350,590 results match your criteria three cases


Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical presentations include acute liver failure or chronic liver failure with liver cirrhosis, which are cruelly progressive and fatal. We report six cases of LT for acute liver failure diagnosed pathogenic MPV17 variants. Read More

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September 2021

Extracranial temporal bone paragangliomas: Re-defining the role of otologic surgery within the scope of function-preserving multimodal concepts.

Am J Otolaryngol 2021 Sep 12;43(1):103212. Epub 2021 Sep 12.

Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Introduction: The aim of this study was to present our concept in the management of extracranial temporal bone paragangliomas and demonstrate the outcome after primary surgical management of the middle ear component, with an individualized indication for adjuvant radiotherapy.

Materials And Methods: The records of all patients treated for extracranial jugulotympanic paragangliomas by means of primary surgical management between 2010 and 2021 were studied retrospectively.

Results: Twenty-nine patients made up our study sample (mean age 58. Read More

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September 2021

Whole-genome analysis of SARS-CoV-2 samples indicate no tissue specific genetic adaptation of the virus in COVID-19 patients' upper and lower respiratory tract.

Diagn Microbiol Infect Dis 2021 Aug 20;101(4):115520. Epub 2021 Aug 20.

Department of General Pathology and Molecular Diagnostics, University of Augsburg, Augsburg, Germany.

Sample panels of SARS-CoV-2 cases were retrospectively whole-genome sequenced. In three individuals, samples of upper and lower respiratory tract resulted in identical sequences suggesting virus stability including the spike protein cleavage site. In a fourth case, low-level intra-host genomic evolution and a unique 5-nucleotide deletion was observed. Read More

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PLS-DA and data fusion of visible Reflectance, XRF and FTIR spectroscopy in the classification of mixed historical pigments.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 10;265:120384. Epub 2021 Sep 10.

Laboratório de Instrumentação e Simulação Computacional. LISCOMP/IFRJ-CPAR, 26600-000, Paracambi, Brazil. Electronic address:

In this work samples of historical pigments of green hue were brushed on a canvas and studied by Visible Reflectance, X-Ray Fluorescence and Fourier Transform Infrared Spectroscopy. One hundred samples were investigated, all with green hue, these prepared from pigments themselves green, such as chromium oxide (CrO) or from a mixture of pigments that result in green, for example, chrome yellow (PbCrO) and Prussian blue (Fe[Fe(CN)]). Because every sample investigated through the spectroscopic techniques were of green hue, the characterization of the pigments present in the mixtures through the visual inspection of spectra has become a complex task in some cases, also, due the large number of recorded spectra. Read More

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September 2021

The impact of SARS-CoV-2 vaccination in Dravet syndrome: A UK survey.

Epilepsy Behav 2021 Aug 21;124:108258. Epub 2021 Aug 21.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK; Chalfont Centre for Epilepsy, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK. Electronic address:

Background: The COVID-19 pandemic led to the urgent need for accelerated vaccine development. Approved vaccines have proved to be safe and well tolerated across millions of people in the general population. Dravet syndrome (DS) is a severe, early onset, developmental and epileptic encephalopathy. Read More

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Dental students' perceptions of the long case.

Eur J Dent Educ 2021 Sep 18. Epub 2021 Sep 18.

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Introduction: The long case examination is used to assess clinical competency in dental education. However, the academic literature, much of which is in medical education, highlights concerns regarding the relevancy and authenticity of the long case. To date, dental students' experiences of the long case have been under-researched. Read More

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September 2021

Experience in reconstruction of esophagus, epiglottis, and upper trachea due to caustic injuries in pediatric patients and establishment of algorithm.

Microsurgery 2021 Sep 18. Epub 2021 Sep 18.

Department of Plastic Reconstructive and Aesthetic Surgery, China Medical University Hospital, Taichung, Taiwan.

Background: Unintentional swallowing of corrosive agents cause problems in the pediatric population. Swallowing dysfunction can be seen after injuring the pharynx and/or epiglottis which leads to the obstruction of esophagus. An algorithm was established taking into account the injury to the epiglottis and restoring gastrointestinal continuity with isolated or combine free and or supercharged jejunum flap, or supercharged colon transposition flap. Read More

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September 2021

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, NSW.

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse. In our established diabetes complications assessment service, we recorded nine cases of sight-threatening retinopathy in youth aged 15-17. Read More

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September 2021

Cytokine profile in Egyptian children and adolescents with COVID-19 pneumonia: a multicenter study.

Pediatr Pulmonol 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, Texas Tech University Health Sciences Center El Paso, Texas, USA.

Background: To date, the cytokine profile in children and adolescent with novel coronavirus disease 2019 (COVID-19) has not been reported.

Objectives: we investigated serum levels of a panel of key cytokines in children and adolescent with COVID-19 pneumonia with a primary focus on "cytokine storm" cytokines such as IL-1β, IL-6, IL-17, IL-2, IL-4, IL-10, interferon (IFN-γ), tumor necrosis factor (TNF)-α and two chemokines interferon inducible protein-10 (IP-10) and IL-8]. We also studied whether these cytokines could be potential markers for illness severity in COVID-19 pneumonia. Read More

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September 2021

Longevity and subject-reported satisfaction after minimally invasive jawline contouring.

J Cosmet Dermatol 2021 Sep 18. Epub 2021 Sep 18.

Department for Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilian University Munich, Munich, Germany.

Background: Minimally invasive treatments as soft tissue filler injections can enhance the appearance of the jawline. This prospective, single-center study investigated aesthetic outcome, patient satisfaction, adverse events, and volume changes after jawline contouring using standardized reporting scales and objectifiable 3D surface analysis.

Methods: A total of 30 patients (1 male and 29 females, mean age: 57. Read More

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September 2021

Acute carbon monoxide poisoning with low saturation of carboxyhaemoglobin: a forensic retrospective study in Shanghai, China.

Sci Rep 2021 Sep 17;11(1):18554. Epub 2021 Sep 17.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, 131 Dongan Road, Shanghai, 200032, China.

Carbon monoxide (CO) poisoning is a common cause of death, leading to morbidity and mortality worldwide. Features of the CO poisoning with low carboxyhemoglobin (COHb) levels remain to be characterized. This study collected a total of 307 CO poisoning cases from Shanghai Public Security Bureau, an official organization that handles the most complicated and life-threatening cases across Shanghai municipality in China, and regrouped these cases into three categories: group 1, 10% < COHb% < 30% (n = 58); group 2, 30% ≤ COHb% < 50% (n = 79); group 3, COHb% ≥ 50% (n = 170). Read More

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September 2021

Childbearing women's experiences of the maternity care system in Australia during the first wave of the COVID-19 pandemic.

Women Birth 2021 Sep 13. Epub 2021 Sep 13.

School of Nursing and Midwifery, Deakin University, Victoria, Australia; Centre for Quality and Patient Safety Research, Western Health Partnership, Victoria, Australia. Electronic address: https://twitter.com/Vidanka2.

Background: Substantial changes occurred in Australian healthcare provision during the COVID-19 pandemic to reduce the risk of infection transmission. Little is known about the impact of these changes on childbearing women.

Aim: To explore and describe childbearing women's experiences of receiving maternity care during the COVID-19 pandemic in Australia. Read More

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September 2021

Interpreting nephrometry scores with three-dimensional virtual modelling for better planning of robotic partial nephrectomy and predicting complications.

Urol Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Laboratory of Bioengineering, University of Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

Objective: 3D models are increasingly used as additional preoperative tools for renal surgery. We aim to evaluate the impact of 3D renal models in the assessment of PADUA, RENAL, Contact Surface Area (CSA) and Arterial Based Complexity (ABC) for the prediction of complications after Robot assisted Partial Nephrectomy (RAPN).

Methods And Materials: Overall, 57 patients with T1 and 1 patient with T2 renal mass referred to RAPN, were prospectively enrolled. Read More

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September 2021

A novel robust PLS regression method inspired from boosting principles: RoBoost-PLSR.

Anal Chim Acta 2021 Sep 7;1179:338823. Epub 2021 Jul 7.

Chem House Research Group, Montpellier, France; CIRAD, UMR SELMET, Montpellier, France; SELMET, Univ Montpellier, CIRAD, INRA, Institut Agro, Montpellier, France.

The calibration of Partial Least Square regression (PLSR) models can be disturbed by outlying samples in the data. In these cases the models can be unstable and their predictive potential can be depreciated. To address this problem, some robust versions of the PLSR Algorithm were proposed. Read More

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September 2021

Use of CytoSorb therapy to treat critically ill coronavirus disease 2019 patients: a case series.

J Med Case Rep 2021 Sep 18;15(1):476. Epub 2021 Sep 18.

Medanta Institute of Education and Research, Medanta The Medicity, Sect 38, Gurgaon, Haryana, India.

Background: Acute respiratory distress syndrome is an important clinical presentation of respiratory complications caused by severe acute respiratory syndrome coronavirus 2, a novel coronavirus responsible for the ongoing pandemic. The disease is poorly understood, and immunopathogenesis is constantly evolving. Cytokine release syndrome remains central to pathology of coronavirus disease 2019. Read More

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September 2021

Primary breast double-hit lymphoma management and outcomes: a real-world multicentre experience.

Cancer Cell Int 2021 Sep 17;21(1):498. Epub 2021 Sep 17.

Haematopoietic Stem Cell Transplantation Centre, State Key Laboratory of Experimental Hematology, National Clinical Research centre for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 288 Nanjing Road, Tianjin, 300020, China.

Background: Primary breast double-hit lymphoma (PB-DHL) is a rare, highly aggressive malignancy that poses challenges regarding accurate diagnosis and selecting optimal treatment regimens.

Methods: We retrospectively reviewed 48 cases of patients diagnosed with PB-DHL in six academic centres between June 2014 and June 2020 in China. Study-specific data were recorded, including treatment options, therapeutic evaluation, prognostic factors and relapse patterns, and the overall survival (OS) and progression-free survival (PFS) were evaluated. Read More

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September 2021

Parental perception of neonatal transfers from level 3 to level 2 neonatal intensive care units in Calgary, Alberta: qualitative findings.

BMC Health Serv Res 2021 Sep 17;21(1):981. Epub 2021 Sep 17.

Department of Community Health Sciences, University of Calgary, Calgary, Canada.

Background: Retro-transfers from level 3 to 2 NICUs in Alberta's regionalization of neonatal care system are essential to ensure the proper utilization of level 3 NICUs for complex neonatal cases. Parents often experience distress that relates to the transfer of their neonates to another hospital. Limited information is available regarding parental perceptions of distress during transfers for neonates requiring care between NICUs in the current Canadian context. Read More

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September 2021

Concepts behind epilepsy among Egyptian patients. Is it a disease or a possession?!

Epilepsy Res 2021 Sep 13;177:106760. Epub 2021 Sep 13.

Faculty of Medicine Ain Shams University, Egypt.

Background: Many epileptic patients visit traditional healers secondary to unaffordability, inaccessibility of medical service and being refractory. This may lead to delay in seeking medical advice and may influence prognosis.

Objectives: Studying concepts behind epilepsy among Egyptian epilepsy sufferers including beliefs behind epilepsy and whether there is difference in these beliefs as regards gender, education and urban to rural socioeconomic status. Read More

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September 2021

The opening size of the laminoplasty is dependent on the groove size: A numerical study.

Clin Biomech (Bristol, Avon) 2021 Sep 11;89:105479. Epub 2021 Sep 11.

Technical University of Liberec, Studentska 2, Liberec 46117, Czech Republic. Electronic address:

Background: The expansion of the cervical vertebrae lamina appears to be crucial to related surgical procedures. The dimensions of the groove influence the strain concentration within the lamina of the vertebra and, thus, the potential success or failure of respective surgical procedure. The aim of this computational study is to clarify both the role of the size of the groove with concern to both the open door and the double door laminoplasty techniques. Read More

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September 2021

Role of SIX1, EYA2, and E-cadherin in ovarian carcinoma. Evidence on epithelial-mesenchymal transition from an immunohistochemical study.

Ann Diagn Pathol 2021 Sep 8;55:151815. Epub 2021 Sep 8.

Department of Pathology, Faculty of Medicine, Menoufia University, Egypt.

This study aims to investigate the expression of SIX1, EYA2, and E-cadherin in ovarian cancer (OC). It was conducted on 97 cases of surface epithelial tumors (SEOTs). Immunohistochemistry (IHC) staining for the three markers was applied to archival paraffin-embedded sections. Read More

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September 2021

"Feel the fear and do it anyway" … nursing students' experiences of confronting poor practice.

Nurse Educ Pract 2021 Sep 6;56:103196. Epub 2021 Sep 6.

Faculty Head of Education, Faculty of Health, Psychology & Social Care, Manchester Metropolitan University, UK.

Aim: The two aims of this study were, first, to explore nursing students' experiences and perspectives of reporting poor care and second, examine the process by which they raised concerns.

Background: The nursing literature is replete with studies which explore nursing students' experiences of clinical placement. However only a small number explore students experiences of challenging poor care and how this is enacted in the practice setting. Read More

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September 2021

Molecular Subtypes of Primary Small Cell Lung Cancer Tumors and Their Associations with Neuroendocrine and Therapeutic Markers.

J Thorac Oncol 2021 Sep 14. Epub 2021 Sep 14.

Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health. Electronic address:

Introduction: A new molecular subtype classification was recently proposed for small cell lung cancer (SCLC). It is necessary to validate it in primary SCLC tumors by immunohistochemical (IHC) staining and define its clinical relevance.

Methods: We used IHC to assess four subtype markers (ASCL1, NEUROD1, POU2F3, and YAP1) in 194 cores from 146 primary SCLC tumors. Read More

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September 2021

Phenotype and genotype of 197 British patients with McArdle disease: an observational single-centre study.

J Inherit Metab Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK.

Objective: McArdle disease is caused by recessive mutations in PYGM gene. The condition is considered to cause a 'pure' muscle phenotype with symptoms including exercise intolerance, inability to perform isometric activities, contracture, acute rhabdomyolysis leading to acute renal failure.

Methods: This is a retrospective observational study aiming to describe phenotypic and genotypic features of a large cohort of patients with McArdle disease between 2011-2019. Read More

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September 2021

MCHP (Monte Carlo + Human Phantom): Platform to facilitate teaching nuclear radiation physics.

PLoS One 2021 17;16(9):e0257638. Epub 2021 Sep 17.

Department of Physics, City University of Hong Kong, Hong Kong, China.

Some concepts in nuclear radiation physics are abstract and intellectually demanding. In the present paper, an "MCHP platform" (MCHP was an acronym for Monte Carlo simulations + Human Phantoms) was proposed to provide assistance to the students through visualization. The platform involved Monte Carlo simulations of interactions between ionizing radiations and the Oak Ridge National Laboratory (ORNL) adult male human phantom. Read More

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September 2021

Examining performance and likelihood ratios for two likelihood ratio systems using the PROVEDIt dataset.

PLoS One 2021 17;16(9):e0256714. Epub 2021 Sep 17.

Applied Genetics Group, National Institute of Standards and Technology, Gaithersburg, Maryland, United States of America.

A likelihood ratio (LR) system is defined as the entire pipeline of the measurement and interpretation processes where probabilistic genotyping software (PGS) is a piece of the whole LR system. To gain understanding on how two LR systems perform, a total of 154 two-person, 147 three-person, and 127 four-person mixture profiles of varying DNA quality, DNA quantity, and mixture ratios were obtained from the filtered (.CSV) files of the GlobalFiler 29 cycles 15s PROVEDIt dataset and deconvolved in two independently developed fully continuous programs, STRmix v2. Read More

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September 2021

A series of eight cases of sleep-related psychogenic dissociative disorders and proposed updated diagnostic criteria.

J Clin Sleep Med 2021 Sep 17. Epub 2021 Sep 17.

Minnesota Regional Sleep Disorders Center.

Study Objectives: To identify the most relevant clinical and video-polysomnographic (vPSG) characteristics of patients with sleep-related dissociative disorders (SRDDs) and to propose a framework for new diagnostic criteria.

Methods: We searched potential SRDD cases from the scientific literature and from a database of patients referred for clinical and vPSG assessment in a single sleep disorders center, for disruptive nocturnal behaviors (n=731). The most relevant clinical and neurophysiological characteristics of the cases were extracted and a descriptive analysis was performed. Read More

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September 2021

Probing the self-defining period in memories of the Bangladesh independence war generation.

Memory 2021 Sep 17:1-12. Epub 2021 Sep 17.

Department of Psychology, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor Darul Ehsan, Malaysia.

This study investigated the self-defining periods (SPs) in private and public memories of Bangladeshi older adults ( = 476; mean age = 67.16 years) who, during adolescence and early adulthood, witnessed the 1960s Bengali nationalist movement and the 1971 Bangladesh War of Independence. Each participant retrieved three private and three public memories they considered to be highly significant. Read More

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September 2021

Congenital Brucellosis: A Case Report.

Vector Borne Zoonotic Dis 2021 Sep;21(9):727-730

Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Brucellosis is the most common zoonotic infection worldwide, and is caused by bacterial genus Brucella. The disease is rarely transmitted through human-to-human transmission. Few cases have been reported about vertical transmission of human brucellosis. Read More

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September 2021

Safety and efficacy of peptide receptor radionuclide therapy with Lu-DOTA-Tyr-octreotate in combination with amino acid solution infusion in Japanese patients with somatostatin receptor-positive, progressive neuroendocrine tumors.

Ann Nucl Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Oncology, Oncology Division, Yokohama City University Graduate School of Medicine, 3-9, Fuku-ura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Purpose: Peptide receptor radionuclide therapy (PRRT) with Lu-DOTA-Tyr-octreotate (Lu-DOTATATE) is one of the most reliable treatments for unresectable, progressive neuroendocrine tumors (NETs) with somatostatin receptor expression. We have, for the first time, reported the results of the tolerability, safety, pharmacokinetics, dosimetry, and efficacy of this treatment for Japanese patients with NET.

Methods: Patients with unresectable, somatostatin receptor scintigraphy (SRS)-positive NETs were enrolled in this phase I clinical trial. Read More

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September 2021

Beyond the visible spectrum - applying 3D multispectral full-body imaging to the VirtoScan system.

Forensic Sci Med Pathol 2021 Sep 17. Epub 2021 Sep 17.

Zurich Institute of Forensic Medicine, University of Zurich, Winterthurerstrasse 190/52, 8057, Zurich, Switzerland.

Multispectral photography offers a wide range of applications for forensic investigations. It is commonly used to detect latent evidence and to enhance the visibility of findings. Additionally, three-dimensional (3D) full-body documentation has become much easier and more affordable in recent years. Read More

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September 2021