29,509 results match your criteria third trimester


Maternal Serum Placental Protein-13 Levels in the Prediction of Pregnancies with Abnormal Invasive Placentation.

Z Geburtshilfe Neonatol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Veris delli Ponti Hospital, Scorrano, Lecce, Italy, Lecce, Italy.

Objective: To evaluate whether placental protein-13 (PP-13) measured in the serum of pregnant women could predict abnormal invasive placentation (AIP) detected by color Doppler ultrasound (US) and magnetic resonance imaging scan in addition to the routine US scan during the third trimester.

Materials And Methods: The prospective case-control study included patients subdivided in 2 groups: 42 pregnant women with a singleton pregnancy at 28-32 weeks of gestation with only suspected AIP, and 32 healthy pregnant women. The serum PP-13 levels were measured in both groups using an enzyme-linked immunosorbent assay (ELISA) method and statistically compared. Read More

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Maternal Selenium Status has Crucial Role on Clinical Outcomes Of Pregnant Women With COVID-19 Infection.

J Med Virol 2021 May 5. Epub 2021 May 5.

University of Health Sciences, Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.

Aim: Adequate maternal selenium level is essential for immune response and healthy pregnancy. This study aimed to enlighten selenium status of pregnant women with COVID-19 and the effects of potential deficiency in serum selenium levels.

Methods: Totally 141 pregnant women, 71 of them was COVID-19 patients, in different trimesters were included in the study. Read More

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Single Fetal Demise in Twin Pregnancy-A Great Concern but Still a Favorable Outcome.

Diseases 2021 Apr 29;9(2). Epub 2021 Apr 29.

Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University "Dunarea de Jos" Galati, 800008 Galati, Romania.

The incidence of multiple pregnancies has increased in the last decades, mostly explained by the more frequent use of ovulation induction drugs and assisted reproduction techniques. Although single fetal death in the first trimester of twin pregnancy is not an uncommon event nor does it have serious consequences on the survival fetus, the death of one fetus in the second or third trimester of pregnancy is associated with a serious increase in morbidity and mortality for the surviving co-twin. Preterm labor, preeclampsia, intrauterine growth restriction (IUGR), neurological complications or even the death of the surviving twin have been associated with single fetal demise after mid gestation. Read More

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Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI.

Int J Environ Res Public Health 2021 Apr 30;18(9). Epub 2021 Apr 30.

National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan.

Previous studies have indicated that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse neuropsychiatric disorders in children and adolescents. This study aimed to determine the association between the concentrations of prenatal EDCs and brain structure changes in teenagers by using MRI. We recruited 49 mother-child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs-including phthalate esters, perfluorochemicals (PFCs), and heavy metals (lead, arsenic, cadmium, and mercury)-in maternal urine and/or serum. Read More

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Different Timing of Prenatal Organophosphate Pesticides Exposure Is Influenced Different Aspects of Infant Developmental Performance.

Toxics 2021 Apr 30;9(5). Epub 2021 Apr 30.

Environmental and Occupational Health Sciences and Non Communicable Diseases Center of Excellence, Chiang Mai University, 110 Inthavaroros Road, Sriphum Subdistrict, Muang District, Chiang Mai 50200, Thailand.

Organophosphate (OP) pesticides can transfer from mother to fetus via the placenta and amniotic fluid and may affect the development of infants. This study aims to evaluate the associations between maternal OP concentrations collected in the 1st-2nd trimester and the 3rd trimester of pregnancy and the infant developmental performance. The Screening Test of the Bayley Scales of Infants and Toddler Development, Third Edition (BSID-III screening test) was used to assess development performance at 2 and 6 months of age. Read More

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Poor sleep quality and its associated factors among pregnant women in Northern Ethiopia, 2020: A cross sectional study.

PLoS One 2021 4;16(5):e0250985. Epub 2021 May 4.

Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Amhara, Ethiopia.

Background: Sleep is a physiologic necessity for all humankind. Pregnant women, in particular, need adequate sleep to develop their fetuses as well as save energy required for delivery. A change in sleep quality and quantity is the most common phenomena during pregnancy due to mechanical and hormonal factors. Read More

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Immunological and physiopathological approach of COVID-19 in pregnancy.

Arch Gynecol Obstet 2021 May 4. Epub 2021 May 4.

Systemic Autoimmune Diseases Unit. Department of Internal Medicine-1, Vall d' Hebron University Hospital, Barcelona, Spain.

Coronavirus disease-2019 (COVID-19) related to Coronavirus-2 (SARS-CoV-2) is a worldwide health concern. Despite the majority of patients will evolve asymptomatic or mild-moderate upper respiratory tract infections, 20% will develop severe disease. Based on current pathogenetic knowledge, a severe COVID-19 form is mainly a hyperinflammatory, immune-mediated disorder, triggered by a viral infection. Read More

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Urine metabolomic biomarkers for prediction of isolated fetal congenital heart defect.

J Matern Fetal Neonatal Med 2021 May 4:1-8. Epub 2021 May 4.

Division of Maternal Fetal Medicine, William Beaumont Health, Royal Oak, MI, USA.

Objective: To identify maternal second and third trimester urine metabolomic biomarkers for the detection of fetal congenital heart defects (CHDs).

Study Design: This was a prospective study. Metabolomic analysis of randomly collected maternal urine was performed, comparing pregnancies with isolated, non-syndromic CHDs versus unaffected controls. Read More

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Prevalence of female sexual dysfunction during pregnancy in Eastern Mediterranean Regional Office Countries (EMRO): a systematic review and meta-analysis.

J Matern Fetal Neonatal Med 2021 May 4:1-9. Epub 2021 May 4.

Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Sexual dysfunction is potential abnormality in the ability of a person to sexual respond or enjoy sexual experience. During pregnancy, sexual function is at risk and disorder due to physical, hormonal and psychological changes. The prevalence of female sexual dysfunction is very variable during pregnancy. Read More

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Establishment of assay method- and trimester-specific reference intervals for thyroid hormones during pregnancy in Chengdu, China.

J Clin Lab Anal 2021 May 4:e23763. Epub 2021 May 4.

Department of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: The reference intervals of thyroid hormone will change at different stages of pregnancy because of physiological alterations. On the other hand, the reference intervals of thyroid hormone will also change in different detection systems due to the manufacturer's methodology as well as a different race. The objective of this study was to establish the assay method- and trimester-specific reference intervals for thyroid-stimulating hormone, free thyroxine and free triiodothyronine for pregnant women in Chengdu. Read More

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Obstetric Outcomes of Women Who Sustained Traumatic Spinal Injury during Pregnancy: A Systematic Review.

Asian Spine J 2021 May 6. Epub 2021 May 6.

KMU Institute of Physical Medicine and Rehabilitation, Khyber Medical University, Peshawar, Pakistan.

Literature regarding pregnant women who sustained traumatic spinal injury during pregnancy is limited. Existing papers are mainly case reports, and this indicates a need for more high-quality research evidence in this area. Therefore, this study was designed to systematically review available literature that reported demographic information, clinical characteristics, and obstetric outcomes of women who sustained spinal injury during pregnancy. Read More

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Combination of Fundal Height and Ultrasound to Predict Small for Gestational Age at Birth.

Am J Perinatol 2021 May 3. Epub 2021 May 3.

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Objective:  The objective of the study was to determine whether adding longitudinal measures of fundal height (FH) to the standard cross-sectional FH to trigger third trimester ultrasound estimated fetal weight (EFW) would improve small for gestational age (SGA) prediction.

Study Design:  We developed a longitudinal FH calculator in a secondary analysis of a prospective cohort study of 1,939 nonobese pregnant women who underwent serial FH evaluations at 12 U.S. Read More

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CE-123, a novel dopamine transporter inhibitor, attenuates locomotor hyperactivity and improves cognitive functions in rat model of fetal alcohol spectrum disorders.

Behav Brain Res 2021 Apr 30:113326. Epub 2021 Apr 30.

Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland. Electronic address:

Perinatal alcohol exposure can lead to fetal alcohol spectrum disorders (FASD), usually first diagnosed in childhood, that are characterized by hyperactivity, impulsivity and learning and memory disability, among others. To test the hypothesis that dopamine signaling is one of the main factors underlying these impairments, a new atypical dopamine transporter (DAT) inhibitor, CE-123 (1, 3 or 10 mg/kg) was assessed for its potential to overcome the ethanol-induced behavioral effects in a rat model of FASD. In the present study, neonatal rats were exposed to alcohol intubations across the neonatal period (postnatal day (PND)4-9, the third trimester equivalent of human gestation) and, after weaning, the animals (male rats) were assigned randomly to three groups. Read More

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Family medicine provision of online medication abortion in three US states during COVID-19.

Contraception 2021 Apr 30. Epub 2021 Apr 30.

Women on Web/Aid Access, Amsterdam, the Netherlands.

Objective: To examine provision of direct-to-patient medication abortion during COVID-19 by US family physicians through a clinician-supported, asynchronous online service, Aid Access.

Study Design: We analyzed data from US residents in New Jersey, New York, and Washington who requested medication abortion from three family physicians using the online service from Aid Access between April and November 2020. This study seeks to examine individual characteristics, motivations, and geographic locations of patients receiving abortion care through the Aid Access platform. Read More

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Third trimester HbA1c and the association with large-for-gestational-age neonates in women with gestational diabetes.

Arch Endocrinol Metab 2021 Apr 29. Epub 2021 Apr 29.

Departamento de Endocrinologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal.

Objective: To evaluate the association between HbA1c levels measured in the third trimester and the risk for large for gestational age (LGA) in neonates of mothers affected by gestational diabetes mellitus (GDM). Secondarily, we aimed to identify an ideal cut-off for increased risk of LGA amongst pregnant women with GDM.

Methods: Observational retrospective review of singleton pregnant women with GDM evaluated in a diabetes and pregnancy clinic of a tertiary and academic hospital. Read More

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Foetal cardiac function in third trimester pregnancies with reduced fetal movements.

J Obstet Gynaecol 2021 May 2:1-7. Epub 2021 May 2.

Department of Obstetrics and Gynecology, Uskudar Yunus Emre Hospital, Istanbul, Turkey.

The objective of our study was to investigate the possible relationship between poor perinatal outcome and foetal cardiac functions in pregnant women with reduced foetal movements (RFM). This cross-sectional study included 126 pregnant women with normal foetal movements (Group 1, Controls) and 42 pregnant women over 32 weeks gestation with RFM (Group 2). Group 2 was further divided into two subgroups according to their perinatal outcome: normal perinatal outcome (Group 2a) and poor perinatal outcome (Group 2b). Read More

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Perinatal depression in migrant and refugee women on the Thai-Myanmar border: does social support matter?

Philos Trans R Soc Lond B Biol Sci 2021 Jun 3;376(1827):20200030. Epub 2021 May 3.

Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, 68/30 Bantung Road, PO Box 46, Mae Sot, Tak 63110, Thailand.

Migrant and refugee women are at risk of perinatal depression due to stressors experienced before, during and after migration. This study assesses the associations between social support and perinatal depression among migrant and refugee women on the Thai-Myanmar border. We conducted a cohort study of pregnant and post-partum women. Read More

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Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia.

Womens Health Rep (New Rochelle) 2021 20;2(1):97-105. Epub 2021 Apr 20.

Division of Cardiology, Department of Internal Medicine, University of California San Francisco, San Francisco, California, USA.

Pregnancy requires a complex physiological adaptation of the maternal cardiovascular system, which is disrupted in women with pregnancies complicated by preeclampsia, putting them at higher risk of future cardiovascular events. The measurement of body movements in response to cardiac ejection ballistocardiogram (BCG) can be used to assess cardiovascular hemodynamics noninvasively in women with preeclampsia. Using a previously validated, modified weighing scale for assessment of cardiovascular hemodynamics through measurement of BCG and electrocardiogram (ECG) signals, we collected serial measurements throughout pregnancy and postpartum and analyzed data in 30 women with preeclampsia and 23 normotensive controls. Read More

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Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection.

BMC Vet Res 2021 May 1;17(1):182. Epub 2021 May 1.

Western College of Veterinary Medicine, Saskatoon, 52 Campus Dr, Saskatoon, Saskatchewan, S7N 5B4, Canada.

Background: Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment due to apoptosis are hypothesized. We performed two experiments examining hypoxia and apoptosis in PRRSV-infected and non-infected, third-trimester fetuses to elucidate possible associations with fetal death. Fetuses were selected based on four phenotypic infection groups: fetuses from non-challenged control gilts (CTRL); low viral load fetuses (LVL; Exp 1) or uninfected fetuses (UNINF; Exp 2) from inoculated gilts; viable high viral load fetuses (HVL-VIA); and HVL meconium-stained fetuses (HVL-MEC). Read More

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Asymptomatic malaria and anaemia among pregnant women during high and low malaria transmission seasons in Burkina Faso: household-based cross-sectional surveys in Burkina Faso, 2013 and 2017.

Malar J 2021 May 1;20(1):211. Epub 2021 May 1.

Centre de Recherche en Epidémiologie, Biostatistique Et Recherche Clinique, Ecole de Santé Publique, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Bruxelles, Belgium.

Background: Malaria in endemic countries is often asymptomatic during pregnancy, but it has substantial consequences for both the mother and her unborn baby. During pregnancy, anaemia is an important consequence of malaria infection. In Burkina Faso, the intensity of malaria varies according to the season, albeit the prevalence of malaria and anaemia as well as their risk factors, during high and low malaria transmission seasons is underexplored at the household level. Read More

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Third trimester repeat HIV testing: It's time we make it universal.

Am J Obstet Gynecol 2021 Apr 28. Epub 2021 Apr 28.

Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Since the 1990s, perinatal transmission of HIV has decreased substantially, largely as a result of improved detection secondary to routine HIV screening in pregnancy and the use of antiretroviral therapy. However, despite reductions, elimination of perinatal transmission, defined as an incidence of perinatal HIV infection of less than 1:100,000 live births and a transmission rate < 1%, remains elusive. An estimated 80% of perinatal transmissions occur after 36 weeks' gestation, which highlights the importance of diagnosis and treatment of maternal HIV infection prior to the highest risk time period for perinatal transmission. Read More

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Free thyroxine in early pregnancy is an independent negative predictor of 3 trimester HbA1c. Odense Child Cohort.

Clin Endocrinol (Oxf) 2021 Apr 30. Epub 2021 Apr 30.

Department of Endocrinology, Odense University Hospital, University of Southern, Denmark.

Background: Lower thyroid function outside pregnancy is associated with increased risk of type 2 diabetes mellitus. The relationship between thyroid function in early pregnancy and glucose status in 3 trimester has not been investigated.

Aims: To study the association between 1 trimester thyroid function and 3 trimester glucose status. Read More

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Aortic dissection during pregnancy and postpartum.

J Card Surg 2021 Apr 29. Epub 2021 Apr 29.

Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Background: Patients with aortic dissection during pregnancy and postpartum period exhibit a high mortality. At present, a complete overview of aortic dissection during pregnancy and postpartum period is lacking. ​Methods: This systematic review included 80 reports published from 2000 to 2020, comprising a total study population of 103 patients with aortic dissection. Read More

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Evaluation of Thyroid Function in Pregnant Women Using Automated Immunoassays.

Clin Chem 2021 Apr;67(5):772-780

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Health System, Lebanon, NH, USA.

Introduction: Automated free thyroxine (FT4) immunoassays are widely available, but professional guidelines discourage their use in pregnant women due to theoretical under-recoveries attributed to increased thyroid hormone binding capacity and instead advocate the use of total T4 (TT4) or free thyroxine index (FTI). The impact of this recommendation on the classification of thyroid status in apparently euthyroid pregnant patients was evaluated.

Methods: After excluding specimens with thyroid autoantibody concentrations above reference limits, thyroid-stimulating hormone (TSH), FT4, TT4, and T-uptake were measured on the Roche Cobas® platform in remnant clinical specimens from at least 147 nonpregnant women of childbearing age and pregnant women at each trimester. Read More

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Pregnancy With Cardiac Arrest in the Emergency Department: Case Report With Review of Literature.

Cureus 2021 Mar 27;13(3):e14148. Epub 2021 Mar 27.

Emergency Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Cardiac arrest in pregnancy is an uncommon encounter, with the incidence being one in every 12,000 hospital admissions for delivery. Here we present, one such patient and our experience in managing the patient. A 23-year-old, third-trimester pregnant female presented with a history of polytrauma following a road traffic accident. Read More

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Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women.

Front Endocrinol (Lausanne) 2021 13;12:670357. Epub 2021 Apr 13.

Department of Physiology, Universidad Nacional de Colombia, Bogota, Colombia.

Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Read More

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Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period.

Biomolecules 2021 Apr 28;11(5). Epub 2021 Apr 28.

Department of Pharmacology and Pharmacodynamics, Medical University, Chodzki 4A, 20-093 Lublin, Poland.

Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR) signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the neonatal period, we investigated the influence of rapamycin, an mTOR Complex 1 (mTORC1) inhibitor, on deficits in spatial memory and reversal learning in the Barnes maze task, as well as the ethanol-induced rewarding effects (1.0 or 1. Read More

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Use of the Renal Artery Doppler to Identify Small for Gestational Age Fetuses at Risk for Adverse Neonatal Outcomes.

J Clin Med 2021 Apr 23;10(9). Epub 2021 Apr 23.

Department of Women and Child Heath, University of Padua School of Medicine, 35122 Padova, Italy.

Objective: To measure the sensitivity and positive predictive value (PPV) for an adverse neonatal outcome among growth-restricted fetuses (FGR) comparing the cerebral-placental ratio (CPR) with the cerebral-renal ratio (CRR).

Methods: Retrospective analysis of 92 women who underwent prenatal ultrasound at the University of Maryland and the University of Padua. Renal, middle cerebral and umbilical artery Doppler waveforms were recorded for all scans during the third trimester. Read More

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The Association between Preterm Birth and Ambient Air Pollution Exposure in Shiyan, China, 2015-2017.

Int J Environ Res Public Health 2021 Apr 19;18(8). Epub 2021 Apr 19.

Department of Healthcare Management, School of Health Sciences, Wuhan University, Wuhan 430072, China.

Shortening of the gestational duration has been found associated with ambient air pollution exposure. However, the critical exposure windows of ambient air pollution for gestational duration remain inconsistent, and the association between ambient air pollution and early term births (ETB, 37 to 38 weeks) has rarely been studied relative to preterm births (PTB, 28-37 weeks). A time-series study was conducted in Shiyan, a medium-sized city in China. Read More

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