584,181 results match your criteria third

Using Individual Residents' Learning Trajectories to Better Understand the Impact of Gaps in Practice.

Acad Med 2021 Aug 3. Epub 2021 Aug 3.

S. Scott is assistant professor and surgical skills coordinator, Department of Obstetrics and Gynecology, Clinical Gynecologic Oncologist, Dalhousie University, Halifax, Nova Scotia, Canada. N. Van Eyk is associate professor and clinical obstetrician and gynecologist, Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada. K. Eva is associate director, Centre for Health Education Scholarship, and professor and director of educational research and scholarship, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose: To optimize learning, health professional training programs need to achieve the right balance between depth of practice (gaining more experience with particular skills) and breadth of practice (spreading experience across an array of activities). Better understanding how training for a particular skill set is impacted by periods of focus on a different skill set would allow improved curriculum and assessment design, thereby enhancing the efficiency of training and effectiveness of care. To this end, learning curves were used to compare performance in surgery after prolonged periods of practice to performance after gaps in surgical training. Read More

View Article and Full-Text PDF

Artificial Intelligence in Undergraduate Medical Education: A Scoping Review.

Acad Med 2021 Aug 3. Epub 2021 Aug 3.

J. Lee is a third-year medical student, University of Toronto, Temerty Faculty of Medicine, Toronto, Ontario, Canada. A.S. Wu is a third-year medical student, University of Toronto, Temerty Faculty of Medicine, Toronto, Ontario, Canada. D. Li is a second-year medical student, University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada. K. Kulasegaram is associate professor, Department of Family and Community Medicine, University of Toronto and The Wilson Centre, University Health Network, Toronto, Ontario, Canada.

Purpose: Artificial intelligence (AI) is a rapidly growing phenomenon poised to instigate large-scale changes in medicine. However, medical education has not kept pace with the rapid advancements of AI. Despite several calls to action, the adoption of teaching on AI in undergraduate medical education (UME) has been limited. Read More

View Article and Full-Text PDF

Training for Professional Uncertainty: Socialization of Medical Students Through the Residency Application Process.

Acad Med 2021 Aug 3. Epub 2021 Aug 3.

S.M. Russel is a second-year resident, Department of Otolaryngology/Head & Neck Surgery, University of North Carolina, Chapel Hill, North Carolina; ORCID: https://orcid.org/0000-0001-9299-8047. J.R. Geraghty is an MD/PhD student who has completed his PhD and returned to his third year of medical school, University of Illinois College of Medicine, Chicago, Illinois; ORCID: https://orcid.org/0000-0002-6828-4893. H. Renaldy is a third-year resident, Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, California. T.M. Thompson is associate dean for admissions and associate professor of emergency medicine and medical toxicology, Department of Emergency Medicine, University of Illinois College of Medicine, Chicago, Illinois. Previously, he was assistant dean for residency preparedness, University of Illinois College of Medicine, Chicago, Illinois. L.E. Hirshfield is associate professor of medical education and sociology, Department of Medical Education, University of Illinois College of Medicine, Chicago, Illinois; ORCID: https://orcid.org/0000-0003-0894-2994.

Purpose: Uncertainty in medical decision making is a well-described phenomenon, and numerous scholars have acknowledged and illustrated the process of training medical students to grapple with this aspect of medical practice. While clinical uncertainty has been defined previously, medical trainees face additional forms of uncertainty beyond the clinical setting that have not, as yet, been investigated empirically. One area in which uncertainty can manifest outside of the clinical setting is during professional development. Read More

View Article and Full-Text PDF

Negative Corneal Fluorescein Staining as an Exceptionally Early Sign of Acanthamoeba Keratitis: A Case Report.

Eye Contact Lens 2021 Aug 3. Epub 2021 Aug 3.

Department of Ophthalmology (I.K., O.B.S., M.P.), Ege University, Izmir, Turkey; and Department of Ophthalmology (C.S.), Mugla Sitki Kocman University, Mugla, Turkey.

Objectives: To report the negative fluorescein staining as an early sign of Acanthamoeba keratitis (AK).

Methods: Case report and brief review of related literature.

Report Of Case: A 30-year-old, contact lens wearer, woman presented with mild irritation and pain in the right eye. Read More

View Article and Full-Text PDF

An Intentionally Designed Walking Program for Seniors Results in Enhanced Community Connection.

J Aging Phys Act 2021 Aug 4:1-10. Epub 2021 Aug 4.

Social connection is vital for older adults' physical and psychological well-being, yet nearly one third of them report feeling lonely. The purpose of this study was to evaluate the influence of a monthly walking program (walking once a month for 8 months) on older adults' community connection. Older adults (Mage = 78. Read More

View Article and Full-Text PDF

Prevalence and risk factors for mental health symptoms in community epidemic prevention workers during the postpandemic era of COVID-19 in China.

Psychiatry Res 2021 Jul 20;304:114132. Epub 2021 Jul 20.

The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, China. Electronic address:

Few people have paid attention to community epidemic prevention workers in the postpandemic era of COVID-19. This study aimed to explore the prevalence and risk factors for mental health symptoms in community epidemic prevention workers during the postpandemic era. Mental health status was evaluated by the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Chinese Perceived Stress Scale, Insomnia Severity Index, and Maslach Burnout Inventory-General Survey. Read More

View Article and Full-Text PDF

Efficacy and safety of photodynamic therapy mediated by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 2: a single-center, prospective, cohort Study.

Photodiagnosis Photodyn Ther 2021 Aug 1:102472. Epub 2021 Aug 1.

Department of Obstetrics and Gynecology, Peking University Third Hospital, 100191, 49 North Garden Rd., Haidian District, Beijing, China. Electronic address:

Background Photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (5-ALA) is a possible minimally-invasive treatment for cervical intraepithelial neoplasia (CIN). The present study was carried out to investigate the effect of 5-ALA-PDT on CIN2 and the influencing factors of 5-ALA-PDT. Methods Patients diagnosed as CIN2 who met the inclusion criteria were enrolled in this study sequentially from January 2019 to April 2020. Read More

View Article and Full-Text PDF

Disassembly and rewiring of a mature converging excitatory circuit following injury.

Cell Rep 2021 Aug;36(5):109463

Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

Specificity and timing of synapse disassembly in the CNS are essential to learning how individual circuits react to neurodegeneration of the postsynaptic neuron. In sensory systems such as the mammalian retina, synaptic connections of second-order neurons are known to remodel and reconnect in the face of sensory cell loss. Here we analyzed whether degenerating third-order neurons can remodel their local presynaptic connectivity. Read More

View Article and Full-Text PDF

Face Recognition by Humans and Machines: Three Fundamental Advances from Deep Learning.

Annu Rev Vis Sci 2021 Aug 4. Epub 2021 Aug 4.

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA; email:

Deep learning models currently achieve human levels of performance on real-world face recognition tasks. We review scientific progress in understanding human face processing using computational approaches based on deep learning. This review is organized around three fundamental advances. Read More

View Article and Full-Text PDF

Maximum Insertion Torque, Stress, and Strain in Bone during Insertion of Three Dental Implants with Different Macroscopic Designs: A Dynamic Finite-Element Analysis.

J Long Term Eff Med Implants 2021 ;31(2):81-89

Assistant Professor, Department of Periodontics, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Using finite element analysis, this study assesses maximum insertion torque, stress, and strain in bone during insertion of three dental implant types with different macroscopic designs. We model a bone block including cancellous and cortical bones and an osteotomy hole matching the size of the final implant drill. We then model three implants of the same length and diameter but with different thread and body designs. Read More

View Article and Full-Text PDF
January 2021

Variant , Defective piRNA Processing, and Azoospermia.

N Engl J Med 2021 Aug 4. Epub 2021 Aug 4.

From the Division of Genetics, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton (L.N., D.F.C.); the Center for Embryonic Cell and Gene Therapy, Oregon Health and Science University, Portland (D.F.C.); the Department of Growth and Reproduction (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.) and the International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (N.M., J.E.N., R.S., I.G., S.B.W., N.E.S., E.R.-D.M., N.J., K.A.), Rigshospitalet, and the Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences (K.A.), University of Copenhagen, Copenhagen; the Laboratory of Molecular Neurooncology, Neuroscience Institute (R.S.), and the Institute of Biology Systems and Genetic Research (I.G.), Lithuanian University of Health Sciences, Kaunas, Lithuania; the Department of Human Genetics, Donders Institute for Brain, Cognition, and Behavior (M.S.O., G.W.H.), and the Department of Obstetrics and Gynecology (G.W.H.), Radboud University Medical Center, Nijmegen, the Netherlands; Serviço de Genética, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto (F.C., C.J.M.), Instituto de Investigação e Inovação em Saúde, Universidade do Porto (F.C., C.J.M., A.M.L.), and the Institute of Molecular Pathology and Immunology of the University of Porto (A.M.L.) - all in Porto, Portugal; the Andrology and In Vitro Fertilization Laboratory, Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City (K.I.A.); the Departments of Pathology and Laboratory Medicine (F.K.) and Urology (P.N.S.), Weill Cornell Medicine, New York; and the Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (J.A.V.).

Background: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ cells, where they regulate aberrant expression of transposable elements and postmeiotic gene expression. Critical to the processing of piRNAs is the protein poly(A)-specific RNase-like domain containing 1 (PNLDC1), which trims their 3' ends and, when disrupted in mice, causes azoospermia and male infertility.

Methods: We performed exome sequencing on DNA samples from 924 men who had received a diagnosis of nonobstructive azoospermia. Read More

View Article and Full-Text PDF

Effect of different levels of SVV on the endothelial glycocalyx of patients undergoing colorectal surgery: A randomised clinical trial.

Exp Physiol 2021 Aug 4. Epub 2021 Aug 4.

The first Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.

New Findings: What is the central question of the study? Massive infusion can destroy the endothelial glycocalyx (EG). We compared the serum concentrations of EG components, atrial natriuretic peptide (ANP), and the outcomes of patients with different levels of stroke volume variation (SVV). What is the main finding and its importance? With a decrease in SVV, the serum concentrations of EG components and ANP increased, while the oxygenation index decreased. Read More

View Article and Full-Text PDF

LDL cholesterol levels and in-hospital bleeding in patients on high-intensity antithrombotic therapy: findings from the CCC-ACS project.

Eur Heart J 2021 Jul 29. Epub 2021 Jul 29.

Department of Cardiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.

Aims : Emerging evidence has linked cholesterol metabolism with platelet responsiveness. We sought to examine the dose-response relationship between low-density lipoprotein cholesterol (LDL-C) and major in-hospital bleeds in acute coronary syndrome (ACS) patients.

Methods And Results : Among 42 378 ACS patients treated with percutaneous coronary intervention (PCI) enrolled in 240 hospitals in the Improving Care for Cardiovascular Disease in China-ACS project from 2014 to 2019, a total of 615 major bleeds, 218 ischaemic events, and 337 deaths were recorded. Read More

View Article and Full-Text PDF

Identification of potential biomarkers in dengue via integrated bioinformatic analysis.

PLoS Negl Trop Dis 2021 Aug 4;15(8):e0009633. Epub 2021 Aug 4.

Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Dengue fever virus (DENV) is a global health threat that is becoming increasingly critical. However, the pathogenesis of dengue has not yet been fully elucidated. In this study, we employed bioinformatics analysis to identify potential biomarkers related to dengue fever and clarify their underlying mechanisms. Read More

View Article and Full-Text PDF

[Seroprevalence of hepatitis B in adult population of a district of Cajamarca].

Rev Gastroenterol Peru 2021 Jan-Mar;41(1):16-20

Servicio de Gastroenterología, Hospital Regional Docente de Cajamarca. Cajamarca, Perú.

Introduction: Hepatitis B is a transmissible disease, it is estimated that globally more than two billion people in the world have been infected with hepatitis B virus, of which 350 million are chronic carriers of hepatitis B surface antigen, and this chronic infection causes cirrhosis and liver cancer. In Peru, hyperendemic zones have been detected in the country's jungle. Cajamarca is the third department with the highest rates of liver and bile duct cancer. Read More

View Article and Full-Text PDF

Gastrointestinal Bleed After Total Pancreatectomy With Islet Autotransplant.

Pancreas 2021 Aug 3. Epub 2021 Aug 3.

From the Departments of Surgery Medicine Pediatrics, University of Minnesota School of Medicine Division of Biostatistics, University of Minnesota School of Public Health Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN.

Objective: Gastrointestinal bleeding (GIB) is an uncommon complication after abdominal surgery. Given the unique risks in the total pancreatectomy with islet autotransplant (TPIAT) population, we aimed to describe this population's incidence of postoperative GIB.

Methods: Prospectively collected data on patients who underwent a TPIAT from 2001 to 2018 at the University of Minnesota were reviewed for postoperative GIB. Read More

View Article and Full-Text PDF

The Effect of Benson Relaxation Technique on Stress, Anxiety, and Depression in Pregnant Women.

Holist Nurs Pract 2021 Aug 2. Epub 2021 Aug 2.

School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran (Ms Zenouzi and Dr Babayanzad); Islamic Azad University, Pishva Branch, Tehran, Iran (Mss Zenouzi and Asghari); Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran (Dr Moghadam); and Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran (Dr Rezaei).

Relaxation programs can be effective in establishing psychological tranquility for maternal and fetal health. This study was conducted to evaluate the effect of this low-cost, effective, easy method on the stress, anxiety, and depression in pregnant women. This randomized clinical trial study was conducted from July 2015 to July 2016. Read More

View Article and Full-Text PDF

Measuring Weak Consistency and Weak Transitivity of Pairwise Comparison Matrices.

IEEE Trans Cybern 2021 Aug 4;PP. Epub 2021 Aug 4.

Under the assumption of rational economics, the opinions of decision makers should exhibit some transitivity properties. It is an important issue on how to measure the transitivity properties of the provided preference relations over a set of alternatives. In this study, we report the methods for measuring weak consistency (w-consistency) and weak transitivity (w-transitivity) of pairwise comparison matrices (PCMs) originating from the analytic hierarchy process (AHP). Read More

View Article and Full-Text PDF

Tin Metal Cluster Compounds as New Third-Order Nonlinear Optical Materials by Computational Study.

J Phys Chem Lett 2021 Aug 4:7537-7544. Epub 2021 Aug 4.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P.R. China.

It is quite appealing but challenging to predict and synthesize new nonlinear optical (NLO) materials with exceptional performance. Herein, the different Sn cluster core structures and third-order NLO properties are studied through electronic structure, excited hole-electron, bonding character, and aromaticity analysis. As a result, Sn clusters with ring core structure (Sn-R) not only have the smallest , the largest UV-vis response intensity, but also the strongest third-order NLO response in our work. Read More

View Article and Full-Text PDF

A phase I clinical trial of human embryonic stem cell-derived retinal pigment epithelial cells for early-stage Stargardt macular degeneration: 5-years' follow-up.

Cell Prolif 2021 Aug 4:e13100. Epub 2021 Aug 4.

Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Objectives: To evaluate the long-term biosafety and efficacy of transplantation of human embryonic stem cells-derived retinal pigment epithelial (hESC-RPE) cells in early-stage of Stargardt macular degeneration (STGD1).

Materials And Methods: Seven patients participated in this prospective clinical study, where they underwent a single subretinal transplantation of 1 × 10 hESC-RPE cells in one eye, whereas the fellow eye served as control. These patients were reassessed for a 60-month follow-up through systemic and ophthalmic examinations. Read More

View Article and Full-Text PDF

Prolonged Symptom Onset to Admission Time is Associated with Severe Coronavirus Disease: A Meta combined Propensity-adjusted Analysis.

J Med Virol 2021 Aug 4. Epub 2021 Aug 4.

Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, P.R. China.

Background: Patients with severe COVID-19 are more likely to develop adverse outcomes with huge medical burden. We aimed to investigate whether a shorter symptom onset to admission time (SOAT) could improve outcomes of COVID-19 patients.

Methods: A single-centre retrospective study combined with a meta-analysis was performed. Read More

View Article and Full-Text PDF

A Two-Generation Reproductive Toxicity Study of Lanthanum Nitrate in SD Rats.

Biol Trace Elem Res 2021 Aug 4. Epub 2021 Aug 4.

Department of Health Toxicology, Faculty of Naval Medicine, The Second Military Medical University, Shanghai, 200433, China.

In order to evaluate the effects of lanthanum nitrate on the development of the parent, offspring, and the third generation of Sprague-Dawley (SD) rats, a two-generation reproductive toxicity experiment, was conducted. Two hundred and forty specific pathogen-free (SPF) healthy SD rats were randomly divided into the control group, low-, medium-, and high-dose group, with 30 male and 30 female rats in each group. The rats in each group were given 0 mg/kg, 10. Read More

View Article and Full-Text PDF

Intrinsically disordered proteins identified in the aggregate proteome serve as biomarkers of neurodegeneration.

Metab Brain Dis 2021 Aug 4. Epub 2021 Aug 4.

Central Arkansas Veterans Healthcare Service, Little Rock, AR, 72205, USA.

A protein's structure is determined by its amino acid sequence and post-translational modifications, and provides the basis for its physiological functions. Across all organisms, roughly a third of the proteome comprises proteins that contain highly unstructured or intrinsically disordered regions. Proteins comprising or containing extensive unstructured regions are referred to as intrinsically disordered proteins (IDPs). Read More

View Article and Full-Text PDF

Percutaneous, intra-articular, chevron osteotomy (PeICO) for the treatment of mild-to-moderate hallux valgus: a case series.

Int Orthop 2021 Aug 4. Epub 2021 Aug 4.

Minimally Invasive Foot and Ankle Society (MIFAS By Grecmip), 2 Rue Georges Negrevergne, 33700, Merignac, France.

Purpose: Treatment for hallux valgus (HV) remains challenging. Third-generation percutaneous procedures try to reproduce chevron-type osteotomies to replicate their benefits, such as intrinsic stability and reproducibility. We report the first results using a percutaneous, intra-articular, chevron osteotomy (PeICO) technique that mimics the classic intra-articular open chevron procedure, associated with a percutaneous adductor tendon release (PATR) for the treatment of mild-to-moderate HV. Read More

View Article and Full-Text PDF

Differential Antibody Response to mRNA COVID-19 Vaccines in Healthy Subjects.

Microbiol Spectr 2021 Aug 4:e0034121. Epub 2021 Aug 4.

Department of Pathology, University of Pittsburghgrid.471408.egrid.21925.3d Medical Center, Pittsburgh, Pennsylvania, USA.

Knowledge about development and duration of virus-specific antibodies after COVID-19 vaccination is important for understanding how to limit the pandemic via vaccination in different populations and societies. However, the clinical utility of postvaccination testing of antibody response and selection of targeted SARS-CoV-2 antigen(s) has not been established. The results of such testing from clinical teams independent from vaccine manufacturers are also limited. Read More

View Article and Full-Text PDF

SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants.

Microbiol Spectr 2021 Aug 4:e0026121. Epub 2021 Aug 4.

Department of Infectious Diseases, Southwest Hospital, Third Military Medical Universitygrid.410570.7 (Army Medial University), Chongqing, China.

The dynamics of quasispecies afford RNA viruses a great fitness on cell tropism and host range. To study the quasispecies features and the intra-host evolution of SARS-CoV-2, we collected nine confirmed patients and sequenced the haplotypes of spike gene using a single-molecule real-time platform. Fourteen samples were extracted from sputum, nasopharyngeal swabs, or stool, which in total produced 283,655 high-quality circular consensus sequences. Read More

View Article and Full-Text PDF

Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.

Microbiol Spectr 2021 Aug 4:e0024821. Epub 2021 Aug 4.

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Konggrid.10784.3a, Prince of Wales Hospital, Hong Kong Special Administrative Region.

Nontyphoidal Salmonella (NTS) gastroenteritis in children remains a significant burden on health care and constitutes a majority of all admissions for Salmonella infections in public hospitals in Hong Kong. In this prospective study, 41% of 241 children hospitalized with gastroenteritis from three public hospitals during 2019 were culture confirmed to have NTS infection. These Salmonella isolates were whole-genome sequenced and predicted for their serovars/serotypes using the Salmonella Typing Resource (SISTR) and SeqSero1, and the antimicrobial resistance (AMR) genes were determined. Read More

View Article and Full-Text PDF

Gut Microbiome and Serum Metabolome Alterations Associated with Isolated Dystonia.

mSphere 2021 Aug 4:e0028321. Epub 2021 Aug 4.

NHC Key Laboratory of Systems Biology of Pathogens, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing, China.

Dystonia is a complex neurological movement disorder characterized by involuntary muscle contractions. Increasing studies implicate the microbiome as a possible key susceptibility factor for neurological disorders, but the relationship between the gut microbiota and dystonia remains poorly explored. Here, the gut microbiota of 57 patients with isolated dystonia and 27 age- and environment-matched healthy controls was analyzed by 16S rRNA gene amplicon sequencing. Read More

View Article and Full-Text PDF