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Novel Indices of Home Blood Pressure Variability and Hypertension-Mediated Organ Damage in Treated Hypertensive Patients.

High Blood Press Cardiovasc Prev 2021 Apr 21. Epub 2021 Apr 21.

Hypertension Section, Internal Medicine Department, Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Perón 4190, C1199ABB, Buenos Aires, Argentina.

Introduction: Although multiple home blood pressure variability (HBPV) indices have been proposed, the superiority of one over another is not clear in treated hypertensives.

Aim: We evaluated the correlation between different indices of HBPV and hypertension-mediated organ damage (HMOD) in this population and determined predictors of greater HBPV.

Methods: We included adult treated hypertensives who performed an HBP monitoring (duplicate sitting BP readings in the morning, afternoon, and evening for 4 days, Omron HEM-705CP-II), laboratory measurements, transthoracic echocardiogram and carotid-femoral pulse wave velocity. Read More

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Effect of Isolated Obesity on Left Ventricular Function and Structure: A Single-Center Experience.

Cureus 2021 Mar 19;13(3):e13988. Epub 2021 Mar 19.

Cardiac Surgery, King Faisal Cardiac Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Science, Jeddah, SAU.

Background and objectives Obesity can increase cardiac mass and affect cardiac performance independently from other risk factors. Several studies have identified an association in patients who already have comorbidities, however, few studies focused on obesity as an isolated risk factor. This study aimed to assess the associations between isolated obesity and heart morphological and functional characteristics. Read More

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Vitamin D Levels and Visual System Measurements in Progressive Multiple Sclerosis: A Cross-sectional Study.

Int J MS Care 2021 Mar-Apr;23(2):53-58. Epub 2020 Apr 28.

Background: Vitamin D deficiency is associated with increased disease activity in multiple sclerosis (MS), but its role in progressive MS has not been elucidated. The objective was to determine the correlation between vitamin D levels and visual parameters in primary progressive MS (PPMS) and secondary progressive MS (SPMS).

Methods: Serum 25-hydroxyvitamin D (25[OH]D) and 25-hydroxyvitamin D (25[OH]D) levels were obtained from the Secondary and Primary Progressive Ibudilast NeuroNEXT Trial in MS (SPRINT-MS). Read More

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Comparison of Macular Thickness Measurements Using Swept-Source and Spectral-Domain Optical Coherence Tomography in Healthy and Diabetic Subjects.

Curr Eye Res 2021 Apr 20:1-7. Epub 2021 Apr 20.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.

: To establish normative data for macular thickness in Chinese aged 30 to 80 years using the swept-source optical coherence tomography (SS-OCT) device.: The study included 290 normal eyes, 430 NDR eyes and 150 DR eyes of community residents aged 30 to 80 years in Guangzhou, China. Mean macular thicknesses in Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, central point thicknesses (CPT), and macular volume was measured by SS-OCT (Triton DRI OCT, Topcon, Tokyo, Japan) and Spectral-Domain OCT (SD-OCT; Heidelberg Engineering, Heidelberg, Germany). Read More

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Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels.

Bone 2021 Apr 17:115963. Epub 2021 Apr 17.

Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Medicine - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Biomedical Engineering, Indiana University Purdue University of Indianapolis, Indianapolis, IN, United States; Roudebush Veterans Administration Medical Center, Indianapolis, IN, United States. Electronic address:

Chronic kidney disease (CKD) leads to loss of cortical bone through cortical thinning and the development of cortical porosity. The goal of this current study was to assess cortical bone alterations to adenine-induced chronic kidney disease (CKD) in two strains of mice with known genetic differences in cortical thickness. We hypothesized that C3H mice with thicker cortices and baseline levels of intracortical remodeling would have greater cortical porosity in response to adenine-induced CKD compared to B6 animals. Read More

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Health-related quality of life in children at the diagnosis of Vernal Keratoconjunctivitis.

Pediatr Allergy Immunol 2021 Apr 20. Epub 2021 Apr 20.

Translational Specialized Pediatrics Research Area, Allergic Diseases Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Background: Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, allergic condition mostly affecting children. Clinical evaluations may not necessarily reflect the impact of the disease on the patients' health-related quality of life (HRQoL). We aimed to evaluate HRQoL in children at VKC diagnosis and to analyze correlations between HRQoL and clinical and laboratory variables. Read More

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Correlation between intraocular pressure obtained with water drinking test versus modified diurnal tension curve measurement in pseudoexfoliation glaucoma.

Int Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Malatya State Hospital, Malatya, Turkey.

Purpose: The aim of this paper was to study the correlation and agreement between the intraocular pressure (IOP) peak value and fluctuations detected with the modified diurnal tension curve (mDTC) and the water drinking test (WDT) in pseudoexfoliation glaucoma (XFG) patients.

Methods: This prospective observational study enrolled 42 eyes of 42 XFG patients. The IOPs were measured at 2-h intervals from 8 am to 4 pm with a Goldmann applanation tonometer by a single observer to establish the mDTC. Read More

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Automated measurement of iris surface smoothness using anterior segment optical coherence tomography.

Sci Rep 2021 Apr 19;11(1):8505. Epub 2021 Apr 19.

Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences and Research Center for Science and Technology in Medicine, Tehran, Iran.

Fuchs uveitis (FU) is a chronic and often unilateral ocular inflammation and characteristic iris atrophic changes, other than heterochromia, are common in FU and are key to the correct diagnosis in many cases. With the advent of anterior segment optical coherence tomography (AS-OCT), some investigators attempted to quantitatively study these atrophic changes; mostly by introducing various methods to measure iris thickness in AS-OCT images. We aimed to present an automated method in an observational case series to measure the smoothness index (SI) of the iris surface in AS-OCT images. Read More

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[Effects of hand continuous passive motion system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-8. Epub 2021 Mar 24.

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To observe the effects of continuous passive motion (CPM) system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand. A retrospective cohort study was conducted in 43 patients who met the inclusion criteria and were admitted to the First Affiliated Hospital of Air Force Medical University from June 2017 to December 2019 with scar contracture after partial-thickness to full-thickness burn on the back of the hand. According to the treatment methods applied, 13 patients were enrolled into pressure glove alone group (9 males and 4 females, aged (31±6) years), 14 patients were enrolled into pressure glove+functional training group (11 males and 3 females, aged (30±5) years), and 16 patients were enrolled into pressure glove+functional training+CPM system group (10 males and 6 females, aged (29±5) years). Read More

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[Clinical effects of retrograde anterolateral thigh perforator flaps assisted with CT angiography in repairing skin and soft tissue defects around the knee or in proximal lower leg].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-7. Epub 2021 Mar 24.

Department of orthopedics, Jizhong Energy Xingtai Mig General Hospital, Xingtai 054000, China.

To investigate the clinical effects of retrograde anterolateral thigh perferator flaps assisted with CT angiography (CTA) in repairing skin and soft tissue defects around the knee or in proxiamal lower leg. A retrospective cohort study was conducted. From May 2015 to October 2019, 17 patients with skin and soft tissue defects around the knee or in proximal lower leg were admitted to Department of orthopedics of Jizhong Energy Xingtai Mig General Hospital, including 12 males and 5 females, aged 16-65 years, with an average age of 35 years. Read More

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[Effect analysis of early application of sequential laser treatment on hypertrophic scar of burn children].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-6. Epub 2021 Mar 24.

Department of Burn Surgery, the First Hospital of Jilin University, Changchun 130061, China.

To explore the effects of early application of sequential treatment of intensive pulsed light and carbon dioxide laser on burn children. The retrospective cohort before-after study in the same patient was conducted. From January 2016 to December 2018, 145 burn children with hypertrophic scar in the early stage and met the inclusion criteria were admitted to the First Hospital of Jilin University. Read More

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Impaired bone microarchitecture in premenopausal women with acromegaly: the possible role of Wnt signaling.

J Clin Endocrinol Metab 2021 Apr 19. Epub 2021 Apr 19.

Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.

Context: Acromegaly can impair bone integrity, increasing the risk of vertebral fractures (VF).

Objective: To evaluate the impact of isolated GH/IGF-I hypersecretion on bone turnover markers,Wnt inhibitors, BMD, microarchitecture, bone strength and vertebral fractures in female patients with acromegaly (Acro), compared to healthy control group (HC).

Design, Setting, And Patients: Cross-sectional study including 83 premenopausal women without any pituitary deficiency:18 acromegaly in remission (AcroR), 12 in group with active acromegaly (AcroA) and 53 HC. Read More

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Different progression pattern between acral and nonacral melanoma: A retrospective, comparative, clinicoprognostic study of 492 cases of primary cutaneous melanoma according to tumor site.

Indian J Dermatol Venereol Leprol 2021 Mar 9:1-12. Epub 2021 Mar 9.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: There are limited data regarding the difference in progression pattern between acral melanoma and nonacral melanoma.

Aims: The objectives of this study were to compare the progression pattern between acral and nonacral melanoma and evaluate its impact on clinical outcomes.

Methods: Clinical and histopathological features, survival outcomes and prognostic factors of 492 patients with acral melanoma or nonacral melanoma were retrospectively evaluated using the Asan Medical Center database. Read More

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Study of melanocyte density and epidermal thickness in vulvar lichen sclerosus lesions.

Int J Dermatol 2021 Apr 18. Epub 2021 Apr 18.

Department of Dermatology, Beijing Hospital, National Center of Gerontology, Beijing, China.

Objective: This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).

Methods: Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell-layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software. Read More

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Cortical Volume, Thickness, and Surface Area in the Motoric Cognitive Risk Syndrome.

J Alzheimers Dis 2021 Apr 13. Epub 2021 Apr 13.

Departments of Medicine Albert Einstein College of Medicine, Bronx, NY, USA.

Background: The motoric cognitive risk (MCR) syndrome is a pre-clinical stage of dementia characterized by slow gait and cognitive complaint. Yet, the brain substrates of MCR are not well established.

Objective: To examine cortical thickness, volume, and surface area associated with MCR in the MCR-Neuroimaging Consortium, which harmonizes image processing/analysis of multiple cohorts. Read More

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Hemodynamic and structural brain measures in high and low sedentary older adults.

J Cereb Blood Flow Metab 2021 Apr 17:271678X211009382. Epub 2021 Apr 17.

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.

Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential structural brain abnormalities associated with cognitive decline. We therefore assessed the association between sedentary behaviour and brain measures of cerebrovascular perfusion and structural abnormalities in community-dwelling older adults. Read More

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Determinants of cardiac structure in frail and sarcopenic elderly adults.

Exp Gerontol 2021 Apr 14;150:111351. Epub 2021 Apr 14.

Department of Medicine and Surgery, University Medical School of Parma, Parma, Italy; University-Hospital of Parma, Parma, Italy; Geriatric Clinic Unit, University-Hospital of Parma, Parma, Italy.

Background: Cardiac structure and function change with age. The higher prevalence of left ventricular hypertrophy (LVH) with concentric remodeling is indicative of a typical geometric pattern of aging associated with a higher cardiovascular (CV) risk and diseases. The recent associations found between low left ventricular and skeletal mass in older patients with frailty and sarcopenia have raised great interest in investigating cardiac characteristics and determinants of left ventricular mass (LVM) in this population. Read More

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Sow-related factors affecting the postweaning feed intake in Landrace × Large White females.

Trop Anim Health Prod 2021 Apr 15;53(2):261. Epub 2021 Apr 15.

Departmento de Medicina Animal, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 91540-000, Brazil.

During the weaning-to-estrus interval (WEI), a high feeding level is usually offered to recover losses due to lactational catabolism. However, several factors can affect the appetite, possibly impairing the efficacy of this strategy. This study aimed to investigate the effect of sow-related factors on average daily feed intake (ADFI) during WEI in 142 primiparous and 458 multiparous sows. Read More

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Peaks ofcircumpapillary retinal nerve fibre layer and associations in healthy eyes: the Beijing Eye Study 2011.

Br J Ophthalmol 2021 Apr 15. Epub 2021 Apr 15.

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.

Aims: To investigate the distribution and associations of the circumpapillary retinal nerve fibre layer thickness (RNFLT) profile, characterised as peak height and peak position, in healthy eyes.

Methods: 667 healthy participants (294 male) were randomly selected from the Beijing Eye Study 2011. RNFLT was measured at 768 points at 3. Read More

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Reduced antioxidant capacity in children with iron deficiency and iron-deficiency anemia.

Minerva Pediatr (Torino) 2021 Apr 15. Epub 2021 Apr 15.

Division of Pediatric Hematology, Department of Pediatrics, İstinye University, İstanbul, Turkey.

Objective: This study aimed to assess the relationship between antioxidant enzymes such as glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), and paraoxonase (PON1) and carotid intima-media thickness (CIMT) and investigate susceptibility to atherosclerosis with decreasing antioxidant capacity in adolescent patients with iron deficiency (ID) and irondeficiency anemia (IDA).

Material And Methods: Twenty-five patients with IDA (14.9±1. Read More

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Autologous fat grafting combined with negative pressure wound therapy in severe diabetic foot ulcer: a case study.

J Wound Care 2021 Apr;30(Sup4):S38-S40

Department of Burns and Plastic Surgery, Tangshan Gongren Hospital, China.

Objective: Hard-to-heal wounds are a surgical challenge, and diabetic foot ulcers (DFUs) are one of the most common and severe varieties. Previous studies have shown that autologous fat grafting (AFG) and negative pressure wound therapy (NPWT) have the potential to promote wound healing. This case study describes how these two methods together helped in the healing of a serious DFU. Read More

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A pilot study comparing daily teriparatide with monthly cycles of teriparatide and raloxifene.

Arch Osteoporos 2021 04 15;16(1):70. Epub 2021 Apr 15.

Osteoporosis Clinical Research Program, University of Wisconsin-Madison, 2870 University Ave, Suite 100, Madison, WI, 53705, USA.

This 6-month pilot study in osteoporotic postmenopausal women evaluated cyclic TPD/RLX compared to daily subcutaneous TPD with the concept of optimizing bone formation. Compared to daily subcutaneous TPD, cyclic therapy showed comparable increase in spine BMD and favorable effects on total proximal femur BMD and cortical thickness.

Purpose: There is no cure for osteoporosis; better medications or different approaches with current agents are needed. Read More

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Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.

Mult Scler 2021 Apr 15:13524585211003479. Epub 2021 Apr 15.

Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany/ NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany/Einstein Center for Neurosciences, Berlin, Germany/Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Background: Cross-sectional studies suggest normal appearing white matter (NAWM) integrity loss may lead to cortical atrophy in late-stage relapsing-remitting multiple sclerosis (MS).

Objective: To investigate the relationship between NAWM integrity and cortical thickness from first clinical presentation longitudinally.

Methods: NAWM integrity and cortical thickness were assessed with 3T magnetic resonance imaging (MRI) in 102 patients with clinically isolated syndrome or early MS (33. Read More

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Biomechanical trade-offs in the pelvic floor constrain the evolution of the human birth canal.

Proc Natl Acad Sci U S A 2021 Apr;118(16)

Department of Evolutionary Biology, University of Vienna, 1090 Vienna, Austria;

Compared with most other primates, humans are characterized by a tight fit between the maternal birth canal and the fetal head, leading to a relatively high risk of neonatal and maternal mortality and morbidities. Obstetric selection is thought to favor a spacious birth canal, whereas the source for opposing selection is frequently assumed to relate to bipedal locomotion. Another, yet underinvestigated, hypothesis is that a more expansive birth canal suspends the soft tissue of the pelvic floor across a larger area, which is disadvantageous for continence and support of the weight of the inner organs and fetus. Read More

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Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand.

BMC Public Health 2021 Apr 14;21(1):724. Epub 2021 Apr 14.

NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.

Background: Rates of overweight and obesity among women of reproductive age have been steadily increasing worldwide and in Thailand. There is mounting evidence that maternal obesity during pregnancy is associated with an increased risk of obesity and other adverse health outcomes in the offspring, but such data are lacking for Thailand. We examined the associations between maternal body mass index (BMI) and anthropometry (particularly the likelihood of obesity) and cardiometabolic parameters in young adult offspring. Read More

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Ultrasound criteria for lipedema diagnosis.

Phlebology 2021 Apr 15:2683555211002340. Epub 2021 Apr 15.

Department of Vascular Surgery, Medical Valens Center, Campinas, Brazil.

Background: Lipedema is characterized by the deposition of abnormal fat in the lower and upper limbs bilaterally. It is a disease with high prevalence and genetic characteristics. Non-specific and non-quantified increases in the thickness of the subcutaneous tissue have previously been demonstrated using magnetic resonance imaging and computed tomography. Read More

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Pregnancy outcomes following different protocols of controlled ovarian hyperstimulation in couples undergoing intrauterine insemination.

Clin Exp Pharmacol Physiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, College of Medicine, Hawler Medical University, Erbil, 44001, Kurdistan, Iraq.

Clomiphene citrate (CC), letrozole, and cetrorelix acetate are frequently used agents in controlled ovarian hyperstimulation (COH). However, these three agents have not yet been compared to one another regarding their pregnancy outcomes. The present study was designed to retrospectively compare pregnancy outcomes among the three aforementioned agents. Read More

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Assessment of the orbital structures using computed tomography in healthy adults.

Niger J Clin Pract 2021 Apr;24(4):561-568

Department of Ophthalmology, Buyukcekmece State Hospital, Istanbul, Turkey.

Objectives: In this study, we retrospectively evaluated the orbital and ocular dimensions using computed tomography (CT) scans in healthy adults.

Materials And Methods: This retrospective study included 302 Turkish adult individuals aged 20-76 years (158 males and 144 females), who underwent paranasal sinus or craniofacial CT due to headache or suspicion of sinusitis, but abnormal orbital or cranial CT findings were not detected. Linear and volumetric measurements of the orbital structures were performed in the sagittal, coronal, and axial planes on CT slices. Read More

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Determination of the thickness of the safe enamel for laminate veneer preparation and orthodontic stripping by CBCT.

Niger J Clin Pract 2021 Apr;24(4):525-533

Department of Orthodontics, Faculty of Dentistry, Medipol University, İstanbul, Turkey.

Aim: The purpose of this study is to determine the thickness and limitation of the safe enamel for laminate veneers and orthodontic stripping applications. Enamel thickness (ET) was determined in detail for each tooth and also it was examined whether there was a relationship between the mesiodistal crown width of the teeth and the thickness of the enamel and whether there was a sexual dimorphism.

Subjects And Methods: CBCT records of 101 subjects (mean age: 20. Read More

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[Timing of HMG supplementation and clinical outcomes of advanced-age patients with diminished ovarian reserve receiving gonadotropin-releasing hormone antagonist protocol].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):412-417

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To assess the effect and timing of human menopausal gonadotropin (HMG) supplementation in advancedage patients with diminished ovarian reserve (DOR) receiving gonadotropin-releasing hormone antagonist protocol.

Objective: A total of 682 patients with DOR aged over 35 years undergoing IVF-ET treatment were included in this study. All the patients underwent a GnRH antagonist protocol, and controlled ovarian stimulation was initiated on day 2-3 of the menstrual cycle with follicle stimulation hormone (FSH). Read More

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