435 results match your criteria threatens safety

Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant.

N Engl J Med 2021 May 5. Epub 2021 May 5.

From Novavax, Gaithersburg, MD (V.S., L. Fries, S.C.-C., M.Z., C.B., G.A., E.F., J.S.P., A.R., S.N., I.C., G.M.G., F.D.); and the South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences (S.B., V.B., A.L.K., A.O.-J., A.T., S.A.M.), Wits Reproductive Health and HIV Institute (L. Fairlie, G.B.), University of the Witwatersrand, and Soweto Clinical Trials Centre (Q.B., A.E.B.), Johannesburg, Josha Research Centre, Bloemfontein (Z.H., J.J.L., S.F.), the Paediatric Infectious Diseases Unit (M.A., R.M.), the Respiratory and Critical Care Unit (U.L., N.L.), the Department of Obstetrics and Gynaecology (D.M.), Centre for the AIDS Programme of Research in South Africa (S.H.), and Kwazulu-Natal Research Innovation and Sequencing Platform (T.O.), Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, the Setshaba Research Centre, Tshwane (M.S.L.M., A.P., K.A.), the Limpopo Clinical Research Initiative, Rustenburg (L. Fouche, P.-L.V.), the Madibeng Centre for Research, Department of Family Medicine, School of Health, University of Pretoria (C.L.), and the Aurum Institute (C.G.), Pretoria, the South African TB Vaccine Initiative (M.T., N.S., A.L.) and the Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine, and UCT Lung Institute (K.D., A.E.), University of Cape Town, and the Health Systems Research Unit and the HIV Prevention Research Unit, South African Medical Research Council (N.S., A.G.), Cape Town, Mzansi Ethical Research Centre, Middelburg (G.K., F.G.P.), and Peermed Clinical Trial Centre, Kempton Park (N.C.-G.) - all in South Africa.

Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control of the coronavirus disease 2019 (Covid-19) pandemic. In a phase 1-2 trial involving healthy adults, the NVX-CoV2373 nanoparticle vaccine had an acceptable safety profile and was associated with strong neutralizing-antibody and antigen-specific polyfunctional CD4+ T-cell responses. Evaluation of vaccine efficacy was needed in a setting of ongoing SARS-CoV-2 transmission. Read More

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Antimicrobial Use, Residues, Resistance and Governance in the Food and Agriculture Sectors, Tanzania.

Antibiotics (Basel) 2021 Apr 16;10(4). Epub 2021 Apr 16.

Emergency Centre for Transboundary Animal Diseases (ECTAD), Food and Agriculture Organization of the United Nations (FAO), Dar es Salaam 14111, Tanzania.

All infections are potentially curable as long as the etiological agents are susceptible to antimicrobials. The increased rate at which antimicrobials are becoming ineffective is a global health risk of increasing concern that threatens withdrawal of beneficial antimicrobials for disease control. The increased demand for food of animal origin, in particular eggs, meat and milk has led to intensification and commercial production systems where excessive use and misuse of antimicrobials may prevail. Read More

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A Novel Application of the Hydrophobic Polyurethane Foam: Expansive Soil Stabilization.

Polymers (Basel) 2021 Apr 19;13(8). Epub 2021 Apr 19.

Department of Engineering Management, College of Engineering, Prince Sultan University, Riyadh 11543, Saudi Arabia.

The reversible shrink-swell behavior of expansive soil imposes a serious challenge that threatens the overlying structures' safety and durability. Traditional chemical additives such as lime and cement still exhibit satisfying performance over their counterparts in terms of swelling potential reduction. Nevertheless, significant concerns are associated with these chemicals, in addition to their environmental impact. Read More

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Health Misinformation about Toxic-Site Harm: The Case for Independent-Party Testing to Confirm Safety.

Int J Environ Res Public Health 2021 Apr 7;18(8). Epub 2021 Apr 7.

Department of Economics, University of Notre Dame, 3060 Jenkins Nanovic Hall, Notre Dame, IN 46556, USA.

Health misinformation can cause harm if regulators or private remediators falsely claim that a hazardous facility is safe. This misinformation especially threatens the health of children, minorities, and poor people, disproportionate numbers of whom live near toxic facilities. Yet, perhaps because of financial incentives, private remediators may use safety misinformation to justify reduced cleanup. Read More

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Improving Patient Flow and Decreasing Patient Length of Stay in the Pediatric Emergency Department Through Implementation of a Fast Track.

Adv Emerg Nurs J 2021 Apr-Jun 01;43(2):162-169

Department of Emergency Medic-ine (Dr Martin), Pediatric Emergency Nursing (Ms Noble), and Emergency Nursing (Ms Wilmarth), Univer-sity of Rochester Medical Center, Rochester, New York.

Increased utilization of the emergency department (ED) for low acuity concerns saturates EDs, leading to overcrowding. As the ED becomes crowded, the quality of care threatens patient safety and increases length of stay. To improve the efficiency of evaluation and discharge of low acuity patients in the pediatric ED, a performance improvement project was implemented to develop a Fast Track. Read More

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Peroxiredoxin alleviates the fitness costs of imidacloprid resistance in an insect pest of rice.

PLoS Biol 2021 Apr 12;19(4):e3001190. Epub 2021 Apr 12.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.

Chemical insecticides have been heavily employed as the most effective measure for control of agricultural and medical pests, but evolution of resistance by pests threatens the sustainability of this approach. Resistance-conferring mutations sometimes impose fitness costs, which may drive subsequent evolution of compensatory modifier mutations alleviating the costs of resistance. However, how modifier mutations evolve and function to overcome the fitness cost of resistance still remains unknown. Read More

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The fire risk of portable batteries in their end-of-life: Investigation of the state of charge of waste lithium-ion batteries in Austria.

Waste Manag Res 2021 Apr 12:734242X211010640. Epub 2021 Apr 12.

Chair of Waste Processing Technology and Waste Management, Montanuniversitaet Leoben, Leoben, Austria.

The increased utilisation of lithium-ion batteries in the last years does not come without cost. Due to thermal runaway and exothermic degradation reactions, portable batteries pose enormous risks to waste management systems and infrastructure in their end-of-life phase. All over Europe, the number of waste fires caused by lithium-ion batteries are rising. Read More

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In-situ monitoring of xenobiotics using genetically engineered whole-cell-based microbial biosensors: recent advances and outlook.

World J Microbiol Biotechnol 2021 Apr 12;37(5):81. Epub 2021 Apr 12.

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052, Sydney, NSW, Australia.

Industrialisation, directly or indirectly, exposes humans to various xenobiotics. The increased magnitude of chemical pesticides and toxic heavy metals in the environment, as well as their intrusion into the food chain, seriously threatens human health. Therefore, the surveillance of xenobiotics is crucial for social safety and security. Read More

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Displacement Identification by Computer Vision for Condition Monitoring of Rail Vehicle Bearings.

Sensors (Basel) 2021 Mar 17;21(6). Epub 2021 Mar 17.

State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu 610036, China.

Bearings of rail vehicles bear various dynamic forces. Any fault of the bearing seriously threatens running safety. For fault diagnosis, vibration and temperature measured from the bogie and acoustic signals measured from trackside are often used. Read More

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Novel Strategy to Combat Antibiotic Resistance: A Sight into the Combination of CRISPR/Cas9 and Nanoparticles.

Pharmaceutics 2021 Mar 8;13(3). Epub 2021 Mar 8.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Antibiotic resistance is a significant crisis that threatens human health and safety worldwide. There is an urgent need for new strategies to control multidrug-resistant (MDR) bacterial infections. The latest breakthrough in gene-editing tools based on CRISPR/Cas9 has potential application in combating MDR bacterial infections because of their high targeting ability to specifically disrupt the drug resistance genes that microbes use for infection or to kill the pathogen directly. Read More

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Seismic behaviour analysis of a wind turbine tower affected by sea ice based on a simplified model.

Sci Rep 2021 Mar 24;11(1):6714. Epub 2021 Mar 24.

China Coal Research Institute, Beijing, 100013, China.

Ice-structure interaction threatens the safety of the offshore structure; however, dynamic seismic action even renders this process more sophisticated. This research constructed a simplified calculation model for the wind turbine tower, ice, and water under seismic loading, which could avoid solving the complex non-linear equations. Then, the seismic behaviour of the structure, i. Read More

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Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria.

Theranostics 2021 4;11(10):4910-4928. Epub 2021 Mar 4.

College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.

Antimicrobial resistance has been a global health challenge that threatens our ability to control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new drugs or alternatives to antibiotics, no new classes of antibiotic or their alternatives have been clinically approved in the last three decades. A combination of antibiotics and non-antibiotic compounds that could inhibit bacterial resistance determinants or enhance antibiotic activity offers a sustainable and effective strategy to confront multidrug-resistant bacteria. Read More

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Influential factors and spatial-temporal distribution of tuberculosis in mainland China.

Sci Rep 2021 Mar 18;11(1):6274. Epub 2021 Mar 18.

Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

Tuberculosis (TB) is an infectious disease that threatens human safety. Mainland China is an area with a high incidence of tuberculosis, and the task of tuberculosis prevention and treatment is arduous. This paper aims to study the impact of seven influencing factors and spatial-temporal distribution of the relative risk (RR) of tuberculosis in mainland China using the spatial-temporal distribution model and INLA algorithm. Read More

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Procedural Competency Among Hospitalists: A Literature Review and Future Considerations.

J Hosp Med 2021 Apr;16(4):230-235

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

Background: As general internists practicing in the inpatient setting, hospitalists at many institutions are expected to perform invasive bedside procedures, as defined by professional standards. In reality, hospitalists are doing fewer procedures and increasingly are referring to specialists, which threatens their ability to maintain procedural skills. The discrepancy between expectations and reality, especially when hospitalists may be fully credentialed to perform procedures, poses significant risks to patients because of morbidity and mortality associated with complications, some of which derive from practitioner inexperience. Read More

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Toxicological and physiological effects of successive exposure to ochratoxin A at food regulatory limits.

Food Chem Toxicol 2021 May 13;151:112128. Epub 2021 Mar 13.

State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science Technology, Anhui Agricultural University, Heifei 230036, China. Electronic address:

Ochratoxin A (OTA), a potent mycotoxin, is a common contaminant of agro-products, which seriously threatens food safety. The OTA regulatory limits vary from different countries/regions. However, little is known about the toxicological effects of successive exposure to regulatory levels of OTA. Read More

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Vaccine Hesitancy and Demand for Immunization in Eastern Europe and Central Asia: Implications for the Region and Beyond.

J Health Commun 2020 Oct;25(10):808-815

Communication for Development, UNICEF Mozambique, Maputo, Mozambique.

Immunization is a global success story. It has saved millions of lives and prevented disease worldwide and millions more have been spared the permanent disabilities caused by diseases such as polio and the long-term morbidity caused by other diseases such as measles. Despite the compelling evidence of the public health and economic value of vaccines, vaccine hesitancy has become a growing concern globally. Read More

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October 2020

Using computable knowledge mined from the literature to elucidate confounders for EHR-based pharmacovigilance.

J Biomed Inform 2021 Mar 11;117:103719. Epub 2021 Mar 11.

University of Washington, Department of Biomedical Informatics and Medical Education, Seattle, WA, United States.

Introduction: Drug safety research asks causal questions but relies on observational data. Confounding bias threatens the reliability of studies using such data. The successful control of confounding requires knowledge of variables called confounders affecting both the exposure and outcome of interest. Read More

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Kratom: The safe legal high?

Epilepsy Behav 2021 04 6;117:107882. Epub 2021 Mar 6.

Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Illicit drugs are used to produce a sense of euphoria in the user. Like marijuana, kratom is a plant-based substance. The leaves of the Mitragyna speciosa tree were used to treat mild medical conditions in Thailand and Malaysia as a stimulant in low doses, and sedative and analgesic at high doses. Read More

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Evidence-Based Strategies for Clinical Organizations to Address COVID-19 Vaccine Hesitancy.

Mayo Clin Proc 2021 03 30;96(3):699-707. Epub 2020 Dec 30.

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; Division of Health Care Policy and Research, Mayo Clinic, Rochester, MN; Department of Medicine, and Division of Community Pediatric and Adolescent Medicine and Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN. Electronic address:

The success of vaccination programs is contingent upon irrefutable scientific safety data combined with high rates of public acceptance and population coverage. Vaccine hesitancy, characterized by lack of confidence in vaccination and/or complacency about vaccination that may lead to delay or refusal of vaccination despite the availability of services, threatens to undermine the success of coronavirus disease 2019 (COVID-19) vaccination programs. The rapid pace of vaccine development, misinformation in popular and social media, the polarized sociopolitical environment, and the inherent complexities of large-scale vaccination efforts may undermine vaccination confidence and increase complacency about COVID-19 vaccination. Read More

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Effects of mind-body exercise on cardiopulmonary function, blood pressure, and quality of life in CHD patients: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Mar;100(9):e25042

Department of Physical Education, Wuhan University of Technology, Wuhan.

Background: Coronary heart disease (CHD) is one of the highest mortality diseases in the world, which seriously threatens human health and quality of life (QOL). The purpose of this study is to systematically analyze the effects of mind-body exercise on cardiopulmonary function, blood pressure and QOL in CHD patients, and to provide scientific evidence-based exercise prescription for patients with coronary heart disease.

Methods: This research review will include the following electronic databases from its establishment to December 2020: PubMed, EMBASE, Web of Science, Cochrane Library, the Chinese National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, and Wanfang. Read More

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Treatment approaches for COVID-19: A critical review.

Mini Rev Med Chem 2021 Feb 24. Epub 2021 Feb 24.

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka. India.

Background: Coronavirus disease 2019 (COVID-19) outbreak was declared as an emergency global public health concern on 30 January 2020. This novel coronavirus (SARS-CoV-2) outbreak was first identified in Wuhan city, China; which soon affected around 185 countries and territories all over the world through various transmission mechanisms. Having found no permanent cure to date, this pandemic threatens humanity for its very existence. Read More

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February 2021

S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.

Toxicol Appl Pharmacol 2021 04 25;416:115469. Epub 2021 Feb 25.

Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base, Ministry of Science and Technology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China. Electronic address:

Heat stress-induced oxidative stress in bovine mammary epithelial cells (BMECs) threatens the normal growth and development of bovine mammary tissue, resulting in lower milk production of dairy cows. The aim of the present study is to investigate the protective effects of S-allyl cysteine (SAC), an organosulfur component extracted from aged garlic, on heat stress-induced oxidative stress and apoptosis in BMECs and to explore its underlying mechanisms. Our results showed that heat stress treatment considerably decreased cell viability, whereas SAC treatment dose-dependently restored cell viability of BMECs under heat-stress conditions. Read More

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Sulfamoylbenzamide-based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication.

ACS Med Chem Lett 2021 Feb 2;12(2):242-248. Epub 2021 Feb 2.

Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.

As the spread of infections caused by hepatitis B virus (HBV) threatens public health worldwide, investigations from multiple perspectives and of various mechanisms of action are urgently required to increase the HBV cure rate. Targeting the encapsidation of the nuclear capsid protein (core protein, HBc) has emerged as an attractive strategy for inhibiting the viral assembly process; however, a drug targeting this mechanism has not yet been approved. We synthesized novel sulfamoylbenzamides (SBAs) as capsid assembly modulators of HBV and found that the effects and safety profiles of compounds and have potential therapeutic applicability against HBV. Read More

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February 2021

Identification and comparison of missed nursing care in the United States of America and South Korea.

J Clin Nurs 2021 Feb 15. Epub 2021 Feb 15.

Innovation and Evaluation, University of Michigan School of Nursing, Ann Arbor, MI, USA.

Aims And Objectives: This study aimed to identify and compare missed nursing care types and reasons between South Korea and the United States of America.

Background: Patient safety has become a significant task of the healthcare delivery systems worldwide. The omission of nursing care constitutes a growing concern because it threatens both patient safety and nursing care quality. Read More

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February 2021

Effects of fulvic acid size on microcystin-LR photodegradation and detoxification in the chlorine/UV process.

Water Res 2021 Apr 2;193:116893. Epub 2021 Feb 2.

Lyles School of Civil Engineering, Purdue University, West Lafayette, IN, 47907, United States; Division of Environmental & Ecological Engineering, Purdue University, West Lafayette, IN, 47907, United States. Electronic address:

Microcystin-LR (MC-LR), a polypeptide toxin generated by cyanobacteria, threatens the safety of drinking water supplies. In this study, fulvic acid (FA) was separated into two molecular weight (MW) ranges to evaluate the effects of FA size on MC-LR degradation in the chlorine/UV process. The rates of MC-LR degradation were significantly reduced in FA-containing water (3. Read More

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Transcriptome analysis reveals liver metabolism programming in kids from nutritional restricted goats during mid-gestation.

PeerJ 2021 29;9:e10593. Epub 2021 Jan 29.

CAS Key Laboratory for Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, South-Central Experimental Station of Animal Nutrition and Feed Science, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan, China.

Background: Maternal nutrient restriction during pregnancy causes a metabolic disorder that threatens the offspring's health in humans and animals. However, the molecular mechanism of how undernutrition affecting hepatic metabolism of fetal or postnatal offspring is still unclear. We aimed to investigate transcriptomic changes of fetal livers in response to maternal malnutrition in goats during mid-gestation and to explore whether these changes would disappear when the nutrition was recovered to normal level during mid-gestation using goats () as the experimental animals. Read More

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January 2021

Cinnamon Oil Inhibits Growth by Disturbing the Carbohydrate Metabolic Process.

J Fungi (Basel) 2021 Feb 9;7(2). Epub 2021 Feb 9.

Research Centre for Plant RNA Signaling, College of Life and Environmental Science, Hangzhou Normal University, Hangzhou 310036, China.

is a major postharvest pathogen that mainly threatens the global pome fruit industry and causes great economic losses annually. In the present study, the antifungal effects and potential mechanism of cinnamon oil against were investigated. Results indicated that 0. Read More

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February 2021

Understanding Drivers of COVID-19 Vaccine Hesitancy Among Blacks.

Clin Infect Dis 2021 Feb 9. Epub 2021 Feb 9.

University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, Pennsylvania.

Introduction: Coronavirus Disease 2019 (COVID-19) has disproportionately affected communities of color, with blacks experiencing the highest rates of disease severity and mortality. A vaccine against SARS-CoV-2 has the potential to reduce the race mortality gap from COVID-19; however, hesitancy of the vaccine in the black community threatens vaccine uptake.

Methods: We conducted focus groups with black barbershop and salon owners living in zip codes of elevated COVID-19 prevalence to assess their attitudes, beliefs, and norms around a COVID-19 vaccine. Read More

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February 2021

Development of a Conceptual Framework for Occupational Safety and Health in Palestinian Manufacturing Industries.

Int J Environ Res Public Health 2021 02 2;18(3). Epub 2021 Feb 2.

Civil Engineering Department, An-Najah National University, P.O. Box 7, Nablus, Palestine.

The annual increase in the number of occupational accidents and diseases in the Palestinian manufacturing industries confirms a serious problem that threatens the Occupational Safety and Health (OSH) in such industries, with negative consequences in the society and economy. As the Palestinian OSH data are insufficient, tightwad, and with discrepancies in published data by different agencies, this study aimed to investigate the OSH status in the Palestinian manufacturing industries and determine the Palestinian OSH trends rates based on international practice in the EU and USA. Also, to shed light on the OSH situation in the manufacturing sector and warrant the inspection and monitoring of industries by the respective officials. Read More

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February 2021

Disruption of interferon-β production by the N of atypical porcine pestivirus.

Virulence 2021 12;12(1):654-665

College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu Province, People's Republic of China.

Atypical porcine pestivirus (APPV) is an emerging porcine virus that threatens global swine production. Pestiviruses can prevent interferon (IFN) production to avoid the host innate immune response, and the N viral protein can play a critical role. Knowledge of the host immune response to APPV infection is limited. Read More

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December 2021