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Developing a person-centered, population based measure of "home time": Perspectives of older patients and unpaid caregivers.

Healthc (Amst) 2021 Oct 20;9(4):100591. Epub 2021 Oct 20.

Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Health Care System; 508 Fulton Street (152), Durham, NC, 27705, USA; Duke University School of Medicine, Department of Population Health Sciences, Durham, NC, USA; Duke University, Margolis Center for Health Policy, Durham, NC, USA.

Measuring "home time," number of days not in facility-based care, with medical claims is a promising approach to assess person-centered outcomes on a population level. Generally, spending more time at home matches long-term care preferences and improves quality of life. However, existing "home time" measures have not incorporated key stakeholder perspectives. Read More

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October 2021

Early onset externalizing behaviors among forensic psychiatric patients: Identification in child and adolescent psychiatric services.

Psychiatry Res 2021 Oct 13;305:114235. Epub 2021 Oct 13.

Child and Adolescent Psychiatry, Department of Clinical Sciences Lund, Lund University, Sofiavägen 2D, Lund SE-22241, Sweden; Centre for Ethics, Law and Mental Health, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Research Department, Regional Forensic Psychiatric Clinic Växjö, Sweden.

Forensic psychiatric patients constitute a heterogeneous patient group, with common comorbidity within the externalizing spectrum. Increased knowledge on early antecedents in the pathway to severe mental illness and criminality is needed. In this study, we investigated early onset externalizing behaviors in three groups of forensic psychiatric patients 1) patients without contact with child and adolescent psychiatry (CAP), 2) patients with CAP contact, and 3) patients with both CAP contact and institutional placement. Read More

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October 2021

A pyroptosis-related lncRNA signature predicts prognosis and immune microenvironment in head and neck squamous cell carcinoma.

Int Immunopharmacol 2021 Oct 20;101(Pt B):108268. Epub 2021 Oct 20.

Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Pyroptosis, a type of regulated cell death controlled by the gasdermin family of proteins to form plasma membrane pores is known. Nonetheless, the function of pyroptosis-related long non-coding RNAs (lncRNAs) in this process still lacks exhaustive elucidation in head and neck squamous cell carcinoma (HNSCC). Other attributes encompassing the function of such lncRNAs in the immune microenvironment and potential prognosis for HNSCC are yet to see the light of the day. Read More

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October 2021

Corticospinal tract abnormalities and ventricular dilatation: A transdiagnostic comparative tractography study.

Neuroimage Clin 2021 Oct 19;32:102862. Epub 2021 Oct 19.

Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy; Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, National Research Council, 88100 Catanzaro, Italy. Electronic address:

Background: Microstructural alterations of corticospinal tract (CST) have been found in idiopathic normal pressure hydrocephalus (iNPH). No study, however, investigated the effect of ventricular dilatation on CST in Progressive Supranuclear Palsy (PSP).

Objective: The aim of this study was to investigate CST diffusion profile in a large cohort of PSP patients with and without ventricular dilatation. Read More

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October 2021

The desire thinking questionnaire-Persian version (DTQ-P) and its association with addictive behaviors in individuals with alcohol use disorder, nicotine dependence, and problematic social media use.

Addict Behav 2021 Oct 11;125:107144. Epub 2021 Oct 11.

Departments of Psychiatry, Behavioral Sciences Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Desire thinking is an emerging construct which has been shown to play a role in addictive behaviors. The present study sought to validate a translated Persian version of the Desire Thinking Questionnaire (DTQ) in three groups of individuals with Alcohol Use Disorder (AUD; n = 300), nicotine dependence (n = 300), and problematic social media use (n = 300). All three groups completed the translated Persian version of the DTQ, the Barratt Impulsiveness Scale-15 (BIS-15), the White Bear Suppression Inventory (WBSI), and the Depression Anxiety and Stress Scale-21 (DASS-21). Read More

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October 2021

Anti-N-methyl-D-aspartate receptor encephalitis: An observational and comparative study in Mexican children and adults.

Clin Neurol Neurosurg 2021 Oct 11;210:106986. Epub 2021 Oct 11.

Department of Neuroinfectology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, México. Electronic address:

Objective: To present a case series of encephalitis patients with anti-N-methyl-D-aspartate receptor antibodies, attending two neurological referral centers in a three-year period.

Methods: A retrospective, descriptive, comparative study included child and adult patients in two neurological populations, positive for antibodies against the NR1 and NR2 subunits of the glutamate (NMDA) receptor in serum and CSF, as determined during a three-year period.

Results: Sixty-six patients were included (40 children and 26 adults). Read More

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October 2021

Association of phase angle with muscle strength and aerobic fitness in different populations: A systematic review.

Nutrition 2021 Sep 12;93:111489. Epub 2021 Sep 12.

Research Center in Kinanthropometry and Human Performance, Sports Center, Federal University of Santa Catarina, Florianópolis, Brazil. Electronic address:

Objectives: The aim of this study was to summarize the evidence on the association of phase angle (PhA) with muscle strength and aerobic fitness in different populations.

Methods: A systematic search on this topic was performed in nine electronic databases (CINAHL, LILACS, PubMed, SciELO, Scopus, SPORTDiscus, ScienceDirect, MEDLINE, and Web of Science) in January 2021. Studies with different designs that permitted extraction of information about the relationships between PhA and muscle strength and between PhA and aerobic fitness were included. Read More

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September 2021

The effect of breastfeeding, kangaroo care, and facilitated tucking positioning in reducing the pain during heel stick in neonates.

J Pediatr Nurs 2021 Oct 20;61:410-416. Epub 2021 Oct 20.

Selcuk University, Faculty of Nursing, Department of Child Health and Disease Nursing, Konya, Turkey. Electronic address:

Purpose: Invasive intervention can negatively affect prognosis, behavior, environmental adaptation in neonates. Some nonpharmacological pain management methods are used for effective pain treatment. This study investigated the effect of breastfeeding, kangaroo care, and facilitated tucking positioning on heel-stick pain in neonates. Read More

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October 2021

Functional bracing is a safe and cost effective treatment for isolated Weber B fracture.

Foot (Edinb) 2021 May 27;49:101839. Epub 2021 May 27.

United Arab Emirates University, Al-Ain, United Arab Emirates. Electronic address:

Background: Despite the current recommendations that stable Weber B ankle fractures can be treated with functional bracing and weightbearing as tolerated, some reluctance exists among trauma surgeons to follow these recommendations. This paper reports on our institution's experience in managing these injuries and compare it to the national guidelines.

Patients And Methods: This is a retrospective cohort study. Read More

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Are critical shoulder angle and acromion index correlated to the size of a rotator cuff tear.

Orthop Traumatol Surg Res 2021 Oct 20:103122. Epub 2021 Oct 20.

Acıbadem Mehmet Ali Aydınlar University School of Medicine Orthopaedics and Traumatology Department, İstanbul, TURKEY.

Purpose: Scapular morphology is an extrinsic factor playing role in rotator cuff tear (RCT) etiology. The objective of this study was to evaluate the relationship between critical shoulder angle (CSA) and acromion index (AI) with partial-bursal side and full thickness RCT and the size of the RCT. Hypothesis The hypothesis was that CSA and AI would be greater in partial bursal-side RCT and full-thickness RCT patients and would increase with the size of the RCT. Read More

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October 2021

Comparison of video-stylet and video-laryngoscope for endotracheal intubation in adults with cervical neck immobilisation: A meta-analysis of randomised controlled trials.

Anaesth Crit Care Pain Med 2021 Oct 20:100965. Epub 2021 Oct 20.

Department of Emergency Medicine, E-Da Hospital, Kaohsiung city, Taiwan; College of Medicine, I-Shou University, Kaohsiung city, Taiwan. Electronic address:

Background: The efficacy of video-stylet versus video-laryngoscope for tracheal intubation in patients with cervical spine immobilisation, which is known to impede the intubation process, remains unclear.

Methods: We searched electronic databases including EMBASE, MEDLINE, Google scholar, and Cochrane Library for randomised controlled trials comparing video-stylets with video-laryngoscopes in human subjects with cervical spine immobilisation from inception to the 25 of January 2021. The primary outcome was the rate of successful first-attempt intubation, while secondary outcomes included overall intubation success rate, time for successful intubation, and risk of tissue damage. Read More

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October 2021

Effect of Benson and Progressive Muscle Relaxation Techniques on Sleep Quality after Coronary Artery Bypass Graft: A Randomized Controlled Trial.

Complement Ther Med 2021 Oct 20:102784. Epub 2021 Oct 20.

Nursing Care Research Center, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: This study aimed to investigate the effect of Benson relaxation (BR) and progressive muscle relaxation (PMR) techniques on the sleep quality of patients undergoing coronary artery bypass graft (CABG) surgery.

Method: This study was a three-arm, parallel, randomized controlled trial. 120 patients who underwent CABG surgery at two academic hospitals in an urban area of Iran were randomly allocated into three groups (40 per group): the BR, PMR, and control groups. Read More

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October 2021

Genome-wide characterization and expression analysis of cystathionine β-synthase genes in plant development and abiotic stresses of cotton (Gossypium spp.).

Int J Biol Macromol 2021 Oct 20. Epub 2021 Oct 20.

Zhengzhou Research Base, State Key Laboratory of Cotton Biology, Zhengzhou University, 450001 Zhengzhou, China; State Key Laboratory of Cotton Biology, Key Laboratory of Biological and Genetic Breeding of Cotton, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang 455000, China. Electronic address:

Cystathionine β-synthase (CBS) domains containing proteins (CDCPs) form a large family and play roles in development via regulation of the thioredoxin system as well as abiotic and biotic stress responses of plant. However, the comprehensive study of CBS genes remained elusive in cotton. Here, we identified 237 CBS genes in 11 plant species and the phylogenetic analysis categorized CBS genes into four groups. Read More

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October 2021

Life''s Simple 7 and the risk of stroke in Finnish men: A prospective cohort study.

Prev Med 2021 Oct 20:106858. Epub 2021 Oct 20.

Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Central Finland Health Care District, Department of Internal Medicine, Jyvaskyla, Finland.

Background: Population-wide preventive measures constitute important approaches towards reducing stroke risk and its associated burden. We sought to examine the association between American Heart Association's (AHA) Life's Simple7 (LS7) score and the risk of stroke in men.

Methods: The study is based on the prospective population-based Kuopio Ischaemic Heart Disease cohort comprising men (42-60 years) without pre-existing history of stroke at baseline (1984-1989). Read More

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October 2021

Reduced mitochondrial DNA copy number in occupational workers from brominated flame retardants manufacturing plants.

Sci Total Environ 2021 Oct 20:151086. Epub 2021 Oct 20.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China. Electronic address:

Decabrominated diphenyl ether (BDE-209) and its substitute decabromodiphenyl ethane (DBDPE) are two flame retardants that have similar structures and are widely used in various industrial products. The accumulation and potential toxicity of them to human health have already aroused attention, and some research showed that they may affect mitochondrial function. Therefore, this study focused on the population with high exposure to brominated flame retardants (BFRs) and the related changes in mtDNA copy number (mtDNAcn) in whole blood. Read More

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October 2021

Prospective, Randomized, Double-Blind, Placebo-Controlled Study on Efficacy of Copaiba Oil in Silicone-Based Gel to Reduce Scar Formation.

Dermatol Ther (Heidelb) 2021 Oct 23. Epub 2021 Oct 23.

Medisca Pharmaceutique Inc., 6090 Henri Bourassa West, Montreal, H4R3A6, Canada.

Introduction: Scars are the end result of a biologic and natural process of wound repair after injury, surgery, acne, illness, burns, and infection. When skin is damaged, a fast and coordinated body response is triggered by four highly integrated and overlapping phases including homeostasis, inflammation, proliferation, and tissue remodeling. Healing of a skin wound may result in an abnormal scar if the balance among these four phases is lost during the healing process. Read More

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October 2021

Regulation of autophagy as a therapeutic option in glioblastoma.

Apoptosis 2021 Oct 23. Epub 2021 Oct 23.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC, 29209, USA.

Around three out of one hundred thousand people are diagnosed with glioblastoma multiforme, simply called glioblastoma, which is the most common primary brain tumor in adults. With a dismal prognosis of a little over a year, receiving a glioblastoma diagnosis is oftentimes fatal. A major advancement in its treatment was made almost two decades ago when the alkylating chemotherapeutic agent temozolomide (TMZ) was combined with radiotherapy (RT). Read More

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October 2021

Intravenous injection of human multilineage-differentiating stress-enduring cells alleviates mouse severe acute pancreatitis without immunosuppressants.

Surg Today 2021 Oct 23. Epub 2021 Oct 23.

Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, 2-1 Seiryomachi, Aobaku, Sendai, Miyagi, 980-8575, Japan.

Introduction: We examined the effect of intravenously injected human multilineage-differentiating stress-enduring (Muse) cells, non-tumorigenic endogenous reparative stem cells already used in clinical trials, on a severe acute pancreatitis (SAP) mouse model without immunosuppressants.

Methods: Human Muse cells (1.0 × 10 cells) collected from mesenchymal stem cells (MSCs) as SSEA-3(+) were injected into a C57BL/6 mouse model via the jugular vein 6 h after SAP-induction with taurocholate. Read More

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October 2021

Progressive lateralization and constant hip geometry in children with DDH, NDH, and LCPD following hip reconstructive surgery: a cohort study of 73 patients with a mean follow-up of 4.9 years.

Arch Orthop Trauma Surg 2021 Oct 23. Epub 2021 Oct 23.

Department for Orthopaedics and Traumatology, Kepler University Hospital GmbH, Krankenhausstrasse 9, 4020, Linz, Austria.

Background: Pelvic and femoral osteotomies have been effective methods to treat developmental dysplasia of the hip (DDH), neurogenic dislocation of the hip (NDH), and Legg-Calvé-Perthes disease (LCPD). The aim of this study was to evaluate the mid-term results after hip reconstruction in children with DDH, NDH, and LCPD.

Methods: In a retrospective study, X-rays of 73 children (2-19 years) with DDH, NDH, and LCPD were measured before, 3 months, and at final follow-up (FU) after hip reconstructive surgery (open reduction, and femoral and/or pelvic osteotomy ± soft-tissue procedures between 2008 and 2018). Read More

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October 2021

Insight into Bacterial Community Responses to Polycyclic Aromatic Hydrocarbons and the Degradation Potentials of Three Bacterial Isolates in Seagrass Halophila ovalis Sediments.

Curr Microbiol 2021 Oct 23. Epub 2021 Oct 23.

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.

Seagrass meadows constitute a prestigious ecosystem in the marine environment, providing valuable ecological and commercial services. Among the various causes, pollutions are considered one of the significant reasons for seagrass decline globally. This study investigates the impacts of polycyclic aromatic hydrocarbons mixture (pyrene, phenanthrene, and fluorene) on bacterial communities in Halophila ovalis sediments. Read More

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October 2021

Variables measured on three-dimensional computed tomography are preferred for predicting the outcomes of shock wave lithotripsy.

World J Urol 2021 Oct 23. Epub 2021 Oct 23.

Department of Urology, Tokyo Metropolitan Ohtsuka Hospital, 2-8-1 Minami-Ohtsuka, Toshima, Tokyo, 170-8476, Japan.

Purpose: Shock wave lithotripsy (SWL) is used to treat upper urinary tract stones. Recently, some volume analyzers have enabled preoperative assessment using three-dimensional computed tomography (3D-CT). We evaluated the efficacy of 3D-CT variables for predicting the outcomes of SWL. Read More

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October 2021

Subjective visual vertical imprecision during lateral head tilt in patients with chronic dizziness.

Exp Brain Res 2021 Oct 23. Epub 2021 Oct 23.

Department of Neurology, Neuro-Medical Scientific Center, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.

Most prior studies of the subjective visual vertical (SVV) focus on inaccuracy of subjects' SVV responses with the head in an upright position. Here we investigated SVV imprecision during lateral head tilt in patients with chronic dizziness compared to healthy controls. Forty-five dizzy patients and 45 healthy controls underwent SVV testing wearing virtual reality (VR) goggles, sitting upright (0°) and during head tilt in the roll plane (± 30°). Read More

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October 2021

Same day barium esophagography and high-resolution manometry during the COVID-19 pandemic.

Abdom Radiol (NY) 2021 Oct 23. Epub 2021 Oct 23.

Department of Radiology, University of Alabama at Birmingham, 619 19th Street South, JT N331, Birmingham, AL, 35294, USA.

Purpose: Double contrast barium esophagography (BAS) and high-resolution manometry (HRM) are traditionally performed on separate days to allow for pre-procedural fasting. In an effort to minimize COVID-19 exposure and improve appointment efficiency with required pre-procedure testing, we permitted same day HRM prior to BAS. Our study aimed to evaluate the adequacy of barium mucosal coating with same day HRM prior to BAS compared to BAS alone. Read More

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October 2021

The Effect of Adding Dry Needling to Physical Therapy in the Treatment of Cervicogenic Headache: A Randomized Controlled Trial.

Pain Med 2021 Oct 23. Epub 2021 Oct 23.

Assistant Professor of Neurosurgery, Department of Surgery, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Objective: To compare the long-term effect of adding real or sham dry needling with conventional physiotherapy in cervicogenic headache.

Design: A randomized controlled trial.

Setting: Physiotherapy Clinic, Rouhani Hospital of Babol University of Medical Sciences, Iran. Read More

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October 2021

Evaluation of LL-37 in healing of hard-to-heal venous leg ulcers: A multicentric prospective randomized placebo-controlled clinical trial.

Wound Repair Regen 2021 Oct 23. Epub 2021 Oct 23.

Department of Endocrinology, University Hospital of Malmö, Malmö, Sweden.

Many patients with venous leg ulcers do not reach complete healing with compression treatment alone, which is current standard care. This clinical trial HEAL LL-37 was a phase IIb double-blind, randomized, placebo-controlled study, with the aim to evaluate the efficacy and safety of a new drug LL-37 for topical administration, in combination with compression therapy, in 148 patients suffering from hard-to-heal venous leg ulcers. The study had three arms, consisting of two groups treated with LL-37 at concentrations of 0. Read More

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October 2021

Glut5 Knockdown in the Nucleus Tractus Solitarii Alleviates Fructose-Induced Hypertension in Rats.

J Nutr 2021 Oct 23. Epub 2021 Oct 23.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.

Background: Several studies have suggested mechanisms whereby excessive fructose intake increases blood pressure (BP). Glucose transporter 5 (GLUT5) is a fructose transporter expressed on enterocytes, and its involvement in the nucleus tractus solitarius (NTS)-modulated increase in BP following fructose intake remains unclear.

Objective: Herein, we investigated whether NTS Glut5 knockdown can alleviate fructose-induced hypertension in rat models. Read More

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October 2021

Promoting Family Integrated Early Childhood Development During the First 1000 Days in Urban Slums of Delhi: Feasibility and Early Implementation Experience.

Indian Pediatr 2021 Nov;58 Suppl 1:S32-S36

The INCLEN Trust International, Okhla Industrial Area, New Delhi. Correspondence to: Dr Manoja Kumar Das, Director Projects, The INCLEN Trust International, F1/5, Okhla Industrial Area, Phase 1, New Delhi 110 020.

The first 1000 days are critical for human development. Children residing in urban slums are at higher risk of suboptimal development. This article reports the feasibility and early implementation experiences of child stimulation directed counselling integrated with nutrition and health services by community functionaries in Delhi slums. Read More

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November 2021

A field efficacy trial of a trivalent vaccine containing porcine circovirus type 2a and 2b, and Mycoplasma hyopneumoniae in three herds.

Vet Med Sci 2021 Oct 22. Epub 2021 Oct 22.

College of Veterinary Medicine, Department of Veterinary Pathology, Seoul National University, Gwanak-gu, Republic of Korea.

Background: This field trial was designed to evaluate the efficacy of a new trivalent vaccine containing porcine circovirus type 2a and 2b (PCV2a/b), and Mycoplasma hyopneumoniae at three independent locations.

Methods: Three farms were selected based on their history of PCV2 and M. hyopneumoniae co-infection. Read More

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October 2021

A clinical score to predict mortality in patients after acute heart failure from Japanese registry.

ESC Heart Fail 2021 Oct 22. Epub 2021 Oct 22.

Department of Cardiology, Hirakata Kohsai Hospital, 1-2-1, Fujisakashigashimachi, Hirakata-shi, Osaka, 573-0153, Japan.

Aims: Clinical scores that consider physical and social factors to predict long-term observations in patients after acute heart failure are limited. This study aimed to develop and validate a prediction model for patients with acute heart failure at the time of discharge.

Methods And Results: This study was retrospective analysis of the Kitakawachi Clinical Background and Outcome of Heart Failure Registry database. Read More

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October 2021

The influence of inhibiting renal neural regeneration on the efficacy of renal denervation to chronic heart failure.

ESC Heart Fail 2021 Oct 22. Epub 2021 Oct 22.

Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, 1 Panfu Road, Guangzhou, 510182, China.

Aims: Some studies support the occurrence of nerve regeneration in renal arteries after renal denervation (RDN). But it is unclear whether inhibiting reinnervation after RDN is beneficial to enhancing the effect of RDN on chronic heart failure (CHF).

Methods And Results: Chronic heart failure Sprague Dawley rats induced by transverse aortic constriction were administered with the analogue of Nogo-B (Nogo group) or its antagonist (NEP group) respectively after RDN. Read More

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October 2021