91,668 results match your criteria three consecutive

Confirmation of infantile spasms resolution by prolonged outpatient EEGs.

Epilepsia Open 2021 Sep 15. Epub 2021 Sep 15.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.

Objective: There is no consensus on the type or duration of the post-treatment EEG needed for assessing treatment response for infantile spasms (IS). We assessed if outpatient electroencephalograms (EEGs) are sufficient to confirm infantile spasms (IS) treatment response.

Methods: Three-year retrospective review identified new onset IS patients. Read More

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September 2021

Low rates of venous thromboembolism in hospitalised COVID-19 patients: an Australian experience.

Intern Med J 2021 Sep 15. Epub 2021 Sep 15.

Department of haematology, Peninsula Health, Victoria.

Background: Venous thromboembolic (VTE) complications appear common in hospitalised COVID-19 patients, particularly among critically ill patients in intensive care units. However, there is significant heterogeneity in the reported use of thromboprophylaxis.

Aims: The primary objective was to determine rates of symptomatic VTE in hospitalised COVID-19 patients. Read More

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September 2021

Vestibular mapping assessment in idiopathic sudden sensorineural hearing loss.

Ear Hear 2021 Sep 14. Epub 2021 Sep 14.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Objective: The aim of this study was to investigate patterns of semicircular canal (SCC) and otolith organ dysfunction by vestibular mapping, and to determine the clinical implications of treatment outcomes in idiopathic sudden sensorineural hearing loss (ISSNHL).

Methods: We retrospectively reviewed 135 consecutive patients diagnosed with ISSNHL from January 2016 to December 2020. Patients underwent video-head impulse tests (vHIT) for each SCC, cervical vestibular-evoked myogenic potential test for the saccules, ocular vestibular-evoked myogenic potential test for the utricles, and hearing tests. Read More

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September 2021

Three-Year Clinical Outcomes of the Innova™ Self-Expanding Nitinol Stent for the Treatment of Femoropopliteal Lesions.

Cardiovasc Intervent Radiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.

Purpose: To report the 3-year results of Innova™ stent implantation for the treatment of femoropopliteal (FP) lesions in a real-world setting.

Methods: This single-arm, retrospective, multicenter clinical study analyzed 481 lesions from 453 consecutive patients with symptomatic peripheral artery diseases (Rutherford category 1-6) who underwent endovascular therapy with implantation of Innova™ self-expanding nitinol stent for FP lesions. The primary outcome measure was the 3-year restenosis rate based on doppler-ultrasound or angiographic criteria. Read More

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September 2021

The role of individual behavioral traits on fishway passage attempt behavior.

Ecol Evol 2021 Sep 1;11(17):11974-11990. Epub 2021 Aug 1.

Department of Biosciences Durham University Durham UK.

Variations in behavioral traits are widely recognized to drive animal behaviors exhibited within a population. However, information on how behavior traits influence behavior in anthropogenically modified habitats is lacking. Many habitats have become highly fragmented as a result of human processes. Read More

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September 2021

Human papillomavirus infection predicts a better survival rate in patients with oropharyngeal cancer.

Arch Med Sci 2021 23;17(5):1308-1316. Epub 2020 Sep 23.

Department of Radiotherapy, Holycross Cancer Centre, Kielce, Poland.

Introduction: Squamous cell carcinoma is the most common malignant tumour occurring in the head and neck region. It is now understood that (human papillomavirus (HPV)- positive and HPV-negative diseases are two very different clinical entities associated with different outcomes. We decided to assess p16 expression status in patients with oropharyngeal cancer and retrospectively evaluate the outcomes of the treatment. Read More

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September 2020

Efficacy and Safety of Regorafenib Monotherapy among Patients with Previously Treated Metastatic Colorectal Cancer in a Chinese Population: A Real-World Exploratory Study.

Int J Gen Med 2021 7;14:5363-5373. Epub 2021 Sep 7.

Department of Oncology, Tianjin Fourth Central Hospital, Tianjin, 300060, People's Republic of China.

Background: Present study was condeucted to investigate the efficacy and safety of regorafenib for patients with previously treated metastatic colorectal cancer (mCRC) in a Chinese population and the prognostic implications of adverse reactions.

Methods: This retrospective study a total of 96 consecutive patients with mCRC who had failed standard chemotherapy regimens from June 2017 to December 2020. Patients received regorafenib at an initial dosage of 160 mg or 120 mg. Read More

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September 2021

Near 100% ethene selectivity achieved by tailoring dual active sites to isolate dehydrogenation and oxidation.

Nat Commun 2021 Sep 14;12(1):5447. Epub 2021 Sep 14.

CAS Key Laboratory of Science and Technology on Applied Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China.

Prohibiting deep oxidation remains a challenging task in oxidative dehydrogenation of light alkane since the targeted alkene is more reactive than parent substrate. Here we tailor dual active sites to isolate dehydrogenation and oxidation instead of homogeneously active sites responsible for these two steps leading to consecutive oxidation of alkene. The introduction of HY zeolite with acid sites, three-dimensional pore structure and supercages gives rise to Ni Lewis acid sites (LAS) and NiO nanoclusters confined in framework wherein catalytic dehydrogenation of ethane occurs on Ni LAS resulting in the formation of ethene and hydrogen while NiO nanoclusters with decreased oxygen reactivity are responsible for selective oxidation of hydrogen rather than over-oxidizing ethene. Read More

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September 2021

Persistence of anaemia among Samoan preschool age children: a longitudinal study.

Public Health Nutr 2021 Sep 15:1-30. Epub 2021 Sep 15.

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT.

Objective: To characterize prevalence and persistence of anaemia among Samoan children over a two-three-year period.

Design: Data were from two consecutive waves (2015 and 2017/2018) of the Ola Tuputupua'e "Growing up" study. Anaemia (haemoglobin <11·0 or 11·5 g/dL for 2-4 and ≥5 years olds, respectively) was considered "transient" when it occurred at only one wave or "persistent" if it was present at two consecutive waves. Read More

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September 2021

Qualitative ultrasonography scale of the intensity of local twitch response during dry needling and its association with modified joint range of motion: a cross-sectional study.

BMC Musculoskelet Disord 2021 Sep 14;22(1):790. Epub 2021 Sep 14.

Departamento de Fisioterapia, Andalucía Tech, Catedra de Fisioterapia y Discapacidad, Instituto de Investigación Biomedica de Málaga (IBIMA), Clinimetria (F-14), Universidad de Málaga, Málaga, Spain.

Background: The relevance of local twitch response (LTR) during dry needling technique (DNT) is controversial, and it is questioned whether LTR is necessary for successful outcomes. Furthermore, because the LTR during the deep DNT may be evoked with different intensities, it is unknown whether the magnitude of LTR intensity is associated with optimal clinical results, especially concerning to the effects of joint maximal range of motion (ROM). This study aimed to (i) determine whether visual inspections can quantify the LTR intensity during the DNT through a qualitative ultrasonography scale of LTR intensity (US-LTR scale), and (ii) assess the differences of US-LTR scale associated with changes in the maximal joint ROM. Read More

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September 2021

Outcomes of Arch Reintervention for Recurrent Coarctation in Young Children.

Thorac Cardiovasc Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Objectives:  To evaluate the outcomes of reintervention for postrepair recoarctation in young children.

Methods:  Between January 2011 and December 2020, all consecutive patients aged ≤3 years who were treated for postrepair recoarctation were included. Recoarctations were classified into two morphological types by three-dimensional imaging. Read More

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September 2021

A systematic review of seizure clusters: Prevalence, risk factors, burden of disease and treatment patterns.

Epilepsy Res 2021 Sep 2;177:106748. Epub 2021 Sep 2.

Yale University School of Medicine, New Haven, CT, USA.

Seizure clusters (SCs) are episodes of consecutive seizures that occur within a short period. The treatment patterns of rescue medications (RMs), as well as the burden of SCs, have not been assessed. A systematic literature search on Embase. Read More

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September 2021

Radiographic and Clinical Evolution of the Oxford Unicompartmental Knee Arthroplasty.

J Knee Surg 2021 Jul 16. Epub 2021 Jul 16.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

The aim of the study is to evaluate whether the use of the new instrumentation Microplasty (MP) improves component positioning and the reliability of the surgical technique, reducing the implant outliers from the recommended range and providing a more accurate resection, while avoiding insufficient or excessive tibial resection and clinical scores. We prospectively analyzed clinical and radiographic outcomes of three consecutive cohorts for a total of 227 implants at a minimum follow-up of 36 months. The first cohort consisted of 67 Oxford unicompartmental knee arthroplasty (OUKA), using the phase III (Ph-III). Read More

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Effect of different exercise training intensities on age-related cardiac damage in male mice.

Aging (Albany NY) 2021 Sep 14;13(undefined). Epub 2021 Sep 14.

Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Aging is the most important risk factor for cardiovascular diseases. Although exercise is known to be beneficial for the health of aging heart, the optimal exercise training intensity to prevent natural aging-induced cardiac damage has not been defined. In this study, we used 32-week-old male mice and randomly divided them into three groups, namely, untrained (UNT) mice, moderate-intensity exercise training (MET) mice, and high-intensity interval training (HIIT) mice. Read More

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September 2021

Switch to SGLT2 Inhibitors and Improved Endothelial Function in Diabetic Patients with Chronic Heart Failure.

Cardiovasc Drugs Ther 2021 Sep 14. Epub 2021 Sep 14.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Purpose: The use of sodium-glucose-cotransporter-type-2 inhibitors (SGLT2i) was associated in previous studies with an improved vascular function in non-human experimental models. We therefore sought to evaluate possible changes in endothelial function assessed by flow-mediated dilation (FMD) in patients with chronic heart failure (CHF) and type-2 diabetes mellitus (T2DM), switching from other oral hypoglycemic agents to SGLT2i in an observational study.

Methods: Twenty-two consecutive outpatients with CHF and T2DM were enrolled after switching to SGLT2i therapy, and compared with 23 consecutive controls from the same registry comparable for principal clinical characteristics. Read More

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September 2021

Impact of blended learning on manual defibrillator's use: A simulation-based randomized trial.

Nurs Crit Care 2021 Sep 13. Epub 2021 Sep 13.

Department of Paediatric Emergency Medicine, Geneva Children's Hospital, Geneva University Hospitals, Geneva, Switzerland.

Background: Blended learning, defined as the combination of traditional face-to-face instructor-led learning and e-learning course, has never been validated as a teaching method for the effective use of manual defibrillators in cardiopulmonary resuscitation.

Aim: To evaluate whether paediatric emergency and critical care providers exposed to a blended learning session performed better and recalled more defibrillator skills than those exposed to face-to-face learning only.

Study Design: A two-period prospective, stratified, single-centre, simulation-based, randomized, controlled trial. Read More

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September 2021

Outcome of pregnancy in patients with primary sclerosing cholangitis.

Dig Liver Dis 2021 Sep 10. Epub 2021 Sep 10.

Liver and Internal Medicine Unit, Medical University of Warsaw, Warsaw, Poland; Translational Medicine Group, Pomeranian Medical University, Szczecin, Poland. Electronic address:

Background: Data on the clinical course of primary sclerosing cholangitis (PSC) during pregnancy remain scarce. Herein, we assessed the maternal and fetal outcomes of pregnancy in this condition.

Methods: We reviewed 104 consecutive female outpatients with PSC using a structured questionnaire. Read More

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September 2021

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients.

Crit Care 2021 09 13;25(1):331. Epub 2021 Sep 13.

Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission.

Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. Read More

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September 2021

Clinical outcomes of severe tricuspid valve infective endocarditis related to intravenous drug abuse - a case series.

Acta Cardiol 2021 Sep 14:1-6. Epub 2021 Sep 14.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Background: Right-sided infective endocarditis (IE) related to intravenous drug use (IVDU) can follow an acute fulminant course. However, there is limited information on its longer-term clinical outcomes.

Aim And Methods: We assessed a cohort of consecutive patients who presented with IVDU complicated by severe tricuspid valve regurgitation to determine their presentation, treatment, and long-term outcomes. Read More

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September 2021

Persistence: A key factor in understanding the circumstances under which dietary restraint predicts restriction of caloric intake.

Eat Behav 2021 Sep 5;43:101563. Epub 2021 Sep 5.

Department of Psychology, University of Wyoming, Laramie, WY, USA.

Dietary restraint refers to the intention to restrict caloric intake, whereas dietary restriction refers to the actual intentional and sustained restriction of caloric intake for weight-control purposes. Findings regarding the relation between dietary restraint and restriction to date are inconsistent. Our study sought to clarify this complex relationship using a novel laboratory task. Read More

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September 2021

Changes in entropy on polarized-sensitive optical coherence tomography images after therapeutic subthreshold micropulse laser for diabetic macular edema: A pilot study.

PLoS One 2021 13;16(9):e0257000. Epub 2021 Sep 13.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: To investigate the dynamics of the healing process after therapeutic subthreshold micropulse laser (SMPL) for diabetic macular edema (DME) using polarization-sensitive optical coherence tomography (PS-OCT).

Methods: Patients with treatment-native or previously-treated DME were prospectively imaged using PS-OCT at baseline, 1, 2, 3, and 6 months. The following outcomes were evaluated: changes in the entropy value per unit area (pixel2) in the retinal pigment epithelium (RPE) on the B-scan image; changes in the entropy value in each stratified layer (retina, RPE, choroid) based on the ETDRS grid circle overlaid with en face entropy mapping, not only the whole ETDRS grid area but also a sector irradiated by the SMPL; and the relationship between edema reduction and entropy changes. Read More

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September 2021

Oral Fluconazole Therapy in Patients With Active Ulcerative Colitis Who Have Detectable Candida in the Stool: A Double-Blind Randomized Placebo-controlled Trial.

J Clin Gastroenterol 2021 Sep 9. Epub 2021 Sep 9.

Departments of Gastroenterology Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: There is an emerging role of fungal dysbiosis in the pathogenesis of inflammatory bowel disease. Prevalence of Candida in patients with active ulcerative colitis (UC) and the effect of fluconazole therapy in reducing disease activity of UC are not known.

Patients And Methods: All consecutive consenting patients with active UC defined as Mayo score ≥3 were evaluated for presence of Candida by stool culture and predictors for presence of Candida were identified. Read More

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September 2021

Clinical assessment of liver metabolism during hypothermic oxygenated machine perfusion using microdialysis.

Artif Organs 2021 Sep 13. Epub 2021 Sep 13.

General Surgery 2U - Liver Transplant Unit, Department of Surgical Sciences. A.O.U. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Background: While growing evidence supports use of hypothermic oxygenated machine perfusion (HOPE) in liver transplantation, its effects on liver metabolism are still incompletely understood.

Methods: To assess liver metabolism during HOPE using microdialysis (MD), we conducted an open-label, observational pilot study on 10 consecutive grafts treated with dual-HOPE (D-HOPE). Microdialysate and perfusate levels of glucose, lactate, pyruvate, glutamate and flavin mononucleotide (FMN) were measured during backtable preparation and D-HOPE and correlated to graft function and patient outcome. Read More

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September 2021

Condylar constrained knee prosthesis and rotating hinge prosthesis for revision total knee arthroplasty for mechanical failure have not the same indications and same results.

SICOT J 2021 10;7:45. Epub 2021 Sep 10.

FIFA Medical Center of Excellence, Orthopaedics Surgery and Sports Medicine Department, Croix-Rousse Hospital, Hospices Civils de Lyon, 103 grande rue de la croix rousse, 69004 Lyon, France - Univ Lyon, Claude Bernard Lyon 1 University, IFSTTAR, LBMC UMR_T9406, 25 Avenue François Mitterand, Lyon, France.

Purpose: This study aimed to evaluate whether there are any differences in outcomes and complication rates between condylar constrained knee (CCK) and rotating hinge knee (RHK) prostheses used for the first revision of total knee arthroplasty (rTKA) after mechanical failure.

Methods: Sixty-three consecutive non-septic revisions of posterior stabilized implants using 33 CCK and 30 RHK prostheses were included. Clinical evaluation and revision rate were compared between the two groups at two years minimum follow-up. Read More

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September 2021

Survival Outcomes of Gemcitabine Plus S-1 Adjuvant Chemotherapy after Surgical Resection for Advanced Biliary Tract Cancer.

Oncology 2021 Aug 25:1-10. Epub 2021 Aug 25.

Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Introduction: The usefulness of adjuvant chemotherapy in biliary tract cancer (BTC) is poorly reported. This study aimed to evaluate the effectiveness and safety of adjuvant gemcitabine plus S-1 (GS) chemotherapy after curative surgical resection for BTC.

Methods: 225 BTC patients who underwent surgical resection between January 2006 and May 2019 were enrolled in this study. Read More

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Establishment of a simplified dichotomic size-exclusion chromatography for isolating extracellular vesicles toward clinical applications.

J Extracell Vesicles 2021 Sep;10(11):e12145

MOE Key Laboratory of Tumor Molecular Biology, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China.

Size-exclusion chromatography (SEC) is a widely adopted method for the isolation of extracellular vesicles (EVs) from complex samples. SEC can efficiently remove high-abundant proteins, while often requires multiple fractionation operation using diversified column settings. In this study, we aim to establish a simplified SEC method to acquire high quality EVs. Read More

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September 2021

Association between coronary dominance pattern and left ventricular mass index; Is there a gender disparity?

Int J Clin Pract 2021 Sep 13:e14835. Epub 2021 Sep 13.

Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

Background: Increased left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH) are independent predictors of adverse cardiovascular events. However, little is known regarding the association between coronary circulation and LVMI. We aimed to investigate the association between coronary dominance and LVMI, and to demonstrate the impact of coronary dominance pattern on emergence of LVH. Read More

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September 2021

Involvement of the medial and lateral epicondyles in distal humeral coronal shear fractures: Case series and literature review.

Eur J Orthop Surg Traumatol 2021 Sep 12. Epub 2021 Sep 12.

Department of Medicine and Surgery, Orthopaedic Clinic, Parma University Hospital, via Gramsci 14, 43100, Parma, Italy.

Purpose: Epicondyle involvement in capitellar and trochlear fractures is often considered a simple associated lesion that does not substantially change treatment or prognosis. Although theoretically predicted in reviews, case series almost never report elbow prosthesis use in comminuted coronal shear injuries associated with epicondylar fracture in the elderly. The purpose of this study is to focus on this underestimated injury pattern that can be a negative risk factor for treatment and prognosis. Read More

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September 2021

Clinical Characteristics, Management, and Outcomes of Cancer Patients With Coronavirus Disease 2019 Admitted to the ICU.

Crit Care Explor 2021 Sep 7;3(9):e0535. Epub 2021 Sep 7.

All authors: Critical Care Center, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Adult patients with cancer have a greater likelihood of developing severe illness and death from coronavirus disease 2019 compared with patients without cancer. We sought to characterize the clinical characteristics and outcomes of cancer patients who tested positive for severe acute respiratory syndrome coronavirus 2 and were admitted to the ICU at the peak of the first wave of the pandemic in the United States.

Design: A single-center retrospective cohort study. Read More

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September 2021

Development of a Prognostic Scoring System for Hepatocellular Carcinoma Patients With Main Portal Vein Tumor Thrombus Undergoing Conventional Transarterial Chemoembolization: An Analysis of 173 Patients.

Front Oncol 2021 26;11:671171. Epub 2021 Aug 26.

Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Patients with hepatocellular carcinoma (HCC) with main portal vein tumor thrombus (mPVTT) have poor prognosis. Promising systemic therapies, such as target therapies, have limited benefits. The purpose of this study is to retrospectively evaluate the benefits of conventional TACE (c-TACE) and to establish a prognostic stratification of HCC patients with mPVTT. Read More

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