143,752 results match your criteria three occurred


Haze episodes before and during the COVID-19 shutdown in Tianjin, China: Contribution of fireworks and residential burning.

Environ Pollut 2021 May 6;286:117252. Epub 2021 May 6.

Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA; Institute for a Sustainable Environment, Clarkson University, Potsdam, NY, 13699, USA.

Potential health benefits from improved ambient air quality during the COVID-19 shutdown have been recently reported and discussed. Despite the shutdown measures being in place, northern China still suffered severe haze episodes (HE) that are not yet fully understood, particularly how the source emissions changed. Thus, the meteorological conditions and source emissions in processing five HEs occurred in Beijing-Tianjin-Hebei area were investigated by analyzing a comprehensive real-time measurement dataset including air quality data, particle physics, optical properties, chemistry, aerosol lidar remote sensing, and meteorology. Read More

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Molecular phylogeny, classification, biogeography and diversification patterns of a diverse group of moths (Geometridae: Boarmiini).

Mol Phylogenet Evol 2021 May 11:107198. Epub 2021 May 11.

Department of Biology, Lund University, Sweden. Electronic address:

Understanding how and why some groups have become more species-rich than others, and how past biogeography may have shaped their current distribution, are questions that evolutionary biologists have long attempted to answer. We investigated diversification patterns and historical biogeography of a hyperdiverse lineage of Lepidoptera, the geometrid moths, by studying its most species-rich tribe Boarmiini, which comprises ca. 200 genera and ca. Read More

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A Novel Fenestrating Device, "Quick Fenestrater," for Reconstructing Supra-aortic Arteries In Situ during Thoracic Endovascular Aortic Repair.

Can J Cardiol 2021 May 11. Epub 2021 May 11.

Department of Vascular and Endovascular Surgery, Changzheng Hospital, Naval Medical University, Shanghai, 200001, China. Electronic address:

Background: In situ fenestration (ISF) is an effective approach for reconstructing supra-aortic branches during thoracic endovascular aortic repair (TEVAR). A dedicated device is needed for ISF.

Methods: The "Quick Fenestrater" (QF) underwent in vitro, animal-based, and initial clinical testing. Read More

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Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, phase 2 trial.

Lancet Oncol 2021 May 11. Epub 2021 May 11.

Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Background: Pembrolizumab (PD-1 inhibitor) and cetuximab (EGFR inhibitor) are active as single agents and in combination with cytotoxic chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Given each drug's single agent activity and unique mechanism of action, we aimed to evaluate the anti-tumour activity of PD-1 blockade with EGFR inhibition in recurrent or metastatic HNSCC.

Methods: This study is an open-label, non-randomised, multi-arm, phase 2 trial done at four academic centres in the USA. Read More

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Factors affecting the seasonal distribution and biomass of E. pacifica and T. spinifera along the Pacific coast of Canada: A spatiotemporal modelling approach.

PLoS One 2021 14;16(5):e0249818. Epub 2021 May 14.

Fisheries and Oceans Canada, Pacific Biological Station, Nanaimo, British Columbia, Canada.

Euphausiids are a keystone species in coastal food webs due to their high lipid content and seasonally high biomass. Understanding the habitat and environmental drivers that lead to areas of high biomass, or 'hotspots', and their seasonal persistence, will support the identification of important foraging regions for mid- and upper- trophic level predators. We quantify the distribution of hotspots of the two dominant species of euphausiid in the north-east Pacific Ocean: Euphausia pacifica and Thysanoessa spinifera, as well as euphausiid larvae (mixed species). Read More

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Systematic Video Analysis of Anterior Cruciate Ligament Injuries in Professional Female Soccer Players.

Am J Sports Med 2021 May 14:3635465211008169. Epub 2021 May 14.

Education and Research Department, Isokinetic Medical Group, Bologna, Italy.

Background: Female soccer players are particularly susceptible to anterior cruciate ligament (ACL) injuries, accounting for 16% to 43% of the injury burden during the season. Despite the advancements in injury prevention programs, the rate of ACL injuries continues to rise.

Purpose: To provide a comprehensive description of the mechanisms, situational pattern, and biomechanics of ACL injuries in women's soccer. Read More

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Recipient vessel selection for multiple free flap transfers in head and neck reconstruction at different periods.

Microsurgery 2021 May 14. Epub 2021 May 14.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China.

Background: Treatment decisions can be challenging in patients undergoing multiple oropharyngeal microsurgical reconstructions at different periods by various causes. We, retrospectively, reviewed patients with at least three consecutive free flap reconstructions to determine the optimal strategy for selecting recipient vessels.

Methods: Then, 36 patients (33 men and 3 women) who underwent at least 3 microsurgical reconstructions with a total of 51 free flap transfers for head and neck defects were included in this report. Read More

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Efficacy of fractional laser, radiofrequency and IPL rejuvenation of periorbital region.

Lasers Med Sci 2021 May 14. Epub 2021 May 14.

Department of Cosmetology and Aesthetic Dermatology, Faculty of Pharmacy, Medical University of Łódź, Muszyńskiego 1 Street, 91-151, Łódź, Poland.

The purpose of this study was to assess skin elasticity, the reduction in the number and the depth of wrinkles and changes in the other skin defects (bags under the eyes, dark circles under the eyes, skin hyperpigmentation in the ageing eye area following the use of non-ablative fractional laser, bipolar radiofrequency and intense pulsed light). Moreover, the study was also comparison which device brought better results than the others. This study included 71 patients (66 women, 5 men), aged 33-63 years (the average age was 45. Read More

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Early adverse events after the first administration of zoledronic acid in Japanese patients with osteoporosis.

J Bone Miner Metab 2021 May 14. Epub 2021 May 14.

Department of Orthopaedic Surgery, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

Introduction: The occurrence of early adverse events and the factors associated with these events in zoledronic acid-treated Japanese patients with osteoporosis were investigated.

Materials And Methods: All patients treated with zoledronic acid for the first time for primary osteoporosis were analyzed. Based on the history of bisphosphonate (BP) administration, the patients were divided into three groups: BP-switch, BP-washout, and naïve groups. Read More

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The presence of ancient core genes reveals endogenization from diverse viral ancestors in parasitoid wasps.

Genome Biol Evol 2021 May 14. Epub 2021 May 14.

Department of Biology, University of Central Florida, Orlando, FL 32816, USA.

The Ichneumonoidea (Ichneumonidae and Braconidae) is an incredibly diverse superfamily of parasitoid wasps that includes species that produce virus-like entities in their reproductive tracts to promote successful parasitism of host insects. Research on these entities has traditionally focused upon two viral genera Bracovirus (in Braconidae) and Ichnovirus (in Ichneumonidae). These viruses are produced using genes known collectively as endogenous viral elements (EVEs) that represent historical, now heritable viral integration events in wasp genomes. Read More

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Characterising patterns of alcohol use among heavy drinkers: A cluster analysis utilising alcohol biosensor data.

Drug Alcohol Rev 2021 May 14. Epub 2021 May 14.

Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, USA.

Introduction: Previous research has predominately relied on person-level or single characteristics of drinking episodes to characterise patterns of drinking that may confer risk. This research often relies on self-report measures. Advancements in wearable alcohol biosensors provide a multi-faceted objective measure of drinking. Read More

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Robotic Posterior Retroperitoneal Adrenalectomy: Patient Selection and Long-Term Outcomes.

Ann Surg Oncol 2021 May 13. Epub 2021 May 13.

Department of Endocrine Surgery, Cleveland Clinic, Cleveland, OH, USA.

Background: Recently, efficacy of laparoscopic posterior retroperitoneal adrenalectomy (PRA) for pheochromocytoma and malignancy has been questioned. Although robotic technique using wristed instruments may improve limitations of laparoscopic PRA, the worldwide experience with robotic PRA is limited. This study aimed to describe patient characteristics, surgical technique, and long-term outcomes of robotic PRA from a 12-year single-center experience. Read More

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Effect of antimicrobial photodynamic therapy with red led and methylene blue on the reduction of halitosis: controlled microbiological clinical trial.

Lasers Med Sci 2021 May 13. Epub 2021 May 13.

Postgraduation Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Vergueiro Street, 235/249, Liberdade, São Paulo, SP, ZIP 01504-001, Brazil.

To determine the effect of antimicrobial photodynamic therapy (aPDT) using a red light-emitting diode (LED) on the reduction of halitosis and microbiological levels in the tongue coating immediately after irradiation, 7, 14, and 30 days after treatment. Forty-five young adults diagnosed with halitosis were allocated to three groups: G1, aPDT with 0.005% methylene blue and red LED (660 nm, four irradiation points, 90 s per point, power of 400 mW, 36 J per point, radiant exposure of 95 J/cm, continuous wave); G2, tongue scraping; and G3, tongue scraping and aPDT. Read More

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Anaerococcus faecalis sp. nov., Isolated from Swine Faeces.

Curr Microbiol 2021 May 13. Epub 2021 May 13.

Korean Collection for Type Cultures, Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Republic of Korea.

An obligate anaerobic, Gram-stain-positive, non-spore forming, non-motile, catalase and oxidase-negative, coccoid-shaped bacterium designated AGMB00486 was isolated from swine faeces. The optimal growth of the isolate occurred at pH 8.0 and 37 ℃. Read More

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Radial stem growth dynamics and phenology of a multi-stemmed species (Corylus avellana L.) across orchards in the Northern and Southern hemispheres.

Tree Physiol 2021 May 13. Epub 2021 May 13.

University of Padova, Department Territorio e Sistemi Agro Forestali (TESAF), Viale dell'Università 16, 350120 Legnaro (PD), Italy.

Climate change and the global economy impose new challenges in the management of food-producing trees and require studying how to model plant physiological responses, namely growth dynamics and phenology. Hazelnut (Corylus avellana L.) is a multi-stemmed forest species domesticated for nut production and now widely spread across different continents. Read More

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Latent profile analysis of blood marker phenotypes and their relationships with clinical pain and interference reports in people with acute musculoskeletal trauma.

Can J Pain 2021 Feb 16;5(1):30-42. Epub 2021 Feb 16.

Faculty of Health Sciences, Western University, London, Ontario, Canada.

: The prevalence of inadequate treatments for chronic pain has necessitated the search for biological factors that influence the transition to chronicity. : Antecubital blood was drawn from those who experienced acute, noncatastrophic musculoskeletal trauma. Follow-up occurred at 1, 3, 6, and 12 months with the primary outcome being Brief Pain Inventory (BPI) Functional Interference scores. Read More

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February 2021

Local patterns of arbuscular mycorrhizal fungal diversity and community structure in a natural var. forest in South Central China.

PeerJ 2021 3;9:e11331. Epub 2021 May 3.

Jiangxi Provincial Key Laboratory of Silviculture/Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization, Nanchang, Jiangxi, China.

var. ( in Meliaceae) () is listed as an endangered species, and there are natural regeneration obstacles due to its long-term excessive exploitation and utilization. Arbuscular mycorrhizal fungi (AMF) can produce beneficial effects for plant growth and natural regeneration. Read More

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Comparative transcriptome analysis reveals key insights into male sterility in Bunge.

PeerJ 2021 27;9:e11326. Epub 2021 Apr 27.

College of Sciences, Sichuan Agricultural University, Ya'an, Sichuan, China.

Background: Large-scale heterosis breeding depends upon stable, inherited male sterility lines. We accidentally discovered a male sterility line (SW-S) in the Fprogeny of a Bunge from Shandong, China (purple flowers) crossed with a f. alba from Sichuan, China (white flowers). Read More

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Real-World Treatment Patterns of Multiple-Inhaler Triple Therapy Among Patients with Chronic Obstructive Pulmonary Disease in UK General Practice.

Int J Chron Obstruct Pulmon Dis 2021 6;16:1255-1264. Epub 2021 May 6.

Value Evidence and Outcomes, GlaxoSmithKline, Collegeville, PA, USA.

Introduction: Until recently, triple therapy for chronic obstructive pulmonary disease (COPD) has only been available through treatment with multiple inhalers. Evidence on real-world use of multiple-inhaler triple therapy (MITT), including duration of use and treatment patterns, is limited.

Methods: A retrospective, observational study of electronic health records and hospital episodes in patients with COPD initiating MITT between 2013 and 2015 in the UK was performed. Read More

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The clinical significance of receiving a kidney allograft from deceased donor with chronic histologic changes.

Mod Pathol 2021 May 13. Epub 2021 May 13.

Surgery, Division of Transplantation, Columbia University Irving Medical Center, New York, NY, USA.

Allograft survival of deceased donor kidneys with suboptimal histology (DRTx/suboptimal histology: >10% glomerulosclerosis, >10% tubulointerstitial scarring, or >mild vascular sclerosis) is inferior to both DRTx with optimal histology (DRTx/optimal histology) and living donor kidneys irrespective of histologic changes (LRTx). In this report, we explored the reasons behind this guarded outcome with a special focus on the role of alloimmunity. We initially assessed gene expression in 39 time-zero allograft biopsies using the Nanostring 770 genes PanCancer Immune Profiling Panel. Read More

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Identification of sensory and motor nerve fascicles by immunofluorescence staining after peripheral nerve injury.

J Transl Med 2021 May 13;19(1):207. Epub 2021 May 13.

Department of Neurosurgery, University of Maryland School of Medicine, 10 South Pine Street, MSTF Building 823, Baltimore, MD, 21201, USA.

Background: Inappropriate matching of motor and sensory fibers after nerve repair or nerve grafting can lead to failure of nerve recovery. Identification of motor and sensory fibers is important for the development of new approaches that facilitate neural regeneration and the next generation of nerve signal-controlled neuro-prosthetic limbs with sensory feedback technology. Only a few methods have been reported to differentiate sensory and motor nerve fascicles, and the reliability of these techniques is unknown. Read More

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Determinants of Remission in a Case Series of Medullary Thyroid Carcinoma.

Turk J Med Sci 2021 May 14. Epub 2021 May 14.

Background/aim: We aimed to present the clinical results of patients with medullary carcinoma under follow-up in our center and to determine parameters affecting remission and lymph node metastases.

Material And Methods: A retrospective analysis was performed of the medical records of 27 patients with MTC who were followed up between 2004 and 2020.

Results: The mean age at diagnosis was 47. Read More

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Patterns of integrating palliative care into standard oncology in an early ESMO designated center: a 10-year experience.

ESMO Open 2021 May 10;6(3):100147. Epub 2021 May 10.

Oncological Palliative Medicine, Clinic Oncology/Hematology, Cantonal Hospital St. Gallen, Switzerland.

Background: Integration of specialist palliative care (PC) into standard oncology care is recommended. This study investigated how integration at the Cantonal Hospital St. Gallen (KSSG) was manifested 10 years after initial accreditation as a European Society for Medical Oncology (ESMO) Designated Center (ESMO-DC) of Integrated Oncology and Palliative Care. Read More

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Prediction of CMV reactivation by recipient CMV-IgG titer before allo-HCT.

Transplant Cell Ther 2021 May 10. Epub 2021 May 10.

Division of Hematology, Jichi Medical University Saitama Medical Center. Electronic address:

Background: Recipient cytomegalovirus (CMV) seropositivity is known to be a risk factor for CMV reactivation after allogeneic hematopoietic stem cell transplantation (allo-HCT).

Objective: We explored the association of CMV-IgG titer of recipients with CMV reactivation after allo-HCT and aimed to establish a model for predicting CMV reactivation for the purpose of identifying a high-risk group. In addition, we evaluated the impact of CMV-IgG titer on survival outcomes and acute graft-versus-host-disease (GVHD). Read More

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Cancer progression as a sequence of atavistic reversions.

Bioessays 2021 May 13:e2000305. Epub 2021 May 13.

Beyond Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, USA.

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi-unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular-to-unicellular reversion predicted by the atavism model has come from phylostratigraphy. Read More

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Trophic ecology of yellowtail rockfish (Sebastes flavidus) during a marine heat wave off central California, USA.

PLoS One 2021 13;16(5):e0251499. Epub 2021 May 13.

Moss Landing Marine Laboratories, Moss Landing, California, United States of America.

The yellowtail rockfish, Sebastes flavidus, is a widespread and abundant mesopredator in the California Current Large Marine Ecosystem. We utilized stomach content and stable isotope analyses to investigate the trophic ecology of this species at three sites off central California just before (August-October 2013) and during (August and October 2014) a marine heat wave. Sebastes flavidus largely consumed pelagic prey (zooplankton and micronekton). Read More

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First Report of Causing Leaf Spot of Tartary Buckwheat () in China.

Plant Dis 2021 May 13. Epub 2021 May 13.

School of Life Science, Hunan University of Science and Technology, Xiangtan, Hunan, China, China.

Buckwheat (Fagopyrum tataricum) is recognized as a healthy food with abundant nutrients and high levels of rutin. In April and May of 2020, an unknown tartary buckwheat leaf spot distinct from Nigrospora leaf spot (Shen et al. 2020) was observed in Xiangxiang, Hunan, China (27°49'54″N, 112°span style="font-family:'Times New Roman'; color:#0000ff">18'48″E. Read More

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Natural variation in fecundity is correlated with species-wide levels of divergence in Caenorhabditis elegans.

G3 (Bethesda) 2021 May 13. Epub 2021 May 13.

Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.

Life history traits underlie the fitness of organisms and are under strong natural selection. A new mutation that positively impacts a life history trait will likely increase in frequency and become fixed in a population (e.g. Read More

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Phenylacrylic acids addition to potato and sweet potato showed no impact on acrylamide concentration oxa-Michael-addition during frying.

Curr Res Food Sci 2021 19;4:262-269. Epub 2021 Apr 19.

Gottfried Wilhelm Leibniz Universität Hannover, Institut für Lebensmittelchemie, Callinstraße 5, 30167, Hannover, Germany.

Three phenolic acids, -coumaric, ferulic and caffeic acid as well as cinnamic acid were added to raw potatoes and sweet potatoes before frying. A distinct mitigation of acrylamide was not detected. Fried samples were analysed for postulated adducts of a direct reaction between acrylamide and these phenolic acids using LC-MS. Read More

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Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis.

Eur Thyroid J 2021 Apr 11;10(2):125-139. Epub 2020 Sep 11.

Endocrine Unit, Department of Medical Therapeutics, School of Medicine, Kapodistrian University of Athens, Athens, Greece.

Introduction: Tyrosine kinase inhibitors (TKIs) have been used in patients with advanced medullary thyroid carcinoma (MTC); however, data on their effectiveness and safety are limited. The aim of this systematic review and meta-analysis was to document clinical response and toxicities of TKIs in advanced MTC.

Methods: We systematically searched major databases for articles or abstracts on TKI use in MTC patients until May 2018. Read More

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