9,906,571 results match your criteria therapy

[Consensus and controversy for the surgical advance of gastric cancer liver metastasis].

K C Zhang L Chen

Zhonghua Yi Xue Za Zhi 2021 Apr;101(14):975-978

Department of General Surgery, the First Medical Center of PLA General Hospital, Beijing 100853, China.

Liver is one of the most common metastatic site of advanced gastric cancer. Surgical resection is one of the key component of multidisciplinary treatment for gastric cancer liver metastasis. Curative-intent surgery rather than reductive surgery could improve prognosis for gastric cancer liver metastasis. Read More

View Article and Full-Text PDF

Postinfectious T-lymphocytic enteral leiomyositis as a rare cause of chronic intestinal pseudoobstruction.

Z Gastroenterol 2021 Apr 12;59(4):326-330. Epub 2021 Apr 12.

Innere Medizin, Schön Klinik Hamburg Eilbek, Hamburg, Germany.

T-lymphocytic enteral leiomyositis (T-lel) is a rare disorder causing chronic intestinal pseudo-obstruction (CIPO), with cases predominantly being reported in the field of veterinary and pediatric medicine. Here, we present a case of T-lel-associated CIPO in an adult female, who initially presented with a paralytic ileus 2 weeks after a common gastroenteritis. The histological diagnosis was established through full-thickness bowel biopsy, exhibiting a dense lymphocytic infiltrate in the lamina muscularis of the intestinal wall. Read More

View Article and Full-Text PDF

Treatment of Localized Vulvar Pain with Neural Therapy: A Case Series and Literature Review.

Complement Med Res 2021 Apr 12:1-7. Epub 2021 Apr 12.

Campus Docent de Sant Joan de Déu, Barcelona, Spain.

Background: Localized vulvar pain (LVP) is a common condition among fertile women, with physical and psychosexual implications. Treatment is complex with limited benefits. Neural therapy is a regulatory therapy that uses injections of local anesthetics in low concentrations in specific points to treat different conditions. Read More

View Article and Full-Text PDF

Chronic Kidney Disease of Undetermined Etiology around the World.

Kidney Blood Press Res 2021 Apr 12:1-10. Epub 2021 Apr 12.

Nephrology and Dialysis, G. Brotzu Hospital, Università degli Studi di Cagliari, Cagliari, Italy.

Background: Epidemics of chronic kidney disease of uncertain etiology (CKDu) are occurring on the Pacific coast of Central America, in Sri Lankan and Indian agricultural communities, and in other hotspots around the world. CKDu primarily affects male agricultural workers, and traditional risk factors such as diabetes and hypertension are not involved in the pathogenesis. Although a causal factor has not yet been identified, culprits include repeated volume depletion-induced kidney injury, as well as exposure to agrichemicals, heavy metals and nephrotoxins contained in drugs, beverages, and traditional medications. Read More

View Article and Full-Text PDF

In vitro anti-oxidant and cytotoxic activities of gold nanoparticles synthesized from an aqueous extract of the Xylopia aethiopica fruit.

Nanotechnology 2021 Apr 12. Epub 2021 Apr 12.

Physiology, Nelson Mandela University, Port Elizabeth, Eastern Cape, SOUTH AFRICA.

The development of gold nanoparticles (AuNPs) using green approach has drawn a considerable interest in the field of nanomedicine. Its wide application in clinical diagnosis, imaging and therapeutics portrays its importance for human existence. In this study, we reported the biogenic synthesis of AuNPs using aqueous extract of Xylopia aethiopica fruit (AEXAf), which act as both reducing and stabilizing agent. Read More

View Article and Full-Text PDF

Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2021 Apr 1;19(4):439-457. Epub 2021 Apr 1.

32National Comprehensive Cancer Network.

Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Read More

View Article and Full-Text PDF

NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021.

J Natl Compr Canc Netw 2021 Apr 1;19(4):364-376. Epub 2021 Apr 1.

32National Comprehensive Cancer Network.

Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways for treatment of microscopic satellitosis (added in v2.2020), and the following Principles sections: Molecular Testing (added in v2.2019), Systemic Therapy Considerations (added in v2. Read More

View Article and Full-Text PDF

Management of BRCA Mutation Carriers With Pancreatic Adenocarcinoma.

J Natl Compr Canc Netw 2021 Apr 1;19(4):469-473. Epub 2021 Apr 1.

2Oncology Department, Hôpital Paul Brousse (AP-HP), Villejuif; and.

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a 5-year survival rate of ≤7% across all stages. Most patients are diagnosed with advanced disease and median overall survival is limited. The limited success of conventional therapies for PDAC is at least partially attributable to its genetic heterogeneity. Read More

View Article and Full-Text PDF

Estrogen-secreting adrenocortical tumor in a postmenopausal woman: a challenging diagnosis.

Endocrinol Diabetes Metab Case Rep 2021 Mar 15;2021. Epub 2021 Mar 15.

Department of Internal MedicineHematology and Oncology, University of Sao Paulo Faculty of Medicine of Ribeirao Preto, Ribeirao Preto, São Paulo, Brazil.

Summary: Adrenocortical carcinoma (ACC) is a malignant disorder with rapid evolution and severe prognosis in adults and most produce cortisol and androgen. Estrogen-secreting adrenocortical carcinomas are extremely rare, especially in women, tend to be larger and have worse prognosis compared with other types of ACCs. We report the case of a 58-year-old woman who presented with bilateral breast enlargement and postmenopausal genital bleeding. Read More

View Article and Full-Text PDF

Symptom Prevalence and Genotype-Phenotype Correlations in Patients With TANGO2-Related Metabolic Encephalopathy and Arrhythmias (TRMEA).

Pediatr Neurol 2021 Mar 8;119:34-39. Epub 2021 Mar 8.

Department of Neurology and Center for Gene Therapy, Nationwide Children's Hospital, Columbus, Ohio. Electronic address:

Background: TANGO2-related metabolic encephalopathy and arrhythmias (TRMEA) is a rare, phenotypically heterogeneous, neurological disease affecting children.

Methods: We conducted a chart review of five children with molecularly confirmed TRMEA diagnosed at our institution and compiled pathogenic variant frequency and symptom prevalence from cases previously reported in the literature.

Results: Including those patients in our case series, 76 patients with TRMEA have been described. Read More

View Article and Full-Text PDF

Development and dosimetric assessment of an automatic dental artifact classification tool to guide artifact management techniques in a fully automated treatment planning workflow.

Comput Med Imaging Graph 2021 Mar 26;90:101907. Epub 2021 Mar 26.

The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, TX, USA; The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, TX, USA.

Purpose: We conducted our study to develop a tool capable of automatically detecting dental artifacts in a CT scan on a slice-by-slice basis and to assess the dosimetric impact of implementing the tool into the Radiation Planning Assistant (RPA), a web-based platform designed to fully automate the radiation therapy treatment planning process.

Methods: We developed an automatic dental artifact identification tool and assessed the dosimetric impact of its use in the RPA. Three users manually annotated 83,676 head-and-neck (HN) CT slices (549 patients). Read More

View Article and Full-Text PDF

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19.

Comput Biol Chem 2021 Apr 5;92:107482. Epub 2021 Apr 5.

Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Odisha, 752050, India. Electronic address:

Complement system plays a dual role; physiological as well as pathophysiological. While physiological role protects the host, pathophysiological role can substantially harm the host, by triggering several hyper-inflammatory pathways, referred as "hypercytokinaemia". Emerging clinical evidence suggests that exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), tricks the complement to aberrantly activate the "hypercytokinaemia" loop, which significantly contributes to the severity of the COVID19. Read More

View Article and Full-Text PDF

Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation.

J Stroke Cerebrovasc Dis 2021 Apr 9;30(6):105753. Epub 2021 Apr 9.

Department of Cardiology, Dijon University Hospital, 21000 Dijon, France. Electronic address:

Introduction: Elevated troponin levels are found in a significant number of patients who are diagnosed with acute embolic stroke (AES) after first diagnosed atrial fibrillation (AF). These myocardial injuries, which are known as cardiocerebral infarction (CCI), are potentially caused by coronary embolism and correspond to simultaneous cardiac and cerebral embolisms. However, this severe condition remains poorly understood. Read More

View Article and Full-Text PDF

Older drivers are at increased risk of fatal crash involvement: Results of a systematic review and meta-analysis.

Arch Gerontol Geriatr 2021 Apr 6;95:104414. Epub 2021 Apr 6.

University of Brasilia, Multidisciplinary Center for the Aged, Brasília, DF, Brazil. Electronic address:

Older adults have become a larger part of the driving population, but whether they are at increased risk of being involved in fatal crashes remains unclear.

Methods: We performed a systematic review of studies investigating fatal crash involvement of older vs non-older drivers by searching the following databases: PubMed, Cochrane Library, Embase, LILACS, SciELO, Web of Science, and ProQuest. Studies that used fatal crash involvement rates per distance driven as a measure of frequency were selected for meta-analysis. Read More

View Article and Full-Text PDF

Light-inducible control of cellular proliferation and differentiation by a Hedgehog signaling inhibitor.

Bioorg Med Chem 2021 Apr 2;38:116144. Epub 2021 Apr 2.

Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan; Department of Chemistry and Biotechnology, The University of Tokyo, Tokyo 153-8505, Japan. Electronic address:

The Hedgehog (Hh) signaling pathway is a major regulator of cell differentiation and proliferation. Aberrant activation of the Hh pathway has been implicated in several types of cancer. To understand the Hedgehog pathway and fight against related diseases, it is important to inhibit Hedgehog signaling in a targeted manner. Read More

View Article and Full-Text PDF

Comparison of Dosing Schemes for Thyroid Hormone Replacement Therapy After Thyroidectomy.

J Surg Res 2021 Apr 9;264:316-320. Epub 2021 Apr 9.

Department of Surgery, Weill Cornell Medicine, New York City, New York. Electronic address:

Background: Current thyroid hormone replacement therapy (THRT) is built on weight-based standard calculation of dose. A novel Poisson regression model, which accounts for seven clinical variables, was recently proposed to improve accuracy of THRT. We aimed to compare the accuracy of estimated THRT dose to reach euthyroid and the difference in predicted dose between the Poisson (scheme A) and the weight-based standard (scheme B) in patients following total thyroidectomy for benign disease. Read More

View Article and Full-Text PDF

Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs.

Biomed Pharmacother 2021 Apr 9;139:111559. Epub 2021 Apr 9.

Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Therapeutic Effectiveness Research, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Background: In a previous drug-drug interaction (DDI) screening study intended to generate hypotheses, clopidogrel + either eszopiclone or zolpidem (vs. clopidogrel alone) were associated with serious bleeding.

Objectives: To confirm or refute these DDI signals and examine associations with other hypnotics in an independent population of United States Medicaid beneficiaries METHODS: We employed a bi-directional self-controlled case series design in eligible individuals concomitantly exposed to one of 12 hypnotics (precipitants, exposures of interest) plus either clopidogrel (the object drug) or pravastatin (the negative control object drug). Read More

View Article and Full-Text PDF

Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin.

Phytomedicine 2021 Feb 24;86:153527. Epub 2021 Feb 24.

College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. Electronic address:

Background: SiNiSan (SNS) is an ancient Chinese herbal prescription, and the current clinical treatment of irritable bowel syndrome (IBS) is effective. In the previous study of the research team, the multi-functional co-synergism of SNS against IBS was presented. Some potential drug targets and candidate ligands were predicted. Read More

View Article and Full-Text PDF
February 2021

Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression.

Neoplasia 2021 Apr 9;23(4):439-455. Epub 2021 Apr 9.

Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil. Electronic address:

Despite advances in therapeutics, the progression of melanoma to metastasis still confers a poor outcome to patients. Nevertheless, there is a scarcity of biological models to understand cellular and molecular changes taking place along disease progression. Here, we characterized the transcriptome profiles of a multi-stage murine model of melanoma progression comprising a nontumorigenic melanocyte lineage (melan-a), premalignant melanocytes (4C), nonmetastatic (4C11-) and metastasis-prone (4C11+) melanoma cells. Read More

View Article and Full-Text PDF

Effects on gait and balance of home-based active video game interventions in persons with multiple sclerosis: A systematic review.

Mult Scler Relat Disord 2021 Mar 28;51:102928. Epub 2021 Mar 28.

ILFOMER, Université de Limoges, Limoges, France; HAVAE, EA 6310, Université de Limoges, Limoges, France. Electronic address:

Background: The current coronavirus disease (COVID-19) pandemic makes it difficult to obtain physical therapy in rehabilitation centres, particularly for persons with multiple sclerosis (pwMS), who are a population at high risk, since viral infections may contribute to MS exacerbations and relapses. Active video games could be a way to maintain physical therapy at home as part of the rehabilitation. The aim of this review is to summarise the current best evidence for the effectiveness of home-based active video games on gait and balance, user compliance, feasibility and safety for pwMS. Read More

View Article and Full-Text PDF

In silico method development for the reversed-phase liquid chromatography separation of proteins using chaotropic mobile phase modifiers.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Feb 24;1173:122587. Epub 2021 Feb 24.

Analytical Research & Development, Merck & Co., Inc., Rahway, NJ 07065, USA. Electronic address:

Recent advances in biomedical and pharmaceutical processes has enabled a notable increase of protein- and peptide-based drug therapies and vaccines that often contain a higher-order structure critical to their efficacy. Hyphenation of chromatographic and spectrometric techniques is at the center of all facets of biopharmaceutical analysis, purification and chemical characterization. Although computer-assisted chromatographic modeling of small molecules has reached a mature stage across the pharmaceutical industry, software-based method optimization approaches for large molecules has yet to see the same revitalization. Read More

View Article and Full-Text PDF
February 2021

Analysis of nationwide multimodal complex treatment and drug pump therapy in Parkinson's disease in times of COVID-19 pandemic in Germany.

Parkinsonism Relat Disord 2021 Mar 18;85:109-113. Epub 2021 Mar 18.

Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Germany; Medical Faculty, Ruhr University Bochum, Germany; Center for Protein Diagnostics (ProDi), Ruhr University Bochum, Bochum, Germany. Electronic address:

Introduction: During the first peak phase of the COVID-19 pandemic, the German Ministry of Health recommended that elective treatments should be postponed to increase hospital capacities. This has also compromised the capacity for application of specialized Parkinson's disease (PD) therapies to an unknown extent.

Methods: We conducted a nationwide cross-sectional study using administrative database of all hospitalized patients with main diagnosis of PD receiving multimodal complex treatment (PD-MCT), initial setup of levodopa/carbidopa intestinal gel (LCIG) or continuous subcutaneous apomorphine infusion (CSAI) in Germany. Read More

View Article and Full-Text PDF

Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model.

J Photochem Photobiol B 2021 Mar 24;218:112181. Epub 2021 Mar 24.

Laboratory of Genomic Studies, São Paulo State University, São José do Rio Preto, São Paulo 15054-000, Brazil. Electronic address:

Breast cancer is the most common neoplasm among women but thanks to innovative therapies, patients' prognosis has considerably improved. In this aspect, nanotechnology has been applied for cancer therapy aiming to reduce its usual side effects. In this study we aimed to evaluate the effects of nanoemulsions containing photosensitizer and chemotherapeutic agents associated with photodynamic therapy in a breast cancer in vivo model. Read More

View Article and Full-Text PDF

Predictive factors for success of awake proning in hypoxemic respiratory failure secondary to COVID-19: A retrospective cohort study.

Respir Med 2021 Apr 2;181:106379. Epub 2021 Apr 2.

Department of Internal Medicine, Divisions of Critical Care, Pulmonary and Sleep Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, TX, 77030, USA. Electronic address:

Background: Awake prone positioning has been recommended as an adjunctive measure in spontaneously breathing patients with hypoxemic respiratory failure during the COVID-19 pandemic. It remains uncertain as to how long this should be implemented, what variables to follow and who would be the ideal candidates for this adjunctive therapy.

Methods: A retrospective chart review of patients admitted from April to August 2020 within our institution with multifocal pneumonia and hypoxemic respiratory failure secondary to COVID-19 who underwent awake-proning for at least 3 hours was conducted. Read More

View Article and Full-Text PDF

Characteristics of pial brain arteriovenous malformations with transdural arterial supply.

Eur J Radiol 2021 Apr 8;139:109670. Epub 2021 Apr 8.

Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

Purpose: Transdural blood supply (TDBS) to pial brain arteriovenous malformations (BAVM) is uncommon and believed to be related to vascular endothelial growth factor - induced angiogenesis. The aim of this study was to define the BAVM characteristics in relation to presence and volume of TDBS.

Methods: BAVMs managed at our institution between January 2006 and December 2016 who subsequently underwent complete digital subtraction angiography (DSA) were included. Read More

View Article and Full-Text PDF

Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis.

Biosens Bioelectron 2021 Mar 27;183:113176. Epub 2021 Mar 27.

BioMEMS and Bioinspired Microfluidic Laboratory, Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta T2N 1N4, Canada; Center for Bioengineering Research and Education, University of Calgary, Calgary, Alberta T2N 1N4, Canada. Electronic address:

Academic and industrial groups worldwide have reported technological advances in exosome-based cancer diagnosis and prognosis. However, the potential translation of these emerging technologies for research and clinical settings remains unknown. This work overviews the role of exosomes in cancer diagnosis and prognosis, followed by a survey on emerging exosome technologies, particularly microfluidic advances for the isolation and detection of exosomes in cancer research. Read More

View Article and Full-Text PDF

Traditional Korean medicine treatment for tamoxifen associated adverse events of breast cancer patient: A CARE - Compliant case report.

Complement Ther Clin Pract 2021 Apr 2;43:101378. Epub 2021 Apr 2.

Chung-Yeon Central Institute, 64, Sangmujungang-ro, Seo-gu, Gwangju, 61949, Republic of Korea. Electronic address:

Background: Adverse events of endocrine therapy reduce the breast cancer patient's quality of life and adversely affect treatment compliance.

Method: A 50-year-old breast cancer patient complained of several symptoms such as hot flush, hyperhidrosis, urinary frequency, and depression. These symptoms occurred after taking tamoxifen. Read More

View Article and Full-Text PDF

Graft-versus-host disease prophylaxis with posttransplantation bendamustine (PTB) in patients with refractory acute leukemia: a dose-ranging study: Category of manuscript: Regular Manuscript.

Transplant Cell Ther 2021 Apr 9. Epub 2021 Apr 9.

RM Gorbacheva Research Institute, Pavlov University, Saint-Petersburg, Russian Federation. Electronic address:

Background: The prognosis of acute leukemia refractory to induction chemotherapy or immunotherapy is dismal. Salvage allogeneic hematopoietic stem cell transplantation (HSCT) is widely used option for these patients, but only 10-15% of patients are cured by the procedure. Preclinical studies indicate that substitution of posttransplantation cyclophosphomide (PTCY) with bendamustine (PTB) in a prophylaxis regimen may be associated with augmented graft-versus-leukemia (GVL) reaction. Read More

View Article and Full-Text PDF