318 results match your criteria thickening arteriolar

High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation.

J Am Heart Assoc 2021 Jul 14;10(14):e016543. Epub 2021 Jul 14.

Department of Internal Medicine and Rehabilitation Science Tohoku University Graduate School of Medicine Sendai Japan.

Background High-fructose diet (HFr) induces hypertension and renal damage. However, it has been unknown whether the HFr-induced hypertension and renal damage are exaggerated in subjects with salt sensitivity. We tested impacts of HFr in Dahl salt-sensitive (DS) and salt-resistant (DR) rats. Read More

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Severity of arterial and/or arteriolar sclerosis in IgA nephropathy and the effects of renin-angiotensin system inhibitors on its prognosis.

J Pathol Clin Res 2021 Jun 29. Epub 2021 Jun 29.

Department of Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

IgA nephropathy (IgAN) patients often suffer from arterial and/or arteriolar sclerosis (AAS); however, it is unclear whether these features are associated with a poor prognosis. This retrospective cohort study aimed to analyse the prognosis of IgAN patients with AAS and assess whether treatment with renin-angiotensin system inhibitors (RASI) improved their survival. The study included 678 IgAN patients, who were grouped into AAS0 (n = 340; AAS absent) and AAS1 (n = 338; AAS present) groups. Read More

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De novo donor-specific HLA antibodies reduce graft survival rates and increase the risk of kidney transplant rejection: A single-center retrospective study.

Transpl Immunol 2021 Jun 18;68:101430. Epub 2021 Jun 18.

Department of Blood Transfusion, Tianjin First Central Hospital, Tianjin, China. Electronic address:

Background: We investigated the impact of de novo donor-specific anti-human leukocyte antigen antibodies (dnDSAs) on long-term death-censored graft survival and renal allograft rejection in kidney transplant recipients.

Methods: The sample for this retrospective cohort study comprised 121 recipients of kidney transplants with negative complement-dependent cytotoxicity crossmatches to their deceased donors. Recipients were divided into two groups: dnDSAs+ (n = 31) and dnDSAs- (n = 90). Read More

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Correlation of Chronic Histologic Changes on Preimplantation Frozen Section Biopsy With Transplant Outcomes After Deceased Donor Kidney Transplantation.

Arch Pathol Lab Med 2021 Jun 4. Epub 2021 Jun 4.

From the Department of Medicine (Ninan, Nair, Heilman), Mayo Clinic Arizona Phoenix, Arizona.

Context.—: It is unclear if preimplantation frozen section biopsy correlates with outcomes after deceased donor kidney transplantation.

Objective. Read More

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Near-Infrared Reflectance Imaging to Detect an Incipient Retinal Arterial Macroaneurysm.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):150-153. Epub 2021 Apr 12.

Retina Division, Centro Oftalmológico Dr. Charles, Ciudad Autónoma de Buenos Aires, Argentina.

Retinal arterial macroaneurysms (RAM) are characterized by a saccular or fusiform dilation of the retinal artery wall. An 84-year-old Caucasian woman with a medical history of poorly controlled hypertension was diagnosed with RAM in the left eye. Previous macular spectral-domain optical coherence tomography images from the patient were available for comparison. Read More

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Structural changes in renal arterioles are closely associated with central hemodynamic parameters in patients with renal disease.

Hypertens Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Nephrology, Tokyo Medical University, Tokyo, Japan.

Although central hemodynamics are known to be closely associated with microvascular damage, their association with lesions in the small renal arteries has not yet been fully clarified. We focused on arterioles in renal biopsy specimens and analyzed whether their structural changes were associated with noninvasive vascular function parameters, including central blood pressure (BP) and brachial-ankle pulse wave velocity (baPWV). Forty-four nondiabetic patients (18-50 years of age) with preserved renal function underwent renal biopsy. Read More

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The relationship between neutrophil-lymphocyte ratio and early renal fibrosis and renal prognosis in patients with lupus nephritis.

Am J Transl Res 2021 15;13(3):1710-1716. Epub 2021 Mar 15.

Department of Nephrology, China-Japan Friendship Hospital Beijing 100029, China.

Objective: To explore the relationship between neutrophil-lymphocyte ratio (NLR) and early renal fibrosis and renal prognosis in patients with lupus nephritis.

Methods: A total of 186 patients with lupus nephritis admitted to our hospital were enrolled and grouped according to the standard of "NLR=3.175". Read More

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Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension.

Am J Physiol Regul Integr Comp Physiol 2021 06 7;320(6):R835-R850. Epub 2021 Apr 7.

Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Pulmonary hypertension (PH) is a serious disease with pulmonary arterial fibrotic remodeling and limited responsiveness to vasodilators. Our data suggest that mild acidosis induced by carbonic anhydrase inhibition could ameliorate PH, but the vascular mechanisms are unclear. We tested the hypothesis that carbonic anhydrase inhibition ameliorates PH by improving pulmonary vascular reactivity and relaxation mechanisms. Read More

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Age-Related Arteriolar Changes With Lipid and Amyloid Deposits in the Gonads of Dogs.

Vet Pathol 2021 May 9;58(3):558-567. Epub 2021 Mar 9.

13143The University of Tokyo, Tokyo, Japan.

Arteriolar lesions with lipid and/or amyloid deposits are frequently detected in canine gonads by routine histopathologic examination; however, they have never been examined in detail. In the present study, a total of 139 testes/epididymides and 200 ovaries from 72 male (4 months to 14 years old) and 105 female (7 months to 16 years old) dogs were examined for arteriolar lesions. Arteriolar lesions were detected in 21 of 72 male dogs (29%) and 54 of 105 female dogs (51%). Read More

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Chronic kidney disease caused by maternally inherited diabetes and deafness: a case report.

CEN Case Rep 2021 May 30;10(2):220-225. Epub 2020 Oct 30.

Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.

Maternally inherited diabetes and deafness (MIDD) is a mitochondrial genetic disorder with variable clinical presentations, which can delay its diagnosis. Herein, we report the case of a 57-year-old Japanese man with MIDD who developed chronic kidney disease. He developed proteinuria long before his diabetes and deafness; at the age of 36 years, a renal biopsy showed minor glomerular abnormality and electron microscopy showed mild mitochondrial degeneration in the distal tubular epithelial cells. Read More

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Brain arteriolosclerosis.

Acta Neuropathol 2021 01 24;141(1):1-24. Epub 2020 Oct 24.

Sanders-Brown Center on Aging, Department of Pathology, University of Kentucky, Lexington, KY, 40536, USA.

Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Read More

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January 2021

Hypertension/prehypertension and its determinants in pediatric IgA nephropathy.

Medicine (Baltimore) 2020 Oct;99(40):e22310

Integrated Chinese and Western Medicine Treatment of Renal Disease Center, Beidaihe Rehabilitation and Recuperation Center, Chinese PLA, Qinhuangdao, China.

Immunoglobulin A nephropathy (IgAN) is a major cause of secondary hypertension (HT) of renal origin - a significant prognostic factor of IgAN. In children, similar to HT, prehypertension (pre-HT) is becoming a significant health issue. However, the role of secondary HT and pre-HT (HT/pre-HT) in the progression of pediatric IgAN remains unclear. Read More

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October 2020

Human kidney graft survival correlates with structural parameters in baseline biopsies: a quantitative observational cohort study with more than 14 years' follow-up.

Virchows Arch 2021 Apr 28;478(4):659-668. Epub 2020 Sep 28.

Electron Microscopy Laboratory, Aarhus University Hospital, 8200, Aarhus N, Denmark.

This prospective cohort study evaluates associations between structural and ultrastructural parameters in baseline biopsies from human kidney transplants and long-term graft survival after more than 14 years' follow-up. Baseline kidney graft biopsies were obtained prospectively from 54 consecutive patients receiving a kidney transplant at a single institution. Quantitative measurements were performed on the baseline biopsies by computer-assisted light microscopy and electron microscopy. Read More

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Characterization of CRB1 splicing in retinal organoids derived from a patient with adult-onset rod-cone dystrophy caused by the c.1892A>G and c.2548G>A variants.

Mol Genet Genomic Med 2020 11 15;8(11):e1489. Epub 2020 Sep 15.

Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, WA, Australia.

Background: Mutations in the human crumbs homologue 1 (CRB1) gene are associated with a spectrum of inherited retinal diseases. However, functional studies demonstrating the impact of individual CRB1 mutations on gene expression are lacking for most variants. Here, we investigated the effect of two CRB1 variants on pre-mRNA splicing using neural retinal organoids (NRO) derived from a patient with recessive rod-cone dystrophy caused by compound heterozygous mutations in CRB1 (c. Read More

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November 2020

Increased serum uric acid levels are associated to renal arteriolopathy and predict poor outcome in IgA nephropathy.

Nutr Metab Cardiovasc Dis 2020 11 30;30(12):2343-2350. Epub 2020 Jul 30.

Ospedale Policlinico San Martino and University of Genoa, Department of Internal Medicine, Genoa, Italy. Electronic address:

Background And Aims: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and a leading cause of end stage renal disease (ESRD). In addition to classical progression factors, other atherosclerosis-related factors, including hyperuricemia (HU), have been associated to the renal progression of IgAN. Increased serum uric acid (SUA) levels are well known to be concomitant of cardiovascular and kidney diseases, and have been proposed to be implicated in the development of arteriolar damage (AD). Read More

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November 2020

Renal arteriolar hyalinosis, not intimal thickening in large arteries, is associated with cardiovascular events in people with biopsy-proven diabetic nephropathy.

Diabet Med 2020 12 7;37(12):2143-2152. Epub 2020 May 7.

First Department of Internal Medicine, Nara Medical University, Nara, Japan.

Aims: Diabetic nephropathy, a pathologically diagnosed microvascular complication of diabetes, is a strong risk factor for cardiovascular events, which mainly involve arteries larger than those affected in diabetic nephropathy. However, the association between diabetic nephropathy pathological findings and cardiovascular events has not been well studied. We aimed to investigate whether the pathological findings in diabetic nephropathy are closely associated with cardiovascular event development. Read More

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December 2020

Cobalamin c deficiency associated with antifactor h antibody-associated hemolytic uremic syndrome in a young adult.

BMC Nephrol 2020 03 12;21(1):96. Epub 2020 Mar 12.

Nephrology, Dialysis and Transplantation Department, CHU Clermont Ferrand, University Clermont Auvergne, Clermont Ferrand, France.

Background: Thrombotic microangiopathy (TMA) syndromes are characterized by the association of hemolytic anemia, thrombocytopenia and organ injury due to arteriolar and capillary thrombosis.

Case Presentation: We report the first case of adult onset cobalamin C (Cbl C) disease associated with anti-factor H antibody-associated hemolytic uremic syndrome (HUS). A 19-year-old woman was admitted to the nephrology department owing to acute kidney failure, proteinuria, and hemolytic anemia with schizocytes. Read More

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Long-term adaptive versus maladaptive remodelling of the pulmonary autograft after the Ross operation.

Eur J Cardiothorac Surg 2020 05;57(5):977-985

Department of Tissue Engineering, Imperial College London and Heart Science Centre, Harefield, Middlesex, UK.

Objectives: Following the Ross operation, the pulmonary autograft undergoes structural changes (remodelling). We sought to determine the extent, nature and possible determinants of long-term remodelling in the different components of the pulmonary autograft.

Methods: Ten pulmonary autografts and 12 normal control valves (6 pulmonary and 6 aortic) were examined by conventional histology, immunocytochemistry and electron microscopy. Read More

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High-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report.

BMC Ophthalmol 2020 Feb 24;20(1):68. Epub 2020 Feb 24.

Centre for Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, 2 Verdun Street, Nedlands, WA, 6009, Australia.

Background: Congenital mydriasis and retinal arteriolar tortuosity are associated with the life-threatening multisystemic smooth muscle dysfunction syndrome (MSMDS) due to mutations in the gene, ACTA2, which encodes alpha-smooth muscle actin (α-SMA). Previous reports attributed MSMDS-related congenital mydriasis to the absence of iris sphincter muscle. Similarly, it has been hypothesized that abnormal proliferation of the vascular smooth muscle cells causes the marked tortuosity of retinal arterioles in MSMDS. Read More

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February 2020

Pulsed Field Ablation Versus Radiofrequency Ablation: Esophageal Injury in a Novel Porcine Model.

Circ Arrhythm Electrophysiol 2020 03 24;13(3):e008303. Epub 2020 Jan 24.

Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New York, NY (J.S.K., K.K., I.K., S.R.D., V.Y.R.).

Background: Pulsed field ablation (PFA) can be myocardium selective, potentially sparing the esophagus during left atrial ablation. In an in vivo porcine esophageal injury model, we compared the effects of newer biphasic PFA with radiofrequency ablation (RFA).

Methods: In 10 animals, under general anesthesia, the lower esophagus was deflected toward the inferior vena cava using an esophageal deviation balloon, and ablation was performed from within the inferior vena cava at areas of esophageal contact. Read More

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Increased rate of any retinopathy risk in patients with masked hypertension.

Clin Exp Hypertens 2020 Aug 19;42(6):479-482. Epub 2019 Dec 19.

Department of Cardiology, Istinye University , Ankara, Turkey.

Purpose: Hypertension is a common chronic disorder with end organ damage. Hypertensive retinopathy is a response to elevated blood pressure characterized retinal arteriolar intimal thickening, hyperplasia of the intima-media end with sclerosis. There is a relationship between high blood pressure and retinopathy grade. Read More

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Carbenoxolone decreases monocrotaline‑induced pulmonary inflammation and pulmonary arteriolar remodeling in rats by decreasing the expression of connexins in T lymphocytes.

Int J Mol Med 2020 Jan 13;45(1):81-92. Epub 2019 Nov 13.

Department of Physiology, Medical College of Shihezi University, Shihezi, Xinjiang 832002, P.R. China.

The adaptive immune response mediated by T lymphocytes is a well‑established factor in the pathogenesis of pulmonary inflammation. Changes in the expression of various connexins (Cxs) or disruption of connexin‑mediated cellular communication in T lymphocytes contribute to inflammation or tissue remodeling. The aim of the present study was to investigate the potential therapeutic value of blocking Cxs in a monocrotaline (MCT)‑induced pulmonary inflammation rat model. Read More

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January 2020

Renal Injury in DENV-4 Fatal Cases: Viremia, Immune Response and Cytokine Profile.

Pathogens 2019 Nov 7;8(4). Epub 2019 Nov 7.

Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz /FIOCRUZ, Rio de Janeiro-RJ 21040900, Brazil.

Dengue virus (DENV) infections may result in asymptomatic cases or evolve into a severe disease, which involves multiple organ failure. Renal involvement in dengue can be potentially related to an increased mortality. Aiming to better understand the role of DENV in renal injury observed in human fatal cases, post-mortem investigations were performed in four DENV-4 renal autopsies during dengue epidemics in Brazil. Read More

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November 2019

The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndrome.

Int J Obes (Lond) 2020 02 21;44(2):457-465. Epub 2019 Oct 21.

University of La Laguna, Santa Cruz de Tenerife, Spain.

Background: The pathogenesis of renal disease in the context of overweight/obesity, metabolic syndrome, and insulin resistance is not completely understood. This may be due to the lack of a definitive animal model of disease, which limits our understanding of obesity-induced renal damage. We evaluated the changes in renal histology and lipid deposits induced by obesity in a model of insulin resistance: the Iberian swine fed with fat-enriched food. Read More

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February 2020

Naringenin Ameliorates Renovascular Hypertensive Renal Damage by Normalizing the Balance of Renin-Angiotensin System Components in Rats.

Int J Med Sci 2019 7;16(5):644-653. Epub 2019 May 7.

Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China.

Naringenin, a member of the dihydroflavone family, has been shown to have a protective function in multiple diseases. We previously demonstrated that naringenin played a protective role in hypertensive myocardial hypertrophy by decreasing angiotensin-converting enzyme (ACE) expression. The kidney is a primary target organ of hypertension. Read More

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December 2019

Conversion to Everolimus in Kidney Transplant Recipients With Calcineurin Inhibitor-Induced Nephropathy: 3 Case Reports.

Transplant Proc 2019 Jun 3;51(5):1424-1427. Epub 2019 May 3.

Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Japan.

Background: Calcineurin inhibitors (CNIs), which remain the most important immunosuppressants in kidney transplant recipients, are a major cause of renal dysfunction due to CNI-induced nephropathy. However, a safe and effective CNI-sparing protocol is yet to be established. Herein, we report a case series of kidney transplant recipients experiencing CNI nephropathy, whose renal function is improved after conversion from CNIs to everolimus. Read More

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IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney.

BMC Nephrol 2019 04 8;20(1):124. Epub 2019 Apr 8.

Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.

Background: Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney allograft function. Read More

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Topotecan prevents hypoxia-induced pulmonary arterial hypertension and inhibits hypoxia-inducible factor-1α and TRPC channels.

Int J Biochem Cell Biol 2018 11 25;104:161-170. Epub 2018 Sep 25.

Respiratory Medicine, Hunan Provincial People's Hospital, Changsha, PR China; Institute of Respiratory Medicine, Changsha Medical College, Changsha, PR China. Electronic address:

Background: This study aimed to investigate the effects of topotecan (TPT) on the hypoxia-induced pulmonary arterial hypertension (PAH) in a rat model, and to explore the underlying mechanism.

Methods: The experiments were carried out in vitro using rat PASMCs and in vivo using a rat model of hypoxia-induced PAH.

Results: TPT significantly suppressed the hypoxia-induced upregulation of HIF-1α and TRPC1/4/6 expression both in pulmonary arterial smooth muscle cells (PASMCs) from normal rats and in pulmonary arteries from PAH model rats. Read More

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November 2018

Bilateral combined central retinal artery and vein occlusion in a 3-year-old child with nephrotic syndrome.

Indian J Ophthalmol 2018 Oct;66(10):1498-1501

Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bengaluru, Karnataka, India.

Nephrotic syndrome (NS) is a common disease of childhood but ophthalmic manifestations are seldom reported. We report a rare occurrence of bilateral combined central retinal artery and vein occlusion in a 3-year-old with NS. The child presented with bilateral painless loss of vision, central pallid retinae with cherry red spots, vascular tortuosity, and retinal hemorrhages. Read More

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October 2018

Anticentromere Antibody-positive Scleroderma Renal Crisis Requiring Dialysis.

Intern Med 2018 Dec 10;57(23):3479-3483. Epub 2018 Aug 10.

Department IV, Internal Medicine, Tokyo Women's Medical University, Japan.

A 70-year-old man with prior Raynaud's phenomena developed hypertension and renal insufficiency. Raynaud's phenomena, finger skin thickening, interstitial lung disease, and positive anticentromere antibody findings indicated systemic sclerosis (SSc). Based on the presence of SSc, severe hypertension with rapidly progressive renal failure, and proliferative and obliterative arteriolar vasculopathy, scleroderma renal crisis (SRC) was diagnosed. Read More

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December 2018