Pain 2021 Mar 26. Epub 2021 Mar 26.
aInstitute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, United States Departments of bAnesthesiology and cBiostatistics, University of North Carolina, Chapel Hill, NC, United States dForensic Nursing Program, Memorial Health System, Colorado Springs, CO, United States eDepartment of Emergency Medicine, Albert Einstein Medical Center, Philadelphia, PA, United States fJaycee Burn Center, University of North Carolina, Chapel Hill, NC, United States gForensic Nursing Program, Albuquerque SANE Collaborative, Albuquerque, NM, United States hDepartment of Emergency Medicine, Sinai Grace Hospital, Detroit, MI, United States iDepartment of Emergency Medicine, Detroit Receiving, Detroit, MI, United States jWashington Hospital Burn Center, Washington, DC, United States kDepartment of Surgery, University of South Florida, Tampa, FL, United States lDepartment of Emergency Medicine, University of North Carolina, Chapel Hill, NC, United States.
Biologic factors that predict risk for and mediate the development of common outcomes of trauma exposure such as chronic posttraumatic pain (CPTP) are poorly understood. In the current study, we examined whether peritraumatic circulating 17β-estradiol (E2) levels influence CPTP trajectories. 17β-estradiol levels were measured in plasma samples (n = 254) collected in the immediate aftermath of trauma exposure from 3 multiethnic longitudinal cohorts of men and women trauma survivors. Read More