18,763 results match your criteria thinning >190μm

Long-tevrm outcomes of the MICOF keratoprosthesis surgery.

Ocul Surf 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China. Electronic address:

Purpose: To evaluate long-term anatomical and functional outcomes of the MICOF keratoprosthesis to treat end-stage corneal blindness.

Design: Re trospective review of consecutive clinical case series.

Participants: Between October 2000 and October 2015, at the Department of Ophthalmology of Chinese PLA General Hospital (PLAGH), a total of 132 eyes of 131 patients had undergone a MICOF keratoprosthesis implantation. Read More

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Anterior chamber angle features in primary congenital glaucoma infants using hand-held anterior segment-oct.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Medicine, Ophthalmology department, Cairo University, Cairo, Egypt.

Purpose: To describe anterior chamber angle (ACA) structures and parameters in primary congenital glaucoma (PCG) and normal infant eyes, using Hand-held anterior segment optical coherence tomography (HH AS-OCT), as an in-office, non-contact technique.

Methods: Normal and PCG-infants <24 months were examined, using HH AS-OCT (RTVue RT- 100, Optovue Inc., Fremont, CA). Read More

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Association of inner retinal reflectivity with qualitative and quantitative changes in retinal layers over time in diabetic eyes without retinopathy.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Pamukkale University, Denizli, Turkey.

Objective: To assess the course of neurodegeneration based on retinal layer thickness and integrity analysis in diabetic patients without retinopathy and to evaluate its association with inner retinal reflectivity.

Methods: This retrospective case-control study included 80 eyes of 80 patients with DM without retinopathy and 40 eyes of 40 healthy subjects with a follow-up of ≥1 year. SD-OCT was used for assessment of retinal reflectivity and macular layer thicknesses. Read More

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Ice-shelf retreat drives recent Pine Island Glacier speedup.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

British Antarctic Survey, High Cross, Madingley Road, Cambridge CB3 0ET, UK.

Speedup of Pine Island Glacier over the past several decades has made it Antarctica's largest contributor to sea-level rise. The past speedup is largely due to grounding-line retreat in response to ocean-induced thinning that reduced ice-shelf buttressing. While speeds remained fairly steady from 2009 to late 2017, our Copernicus Sentinel 1A/B-derived velocity data show a >12% speedup over the past 3 years, coincident with a 19-km retreat of the ice shelf. Read More

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Fluid-structure interaction modeling of lactating breast: Newtonian vs. non-Newtonian milk.

J Biomech 2021 May 13;124:110500. Epub 2021 May 13.

Department of Mechanical Engineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. Electronic address:

Breastfeeding is a highly dynamic and complex mechanism. The suckling process by the infant involves compression and intra-oral vacuum pressure, leading to milk expression from breast. The accumulated milk from the nipple varies depending on the milk properties and transient flow rate during the suckling cycle. Read More

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Megalocornea, anterior megalophthalmos, keratoglobus and associated anterior segment disorders: A Review.

Clin Exp Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Megalocornea and anterior megalophthalmos (megalocornea spectrum) disorders are typically defined by corneal diameter >12.5 mm in the absence of elevated intraocular pressure. Clinical features overlap with keratoglobus but are distinct from buphthalmos and severe (globus) keratoconus. Read More

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Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy.

Clin Ophthalmol 2021 3;15:2327-2333. Epub 2021 Jun 3.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

Purpose: Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR). Read More

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Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients.

BMC Psychiatry 2021 Jun 10;21(1):301. Epub 2021 Jun 10.

Department of Psychiatry, Peking University Huilongguan Clinical Medical School, Nandian Road, Changping District, Beijing, 100096, China.

Background: We analyzed the correlation of the clinical data with retinal nerve fiber layer (RNFL) thickness and macular thickness in bipolar disorder patients and major depression patients. The aim of this study is to explore factors that affect RNFL thickness in bipolar disorder patients and major depression patients, with a view to providing a new diagnostic strategy.

Methods: Eighty-two bipolar disorder patients, 35 major depression patients and 274 people who were age and gender matched with the patients were enrolled. Read More

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TET2 Protects Against VSMC Apoptosis and Intimal Thickening in Transplant Vasculopathy.

Circulation 2021 Jun 11. Epub 2021 Jun 11.

Department of Medicine (Cardiovascular Medicine), Yale University School of Medicine, New Haven, CT.

Coronary allograft vasculopathy (CAV) is a devastating sequelae of heart transplant in which arterial intimal thickening limits coronary blood flow. There are currently no targeted therapies to prevent or reduce this pathology that leads to transplant failure. Vascular smooth muscle cell (VSMC) phenotypic plasticity is critical in CAV neointima formation. Read More

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Clinical and morphologic features of posterior staphyloma edges by ultra-widefield imaging in pathologic myopia.

Retina 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan Faculty of Medicine, Imperial College London, London, United Kingdom Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate morphologic features along posterior staphyloma edges in eyes with pathologic myopia using ultra-widefield optical coherence tomography (UWF-OCT) imaging.

Methods: Highly myopic patients (refractive error < 8.0 diopters or axial length ≥ 26. Read More

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Thyme oil alleviates Ova-induced bronchial asthma through modulating Th2 cytokines, IgE, TSLP and ROS.

Biomed Pharmacother 2021 Jun 8;140:111726. Epub 2021 Jun 8.

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. Electronic address:

Bronchial asthma (BA) is a heterogeneous allergic respiratory disease with diverse inflammatory symptoms, pathology, and responses to treatment. Thyme is a natural product which is consisted of multiple phenolic compounds of therapeutic significance for treatment of cough and bronchitis. This study evaluated the efficacy of thyme oil against ovalbumin (OVA)-induced BA in an experimental rabbit model. Read More

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Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage.

Bone 2021 Jun 7:116035. Epub 2021 Jun 7.

Division of Pediatric Endocrinology and Center for Molecular Medicine, L8:01, Department of Women's and Children's Health, Karolinska Institutet and University Hospital, Stockholm, Sweden; School of Medical Sciences, Örebro University and University Hospital, Örebro, Sweden. Electronic address:

Objective: Perichondrium autotransplants have been used to reconstruct articular surfaces destroyed by infection or trauma. However, the role of the transplanted perichondrium in the healing of resurfaced joints have not been investigated.

Design: Perichondrial and periosteal tissues were harvested from rats hemizygous for a ubiquitously expressed enhanced green fluorescent protein (EGFP) transgene and transplanted into full-thickness articular cartilage defects at the trochlear groove of distal femur in wild-type littermates. Read More

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Optical coherence tomography quantifying photo aging: skin microvasculature depth, epidermal thickness and UV exposure.

Arch Dermatol Res 2021 Jun 10. Epub 2021 Jun 10.

Department of Dermatology, Health Sciences Faculty, Zealand University Hospital, University of Copenhagen, Sygehusvej 10, 4000, Roskilde, Denmark.

Introduction: Photo aging predominantly occurs in the face, neck and hands due to UVA and UVB irradiation. It is associated with skin cancer and histological studies indicate thinning of the epidermis and elastosis occurs. Dynamic Optical coherence tomography (D-OCT) is a non-invasive imaging tool able to visualize the epidermis and upper dermis and its blood vessels as well as to evaluate epidermal thickness (ET) and blood flow. Read More

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Optic Neuritis-Independent Retinal Atrophy in Neuromyelitis Optica Spectrum Disorder.

J Neuroophthalmol 2021 May 17. Epub 2021 May 17.

Department of Neurology (AGF, ESV, KCF, GK, JL, MAM, EMM, SS, PAC, ESS), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Electrical and Computer Engineering (YH, YL, JLP), Johns Hopkins University, Baltimore, Maryland; Viela Bio (MAM), Gaithersburg, Maryland; and Department of Neurology (ML), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Background: A limited number of studies have investigated the presence of ongoing disease activity independent of clinical relapses in neuromyelitis optica spectrum disorder (NMOSD), and data are conflicting. The objective of our study was to examine whether patients with aquaporin-4 (AQP4)-IgG seropositive NMOSD exhibit progressive retinal neuroaxonal loss, independently of optic neuritis (ON) attacks.

Methods: In this single-center, longitudinal study, 32 AQP4-IgG+ NMOSD patients and 48 healthy controls (HC) were followed with serial spectral-domain optical coherence tomography and visual acuity (VA) assessments. Read More

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Retinal imaging in Alzheimer's disease.

J Neurol Neurosurg Psychiatry 2021 Jun 9. Epub 2021 Jun 9.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Identifying biomarkers of Alzheimer's disease (AD) will accelerate the understanding of its pathophysiology, facilitate screening and risk stratification, and aid in developing new therapies. Developments in non-invasive retinal imaging technologies, including optical coherence tomography (OCT), OCT angiography and digital retinal photography, have provided a means to study neuronal and vascular structures in the retina in people with AD. Both qualitative and quantitative measurements from these retinal imaging technologies (eg, thinning of peripapillary retinal nerve fibre layer, inner retinal layer, and choroidal layer, reduced capillary density, abnormal vasodilatory response) have been shown to be associated with cognitive function impairment and risk of AD. Read More

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Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos.

Aquat Toxicol 2021 May 19;237:105870. Epub 2021 May 19.

Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, Jiangxi, China. Electronic address:

Pyridaben is a widely used acaricide in agriculture and reaches a high concentration (97 μg/L) in paddy water for a short time when pyridaben was applied to rice. However, its toxicity to aquatic organisms is still poorly understood. Therefore, we assessed the pyridaben cardiotoxicity to aquatic organisms using the zebrafish (Danio rerio) model. Read More

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Spinocerebellar Ataxia Type 1: One-Year Longitudinal Study to Identify Clinical and MRI Measures of Disease Progression in Patients and Presymptomatic Carriers.

Cerebellum 2021 Jun 9. Epub 2021 Jun 9.

Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, 20133, Milan, Italy.

Spinocerebellar ataxias type 1 (SCA1) is an autosomal dominant disease usually manifesting in adulthood. We performed a prospective 1-year longitudinal study in 14 presymptomatic mutation carriers (preSCA1), 11 ataxic patients, and 21 healthy controls. SCA1 patients had a median disease duration of 6 years (range 2-16) and SARA score of 7 points (range 3. Read More

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Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis.

Ther Adv Neurol Disord 2021 25;14:17562864211003478. Epub 2021 May 25.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, Mainz 55131, Germany.

Background: Serum neurofilament light chain (sNfL) and distinct intra-retinal layers are both promising biomarkers of neuro-axonal injury in multiple sclerosis (MS). We aimed to unravel the association of both markers in early MS, having identified that neurofilament has a distinct immunohistochemical expression pattern among intra-retinal layers.

Methods: Three-dimensional (3D) spectral domain macular optical coherence tomography scans and sNfL levels were investigated in 156 early MS patients (female/male: 109/47, mean age: 33. Read More

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Light absorption enhancement and radiation hardening for triple junction solar cell through bio-inspired nano-structures.

Bioinspir Biomim 2021 Jun 8. Epub 2021 Jun 8.

Advanced Concepts Team, ESTEC, Keplerlaan 1, Noordwijk, 2200 AG, NETHERLANDS.

Multi-junction solar cells constitute the main source of power for space applications. However, exposure of solar cells to the space radiation environment significantly degrades their performance across the mission lifetime. Here, we seek to improve the radiation hardness of triple junction solar cell, GaInP/Ga(In)As/Ge, by decreasing the thickness of the more sensitive middle junction. Read More

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Dynamic interplay of frontoparietal cholinergic innervation and cortical reorganization in the regulation of attentional capacities in aging.

Neurobiol Aging 2021 May 6;105:186-198. Epub 2021 May 6.

Department of Psychology and Neuroscience Program, Temple University, Philadelphia, PA, USA. Electronic address:

Cortical remodeling is linked to age-related cognitive changes in humans; however, the mechanisms underlying cortical reorganization in aging remain unknown. Here we examined the consequences of mild cholinergic thinning of the prefrontal cortex (PFC) and parietal cortex (PC) on attention performance-associated changes in cortical activity in young and aged rats. Prefrontal manipulation produced attentional deficits in aged but not young rats regardless of cholinergic pruning. Read More

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An Inverse Thermogelling Bioink Based on an ABA-Type Poly(2-oxazoline) Amphiphile.

Biomacromolecules 2021 Jun 8. Epub 2021 Jun 8.

Functional Polymer Materials, Chair for Advanced Materials Synthesis, Institute for Functional Materials and Biofabrication, Department of Chemistry and Pharmacy, Julius-Maximilians-University Würzburg, Röntgenring 11, Würzburg 97070, Germany.

Hydrogels are key components in several biomedical research areas such as drug delivery, tissue engineering, and biofabrication. Here, a novel ABA-type triblock copolymer comprising poly(2-methyl-2-oxazoline) as the hydrophilic A blocks and poly(2-phenethyl-2-oxazoline) as the aromatic and hydrophobic B block is introduced. Above the critical micelle concentration, the polymer self-assembles into small spherical polymer micelles with a hydrodynamic radius of approx 8-8. Read More

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Droplet detachment and pinch-off of bidisperse particulate suspensions.

Soft Matter 2021 Jun 8. Epub 2021 Jun 8.

Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, USA.

When a droplet is generated, the ligament connecting the drop to the nozzle thins down and eventually pinches off. Adding solid particles to the liquid phase leads to a more complex dynamic, notably by increasing the shear viscosity. Moreover, it introduces an additional length scale to the system, the diameter of the particles, which eventually becomes comparable to the diameter of the ligament. Read More

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[Research advances of morphological changes of the choroid in high myopia].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):459-464

Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing 100191, China.

Choroidal thinning is an important feature of high myopia and has a negative correlation with the degree of myopia. However, due to the limitations of choroidal imaging, specific changes in choroidal thickness and vasculature are unclear. In recent years, the development of optical coherence tomography technology and optical coherence tomography angiography technology has made it possible to solve the problem. Read More

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[Deep learning based lesion detection from anterior segment optical coherence tomography images and its application in the diagnosis of keratoconus].

Zhonghua Yan Ke Za Zhi 2021 Jun;57(6):447-453

Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To developed an image analysis system of anterior segment optical coherence tomography (AS-OCT) examination results based on deep learning technology, and to evaluate its effect in identifying various types of corneal pathologies and quantified indices. A total of 4 026 patients (5 617 eyes), including 1 977 males and 2 049 females, aged (45±23) years, were enrolled in Qingdao Eye Hospital from January 2011 to August 2019. The AS-OCT images were used as a training dataset, which were labeled with location information of 16 corneal pathologies (including corneal epithelial defect, corneal epithelial thickening, corneal thinning and so on) by clinical experts, as well as the tissue stratification of the corneal epithelium and stroma. Read More

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In vivo evaluation of outer retinal function and structure after retrobulbar optic nerve crush by lateral orbitotomy in goats.

Exp Eye Res 2021 Jun 4:108652. Epub 2021 Jun 4.

The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China. Electronic address:

Large animal model of optic nerve crush (ONC) plays an important role in translating novel therapeutic strategies developed in rodent model to clinical application. Due to the poor accessibility of the optic nerve (ON) in humans and large animals, lateral orbitotomy is needed to expose the retrobulbar ON. This study was to explore the effects of ONC and ON exposure with lateral orbitotomy (sham surgery) on the outer retinal function and structure in goats by using standard flash electroretinogram (FERG) and spectral-domain optical coherence tomography (SD-OCT). Read More

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Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices: Comparison of GCIPL change between OCT devices.

Am J Ophthalmol 2021 Jun 4. Epub 2021 Jun 4.

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address:

Purpose: Compare rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from two OCT devices in a cohort of glaucoma eyes.

Methods: Design: Longitudinal cohort study.

Setting: Tertiary glaucoma clinic. Read More

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Renal Osteodystrophy due to Secondary Hyperparathyroidism in a Cat.

J Am Anim Hosp Assoc 2021 Jun 7. Epub 2021 Jun 7.

A 6 yr old neutered male mixed-breed cat presented for renal transplantation (RTx) for chronic kidney disease. Severe periodontal disease was identified, and before initiation of immunosuppressive therapy, a comprehensive oral health assessment and treatment procedure was performed to reduce the burden of existing oral infection. Dental radiography revealed diffuse, severe bone demineralization across the mandible and maxilla, with thinning of the cortices. Read More

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Reconceptualizing the permanence of alexandrite laser hair removal results: a long-term follow-up study.

J Cosmet Laser Ther 2021 Jun 5:1-4. Epub 2021 Jun 5.

Department of Dermatology, University of Health Sciences Turkey, Ankara Diskapi Education and Research Hospital, Ankara, Turkey.

: The permanence of Alexandrite laser hair removal (LHR) has been of great interest. However, studies on long-term outcome are lacking.To evaluate the hair reduction rates (HRRs) and laser parameters of patients who no longer need epilation after LHR, and redefine permanence. Read More

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Molecular Dynamics Simulations of Human Beta-Defensin Type 3 Crossing Different Lipid Bilayers.

ACS Omega 2021 Jun 18;6(21):13926-13939. Epub 2021 May 18.

Chemical Engineering department, Tennessee Technological University, 1 William L Jones Dr, Cookeville, Tennessee 38505, United States.

Human β defensin type 3 (hBD-3) is a small cationic cysteine-rich peptide. It has a broad spectrum of antimicrobial activities. However, at high concentrations, it also shows hemolytic activity by interrupting red blood cells. Read More

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Knock-Out of Tenascin-C Ameliorates Ischemia-Induced Rod-Photoreceptor Degeneration and Retinal Dysfunction.

Front Neurosci 2021 20;15:642176. Epub 2021 May 20.

Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr-University Bochum, Bochum, Germany.

Retinal ischemia is a common pathomechanism in various eye diseases. Recently, evidence accumulated suggesting that the extracellular matrix (ECM) glycoprotein tenascin-C (Tnc) plays a key role in ischemic degeneration. However, the possible functional role of Tnc in retinal ischemia is not yet known. Read More

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