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Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019), a Dutch population based study.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Radboud university medical centre, Radboud Institute for Health Sciences, Department of Surgery, Nijmegen, The Netherlands.

Aim: Anastomotic leakage (AL) after colon cancer (CC) and rectal cancer (RC) surgery often requires reintervention. Prevalence and morbidity may change over time with evolutions in treatment strategies and changes in patient characteristics. This nationwide study aimed to evaluate changes in the incidence, risk factors and mortality from AL during the past nine years. Read More

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September 2021

The anatomy of agency: Improving academic performance in first year university students.

Anat Sci Educ 2021 Sep 18. Epub 2021 Sep 18.

The School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.

The transition from secondary to tertiary education can be challenging, as students must adapt to independent learning. For students in the allied health and nursing disciplines, this transition may coincide with compulsory first year courses in anatomy, which are traditionally difficult to master. Students' agency - their capacity to make intentional choices to alter the path of their learning - may play a role in their successful completion of first year anatomy courses. Read More

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September 2021

Longitudinal asthma and allergy study showed that childhood symptoms frequently persisted into adulthood.

Acta Paediatr 2021 Sep 18. Epub 2021 Sep 18.

University of Iceland, Faculty of Medicine, Reykjavík, Iceland.

Aims: The prevalence of allergic diseases is high and increasing in many countries. The aim of this study was to describe the prevalence of allergic diseases and changes in clinical expression in a birth cohort followed for three decades.

Methods: We followed Icelandic citizens born in 1987 for allergic diseases when they were two, four, eight, 15, 21 and 29 years of age. Read More

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September 2021

Development of accelerometer-based light to vigorous physical activity in fitness profiles of school-aged children.

Scand J Med Sci Sports 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, Jyväskylä, Finland, 40014.

This study examined the developmental trajectories of light (LPA) and moderate-to-vigorous physical activity (MVPA) in fitness profiles derived from motor competence, perceived motor competence, health-related fitness, and MVPA behaviour. Locomotor, stability, and object-control skills, muscular and cardiovascular fitness, and physical activity were assessed in 510 (girls 285, boys 225) Finnish school-aged children (M = 11.26 ± . Read More

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September 2021

Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical presentations include acute liver failure or chronic liver failure with liver cirrhosis, which are cruelly progressive and fatal. We report six cases of LT for acute liver failure diagnosed pathogenic MPV17 variants. Read More

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September 2021

Saliva testing as a means to monitor therapeutic lithium levels in patients with psychiatric disorders: identification of clinical and environmental covariates, and their incorporation into a prediction model.

Bipolar Disord 2021 Sep 18. Epub 2021 Sep 18.

Department of Epidemiology, University of California Irvine, Irvine, 92697, CA, USA.

Objective: The narrow therapeutic window of lithium medications necessitates frequent serum monitoring, which can be expensive and inconvenient for the patient. Compared to blood, saliva collection is easier, non-invasive, requires less processing, and can be done without the need for trained personnel. This study investigated the utility of longitudinal salivary lithium level monitoring. Read More

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September 2021

Early Versus Delayed Feeding After Therapeutic Endoscopic Procedures: A Meta-Analysis of Randomized Controlled Trials.

Dig Endosc 2021 Sep 18. Epub 2021 Sep 18.

Division of Emergency Medicine, Department of Emergency and Critical Care, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.

Introduction: Early feeding was previously considered to increase the risk of postprocedural bleeding. However, many trials have demonstrated the benefits of early feeding after therapeutic endoscopic procedures. We conducted a meta-analysis of randomized controlled trials to evaluate the safety and outcomes between early feeding and delayed feeding after therapeutic endoscopic procedures. Read More

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September 2021

Complications and prognosis associated with intra-tympanic steroid injection to treat sudden sensorineural hearing impairment.

Am J Otolaryngol 2021 Sep 10;43(1):103221. Epub 2021 Sep 10.

Division of Otology, Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Medicine, Chang Gung University, Taiwan. Electronic address:

Purpose: The purpose of this study was to measure the incidence of complications in sudden sensorineural hearing loss (SSNHL) patients treated with intra-tympanic steroid injection (ITSI) and compare hearing recovery rates.

Materials And Methods: 123 patients with unilateral SSNHL receiving ITSIs were included in this study. Post-ITSI complications were documented including otalgia, dysgeusia, vertigo (duration>1 h), and persistent eardrum perforation. Read More

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September 2021

Extracranial temporal bone paragangliomas: Re-defining the role of otologic surgery within the scope of function-preserving multimodal concepts.

Am J Otolaryngol 2021 Sep 12;43(1):103212. Epub 2021 Sep 12.

Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Introduction: The aim of this study was to present our concept in the management of extracranial temporal bone paragangliomas and demonstrate the outcome after primary surgical management of the middle ear component, with an individualized indication for adjuvant radiotherapy.

Materials And Methods: The records of all patients treated for extracranial jugulotympanic paragangliomas by means of primary surgical management between 2010 and 2021 were studied retrospectively.

Results: Twenty-nine patients made up our study sample (mean age 58. Read More

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September 2021

Virtual reality surgical planning for endoscopic endonasal approaches to the craniovertebral junction.

Am J Otolaryngol 2021 Sep 11;43(1):103219. Epub 2021 Sep 11.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Otolaryngology Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.

Purpose: To demonstrate the utility of virtual reality (VR) for preoperative surgical planning of endoscopic endonasal craniovertebral junction (CVJ) surgery.

Materials And Methods: Five patients who had undergone endoscopic endonasal surgery of the craniovertebral junction with preoperative virtual reality surgical planning were identified and described.

Results: The anterior approach to the CVJ has been traditionally accomplished transorally. Read More

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September 2021

Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.

Diagn Microbiol Infect Dis 2021 Aug 20;101(4):115520. Epub 2021 Aug 20.

Department of General Pathology and Molecular Diagnostics, University of Augsburg, Augsburg, Germany.

Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed. Read More

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Review of prophylactic swallowing interventions for head and neck cancer.

Int J Nurs Stud 2021 Aug 27;123:104074. Epub 2021 Aug 27.

The First Hospital of Jilin University, No.71 Xinmin street, Changchun, Jilin 130021, China. Electronic address:

Background: Head and neck cancer treatment destroys nerves and/or organs associated with swallowing. Previous studies have investigated the efficacy of exercises for muscles used in swallowing before treatment in reducing disuse atrophy and delaying the occurrence of muscle fibrosis. However, the rehabilitation effects of training and the optimal intervention strategy are unknown. Read More

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Computational prediction of NO-dependent posttranslational modifications in plants: Current status and perspectives.

Plant Physiol Biochem 2021 Sep 13;167:851-861. Epub 2021 Sep 13.

Institute of Biochemical Plant Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstr. 1, D-85764, Oberschleißheim, München, Germany. Electronic address:

The perception and transduction of nitric oxide (NO) signal is achieved by NO-dependent posttranslational modifications (PTMs) among which S-nitrosation and tyrosine nitration has biological significance. In plants, 100-1000 S-nitrosated and tyrosine nitrated proteins have been identified so far by mass spectrometry. The determination of NO-modified protein targets/amino acid residues is often methodologically challenging. Read More

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September 2021

PLS-DA and data fusion of visible Reflectance, XRF and FTIR spectroscopy in the classification of mixed historical pigments.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 10;265:120384. Epub 2021 Sep 10.

Laboratório de Instrumentação e Simulação Computacional. LISCOMP/IFRJ-CPAR, 26600-000, Paracambi, Brazil. Electronic address:

In this work samples of historical pigments of green hue were brushed on a canvas and studied by Visible Reflectance, X-Ray Fluorescence and Fourier Transform Infrared Spectroscopy. One hundred samples were investigated, all with green hue, these prepared from pigments themselves green, such as chromium oxide (CrO) or from a mixture of pigments that result in green, for example, chrome yellow (PbCrO) and Prussian blue (Fe[Fe(CN)]). Because every sample investigated through the spectroscopic techniques were of green hue, the characterization of the pigments present in the mixtures through the visual inspection of spectra has become a complex task in some cases, also, due the large number of recorded spectra. Read More

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September 2021

Solvent polarity dependent ESIPT behavior for the novel flavonoid-based solvatofluorochromic chemosensors.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 10;265:120383. Epub 2021 Sep 10.

Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China. Electronic address:

In this work, we explore the excited-state intramolecular proton transfer (ESIPT) mechanisms and relative solvent effects for three novel 3-hydroxylflavone derivatives (i.e., HOF, SHOF, and NSHOF) in acetonitrile, dichloromethane, and toluene solvents. Read More

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September 2021

Magnetic resonance imaging radiomics signatures for predicting endocrine resistance in hormone receptor-positive non-metastatic breast cancer.

Breast 2021 Sep 11;60:90-97. Epub 2021 Sep 11.

Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China. Electronic address:

Background: One-third of patients with hormone receptor (HR)-positive breast cancers fail to respond to hormone therapy, and some patients even progress within two years of adjuvant endocrine therapy (ET) toward primary endocrine resistance. However, there is no effective way to predict endocrine resistance.

Objective: To build a model that incorporates the radiomic signature of pretreatment magnetic resonance imaging (MRI) with clinical information to predict endocrine resistance. Read More

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September 2021

Determination of anthropogenic organics in dichlomethane extracts of aerosol particulate matter collected from four different locations in China and Republic of Korea by GC-MS and FTICR-MS.

Sci Total Environ 2021 Sep 9;805:150230. Epub 2021 Sep 9.

Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea; Mass Spectrometry Convergence Research Center and Green-Nano Materials Research Center, Daegu 41566, Republic of Korea. Electronic address:

In this study, the hypothesis that particulate matter in east of Korea peninsula would be significantly influenced by particulate matter originated from east of China was evaluated. To test the hypothesis, water-insoluble compounds in particulate matter samples collected from three different locations in Korea and one in China were characterized by atmospheric pressure photoionization (APPI) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and gas chromatography mass spectrometry (GC-MS). Each sample was collected twice, in winter and in spring. Read More

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September 2021

SARS-CoV-2 variant detection at a university dormitory using wastewater genomic tools.

Sci Total Environ 2021 Sep 7;805:149930. Epub 2021 Sep 7.

Laboratory of Neurogenetics and Precision Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA; Department of Internal Medicine, UNLV School of Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA. Electronic address:

In the Fall of 2020, university campuses in the United States resumed on-campus instruction and implemented wastewater monitoring for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While quantitative polymerase chain reaction (qPCR) tests were deployed successfully to detect viral RNA in wastewater across campuses, the feasibility of detecting viral variants from a residential building like a dormitory was unclear. Here, we demonstrate that wastewater surveillance from a dormitory with at least three infected students could lead to the identification of viral genomes with more than 95% coverage. Read More

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September 2021

Compositions of sequestrated soil carbon in constructed wetlands of Taiwan.

Sci Total Environ 2021 Sep 11;805:150290. Epub 2021 Sep 11.

Department of Safety, Health and Environmental Engineering, National Kaohsiung University of Science and Technology, Taiwan.

Constructed wetlands are an ecological engineering technology that has been widely applied to treat anthropogenic wastewater. Until now, few studies have focused on soil carbon (C) in the constructed treatment wetlands in tropical regions. Therefore, this study provides insight into the changes in soil C composition of tropically constructed wetlands at different ages. Read More

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September 2021

Polycyclic aromatic hydrocarbon (PAH) accumulation in Quercus palustris and Pinus nigra in the urban landscape of Gothenburg, Sweden.

Sci Total Environ 2021 Sep 7;805:150163. Epub 2021 Sep 7.

Gothenburg University, Department of Biological and Environmental Sciences, Box 461, 405 30 Gothenburg, Sweden. Electronic address:

Trees have the potential to improve urban air quality as leaves and needles capture air pollutants from the air, but further empirical data has been requested to quantify these effects. We measured the concentration of 32 polycyclic aromatic hydrocarbons (PAHs) in leaves of pin oak (Quercus palustris) and needles of black pine (Pinus nigra) in the City of Gothenburg, Sweden, during the summer of 2018. Oak leaves were collected twice (June, September), while one-year-old (C + 1) and three-year-old (C + 3) pine needles were sampled in June to study the temporal development of leaf/needle PAH concentrations. Read More

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September 2021

Artificial intelligence-based hybrid deep learning models for image classification: The first narrative review.

Comput Biol Med 2021 Aug 27;137:104803. Epub 2021 Aug 27.

Stroke Diagnosis and Monitoring Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

Background: Artificial intelligence (AI) has served humanity in many applications since its inception. Currently, it dominates the imaging field-in particular, image classification. The task of image classification became much easier with machine learning (ML) and subsequently got automated and more accurate by using deep learning (DL). Read More

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Assessment of the potential for phytoremediation of cadmium polluted soils by various crop rotation patterns based on the annual input and output fluxes.

J Hazard Mater 2021 Sep 12;423(Pt B):127183. Epub 2021 Sep 12.

College of Resources and Environment, Hunan Agricultural University, Changsha 410128, Hunan, China. Electronic address:

Phytoremediation potential of two oil crop rotations (oilseed sunflower-rape (O+Ra) and peanut-oilseed rape (P+Ra)) was compared with three conventional cropping patterns (rice-rape (R+Ra), rice-rice (R+R), single cropped rice (SR)) in experimental plots with cadmium (Cd)-contaminated soil. A new approach was used to evaluate phytoremediation potential based on the balance between annual input and output fluxes of Cd in farmland soil. In O+Ra and P+Ra rotations, 77. Read More

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September 2021

Fermentative volatile fatty acid production and recovery from grass using a novel combination of solids separation, pervaporation, and electrodialysis technologies.

Bioresour Technol 2021 Sep 13;342:125926. Epub 2021 Sep 13.

Sustainable Environment Research Centre, University of South Wales, Llantwit Road, Pontypridd, Rhondda Cynon Taff, CF37 1DL, UK.

A novel combination of solids screening, centrifugation, microfiltration, pervaporation, and electrodialysis were used for the targeted and exclusive recovery of volatile fatty acids (VFAs) from an 80L bioreactor. The bioreactor was continually-fed with grass waste, containing 40gL total solids, over three, seven-day, hydraulic retention times. A VFA solution with a concentration up to 4,500 mgL was recovered. Read More

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September 2021

Benzyl isothiocyanate-modified α-lactalbumin - Two-dimensional high-performance thin-layer chromatography for analyzing modified peptides.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Sep 15;1181:122937. Epub 2021 Sep 15.

University of Hamburg, Hamburg School of Food Science, Institute of Food Chemistry, Grindelallee 117, D-20146 Hamburg, Germany; Technische Universität Berlin, Institute of Food Technology and Food Chemistry, Department of Food Chemistry and Analysis, TIB 4/3-1, Gustav-Meyer-Allee 25, 13355 Berlin, Germany. Electronic address:

In complex food matrices, non-directed reactions between food proteins and secondary plant metabolites (SPM) are conceivable. In this study, the interaction between the bioactive metabolite from garden cress (Lepidium sativum) and selected Brassicaceae - benzyl isothiocyanate (BITC) - and the dairy protein α-lactalbumin (α-LA) was investigated. It was focused on monitoring the proteolytic degradation behaviour of unmodified and BITC-modified α-LA with two-dimensional high-performance thin-layer chromatography (2D-HPTLC). Read More

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September 2021

Real-time replication of three-dimensional and time-varying physiological loading cycles for bone and implant testing: A novel protocol demonstrated for the proximal human femur while walking.

J Mech Behav Biomed Mater 2021 Sep 4;124:104817. Epub 2021 Sep 4.

Medical Device Research Institute, College of Science and Engineering, Flinders University, Tonsley, SA, Australia.

In vitro real-time replication of three-dimensional, time-varying load profiles acting on human bones during physical activity can advance bone and implant testing protocols. This study aimed to develop a novel protocol for applying the three-dimensional, time-varying hip contact force while walking to a human femur specimen. The target force profile was obtained from the literature. Read More

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September 2021

Hydrothermal aging affects the three-dimensional fit and fatigue lifetime of zirconia abutments.

J Mech Behav Biomed Mater 2021 Sep 8;124:104832. Epub 2021 Sep 8.

Department of Prosthodontics and Periodontology, Bauru School of Dentistry - University of Sao Paulo, 9-75 Octavio Pinheiro Brizolla, 17012-901, Bauru, SP, Brazil.

Objective: Evaluate the effect of aging using two different methods on the three-dimensional fit of zirconia abutments at the implant-abutment connection and estimate the probability of survival of anterior crowns supported by straight and 17-degree angled abutments.

Materials And Methods: Two different zirconia abutment designs, straight and 17-degree angled abutments (n = 63/group), were evaluated in the current study. The abutments were randomly allocated into three experimental groups according to laboratory aging condition (134°C, 2. Read More

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September 2021

Racial and ethnic disparities in treatment response and tolerability in multiple sclerosis: A comparative study.

Mult Scler Relat Disord 2021 Sep 9;56:103248. Epub 2021 Sep 9.

Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Inter-individual response and tolerability profiles associated with available disease-modifying treatments (DMTs) are an important aspect of the therapeutic decision-making process in multiple sclerosis (MS). In the absence of racially diverse clinical studies, the possible effect of race and ethnicity on treatment outcome remains uncertain. This study aims to compare disease outcome among Hispanic, Black, and White patients with MS, and assess the impact of race/ethnicity on long-term outcome. Read More

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September 2021

Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats.

Biomed Pharmacother 2021 Sep 15;143:112180. Epub 2021 Sep 15.

Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt; Department of Biological Sciences, Faculty of Science, Beirut Arab University, Lebanon. Electronic address:

The current work aims to study the nephroprotective potential of naringin (NG), a flavanone derived from citrus fruits, in methotrexate (MTX)-induced renal toxicity. Thirty male rats were divided into five groups; control group (IP saline), MTX group (IP single dose, 20 mg/kg), and three groups co-treated with MTX and naringin (IP daily dose; 20, 40, and 80 mg/kg, respectively). Kidney tissues were used to investigate renal function, oxidative stress, lipid peroxidation, and caspase-3 activity. Read More

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September 2021

A possible pathogenic correlation between neutrophil elastase (NE) enzyme and inflammation in the pathogenesis of coronavirus disease 2019 (COVID-19).

Int Immunopharmacol 2021 Sep 14;100:108137. Epub 2021 Sep 14.

Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

A growing body of evidence indicates that neutrophil elastase (NE) is involved in the pathogenesis of respiratory infectious diseases, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to analyze the dynamic changes in serum levels of NE associated with inflammation, disease activity, and mortality rate in patients with COVID-19. We measured the serum concentrations of NE, C-Reactive protein (CRP), interleukin (IL)- 4, IL-6, IL-8, IL-10, and vitamin D levels in 83 ICU and 69 non-ICU patients compared with 82 healthy subjects (HS) in three-time points (T1-T3). Read More

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September 2021

Concentration, distribution, and assessment of dissolved heavy metals in rivers of Lake Chaohu Basin, China.

J Environ Manage 2021 Sep 15;300:113744. Epub 2021 Sep 15.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100049, China; College of Chemical and Environmental Engineering, Chongqing Three Gorges University, Wanzhou, 404000, China. Electronic address:

This study aimed at establishing the spatial and seasonal distribution patterns of dissolved metals, and assessing the water quality and potential human health risk, in rivers of Lake Chaohu Basin (LCB, China). Four seasonal samplings were conducted at 83 sites from April to December in 2018. The water quality was assessed using heavy metal evaluation index (HEI), while hazard index (HI) and carcinogenic risks indicated potential human risk, according to 12 metals (Cr, Mn, Fe, Ni, Cu, Zn, As, Mo, Cd, Sb, Ba, and Pb). Read More

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September 2021