17,027 results match your criteria therapy intensity-modulated


Intensity-modulated radiation therapy and doxorubicin in thyroid cancer: A prospective phase 2 trial.

Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: The use of external-beam radiotherapy for locally advanced nonanaplastic thyroid cancer remains controversial. This prospective study evaluated the efficacy and tolerability of intensity-modulated radiation therapy (IMRT) with or without concurrent chemotherapy in patients with locally advanced thyroid cancer.

Methods: The authors conducted a nonrandomized phase 2 trial of IMRT with or without concurrent doxorubicin in patients with gross residual or unresectable nonanaplastic thyroid carcinoma (ClinicalTrials. Read More

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Incidental axillary dose delivery to axillary lymph node levels I-III by different techniques of whole-breast irradiation: a systematic literature review.

Strahlenther Onkol 2021 Jul 22. Epub 2021 Jul 22.

Radiotherapy Department, Strasbourg Europe Cancer Institute, 17 Rue Albert Calmette, 67200, Strasbourg Cedex, France.

Background And Objective: In breast cancer treatment, radiotherapy is an essential component for locoregional management. Axillary recurrence in patients with invasive breast carcinoma remains an issue. The question of whether breast irradiation may unintentionally include levels I, II, and III, and may decrease the risk of axillary recurrence, remains a topic of discussion. Read More

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Dosimetric comparison of MR-linac-based IMRT and conventional VMAT treatment plans for prostate cancer.

Radiat Oncol 2021 Jul 21;16(1):133. Epub 2021 Jul 21.

Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.

Background: The aim of this study was to evaluate and compare the performance of intensity modulated radiation therapy (IMRT) plans, planned for low-field strength magnetic resonance (MR) guided linear accelerator (linac) delivery (labelled IMRT MRL plans), and clinical conventional volumetric modulated arc therapy (VMAT) plans, for the treatment of prostate cancer (PCa). Both plans used the original planning target volume (PTV) margins. Additionally, the potential dosimetric benefits of MR-guidance were estimated, by creating IMRT MRL plans using smaller PTV margins. Read More

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Assessment of a Diaphragm Override Strategy for Robustly Optimized Proton Therapy Planning for Esophageal Cancer Patients.

Med Phys 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Purpose: To ensure target coverage in the treatment of esophageal cancer, a density override to the region of diaphragm motion can be applied in the optimization process. Here, we evaluate the benefit of this approach during robust optimization for intensity modulated proton therapy (IMPT) planning.

Materials And Methods: For ten esophageal cancer patients, two robustly optimized IMPT plans were created either using (WDO) or not using (NDO) a diaphragm density override of 1. Read More

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A Phase 1 study Combining Pexidartinib, Radiation Therapy, and Androgen Deprivation Therapy in Men With Intermediate- and High-Risk Prostate Cancer.

Adv Radiat Oncol 2021 Jul-Aug;6(4):100679. Epub 2021 Mar 3.

Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan.

Purpose: This study aimed to evaluate a combination of radiation therapy (RT), androgen deprivation therapy (ADT), and pexidartinib (colony-stimulating factor 1 receptor [CSF1R]) inhibitor in men with intermediate- and high-risk prostate cancer. CSF1R signaling promotes tumor infiltration and survival of tumor-associated macrophages, which in turn promote progression and resistance. Counteracting protumorigenic actions of tumor-associated macrophages via CSF1R inhibition may enhance therapeutic efficacy of RT and ADT for prostate cancer. Read More

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Activity-Based Costing of Intensity-Modulated Proton versus Photon Therapy for Oropharyngeal Cancer.

Int J Part Ther 2021 25;8(1):374-382. Epub 2021 Jun 25.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: In value-based health care delivery, radiation oncologists need to compare empiric costs of care delivery with advanced technologies, such as intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT). We used time-driven activity-based costing (TDABC) to compare the costs of delivering IMPT and IMRT in a case-matched pilot study of patients with newly diagnosed oropharyngeal (OPC) cancer.

Materials And Methods: We used clinicopathologic factors to match 25 patients with OPC who received IMPT in 2011-12 with 25 patients with OPC treated with IMRT in 2000-09. Read More

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Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer.

Int J Part Ther 2021 25;8(1):319-327. Epub 2021 Jun 25.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: We compared work outcomes in patients with oropharyngeal cancer (OPC), randomized to intensity-modulated proton (IMPT) versus intensity-modulated photon therapy (IMRT) for chemoradiation therapy (CRT).

Patients And Methods: In 147 patients with stage II-IVB squamous cell OPC participating in patient-reported outcomes assessments, a prespecified secondary aim of a randomized phase II/III trial of IMPT (n = 69) versus IMRT (n = 78), we compared absenteeism, presenteeism (i.e. Read More

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Initial Experience with Proton Beam Therapy for Differentiated Thyroid Cancer.

Int J Part Ther 2021 25;8(1):311-318. Epub 2021 Jun 25.

Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.

Purpose: External beam radiotherapy is used in a subset of high-risk patients with differentiated thyroid cancer (DTC). Recurrent, radioactive iodine (RAI)-refractory DTC carries a poor prognosis. We report our initial experience of intensity-modulated proton therapy (IMPT) for recurrent, RAI-refractory DTC. Read More

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Intensity-Modulated Proton Therapy (IMPT) Treatment of Angiosarcoma of the Face and Scalp.

Int J Part Ther 2021 25;8(1):304-310. Epub 2021 Jun 25.

Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.

Purpose: To successfully plan and treat a patient with diffuse angiosarcoma involving the face and scalp with intensity-modulated proton therapy (IMPT) before surgical resection.

Materials And Methods: A patient presented to the radiation oncology department for preoperative treatment of an angiosarcoma diffusely involving the face and scalp. A 4-field IMPT technique was used to create a homogeneous dose distribution to the entire target volume while sparing underlying critical structures from toxicity and low-dose spread. Read More

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Oncologic Outcomes for Head and Neck Skin Malignancies Treated with Protons.

Int J Part Ther 2021 25;8(1):294-303. Epub 2021 Jun 25.

Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.

Purpose: Radiation therapy (RT) is the standard treatment for patients with inoperable skin malignancies of the head and neck region (H&N), and as adjuvant treatment post surgery in patients at high risk for local or regional recurrence. This study reports clinical outcomes of intensity-modulated proton therapy (IMPT) for these malignancies.

Materials And Methods: We retrospectively reviewed cases involving 47 patients with H&N malignancies of the skin (squamous cell, basal cell, melanoma, Merkel cell, angiosarcoma, other) who underwent IMPT for curative intent between July 2016 and July 2019. Read More

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Proton Therapy for Major Salivary Gland Cancer: Clinical Outcomes.

Int J Part Ther 2021 25;8(1):261-272. Epub 2021 Jun 25.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: To report clinical outcomes in terms of disease control and toxicity in patients with major salivary gland cancers (SGCs) treated with proton beam therapy.

Materials And Methods: Clinical and dosimetric characteristics of patients with SGCs treated from August 2011 to February 2020 on an observational, prospective, single-institution protocol were abstracted. Local control and overall survival were calculated by the Kaplan-Meier method. Read More

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Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life.

Int J Part Ther 2021 25;8(1):234-247. Epub 2021 Jun 25.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: Proton radiation therapy (PRT) may offer dosimetric and clinical benefit in the treatment of head and neck carcinoma of unknown primary (HNCUP). We sought to describe toxicity and quality of life (QOL) in patients with HNCUP treated with PRT.

Patients And Methods: Toxicity and QOL were prospectively tracked in patients with HNCUP from 2011 to 2019 after institutional review board approval. Read More

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Patient-Reported Outcomes after Intensity-Modulated Proton Therapy for Oropharynx Cancer.

Int J Part Ther 2021 25;8(1):213-222. Epub 2021 Jun 25.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Purpose: To report patient-reported outcomes (PROs) derived from the Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN) tool, in patients with oropharynx cancer (OPC) treated with intensity-modulated proton therapy (IMPT) in the context of first-course irradiation.

Materials And Methods: Patients with locally advanced OPC treated with radical IMPT between 2011 and 2018 were included in a prospective registry. FACT-HN scores were measured serially during and 24 months following IMPT. Read More

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Proton Radiotherapy to Reduce Late Complications in Childhood Head and Neck Cancers.

Int J Part Ther 2021 25;8(1):155-167. Epub 2021 Jun 25.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

In most childhood head and neck cancers, radiotherapy is an essential component of treatment; however, it can be associated with problematic long-term complications. Proton beam therapy is accepted as a preferred radiation modality in pediatric cancers to minimize the late radiation side effects. Given that childhood cancers are a rare and heterogeneous disease, the support for proton therapy comes from risk modeling and a limited number of cohort series. Read More

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A Systematic Review of Proton Therapy for the Management of Nasopharyngeal Cancer.

Int J Part Ther 2021 25;8(1):119-130. Epub 2021 Jun 25.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: With improved technology, more patients with nasopharyngeal cancer (NPC) are receiving definitive treatment with proton therapy, which allows greater sparing of dose to normal tissues without compromising efficacy. As there is no randomized data, the purpose of this study was to systematically review the available literature on proton therapy in this setting, focusing on the toxicity endpoints.

Materials And Methods: A systematic search using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was conducted in 5 databases: PubMed, Embase, SCOPUS, Web of Science, and the Cochrane Central Register of Controlled Trials. Read More

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A Critical Review of LET-Based Intensity-Modulated Proton Therapy Plan Evaluation and Optimization for Head and Neck Cancer Management.

Int J Part Ther 2021 25;8(1):36-49. Epub 2021 Jun 25.

Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.

In this review article, we review the 3 important aspects of linear-energy-transfer (LET) in intensity-modulated proton therapy (IMPT) for head and neck (H&N) cancer management. Accurate LET calculation methods are essential for LET-guided plan evaluation and optimization, which can be calculated either by analytical methods or by Monte Carlo (MC) simulations. Recently, some new 3D analytical approaches to calculate LET accurately and efficiently have been proposed. Read More

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A Review of the Robust Optimization Process and Advances with Monte Carlo in the Proton Therapy Management of Head and Neck Tumors.

Authors:
Xiaodong Zhang

Int J Part Ther 2021 25;8(1):14-24. Epub 2021 Jun 25.

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

In intensity-modulated proton therapy, robust optimization processes have been developed to manage uncertainties associated with (1) range, (2) setup, (3) anatomic changes, (4) dose calculation, and (5) biological effects. Here we review our experience using a robust optimization technique that directly incorporates range and setup uncertainties into the optimization process to manage those sources of uncertainty. We also review procedures for implementing adaptive planning to manage the anatomic uncertainties. Read More

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A nomogram for predicting late radiation-induced xerostomia among locoregionally advanced nasopharyngeal carcinoma in intensity modulated radiation therapy era.

Aging (Albany NY) 2021 Jul 19;13(undefined). Epub 2021 Jul 19.

Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

Background: Dry mouth sensation cannot be improved completely even though parotids are spared correctly. Our purpose is to develop a nomogram to predict the moderate-to-severe late radiation xerostomia for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) in intensity modulated radiation therapy (IMRT) / volumetric modulated arc radiotherapy (VMAT) era.

Methods: A dataset of 311 patients was retrospectively collected between January 2010 and February 2013. Read More

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Plan Quality Comparisons Between 3D-CRT, IMRT, and VMAT Based on 4D-CT for Gastric MALT Lymphoma.

Anticancer Res 2021 Aug;41(8):3941-3947

Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Background/aim: We compared three-dimensional conformal RT (3D-CRT), intensity-modulated radiotherapy (IMRT), and volumetric modulated arc therapy (VMAT) for gastric mucosa-associated lymphoid tissue (MALT) lymphoma using four-dimensional computed tomography (4D-CT) images.

Patients And Methods: Three treatment plans of 3D-CRT, IMRT, and VMAT with 30 Gy were created based on 4D-CT images of seven patients. We calculated D95, homogeneity index (HI), and conformity index (CI) of planning target volume, and organs at risk doses. Read More

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FDG-PET/CT in the Radiotherapy Treatment Planning of Locally Advanced Anal Cancer: A Monoinstitutional Experience.

Front Oncol 2021 1;11:655322. Epub 2021 Jul 1.

Department of Radiation Oncology, Ospedali Riuniti Umberto I°, GM Lancisi, G Salesi, Ancona, Italy.

Aims: Radiotherapy with concurrent 5-fluorouracil/mitomycin-C based chemotherapy has been established as definitive standard therapy approach for anal cancer. Intensity Modulated Radiotherapy (IMRT) leads to a precise treatment of the tumor, allowing dose escalation on Gross Tumor Volume (GTV), with a surrounding healthy tissues sparing. Our study assessed the impact of 18-Fluorodeoxyglucose positron emission tomography (18FDG-PET/CT) on the radiotherapy contouring process and its contribution to lymphatic spread detection, resulting to a personalization of Clinical Target Volume (CTV) and dose prescription. Read More

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Locally Advanced Breast Cancer: Treatment Patterns and Predictors of Survival in a Saudi Tertiary Center.

Cureus 2021 Jun 8;13(6):e15526. Epub 2021 Jun 8.

Department of Surgery, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.

Background  Breast cancer (BC) is the most common cancer in the Kingdom of Saudi Arabia (KSA) and the second leading cause of cancer-related mortality. About 40% of BC in KSA is locally advanced BC (LABC), which has been associated with poorer survival compared with early diagnosed BC. Objective To review the presentation and outcomes of LABC, including the characteristics of the disease, different treatment modalities, overall survival (OS), disease-free survival (DFS), and local recurrence in relation to different radiotherapy (RT) techniques. Read More

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Comparison of 2 dynamic conformal arc plans based on high-dose rate flattening filter free beams for peripheral lung cancer.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Jun;46(6):615-619

Department of Radiation Therapy, Cancer Hospital of Shantou University Medical College, Shantou Guangdong 515000, China.

Objectives: To compare 2 dynamic conformal arc plans based on the high dose rate flattening filter free (FFF) beams, and to evaluate the dosimetric differences.

Methods: A total of 20 patients with early peripheral non-small cell lung cancer were selected, and 2 dynamic conformal arc plans were designed in the Eclipse 10.0 treatment planning system (TPS). Read More

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Head and neck proton therapy in France: A missed opportunity or a challenge in front of us?

Cancer Radiother 2021 Jul 13. Epub 2021 Jul 13.

Radiation Oncology Department, Centre Léon-Bérard, Lyon, France.

Following major advances of the best of photon-techniques such as intensity-modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT) and, to arrive soon, magnetic resonance (MR)-linac radiotherapy, there are still substantial opportunities in the treatment of head and neck cancers to further reduce the toxicity burden. Proton therapy represents another attractive option in this high-quality and highly competitive precision radiotherapy landscape. Proton therapy holds promises to reduce toxicities and to escalate the dose in radioresistant cases or cases where dose distribution is not satisfactory with photons. Read More

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Ad Astra - telomeres in space!

Int J Radiat Biol 2021 Jul 26:1-9. Epub 2021 Jul 26.

Baylor Scott & White Medical Center, Temple, TX, USA.

Purpose: My journey to the stars began as I - along with the whole world - stood still and watched Neil Armstrong take those first small steps on the Moon. Fast forward 50 years and NASA astronauts Scott Kelly and Christina Koch each spend nearly a year in space aboard the International Space Station (ISS), a remarkable multinational collaborative project and floating U.S. Read More

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Efficacy comparison between microwave ablation combined with radiation therapy and radiation therapy alone for locally advanced nonsmall-cell lung cancer.

J Cancer Res Ther 2021 Jul;17(3):715-719

The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, China.

Purpose: Comparing the efficacy and complications of microwave ablation (MA) combined with intensity-modulated radiation therapy (IMRT) and IMRT alone for locally advanced peripheral nonsmall-cell lung cancer (NSCLC).

Methods: Retrospective analysis was conducted on 76 patients with locally advanced peripheral NSCLC undergoing chemotherapy and metastatic lymph node radiation therapy from June 2014 to June 2016. Either MA or IMRT was used to treat primary lesions. Read More

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Proton re-irradiation of unresectable recurrent brain gliomas: clinical outcomes and toxicity.

J BUON 2021 May-Jun;26(3):970-976

Department of proton therapy, A. Tsyb Medical radiological research center - branch of the National medical research radiological center, Obninsk, Russia.

Purpose: To assess the efficacy and tolerance of proton re-irradiation in patients with unresectable recurrence of previously irradiated brain gliomas.

Methods: Between February 2016 and December 2019, 44 patients with in-field recurrence after prior irradiation of brain gliomas were irradiated with intensity-modulated proton therapy. Seven patients (15. Read More

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Image-guided radiation therapy produces lower acute and chronic gastrointestinal and genitourinary toxicity in prostate cancer patients.

J BUON 2021 May-Jun;26(3):940-948

Department of Clinical and Radiation Oncology, Oncology Centre, Multiscan and Pardubice Hospital, Pardubice, Czech Republic.

Purpose: This paper compares individual radiation therapy techniques used for prostate cancer and their benefits in clinical practice.

Methods: We retrospectively analyzed 921 patients with localized prostate tumors treated between 1997 and 2012. We divided the patients into four groups according to the selected treatment technique (conformal radiation therapy [3DCRT], intensity-modulated radiation therapy [IMRT], image-guided radiation therapy [IGRT], and volumetric-modulated arc therapy [VMAT]) and evaluated the incidence of acute and chronic gastrointestinal (GI) and genitourinary (GU) toxicity. Read More

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Which is the best combination of surgery for hepatocellular carcinoma with hepatic/portal vein thrombosis in China: a network meta-analysis of randomized controlled trials.

J BUON 2021 May-Jun;26(3):889-896

Department of Radiation Oncology, Fudan University Zhongshan Hospital, Xiamen Branch, Xiamen, China.

Purpose: To assess the efficacy and safety of different perioperative regimens using network meta-analysis for hepatocellular carcinoma (HCC) with hepatic/portal vein thrombosis. The interested modalities included neoadjuvant three-dimensional conformal radiotherapy (3D-CRT), post-operative intensity modulated radiation therapy (IMRT). post-operative transarterial chemoembolization (TACE) and surgery alone. Read More

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Manufacturing and evaluation of a multi-purpose Iranian head and neck anthropomorphic phantom called MIHAN.

Med Biol Eng Comput 2021 Jul 16. Epub 2021 Jul 16.

Department of Medical Radiation Engineering, Shahid Beheshti University, Tehran, Iran.

A new multi-purpose Iranian head and neck (MIHAN) anthropomorphic phantom was designed and manufactured to be used in diagnostic and therapeutic applications. Geometry of MIHAN phantom was determined based on the average dimensions acquired by CT scans of twenty patients without any medical problems in their head and neck site. Because the phantom was expected to be used with different modalities with a wide range of photon energies, attenuation coefficients of some selected materials were determined using Monte Carlo simulation. Read More

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Probability Distribution of Pixel Intensities of EBT3 Films and its Application in the Correction of Uncertainty Budget.

J Med Phys 2021 Jan-Mar;46(1):26-32. Epub 2021 May 5.

Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.

Background And Aim: Modern radiotherapy modalities, such as Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy involve complex dose delivery. The dose delivery is complex as it involves beam modulation, hence, manual dose calculations for these techniques are not possible. Film dosimetry is commonly used method of dose verification for these modalities because of the advantages associated with it. Read More

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