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Development of retinal atrophy after subretinal gene therapy with voretigene neparvovec.

Br J Ophthalmol 2022 May 24. Epub 2022 May 24.

Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany

Background/aims: Voretigene neparvovec (VN) is the first and only subretinal gene therapy approved by the Food and Drug Administration and European Medicines Agency. Real-world application has started in 2018 in patients with vision impairment due to biallelic retinal pigment epithelium () mutation-associated inherited retinal degenerations. Herein, we evaluated the development of retinal atrophy within in a single-centre patient cohort treated with VN. Read More

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Paraneoplastic limbic encephalitis following treatment with single-agent pembrolizumab for advanced gastroesophageal adenocarcinoma.

BMJ Case Rep 2022 May 24;15(5). Epub 2022 May 24.

Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

The use of immune checkpoint inhibitors is increasing in clinical practice. While they have provided significant benefit to many patients, a new category of adverse effects, immune-related adverse effects, has emerged with their use. These effects can range from mild to severe and affect nearly every organ system. Read More

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Lidocaine infusions for refractory chronic migraine: a retrospective analysis.

Reg Anesth Pain Med 2022 Jul;47(7):408-413

Neurology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Introduction: Patients with refractory chronic migraine have poor quality of life. Intravenous infusions are indicated to rapidly 'break the cycle' of pain. Lidocaine infusions may be effective but evidence is limited. Read More

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Epidemiological data on nutritional disorders and outcomes in hospitalized Thai children: national health database 2015-2019.

Epidemiol Health 2022 May 16:e2022047. Epub 2022 May 16.

Division of Nutrition, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objectives: Malnutrition in hospitalized patients is a frequently overlooked health issue. We aimed to assess the prevalence and pattern of nutritional disorders in hospitalized Thai children from a National Health database.

Methods: Hospitalized children aged 1 month-18 years diagnosed with nutritional disorders between 2015 and 2019 were retrospectively reviewed using the National Health Security Office data. Read More

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Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study.

Diabetes Metab J 2022 May 24. Epub 2022 May 24.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: We investigated whether fasting glucose (FG) variability could predict the risk of dementia.

Methods: This cohort study analyzed data from Koreans with diabetes after at least three health examinations by the Korean National Health Insurance Corporation between 2005 and 2010, which included at least one examination between 2009 and 2010. A total of 769,554 individuals were included, excluding those aged <40 years and those with dementia. Read More

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Multicentre match-paired analysis of advanced biliary cancer long-term survivors: the BILONG study.

Clin Res Hepatol Gastroenterol 2022 May 21:101955. Epub 2022 May 21.

Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy; PhD Program Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Background: Advanced biliary cancers (ABC) are aggressive malignancies with a median overall survival (mOS) <12 months when treated with first-line chemotherapy. Nevertheless, a subset of patients experiencing longer survival has been described in the updated analysis of ABC-02 trial. We aimed to provide a real-world description of ABC long-term survivors (LS), identifying which factors impact on survival. Read More

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Perilunate dislocation and fracture dislocation of the wrist: outcomes and long-term prognostic factors.

Orthop Traumatol Surg Res 2022 May 21:103332. Epub 2022 May 21.

Orthopedic surgery of the upper limb, hand and peripheral nerve surgery, CHU Lapeyronie, 371 Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.

Introduction: Perilunate dislocations and fracture-dislocations are severe injuries that often have serious functional sequelae. Our goal was to evaluate the long-term clinical and radiological results of these perilunate injuries, and to look for prognostic factors of a poor clinical outcome.

Hypothesis: All patients who suffered perilunate injuries in their wrist have functional sequelae and long-term radiographic changes despite optimal treatment with anatomical surgical reduction. Read More

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Retinal Detachments Associated with Topical Pilocarpine Use for Presbyopia: Pilocarpine-Associated Retinal Detachments.

Am J Ophthalmol 2022 May 21. Epub 2022 May 21.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL 33136. Electronic address:

Purpose: To present a case series of retinal detachments associated with the use of pilocarpine for presbyopia.

Design: Multicenter case series of 3 eyes from 2 patients.

Results: Patient 1, a 47-year-old male, presented with flashes and floaters in both eyes. Read More

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Stakeholder perspectives in New York State on reproductive health and pregnancy intention screening in primary care: A qualitative study.

Contraception 2022 May 21. Epub 2022 May 21.

CUNY School of Public Health: City University of New York School of Public Health, United States.

Objective: To assess New York State stakeholders' perspectives regarding providing reproductive health services in primary care settings, including asking patients about pregnancy intentions and providing long-acting reversible contraception (LARC).

Study Design: We conducted semi-structured key-informant interviews (n=22) with stakeholders representing diverse sectors, including primary care (family medicine) and specialty (obstetrician/gynecologist) physicians, health educators/promoters, advocates, and public health/healthcare professionals. Grounded theory methodology informed sampling and thematic analysis within and across sectors. Read More

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The Efficacy of Alternate Systemic Intravenous Chemotherapy and Intra-Arterial Chemotherapy Approach for Eye Globe Salvage in Retinoblastoma.

Cancer Res Treat 2022 May 24. Epub 2022 May 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.

Purpose: The advances in the treatment of retinoblastoma have enabled salvaging the globe in advanced stages with intra-arterial chemotherapy (IAC). We developed a strategy of alternate application of systemic intravenous chemotherapy (IVC) and IAC (referred to as alternate systemic IVC and IAC; ASIAC) to reduce central nervous metastases during IAC and examined its efficacy and safety in eye globe salvage in this study.

Materials And Methods: Between January 2010 and February 2021, 43 eyes of 40 patients received ASIAC treatment for retinoblastoma at the Yonsei Cancer Center, Yonsei University Health System. Read More

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Magnetic Resonance Imaging of Nerve Tumors.

Semin Musculoskelet Radiol 2022 Apr 24;26(2):172-181. Epub 2022 May 24.

Department of Radiology, Division of Musculoskeletal Radiology, Penn Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Nerve tumors are uncommon soft tissue neoplasms predominantly arising from peripheral nerve sheath and Schwann cells. We review the manifestations of benign peripheral nerve sheath tumors, concentrating on distinguishing imaging features of schwannomas versus neurofibromas with an emphasis on treatment implications. Nevertheless, there is often an overlap between the imaging presentation of these two conditions, making the accurate radiologic diagnosis challenging. Read More

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A comprehensive profiling of the immune microenvironment of breast cancer brain metastases.

Neuro Oncol 2022 May 24. Epub 2022 May 24.

Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

Background: Despite potential clinical implications, the complexity of breast cancer (BC) brain metastases (BM) immune microenvironment is poorly understood. Through multiplex immunofluorescence, we here describe the main features of BCBM immune microenvironment (density and spatial distribution) and evaluate its prognostic impact.

Methods: 60 BCBM from patients undergoing neurosurgery at three institutions (2003-2018) was comprehensively assessed using two multiplex immunofluorescence panels (CD4, CD8, Granzyme B, FoxP3, CD68, pan-cytokeratin, DAPI; CD3, PD-1, PD-L1, LAG-3, TIM-3, CD163, pan-cytokeratin, DAPI). Read More

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Improving the spatial resolution of artificial vision using midget retinal ganglion cell populations modelled at the human fovea.

J Neural Eng 2022 May 24. Epub 2022 May 24.

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Sydney, New South Wales, 2052, AUSTRALIA.

Objective: Retinal prostheses seek to create artificial vision by stimulating surviving retinal neurons of patients with profound vision impairment. Notwithstanding tremendous research efforts, the performance of all implants tested to date has remained rudimentary, incapable of overcoming the threshold for legal blindness. To maximize the perceptual efficacy of retinal prostheses, a device must be capable of controlling retinal neurons with greater spatiotemporal precision. Read More

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Outcome of Dopamine Agonist Therapy Withdrawal in Children with Prolactinomas.

Horm Res Paediatr 2022 May 24. Epub 2022 May 24.

Background: Prolactinomas are rare in children and adolescents. As in adults, the dopamine agonists (DAs) are the treatment of choice in the majority of patients. However, at what point children should be taken off of therapy and what the recurrence risk of hyperprolactinemia is following treatment withdrawal is not well described. Read More

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Effect of high-dose glucocorticoids on markers of inflammation and bone metabolism in patients with primary glomerular disease.

Kidney Blood Press Res 2022 May 24. Epub 2022 May 24.

Background: Glucocorticoids are one of the most commonly used drugs for treatment of inflammatory and autoimmune diseases. Sirtuin-1 (SIRT-1) belongs to family of proteins involved in protection against inflammation and oxidative stress. A role of SIRT-1 in regulation of bone metabolism during high-dose steroid therapy is unknown. Read More

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Effects of gait training with the Hybrid Assistive Limb on gait ability in stroke patients: A systematic review of randomized controlled trials.

J Clin Neurosci 2022 May 21;101:186-192. Epub 2022 May 21.

Graduate School of Humanities and Social Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima-city, Hiroshima 739-8521, Japan.

The Hybrid Assistive Limb (HAL) is used in training to improve walking ability for stroke patients; however, the quality of the evidence for its effects has not been fully critiqued to date. This study conducted a systematic review of randomized controlled trials to investigate the effectiveness of post-stroke gait training with the HAL. PubMed, the Cochrane Library, the Physiotherapy Evidence Database (PEDro), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) were searched for randomized controlled clinical trials evaluating the effect of HAL on gait training in stroke patients, published from the inception of each database until March 2021. Read More

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Neuroendocrine transformation from EGFR/ALK-wild type or TKI-naïve non-small cell lung cancer: An under-recognized phenomenon.

Lung Cancer 2022 May 17;169:22-30. Epub 2022 May 17.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address:

Introduction: Neuroendocrine transformation (NET) is a resistance mechanism for epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). We aimed to elucidate whether NET develops in TKI-naïve NSCLC by using molecular fingerprinting in paired pre- and post-NET tissues.

Patients And Methods: NET cases were identified based on the following criteria: the pre- and post-NET lesions must harbor mutual somatic mutations; neuroendocrine component should be absent in the sampled specimens of pre-NET lesions; and re-biopsy should be performed in either previously biopsied baseline lesions or newly developed lesions, but not in baseline-existing non-biopsied lesions, excluding synchronous neuroendocrine malignancy. Read More

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Criteria-unfulfilled multiple system atrophy at an initial stage exhibits laterality of middle cerebellar peduncles.

J Neurol Sci 2022 May 14;438:120281. Epub 2022 May 14.

Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan. Electronic address:

To elucidate clinically useful imaging characteristics of multiple system atrophy with predominant cerebellar ataxia (MSA-C) at the initial stage showing pure cerebellar ataxia but unfilling consensus criteria (MSA-pc), clinical and neuroradiological analyses on cerebral MRI and single-photon emission computed tomography (SPECT) for measuring regional cerebral blood flow (rCBF) were performed. Seven MSA-pc patients meeting the above condition at an initial evaluation were identified, and all the MSA-pc patients later developed autonomic dysfunction and finally fulfilled the criteria for probable or possible category of MSA-C. For comparison, two patients with spinocerebellar ataxia type 6 and three patients with idiopathic cerebellar ataxia who did not exhibit autonomic dysfunction for more than three years were enrolled in this study (non-MSA-pc). Read More

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Shaped before birth: Obstetric complications identify a more severe clinical phenotype among patients presenting a first affective or non-affective episode of psychosis.

J Psychiatr Res 2022 May 17;151:461-468. Epub 2022 May 17.

Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain; Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain.

Obstetric complications (OCs) may contribute to the heterogeneity that characterizes psychiatric illness, particularly the phenotypic presentation of first episode psychoses (FEP). Our aim was to examine the relationship between OCs and socio-demographic, clinical, functioning and neuropsychological characteristics in affective and non-affective FEP. We performed a cross-sectional,study where we recruited participants with FEP between 2011 and 2021, and retrospectively assessed OCs using the Lewis-Murray scale. Read More

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Genetic changes during leukemic transformation to secondary acute myeloid leukemia from myeloproliferative neoplasms.

Leuk Res 2022 May 11;118:106858. Epub 2022 May 11.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada. Electronic address:

Leukemic transformation (LT) is the main cause of death for patients with myeloproliferative neoplasms (MPNs). To study genetic changes associated with the LT, we performed targeted sequencing in 26 MPN patients including 21 with paired samples. We observed that, besides three driver genes, IDH2 (19%) and ASXL1 (14%) were also frequently mutated at MPN diagnosis. Read More

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Monitoring Symptoms of COVID-19: A Review of Mobile Applications.

JMIR Mhealth Uhealth 2022 May 3. Epub 2022 May 3.

Weill Cornell Medicine, 425 E 61st Street, New York, US.

Background: Mobile health (mHealth) apps have facilitated symptom monitoring of COVID-19 symptoms globally and have been used to share data with healthcare professionals, support disease prediction, prevention, management, diagnostics, and improvements in treatments and patient education.

Objective: The aim of this review was to evaluate the quality and functionality of COVID-19 mHealth apps that support tracking acute and long-term symptoms of COVID-19.

Methods: We systematically reviewed commercially available mHealth apps for COVID-19 symptom monitoring by searching Google Play and Apple iTunes using search terms such as: "COVID-19," "Coronavirus," and "COVID-19 and symptoms. Read More

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Community living after in-hospital specialized rehabilitation in patients with severe disability after stroke: a long-term follow-up after a randomized controlled trial.

Disabil Rehabil 2022 May 24:1-8. Epub 2022 May 24.

Department of Global Public Health and Primary Care, Physiotherapy Research Group, University of Bergen, Bergen, Norway.

Purpose: Physical functioning after discharge from specialized rehabilitation is a concern. The purpose of this study was to investigate functioning and health after a long period of community living in participants with severe disability after stroke.

Materials And Methods: An observational, longitudinal follow-up design was used to investigate 60 participants from a randomized controlled trial. Read More

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Efficacy and Cost of Maxillary Patient-Specific Implants in Orthognathic Surgery: A Review of Three Patient Cases.

Perm J 2022 Apr 5;26(1):137-142. Epub 2022 Apr 5.

Division of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA.

Introduction: Patient-specific implants (PSIs) are accurate, efficient alternatives to traditional plate fixation. They are well-suited for use in procedures that require the utmost accuracy, stability, and efficiency. Although PSIs have demonstrated such qualities in craniomaxillofacial reconstruction, they have so far found limited utilization elsewhere. Read More

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Risk stratification for hospital-acquired venous thromboembolism in medical patients (RISE): Protocol for a prospective cohort study.

PLoS One 2022 24;17(5):e0268833. Epub 2022 May 24.

Division of Internal Medicine, Department of Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Background: Hospital-acquired venous thromboembolism (VTE) is one of the leading preventable causes of in-hospital mortality. However, its risk assessment in medically ill inpatients is complicated due to the patients' heterogeneity and complexity of currently available risk assessment models (RAMs). The simplified Geneva score provides simplicity but has not yet been prospectively validated. Read More

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Agreement of total corneal power between 2 swept-source optical coherence tomography and Scheimpflug tomography in normal and keratoconic patients.

PLoS One 2022 24;17(5):e0268856. Epub 2022 May 24.

Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: To evaluate agreement of total corneal power (TCP) measured by swept-source anterior segment optical coherence tomography (CASIA 2), Scheimpflug tomography (Pentacam AXL), and swept-source optical biometer (IOLMaster 700) in normal and keratoconic patients.

Methods: This is a prospective observational study conducted at King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Biometric values were measured by each device for three times by two operators to evaluate repeatability and reproducibility of TCP. Read More

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Targeted therapies in non-small cell lung cancer and the potential role of AI interventions in cancer treatment.

Biotechnol Appl Biochem 2022 May 24. Epub 2022 May 24.

Department of Biotechnology, Delhi Technological University, Delhi, India.

Non-small cell lung cancer is the most prevalent lung cancer, and almost three-fourths of patients are diagnosed in the advanced stage directly. In this stage, chemotherapy gives only a 15% five-year survival rate. Since people have varied symptoms and reactions to a specific cancer type, treatment for that tumor is likely to fall short, complicating cancer therapy. Read More

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Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey.

Transl Behav Med 2022 May 24. Epub 2022 May 24.

Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Tobacco use disorder (TUD) is a major threat to health among people with HIV (PWH), but it is often untreated. Among HIV clinicians and staff, we sought to characterize practices, attitudes, and confidence addressing TUD among PWH to identify potential opportunities to enhance provision of care. Cross-sectional deidentified, web-based surveys were administered from November 4, 2020 through December 15, 2020 in HIV clinics in three health systems in the United States Northeast. Read More

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Post thrombotic syndrome after upper extremity deep vein thrombosis; An international Delphi consensus study.

J Thromb Haemost 2022 May 24. Epub 2022 May 24.

Department of Vascular Surgery, University Medical Center Utrecht, Netherlands.

Objectives: Primary deep venous thrombosis of the upper extremity (UEDVT) is a rare condition but up to 60% of patients may develop post thrombotic syndrome in the upper extremity (UE-PTS) with significant morbidity and decreased quality of life. However, there is no universally accepted method to diagnose and classify UE-PTS, hampering scientific research on UEDVT treatment. Through this international Delphi consensus study we aimed to determine what a clinical score for diagnosing UE-PTS should entail. Read More

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Insulin signaling in the heart is directly and early impaired by growth hormone.

J Mol Endocrinol 2022 May 1. Epub 2022 May 1.

J Miquet, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Consejo Nacional de lnvestigaciones Científicas y Técnicas, Buenos Aires, Argentina.

Growth hormone (GH) exerts major actions in cardiac growth and metabolism. Considering the important role of insulin in the heart and the well-established anti-insulin effects of GH, cardiac insulin resistance may play a role in the cardiopathology observed in acromegalic patients. As conditions of prolonged exposure to GH are associated with a concomitant increase of circulating GH, IGF-1 and insulin levels, to dissect the direct effects of GH, in this study we evaluated the activation of insulin signaling in the heart using four different models: 1) transgenic mice overexpressing GH, with chronically elevated GH, IGF-1 and insulin circulating levels, 2) liver IGF-1-deficient mice, with chronically elevated GH and insulin but decreased IGF-1 circulating levels, 3) mice treated with GH for a short period of time, and 4) primary culture of rat cardiomyocytes incubated with GH. Read More

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Systematic Analysis of Kaposi's Sarcoma-associated Herpesvirus Genomes from a Kaposi's Sarcoma (KS) Case-Control Study in Cameroon: Evidence of Dual Infections but No Association Between Viral Sequence Variation and KS Risk.

Int J Cancer 2022 May 24. Epub 2022 May 24.

Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland.

In sub-Saharan Africa, Kaposi's Sarcoma-associated Herpesvirus (KSHV) is endemic, and Kaposi's sarcoma (KS) is a significant public health problem. Until recently, KSHV genotype analysis was performed using variable gene regions, representing a small fraction of the genome, and thus the contribution of sequence variation to viral transmission or pathogenesis are understudied. We performed near full-length KSHV genome sequence analysis on samples from 43 individuals selected from a large Cameroonian KS case-control study. Read More

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