Cortex 2021 May 12;138:113-126. Epub 2021 Feb 12.
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA; Life-Span Cognitive Neuroscience Program, Institute of Gerontology, Wayne State University, Detroit, MI, USA. Electronic address:
How does the human brain integrate spatial and temporal information into unified mnemonic representations? Building on classic theories of feature binding, we first define the oscillatory signatures of integrating 'where' and 'when' information in working memory (WM) and then investigate the role of prefrontal cortex (PFC) in spatiotemporal integration. Fourteen individuals with lateral PFC damage and 20 healthy controls completed a visuospatial WM task while electroencephalography (EEG) was recorded. On each trial, two shapes were presented sequentially in a top/bottom spatial orientation. Read More