depressive symptom trajectories and their relation to body mass index in women of child-bearing age: The Korea Nurses' Health Study.

J Affect Disord 2021 May 27;292:114-120. Epub 2021 May 27.

College of Nursing, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, South Korea. Electronic address:

Background: This study investigated the sub-trajectory groups of depressive symptoms in women of child-bearing age and the factors impacting latent class membership. Moreover, differences in body mass index (BMI) as an outcome variable were identified among the sub-trajectory groups.

Methods: Data from the Korea Nurses' Health Study (KNHS) were analyzed, comprising that from 6,918 participants who filled out surveys during modules 1, 5, and 7. Read More

View Article and Full-Text PDF

Effects of auditory feedback on gait behavior, gaze patterns and outcome performance in long jumping.

Hum Mov Sci 2021 Jun 9;78:102827. Epub 2021 Jun 9.

Department for the Psychology of Human Movement and Sport, Institute of Sport Science, Friedrich Schiller University Jena, Germany.

In the current study, we conducted two experiments to investigate the impact of concurrent, action-induced auditory feedback on gait patterns, gaze behavior and outcome performance in long jumping. In Experiment 1, we examined the effects of present vs. absent auditory feedback on gait, gaze and performance outcome measures. Read More

View Article and Full-Text PDF