904 results match your criteria thermal ablative

MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment.

Lasers Med Sci 2021 May 14. Epub 2021 May 14.

Department of Dermatology and Allergology, Medical Faculty RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

Ablative fractional laser treatment leads to a loss of matrix metalloproteinase-3 (MMP-3) expression; therefore, in the present in vitro study, we addressed the role of MMP-3 and its regulation by calcium pantothenate in wound healing processes at the molecular level. Utilizing confocal laser microscopy, we investigated MMP-3 protein expression in fractional ablative CO laser-irradiated skin models. In addition, we established full-thickness 3D skin models using fibroblasts and keratinocytes with a MMP-3 knockdown that were irradiated with a fractional ablative Er:YAG laser to set superficial injuries with standardized dimensions and minimal thermal damage to the surrounding tissue. Read More

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Real-Time US-CT fusion imaging for guidance of thermal ablation in of renal tumors invisible or poorly visible with US: results in 97 cases.

Int J Hyperthermia 2021 ;38(1):771-776

Division of Interventional Radiology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Purpose: To assess the capability of ultrasound-computed tomography (US-CT) fusion imaging to guide a precise targeting of renal tumors invisible or poorly visible with US.

Materials And Methods: From 2016 renal tumors poorly visible or inconspicuous/invisible at US were treated at our institution with the guidance of US/CT fusion in a room equipped with CT scanner. Feasibility of the procedure, accuracy of targeting, complications, and technique efficacy were evaluated. Read More

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January 2021

Immune Modulation Plus Tumor Ablation: Adjuvants and Antibodies to Prime and Boost Anti-Tumor Immunity .

Front Immunol 2021 14;12:617365. Epub 2021 Apr 14.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, Netherlands.

tumor ablation techniques, like radiotherapy, cryo- and heat-based thermal ablation are successfully applied in oncology for local destruction of tumor masses. Although diverse in technology and mechanism of inducing cell death, ablative techniques share one key feature: they generate tumor debris which remains . This tumor debris functions as an unbiased source of tumor antigens available to the immune system and has led to the concept of cancer vaccination. Read More

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Irreversible Electroporation for the Treatment of Small Renal Masses: 5-Year Outcomes.

J Endourol 2021 Apr 30. Epub 2021 Apr 30.

UT Southwestern, 12334, Urology, Dallas, Texas, United States;

Introduction: Irreversible electroporation (IRE) is a nonthermal ablative technology that applies high voltage, short pulse electrical current to create cellular membrane nanopores and ultimately results in apoptosis. This is thought to overcome thermal limitations of other ablative technologies. We report 5-year oncologic outcomes of percutaneous IRE for small renal masses. Read More

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The Optimal Application of Medium Potency Topical Corticosteroids in Preventing Laser-Induced Inflammatory Responses-An Animal Study.

Life (Basel) 2021 Apr 17;11(4). Epub 2021 Apr 17.

Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei 114, Taiwan.

Background: During ablative fractional resurfacing (AFR) laser therapy, thermal damage to the skin is inevitable, resulting in inflammatory responses and small wounds. Corticosteroids are known for their anti-inflammatory effect. However, inappropriate application of corticosteroids carries the risk of delayed wound healing. Read More

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Image-guided percutaneous ablation for the treatment of lung malignancies: current state of the art.

Insights Imaging 2021 Apr 29;12(1):57. Epub 2021 Apr 29.

Department of Radiology, CDI, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Image-guided percutaneous lung ablation has proven to be a valid treatment alternative in patients with early-stage non-small cell lung carcinoma or oligometastatic lung disease. Available ablative modalities include radiofrequency ablation, microwave ablation, and cryoablation. Currently, there are no sufficiently representative studies to determine significant differences between the results of these techniques. Read More

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Thrombotic complications of superficial endovenous ablation: a contemporary review of thermal and non-thermal techniques.

J Cardiovasc Surg (Torino) 2021 Apr 23. Epub 2021 Apr 23.

Division of Vascular and Endovascular Surgery, University of California San Francisco-Fresno, Fresno, CA, USA -

Endovenous ablation has become the preferred means to treat superficial venous insufficiency. Ablative technologies have evolved to include a variety of both thermal and nonthermal techniques. The reported thrombotic complications of endovenous heat induced thrombosis (EHIT) and deep venous thrombosis (DVT) associated with thermal techniques are low (<2% overall). Read More

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Magnetic Resonance-Guided Focused Ultrasound Surgery for Obsessive-Compulsive Disorders: Potential for use as a Novel Ablative Surgical Technique.

Front Psychiatry 2021 6;12:640832. Epub 2021 Apr 6.

Department of Neurosurgery & Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

Surgical treatment for psychiatric disorders, such as obsessive-compulsive disorder (OCD) and depression, using ablative techniques, such as cingulotomy and capsulotomy, have historically been controversial for a number of scientific, social, and ethical reasons. Recently, with the elucidation of anatomical and neurochemical substrates of brain function in healthy controls and patients with such disorders using various functional neuroimaging techniques, these criticisms are becoming less valid. Furthermore, by using new techniques, such as deep brain stimulation (DBS), and identifying more precise targets, beneficial effects and the lack of serious complications have been demonstrated in patients with psychiatric disorders. Read More

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Feasibility of palliating recurrent gynecological tumors with MRGHIFU: comparison of symptom, quality-of-life, and imaging response in intra and extra-pelvic disease.

Int J Hyperthermia 2021 ;38(1):623-632

Division of Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, UK.

Objective: To document longitudinal symptom, quality-of-life and imaging response in patients with recurrent gynecological tumors treated with magnetic resonance guided high intensity focused ultrasound (MRgHIFU), and compare changes in patients with intra- versus extra-pelvic lesions.

Methods: Eleven symptomatic patients with painful recurrent gynecological tumors were treated with MRgHIFU (Profound Sonalleve) in a prospective single center study (NCT02714621). Pain scores, analgesic intake and quality-of-life metrics, whole tumor volume, and perfused tumor volume from Gadolinium-enhanced T1W imaging documented before and up to 90 days after treatment were compared between patients with intra- and extra-pelvic tumors. Read More

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January 2021

Prevention of cervical cancer through two HPV-based screen-and-treat implementation models in Malawi: protocol for a cluster randomized feasibility trial.

Pilot Feasibility Stud 2021 Apr 20;7(1):98. Epub 2021 Apr 20.

Department of OB-GYN, University of North Carolina, 4002 Old Clinic Building, CB #7570, Chapel Hill, NC, 27599-7570, USA.

Background: Cervical cancer is the leading cause of cancer incidence and mortality among Malawian women, despite being a largely preventable disease. Implementing a cervical cancer screening and preventive treatment (CCSPT) program that utilizes rapid human papillomavirus (HPV) testing on self-collected cervicovaginal samples for screening and thermal ablation for treatment may achieve greater coverage than current programs that use visual inspection with acetic acid (VIA) for screening and cryotherapy for treatment. Furthermore, self-sampling creates the opportunity for community-based screening to increase uptake in populations with low screening rates. Read More

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Network Visualization and Pyramidal Feature Comparison for Ablative Treatability Classification Using Digitized Cervix Images.

J Clin Med 2021 Mar 1;10(5). Epub 2021 Mar 1.

Communications Engineering Branch, Lister Hill National Center for Biomedical Communications, U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

Uterine cervical cancer is a leading cause of women's mortality worldwide. Cervical tissue ablation is an effective surgical excision of high grade lesions that are determined to be precancerous. Our prior work on the Automated Visual Examination (AVE) method demonstrated a highly effective technique to analyze digital images of the cervix for identifying precancer. Read More

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Characteristics of Non-Ablative Resurfacing of Soft Tissues by Repetitive Er:YAG Laser Pulse Irradiation.

Lasers Surg Med 2021 Apr 1. Epub 2021 Apr 1.

Faculty of Mechanical Engineering, University of Ljubljana, Askerceva 6 SI-1000, Ljubljana, Slovenia.

Background And Objectives: Recently, several minimally invasive gynecological, ENT and esthetic procedures have been introduced that are based on delivering "smooth" sequences of Er:YAG laser pulses to cutaneous or mucosal tissue at moderate cumulative fluences that are not only below the ablation threshold but typically also do not require local anesthesia.  To explain the observed clinical results using "smooth-resurfacing," it has been suggested that in addition to the direct heat injury to deeper-lying connective tissues, there is an additional mechanism based on indirect triggering of tissue regeneration through short-exposure, intense heat shocking of epithelia. The goal of this study is to improve understanding of the complex dynamics of the exposure of tissues to a series of short Er:YAG laser pulses, during which the thermal exposure times transition from extremely short to long durations. Read More

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Bronchoscopic Thermal Vapour Ablation for Localized Cancer Lesions of the Lung: A Clinical Feasibility Treat-and-Resect Study.

Respiration 2021 17;100(5):432-442. Epub 2021 Mar 17.

Department of Respiratory and Critical Care Medicine, Karl-Landsteiner-Institute for Lung Research and Pulmonary Oncology, Klinik Floridsdorf, Vienna, Austria.

Background: Bronchoscopic thermal vapour ablation (BTVA) is an established and approved modality for minimally invasive lung volume reduction in severe emphysema. Preclinical data suggest potential for BTVA in minimally invasive ablation of lung cancer lesions.

Objectives: The objective of this study is to establish the safety, feasibility, and ablative efficacy of BTVA for minimally invasive ablation of lung cancers. Read More

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Irreversible Electroporation to Treat Unresectable Colorectal Liver Metastases (COLDFIRE-2): A Phase II, Two-Center, Single-Arm Clinical Trial.

Radiology 2021 May 16;299(2):470-480. Epub 2021 Mar 16.

From the Department of Radiology and Nuclear Medicine (M.R.M., A.H.R., L.G.P.H.V., R.S.P., B.G., S.N., B.A.T.v.d.B., J.J.J.d.V., H.J.S.) and Department of Surgery (K.N., M.P.v.d.T.), Cancer Center Amsterdam, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Location AMC, Amsterdam, the Netherlands (K.P.v.L.); and Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (B.I.L.W.).

Background Irreversible electroporation (IRE), an ablative technique that uses high-voltage electrical pulses, has shown promise for eradicating tumors near critical structures, including blood vessels and bile ducts. Purpose To investigate the efficacy and safety of IRE for colorectal liver metastases (CRLMs) unsuitable for resection or thermal ablation because of proximity to critical structures and for further systemically administered treatments. Materials and Methods Between June 2014 and November 2018, participants with fluorine 18 (F) fluorodeoxyglucose (FDG) PET-avid CRLMs measuring 5. Read More

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Role of Intraductal RFA: A Novel Tool in the Palliative Care of Perihilar Cholangiocarcinoma.

Visc Med 2021 Feb 7;37(1):39-47. Epub 2021 Jan 7.

Department of Medicine 1, University Hospital Bonn, Bonn, Germany.

Background: Patients with irresectable perihilar cholangiocarcinoma (PHC) have a limited prognosis with median survival times still less than 1 year. In addition to the current standard first-line systemic chemotherapy (gemcitabine and a platinum derivate), endoscopic treatment aims to ensure adequate drainage of the biliary system by placing biliary plastic or metal stents. Local ablative procedures like intraluminal biliary brachytherapy (ILBT) or photodynamic therapy (PDT) are used to improve local tumor control and to optimize the stent patency. Read More

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February 2021

Magnetic Resonance Imaging-Guided Laser Thermal Ventral Capsulotomy for Intractable Obsessive-Compulsive Disorder.

Neurosurgery 2021 May;88(6):1128-1135

Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island, USA.

Background: Obsessive-compulsive disorder (OCD) is a disabling condition characterized by intrusive thoughts and repetitive behaviors. A subset of individuals have severe, treatment-resistant illness and are nonresponsive to medication or behavioral therapies. Without response to conventional therapeutic options, surgical intervention becomes an appropriate consideration. Read More

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Uptake and safety of community-based "screen-and-treat" with thermal ablation preventive therapy for cervical cancer prevention in rural Lilongwe, Malawi.

Int J Cancer 2021 Mar 9. Epub 2021 Mar 9.

Department of Obstetrics & Gynecology, Division of Global Women's Health, University of North Carolina Project-Malawi, Lilongwe, Malawi.

Malawi has the highest invasive cervical cancer (ICC) mortality rate worldwide, and ICC is the leading cause of cancer death among women. In 2004, Malawi adopted visual inspection with acetic acid (VIA) and ablative treatment with cryotherapy. However, screening coverage has remained low (<30%) and few women (<50%) who require ablative treatment receive it. Read More

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Treatment approaches for women with positive cervical screening results in low-and middle-income countries.

Prev Med 2021 Mar 4;144:106439. Epub 2021 Mar 4.

IARC, Lyon, France.

The primary goal of cervical screening is to identify women with cervical precancers who need treatment to prevent invasive cervical cancer. Cervical cancer screening programs in high-resource settings rely on a multi-step process to reassure the majority of women of low cancer risk and treat the small number of women at high risk of precancer and cancer. The requirement of major resource investment for training and capacity building of multi-step cervical cancer screening programs prevents their introduction in low- and middle-income countries (LMICs). Read More

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Role of Thermal Ablation in Colorectal Cancer Lung Metastases.

Cancers (Basel) 2021 Feb 22;13(4). Epub 2021 Feb 22.

Interventional Radiology Unit, Medical Imaging Department, Gustave Roussy, 94800 Villejuif, France.

: Consensus guidelines of the European Society for Medical Oncology (ESMO) (2016) provided recommendations for the management of lung metastases. Thermal ablation appears as a tool in the management of these secondary pulmonary lesions, in the same manner as surgical resection or stereotactic ablative radiotherapy (SABR). : Indications, technical considerations, oncological outcomes such as survival (OS) or local control (LC), prognostic factors and complications of thermal ablation in colorectal cancer lung metastases were reviewed and put into perspective with results of surgery and SABR. Read More

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February 2021

Irreversible Electroporation of Recurrent Hepatocellular Carcinoma After Liver Transplantation: Report of Two Cases.

Cardiovasc Intervent Radiol 2021 May 2;44(5):807-811. Epub 2021 Mar 2.

Departmant of Radiology, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100, Ankara, Turkey.

The treatment strategies of post-transplant hepatocellular carcinoma (HCC) recurrence have not been completely clarified. Thermal ablative techniques have been increasingly performed for the treatment of post-transplant HCC recurrences. However, thermal ablation can create abnormal communication with the biliary tract and the ablation site by causing biliary injury. Read More

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Irreversible electroporation of locally advanced pancreatic cancer.

Semin Oncol 2021 Feb 18. Epub 2021 Feb 18.

Division of GI/Endocrine Surgery, Department of Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. Electronic address:

Locally advanced pancreatic cancer (LAPC) constitutes approximately one-third of all pancreatic cancer, with standard of care inconsistently defined and achieving modest outcomes at best. While resection after downstaging offers the chance for cure, only a fraction of patients with LAPC become candidates for resection. Chemotherapy remains the mainstay of treatment for the remainder. Read More

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February 2021

Wound Healing Profile After 1064- and 532-nm Picosecond Lasers With Microlens Array of In Vivo Human Skin.

Lasers Surg Med 2021 Feb 28. Epub 2021 Feb 28.

Department of Dermatology, Harvard Medical School, Boston, Massachusetts, 02215.

Background And Objectives: The aim of this study is to histologically characterize the wound healing process of in vivo human skin treated with 1064- and 532-nm microlens array (MLA)-type picosecond lasers.

Study Design/materials And Methods: Three patients (Fitzpatrick skin types II-IV), who were undergoing future cosmetic abdominoplasties, were treated with 1064- and 532-nm MLA-type lasers under different fluence settings. Treatments were performed 2 weeks, 1 week, and immediately prior to surgery. Read More

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February 2021

Bipolar radiofrequency ablation treatment of liver cancer employing monopolar needles: A comprehensive investigation on the efficacy of time-based switching.

Comput Biol Med 2021 Apr 16;131:104273. Epub 2021 Feb 16.

School of Engineering and Information Technology, Faculty of Science and Technology, Federation University, VIC, 3350, Australia.

Radiofrequency ablation (RFA) is a thermal ablative treatment method that is commonly used to treat liver cancer. However, the thermal coagulation zone generated using the conventional RFA system can only successfully treat tumours up to 3 cm in diameter. Switching bipolar RFA has been proposed as a way to increase the thermal coagulation zone. Read More

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The Landmark Series: Locally Advanced Pancreatic Cancer and Ablative Therapy Options.

Ann Surg Oncol 2021 Feb 14. Epub 2021 Feb 14.

Department of Surgery, University of Louisville, Louisville, KY, USA.

Locally advanced pancreatic cancer (LAPC) is a challenging disease to treat. There is consensus that systemic chemotherapy should be the first line of therapy for most patients. However, there is no consensus on how to manage those patients who do not have sufficient response to become candidates for resection but also do not have distant progression after weeks or months of systemic therapy. Read More

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February 2021

Low intensity focused ultrasound responsive microcapsules for non-ablative ultrafast intracellular release of small molecules.

J Mater Chem B 2021 03;9(10):2384-2393

School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.

Focused ultrasound (FU) is in demand for clinical cancer therapy, but the possible thermal injury to the normal peripheral tissues limits the usage of the ablative FU for tumors with a large size; therefore research efforts have been made to minimize the possible side effects induced by the FU treatment. Non-ablative focused ultrasound assisted chemotherapy could open a new avenue for the development of cancer therapy technology. Here, low intensity focused ultrasound (LIFU) for controlled quick intracellular release of small molecules (Mw ≤ 1000 Da) without acute cell damage is demonstrated. Read More

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Uterine Myomas: Extravascular Treatment.

Semin Ultrasound CT MR 2021 Feb 29;42(1):56-74. Epub 2020 Aug 29.

Radiology Unit, Foundation IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Uterine fibroids are common benign tumors that affect the female reproductive tract. They are responsible for considerable morbidity and deterioration of life quality. The main advantages offered by mini invasive techniques are low grade of invasiveness and short times of hospitalization. Read More

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February 2021

[Ablative therapies of pancreatic neoplasms.]

Recenti Prog Med 2021 Jan;112(1):75-80

The interest for pancreatic neoplasm ablation under endoscopic ultrasound (EUS) guidance has increased during the last decade because of technology advancement and availability of dedicated devices for thermal ablation. The most commonly used technique is radiofrequency ablation (RFA). Currently, three needle-electrodes and one "through-the-needle" probe are available. Read More

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January 2021

Mathematical Modeling of Thermal Damage Estimate Volumes in MR-guided Laser Interstitial Thermal Therapy.

J Neuroimaging 2021 Mar 20;31(2):334-340. Epub 2021 Jan 20.

Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Background And Purpose: Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive procedure that produces real-time thermal damage estimates (TDEs) of ablation. Currently, MRgLITT software provides limited quantitative parameters for intraoperative monitoring, but orthogonal TDE-MRI slices can be utilized to mathematically estimate ablation volume. The objective of this study was to model TDE volumes and validate using post-24 hours MRI ablative volumes. Read More

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Advanced Interventional Pain Management Approach to Neoplastic Disease Outside the Spine.

Tech Vasc Interv Radiol 2020 Dec 5;23(4):100705. Epub 2020 Oct 5.

Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Neoplastic disease of the musculoskeletal system may result in serious morbidity and mortality secondary to cancer related bone pain, pathologic fracture, altered structural mechanics, and involvement of adjacent structures. Recent advances in cancer detection and treatment have allowed more patients to live longer. The prevalence of osseous metastatic disease has increased to 100,000 new patients developing bone metastases each year. Read More

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December 2020

Feasibility of Controlling Metastatic Osseous Pain Using Three Kinds of Image-Guided Procedures for Thermal Microwave Ablation: A Retrospective Study.

Orthop Surg 2021 Feb 10;13(1):116-125. Epub 2020 Dec 10.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Objectives: To evaluate the feasibility and safety of treating painful osseous metastases using image-guided percutaneous thermal microwave ablation.

Methods: This is a retrospective study of patients treated from December 2016 to December 2019 in one institute. A total of 50 patients (35 men, 15 women; mean age 55. Read More

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February 2021