Int J Pharm 2021 Jun 8:120791. Epub 2021 Jun 8.
Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06084, USA; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06084, USA. Electronic address:
This paper reports a custom-built binder jet 3D printer for pilot-scale manufacturing of pharmaceutical tablets. The printer is equipped with high-throughput piezoelectric inkjet print heads and allows direct control of several key process parameters, including the build layer thickness, amount of jetted liquid binder, and powder spreading rate. The effects of these parameters on the properties of the as-printed tablets were studied using a powder mixture of lactose monohydrate and Kollidon® VA64 (KL) and an aqueous binder containing 5% of KL. Read More