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8-Hydroxy-2'-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis.

Psychiatry Investig 2021 Jul 22;18(7):603-618. Epub 2021 Jul 22.

Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kajang, Malaysia.

Objective: Mental illnesses may be caused by genetic and environmental factors. Recent studies reported that mental illnesses were accompanied by higher oxidative stress level. However, the results were inconsistent. Read More

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Prediction of diabetic protein markers based on an ensemble method.

Front Biosci (Landmark Ed) 2021 Jul;26(7):207-221

School of Opto-electronic and Communication Engineering, Xiamen University of Technology, 361024 Xiamen, Fujian, China.

: A diabetic protein marker is a type of protein that is closely related to diabetes. This kind of protein plays an important role in the prevention and diagnosis of diabetes. Therefore, it is necessary to identify an effective method for predicting diabetic protein markers. Read More

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Can commercial automated immunoassays be utilized to predict neutralizing antibodies after SARS-CoV-2 infection? A comparative study between three different assays.

Front Biosci (Landmark Ed) 2021 Jul;26(7):198-206

Biomedical Research Center, Qatar University, 2713 Doha, Qatar.

: High-throughput assays that can infer neutralizing activity against SARS-CoV-2 are of great importance for assessing the immunity induced by natural infection and COVID-19 vaccines. We aimed to evaluate the performance and degree of correlation of three fully automated anti-SARS-CoV-2 immunoassays with neutralization activity using a surrogate virus-neutralizing test (sVNT) from GenScript, targeting the receptor-binding domain. : 110 sera collected from PCR-confirmed asymptomatic COVID-19 individuals were tested for neutralizing antibodies (nAbs) using the sVNT. Read More

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Pilot evaluation of a consumer wearable device to assess sleep in a clinical polysomnography trial of suvorexant for treating insomnia in patients with Alzheimer's disease.

J Sleep Res 2021 Aug 2:e13328. Epub 2021 Aug 2.

Merck & Co., Inc., Kenilworth, NJ, USA.

The orexin receptor antagonist suvorexant was previously reported to significantly improve total sleep time (TST), by 28 min per night versus placebo after 4 weeks, in a sleep laboratory polysomnography (PSG) study of patients with Alzheimer's disease and insomnia. The study included an exploratory evaluation of a consumer-grade wearable "watch" device for assessing sleep that we report on here. Participants who met diagnostic criteria for both probable Alzheimer's disease dementia and insomnia were randomized to suvorexant 10-20 mg (N = 142) or placebo (N = 143) in a double-blind, 4-week trial. Read More

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Meta-Analyses of Multiple Gene Expression Profiles to Screen Hub Genes Related to Osteoarthritis.

Public Health Genomics 2021 Aug 2:1-13. Epub 2021 Aug 2.

Department of Orthopedics, Taizhou People's Hospital, Taizhou, China.

Background: This study aimed to screen and validate the crucial genes involved in osteoarthritis (OA) and explore its potential molecular mechanisms.

Methods: Four expression profile datasets related to OA were downloaded from the Gene Expression Omnibus (GEO). The differentially expressed genes (DEGs) from 4 microarray patterns were identified by the meta-analysis method. Read More

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The Role of Apolipoprotein E ε4 in Early and Late Mild Cognitive Impairment.

Eur Neurol 2021 Aug 2:1-9. Epub 2021 Aug 2.

General Medical Wards, The Affiliated Children's Hospital of Chongqing Medical University, Chongqing, China.

Background: Apolipoprotein E (APOE) ε4 is highly associated with mild cognitive impairment (MCI). However, the specific influence of APOE ε4 status on tau pathology and cognitive decline in early MCI (EMCI) and late MCI (LMCI) is poorly understood. Our goal was to evaluate the association of APOE ε4 with cerebrospinal fluid (CSF) tau levels and cognition in EMCI and LMCI patients in the Alzheimer's Disease Neuroimaging Initiative database, and whether this association was mediated by amyloid-β (Aβ). Read More

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Recycled windshield glass as new material for producing ultrasonic phantoms of cortical bone-healing stages.

Biomed Phys Eng Express 2021 Aug 2. Epub 2021 Aug 2.

Biomedical Engineering Program - COPPE, Federal University of Rio de Janeiro, Av. Horácio Macedo 2030, Centro de Tecnologia, COPPE/UFRJ, Bloco H, Rio de Janeiro, RJ, 21941-901, BRAZIL.

Quantitative ultrasound technique is used to evaluate bone-mimicking phantoms; however, these phantoms do not mimic the intermediate stages of cortical bone healing. We propose to use windshield glass as an original material to produce phantoms that mimic characteristics of three different stages of cortical bone healing. This material was processed via a route that included breaking, grinding, compacting, drying, and sintering that occurred in four temperature groups: 625, 645, 657, and 663 ºC. Read More

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Validation of ambulatory monitoring devices to measure energy expenditure and heart rate in a military setting.

Physiol Meas 2021 Aug 2. Epub 2021 Aug 2.

US Army Research Institute of Environmental Medicine, Natick, Massachusetts, UNITED STATES.

Objectives: To investigate the validity of different devices and algorithms used in military organizations worldwide to assess physical activity energy expenditure (PAEE) and heart rate (HR) among soldiers.

Design: Device validation study.

Methods: Twenty-three male participants serving their mandatory military service accomplished, firstly, nine different military specific activities indoors, and secondly, a normal military routine outdoors. Read More

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Patients characteristics related to screening mammography cancellation and rescheduling rates during the COVID-19 pandemic.

Clin Imaging 2021 Jul 29;80:205-210. Epub 2021 Jul 29.

Center for Evidence-Based Imaging, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, United States of America. Electronic address:

Purpose: To identify patient characteristics associated with screening mammography cancellations and rescheduling during the COVID-19 pandemic.

Methods: Scheduled screening mammograms during three time periods were retrospectively reviewed: state-mandated shutdown (3/17/2020-6/16/2020) during which screening mammography was cancelled, a period of 2 months immediately after screening mammography resumed (6/17/2020-8/16/2020), and a representative period prior to COVID-19 (6/17/2019-8/16/2019). Relative risk of cancellation before COVID-19 and after reopening was compared for age, race/ethnicity, insurance, history of chronic disease, and exam location, controlling for other collected variables. Read More

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Proton beam therapy in rectal cancer: A systematic review and meta-analysis.

Surg Oncol 2021 Jul 27;38:101638. Epub 2021 Jul 27.

Department of Colorectal Surgery, Countess of Chester NHS Foundation Trust, UK; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, 200 London Road, Liverpool, L3 9TA, UK. Electronic address:

Introduction: Locally advanced rectal cancer is often treated with neoadjuvant chemoradiotherapy and surgery. Radiotherapy carries significant risk of toxicity to organs at risk (OAR). Proton beam therapy (PBT) has demonstrated to be effective in other cancers, delivering equivalent dosimetric radiation but with the benefit of improved sparing of OAR. Read More

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Parents' experiences of their child's assessment on an epilepsy surgery pathway: A qualitative study.

Seizure 2021 Jul 17;91:456-461. Epub 2021 Jul 17.

Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool L69 3G, United Kingdom. Electronic address:

Purpose: Children's epilepsy surgery services (CESS) in the UK aim to improve outcomes for young children by increasing access to surgery. Consideration for surgery is complex and time consuming, yet there is lack of research exploring how this process might impact on families. This study aimed to explore parents' experiences of their child consideration for epilepsy surgery to inform future service development and delivery. Read More

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Spatio-temporal modeling of PM risk mapping using three machine learning algorithms.

Environ Pollut 2021 Jul 28;289:117859. Epub 2021 Jul 28.

Department of Geography, Faculty of Literature and Humanities, Razi University, Kermanshah, Iran. Electronic address:

Urban air pollution is one of the most critical issues that affect the environment, community health, economy, and management of urban areas. From a public health perspective, PM is one of the primary air pollutants, especially in Tehran's metropolis. Owing to the different patterns of PM in different seasons, Spatio-temporal modeling and identification of high-risk areas to reduce its effects seems necessary. Read More

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Land use regression modelling of NO in São Paulo, Brazil.

Environ Pollut 2021 Jul 24;289:117832. Epub 2021 Jul 24.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O.Box, 4002 Basel, Switzerland; University of Basel, Petersplatz 1, P. O. Box, 4001, Basel, Switzerland. Electronic address:

Background: Air pollution is a major global public health problem. The situation is most severe in low- and middle-income countries, where pollution control measures and monitoring systems are largely lacking. Data to quantify the exposure to air pollution in low-income settings are scarce. Read More

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Effectiveness and implementability of state-level naloxone access policies: Expert consensus from an online modified-Delphi process.

Int J Drug Policy 2021 Jul 30;98:103383. Epub 2021 Jul 30.

Department of Social & Behavioral Sciences, Indiana University Richard M. Fairbanks School of Public Health, 1050 Wishard Blvd, RG 6046, Indianapolis, IN 46202, USA.

Background: Naloxone distribution, a key global strategy to prevent fatal opioid overdose, has been a recent target of legislation in the U.S., but there is insufficient empirical evidence from causal inference methods to identify which components of these policies successfully reduce opioid-related harms. Read More

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Targeting immunosuppressor cells with nanoparticles in autoimmunity: How far have we come to?

Cell Immunol 2021 Jul 27;368:104412. Epub 2021 Jul 27.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

Autoimmunity is the assault of immune response towards self-antigens, resulting to inflammation and tissue injury. It is staged into three phases and caused by malfunction of immune tolerance. In our body, immune tolerance is synchronized by several immunosuppressor cells such as regulatory T cells and B cells as well as myeloid-derived suppressor cells, which are prominently dysregulated in autoimmunity. Read More

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Effects of three essential oils and their nano-emulsions on Listeria monocytogenes and Shigella flexneri in Egyptian Talaga cheese.

Int J Food Microbiol 2021 Jul 27;355:109334. Epub 2021 Jul 27.

Certified Food Lab, Animal Health Research Institute, Agriculture Research Center, Egypt.

Talaga cheese is a soft Egyptian cheese that has been associated with foodborne pathogens such as Listeria monocytogenes and Shigella flexneri. Essential oils (EOs) play a pivotal role in sustainably controlling foodborne diseases and as a potential preservative in soft cheeses. However, limited data is available comparing the antibacterial activity of EOs and their nano-emulsions (NEs) when inoculated into Talaga cheese. Read More

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The partitioning behavior of PAHs between settled dust and its extracted water phase: Coefficients and effects of the fluorescent organic matter.

Ecotoxicol Environ Saf 2021 Jul 30;223:112573. Epub 2021 Jul 30.

School of Geography and Environment, Key Laboratory of Poyang Lake Wetland and Watershed Research, Ministry of Education, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China.

The occurrence and distribution of polycyclic aromatic hydrocarbons (PAHs) in a city of Central China were determined in the settled dust and its extracted water phase from different land use types and bus stops in Nanchang City. The physicochemical properties of its water extracted dissolved organic matter (WEOM) were characterized to investigate the effect of fluorescence organic matter on the dust-water partitioning coefficients (K) using three-dimensional excitation-emission matrix fluorescence spectroscopy combined parallel factor analysis. Results showed that the range of ∑PAHs in settled dust and the extracted water phase was 0. Read More

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Effect of hydrogel composite reinforced with natural char nanoparticles on improvement of soil biological properties and the growth of water deficit-stressed tomato plant.

Ecotoxicol Environ Saf 2021 Jul 30;223:112576. Epub 2021 Jul 30.

Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

Hydrogel polymers have been used to enhance water and nutrient retention in agricultural soils. The incorporation of nanoparticles to yield composite hydrogels has also gained substantial momentum over the years. The aim of the research was to investigate the effect of hydrogel-nano natural char composite (reinforced starch-based hydrogels with natural char nanoparticles) at three levels 0%, 0. Read More

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Effects of oxygen concentration during incubation and broiler breeder age on embryonic heat production, chicken development, and 7-day performance.

Animal 2021 Jul 30;15(9):100323. Epub 2021 Jul 30.

Adaptation Physiology Group, Wageningen University and Research, P.O. Box 338, 6700 AH Wageningen, the Netherlands.

Older breeder flocks produce eggs with a relatively larger yolk and thereby a higher nutrient availability than young breeder flocks. To optimise nutrient utilisation and embryonic development throughout incubation and posthatch period, embryos originating from older breeder flocks may require a higher oxygen availability. The current study investigated effects of broiler breeder flock age and incubational oxygen concentration on embryonic metabolism and chicken development until 7-day posthatch. Read More

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Study of the structure and dynamics at various parts of the antibacterial drug molecule cefpodoxime proxetil.

Solid State Nucl Magn Reson 2021 Jul 29;115:101752. Epub 2021 Jul 29.

Physics Section, MMV, Banaras Hindu University, Varanasi, 221005, Uttar-Pradesh, India. Electronic address:

The structure and dynamics of cefpodoxime proxetil are elucidated by measuring chemical shift anisotropy (CSA) tensor, spin-lattice relaxation time, and local correlation time at twenty-one crystallographically different C nuclei sites. The principal components of CSA tensor of cefpodoxime proxetil are extracted by the two-dimensional phase adjusted sinning sideband (2DPASS) cross-polarization magic angle spinning (CP-MAS) solid-state NMR experiment, and the spin-lattice relaxation time is measured by the method outlined by Torchia(T1CP). The local correlation time is calculated by bearing in mind that the spin-lattice relaxation mechanism of C nuclei is mainly governed by the CSA interaction and the heteronuclear dipole-dipole interaction. Read More

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Temporal changes of microbial community structure and nitrogen cycling processes during the aerobic degradation of phenanthrene.

Chemosphere 2021 Jul 28;286(Pt 2):131709. Epub 2021 Jul 28.

Key Laboratory of Three Gorges Reservoir Region's Eco-environment, Ministry of Education, Chongqing University, Chongqing, 400045, China; State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing, 400044, People's Republic of China.

Phenanthrene (PHE) is frequently detected in worldwide soils. But it is still not clear that how the microbial community succession happens and the nitrogen-cycling processes alter during PHE degradation. In this study, the temporal changes of soil microbial community composition and nitrogen-cycling processes during the biodegradation of PHE (12 μg g) were explored. Read More

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Monitoring morphological changes from activated sludge to aerobic granular sludge under distinct organic loading rates and increasing minimal imposed sludge settling velocities through quantitative image analysis.

Chemosphere 2021 Jul 24;286(Pt 2):131637. Epub 2021 Jul 24.

CEB - Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal. Electronic address:

Quantitative image analysis (QIA) was used for monitoring the morphology of activated sludge (AS) during a granulation process and, thus, to define and quantify, unequivocally, structural changes in microbial aggregates correlated with the sludge properties and granulation rates. Two sequencing batch reactors fed with acetate at organic loading rates of 1.1 ± 0. Read More

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Joint fully convolutional and graph convolutional networks for weakly-supervised segmentation of pathology images.

Med Image Anal 2021 Jul 24;73:102183. Epub 2021 Jul 24.

Tencent AI Lab, Shenzhen, Guangdong 518057, China. Electronic address:

Tissue/region segmentation of pathology images is essential for quantitative analysis in digital pathology. Previous studies usually require full supervision (e.g. Read More

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Chronic plantar fasciitis reduces rearfoot to medial-forefoot anti-phase coordination.

Clin Biomech (Bristol, Avon) 2021 Jul 26;88:105439. Epub 2021 Jul 26.

Biomechanics Laboratory, Department of Kinesiology, University of Massachusetts Amherst, Amherst 01003, USA.

Background: It is commonly assumed that abnormal foot biomechanics cause plantar fasciitis; however, this assumption is not well supported. In this study, we investigated rearfoot to medial-forefoot coordination of healthy and plantar fasciitis individuals. We hypothesized that chronic plantar fasciitis individuals would exhibit greater intersegmental rearfoot to medial-forefoot anti-phase coordination and greater coordinative variability than a healthy cohort. Read More

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Verifying the usefulness of macrophytes as an indicator of the status of small waterbodies.

Sci Total Environ 2021 Jul 26;798:149279. Epub 2021 Jul 26.

Department of Water Protection, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.

Small waterbodies are characterised by a high variability of physicochemical parameters. This has an impact on aquatic macrophytes, which are functional components of aquatic ecosystems that also exert a strong influence on other components of these ecosystems. Therefore, their importance in the classification of reservoirs is unquestionable. Read More

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Microplastics deteriorate the removal efficiency of antibiotic resistance genes during aerobic sludge digestion.

Sci Total Environ 2021 Jul 30;798:149344. Epub 2021 Jul 30.

Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address:

Sludge from wastewater treatment plants (WWTPs) is considered to be reservoirs of antibiotic resistance genes (ARGs), which can be efficiently removed by sludge treatment processes, e.g., aerobic sludge digestion. Read More

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Storage strategy for shale gas flowback water based on non-bactericide microorganism control.

Sci Total Environ 2021 Jul 22;798:149187. Epub 2021 Jul 22.

State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China; Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing 400044, China; Department of Environmental Science, Chongqing University, Chongqing 400044, China. Electronic address:

Shale gas is a promising unconventional natural gas in the world, however the produced flowback water have severe challenges to surrounding water resource. Conventional reuse technology uses bactericide to control corrosive microorganism, which might bring uncontrolled drug resistance and other secondary pollution. In this study, storage strategy of flowback water was designed as a pre-control stage to decline corrosive microorganism. Read More

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Microplastics in agricultural soils, wastewater effluents and sewage sludge in Mauritius.

Sci Total Environ 2021 Jul 28;798:149326. Epub 2021 Jul 28.

Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Mauritius, Réduit 80837, Mauritius. Electronic address:

The rapid and silent emergence of microplastics (MPs) in the environment has recently become a global problem with more and more studies are showing the harmful effects of MPs on different ecosystems. The aim of this study was to investigate the presence of MPs in agricultural soils, wastewater effluents and sewage sludge in Mauritius. The soil samples were collected randomly from three different agricultural lands which have been used for conventional agriculture for more than 25 years. Read More

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Past variations and future projection of runoff in typical basins in 10 water zones, China.

Sci Total Environ 2021 Jul 30;798:149277. Epub 2021 Jul 30.

Research Center for Climate Change, Ministry of Water Resources, Nanjing 210029, China; Yangtze Institute for Conservation and Development, Nanjing 210098, China; State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Nanjing Hydraulic Research Institute, Nanjing 210029, China. Electronic address:

Understanding the historical and future changing characteristics of key climatic variables and runoff in 10 major river zones in China is essential for water resources evaluation and management. To this end, the historical and future changing trends of key hydrometeorological variables, including precipitation, potential evapotranspiration, and runoff were analyzed in detail for each water zone across China. The climate elasticity method was also established to quantify the impacts of climate change and human activities on historical runoff variations. Read More

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Hypochlorous acid initiated lipid chlorination at air-water interface.

Sci Total Environ 2021 Jul 29;798:149320. Epub 2021 Jul 29.

School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai, Shandong 264209, China. Electronic address:

There has been a surge of interest in interfacial hypochlorous acid (HOCl) chemistry for indoor air quality and public health. Here we combined nanoelectrospray mass spectrometry (nESI-MS) and acoustic levitation (AL) techniques to study the chlorination chemistry of three model lipids (DPPE, POPG, DOPG) mediated by HOCl at the air-water interface of levitated water droplet. For DPPE with no CC double bonds, HOCl was insensitive to the alkane chains, and showed considerable delay directing to head amino groups compared to that in aqueous environment. Read More

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