554 results match your criteria tgp

How EU policies could reduce nutrient pollution in European inland and coastal waters.

Glob Environ Change 2021 Jul;69:102281

Seidor, Barcelona, Spain.

Intensive agriculture and densely populated areas represent major sources of nutrient pollution for European inland and coastal waters, altering the aquatic ecosystems and affecting their capacity to provide ecosystem services and support economic activities. Ambitious water policies are in place in the European Union (EU) for protecting and restoring aquatic ecosystems under the Water Framework Directive and the Marine Strategy Framework Directive. This research quantified the current pressures of point and diffuse nitrogen and phosphorus emissions to European fresh and coastal waters (2005-2012), and analysed the effects of three policy scenarios of nutrient reduction: 1) the application of measures currently planned in the Rural Development Programmes and under the Urban Waste Water Treatment Directive (UWWTD); 2) the full implementation of the UWWTD and the absence of derogations in the Nitrates Directive; 3) high reduction of nutrient, using best technologies in wastewaters treatment and optimal fertilisation in agriculture. Read More

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Organoid culture of mouse fallopian tube epithelial stem cells with a thermo-reversible gelation polymer.

Tissue Cell 2021 Aug 19;73:101622. Epub 2021 Aug 19.

Laboratory of Clinical Applied Anatomy, Department of Human Anatomy, School of Basic Medicine, Fujian Medical University, PR China. Electronic address:

In this study, a three-dimensional (3D) thermo-reversible gelation polymer (TGP) culture system was established for organoid culture of mouse fallopian tube (FT) epithelial stem cells (FTESCs) without cell isolation. FT tissues from 6- to 8-week-old ICR mice were digested with collagenase, and whole FT cells (FTCs) were inoculated into the TGP. After 6 days of culture, many spheres in the TGP formed. Read More

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Using evaluation to enhance a pre-exposure prophylaxis (PrEP) social marketing campaign in real time in Los Angeles County, California.

Eval Program Plann 2021 Aug 13:101988. Epub 2021 Aug 13.

Division of HIV and STD Programs, Los Angeles County Department of Public Health, 600 S. Commonwealth Ave, Los Angeles, CA, USA.

Objective: To describe the application of a formative evaluation conducted concurrently with implementation of a public health social marketing campaign to allow for substantive changes to the campaign messaging to subsequently improve acceptability.

Method: A serial cross-sectional survey was used to evaluate the acceptability of two campaign messages among Black and Latino men who have sex with men (MSM) and transgender persons (TGP) in Los Angeles County from 2016 to 2018 through an online survey. Theinitial message, which presented the PrEP Protectors, a trio of superheroes embodying the power, knowledge, and protection pre-exposure prophylaxis (PrEP) can provide, was revised based on respondent feedback collected in the survey to increase specificity and clarity. Read More

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Patterns of Whole Exome Sequencing in Resected Cholangiocarcinoma.

Cancers (Basel) 2021 Aug 12;13(16). Epub 2021 Aug 12.

Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA.

Background: With minimally effective chemotherapy options, cholangiocarcinoma patients have 5 year survival rate of 10%. Tumor genetic profiling (TGP) can identify mutations susceptible to targeted therapies. We sought to describe the use of TGP and frequency of actionable results in resected cholangiocarcinoma. Read More

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Transgenerational plasticity responses of oysters to ocean acidification differ with habitat.

J Exp Biol 2021 Jun 18;224(12). Epub 2021 Jun 18.

The University of Sydney, School of Life and Environmental Sciences, Camperdown, NSW 2006, Australia.

Transgenerational plasticity (TGP) has been identified as a critical mechanism of acclimation that may buffer marine organisms against climate change, yet whether the TGP response of marine organisms is altered depending on their habitat is unknown. Many marine organisms are found in intertidal zones where they experience episodes of emersion (air exposure) daily as the tide rises and recedes. During episodes of emersion, the accumulation of metabolic carbon dioxide (CO2) leads to hypercapnia for many species. Read More

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Physicians' perceptions of the factors influencing disclosure of secondary findings in tumour genomic profiling in Japan: a qualitative study.

Eur J Hum Genet 2021 Aug 16. Epub 2021 Aug 16.

Medical Ethics/Medical Genetics, School of Public Health, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Tumour genomic profiling (TGP), conducted in search of therapeutics, sometimes reveals potentially pathogenic germline variants as secondary findings (SFs). Physicians involved in TGP are often specialised in oncology and not in clinical genetics. To better utilise SFs, we explored issues physicians have during disclosure and the potential for collaborations with clinical genetics professionals. Read More

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Myopathic Cardiac Genotypes Increase Risk for Myocarditis.

JACC Basic Transl Sci 2021 Jul 26;6(7):584-592. Epub 2021 Jul 26.

The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac genes were found in 19 of 117 acute myocarditis cases vs 34 of 468 control subjects 0. Read More

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Oncologists' Perceptions of Tumor Genomic Profiling and the Communication of Test Results and Risks.

Public Health Genomics 2021 Jul 29:1-6. Epub 2021 Jul 29.

College of Public Health, Cancer Prevention and Control Program, Fox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania, USA.

Tumor genomic profiling (TGP) identifies genetic targets for precision cancer treatments. The complexity of TGP can expose gaps in oncologists' skills, complicating test interpretation and patient communication. Research on oncologists' use and perceptions of TGP could inform practice patterns and training needs. Read More

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Development of a distributive Three Gorges Project input-output model to investigate the disaggregated sectoral effects of Three Gorges Project.

Sci Total Environ 2021 Jul 1;797:148817. Epub 2021 Jul 1.

China State Grid Integrated Energy Planning and D&R Institute, 100032 Beijing, China; State Grid Integrated Energy Group Co.Ltd, Beijing 100032, China.

Research on the overall social, economic and environmental (SEE) impacts of water resources projects (WRP) has gradually attracted attention. However, the WRP-related indirect impacts as linked through various supply chains from a number of disaggregated sectors and their interactive relationship are rarely studied. Here in this study, under a general disaggregated input-output (IO) framework, a distributive Three Gorges Project input-output (DTGIO) model is developed to investigate the composite effects of Three Gorges Project (TGP) based on a disaggregated TGP-IO table for the Yangtze River economic belt (YREB). Read More

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Total Glucosides of Paeony Ameliorate Pristane-Induced Lupus Nephritis by Inducing PD-1 ligands Macrophages Activating IL-4/STAT6/PD-L2 Signaling.

Front Immunol 2021 5;12:683249. Epub 2021 Jul 5.

Section of Immunology & Joint Immunology Program, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.

Macrophages, a major subset of innate immune cells, are main infiltrating cells in the kidney in lupus nephritis. Macrophages with different phenotypes exert diverse or even opposite effects on the development of lupus nephritis. Substantial evidence has shown that macrophage M2 polarization is beneficial to individuals with chronic kidney disease. Read More

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Efficacy and safety of Tripterygium glycosides in Sjögren's syndrome treatment: evidence from 12 randomized controlled trials.

Ann Palliat Med 2021 Jul 5;10(7):8215-8231. Epub 2021 Jul 5.

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.

Background: Tripterygium glycosides (TGs) has been widely used in the treatment of Sjögren's syndrome (SS).

Methods: Seven databases, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Medical Database, China Science and Technology Journal Database, and the Chinese Biomedicine database, were selected to collect randomized controlled trials (RCTs) related to the treatment of SS with TGs alone or in combination. The participants, intervention, comparison, outcome, and study design principle were adopted for the inclusion of related studies. Read More

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Reversal of senescence-associated beta-galactosidase expression during in vitro three-dimensional tissue-engineering of human chondrocytes in a polymer scaffold.

Sci Rep 2021 Jul 7;11(1):14059. Epub 2021 Jul 7.

Centre for Advancing Clinical Research (CACR), University of Yamanashi-Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Regenerative medicine applications require cells that are not inflicted with senescence after in vitro culture for an optimal in vivo outcome. Methods to overcome replicative senescence include genomic modifications which have their own disadvantages. We have evaluated a three-dimensional (3D) thermo-reversible gelation polymer (TGP) matrix environment for its capabilities to reverse cellular senescence. Read More

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Genome Wide Prediction, Mapping and Development of Genomic Resources of Mastitis Associated Genes in Water Buffalo.

Front Vet Sci 2021 18;8:593871. Epub 2021 Jun 18.

Centre for Agricultural Bioinformatics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Statistics Research Institute, New Delhi, India.

Water buffalo () are an important animal resource that contributes milk, meat, leather, dairy products, and power for plowing and transport. However, mastitis, a bacterial disease affecting milk production and reproduction efficiency, is most prevalent in populations having intensive selection for higher milk yield, especially where the inbreeding level is also high. Climate change and poor hygiene management practices further complicate the issue. Read More

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Successful engraftment of epithelial cells derived from autologous rabbit buccal mucosal tissue, encapsulated in a polymer scaffold in a rabbit model of a urethral stricture, transplanted using the transurethral approach.

Regen Ther 2021 Dec 8;18:127-132. Epub 2021 Jun 8.

Center for Advancing Clinical Research (CACR), University of Yamanashi -Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Background: A pilot study reported an autologous buccal mucosal cell transplant in humans through the trans-urethral route using the buccal epithelium expanded and encapsulated in scaffold-hybrid approach to urethral stricture (BEES-HAUS), a minimally invasive approach to treat urethral stricture. Although successful outcomes were achieved in that study, for further validation, it is essential to prove that the transplanted buccal epithelium was engrafted over the urothelium through histological examination of the urethra, harvested post-transplant, which is infeasible in humans. Herein, we report the successful creation of an animal model of urethral stricture and the engraftment of epithelial cells derived from autologous buccal mucosal tissue, encapsulated in a thermo-reversible gelation polymer (TGP) scaffold, transplanted by trans-urethral route. Read More

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December 2021

A pharmacokinetics-pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats.

Pharm Biol 2021 Dec;59(1):769-777

Department of Pharmacy, College of Medicine, Jiaxing University, Jiaxing, China.

Context: Total Glucosides of Paeony (TGP) capsule possesses various hepatoprotective activities. No study is available concerning TGP's concentration-effect relationship on hepatoprotection.

Objective: To establish a pharmacokinetics-pharmacodynamics (PK-PD) modelling on TGP capsule's hepatoprotection after a single oral administration in hepatic injury rats. Read More

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December 2021

Transgenerational plasticity in the eye size of .

Biol Lett 2021 06 16;17(6):20210143. Epub 2021 Jun 16.

Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.

It is well established that environmental signals can induce phenotypic responses that persist for multiple generations. The induction of such 'transgenerational plasticity' (TGP) depends upon the ability of organisms to accurately receive and process information from environmental signals. Thus, sensory systems are likely intertwined with TGP. Read More

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Plasticity of cold hardiness in the eastern spruce budworm, Choristoneura fumiferana.

Comp Biochem Physiol A Mol Integr Physiol 2021 09 1;259:110998. Epub 2021 Jun 1.

Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address:

High latitude insect populations must cope with extreme conditions, particularly low temperatures. Insects use a variety of cold hardiness mechanisms to withstand this temperature stress, and these can drive geographic distributions through overwintering mortality. The degree of cold hardiness can be altered by two evolved responses: phenotypic plasticity and local adaptation. Read More

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September 2021

Total Glucosides of Paeony Inhibited Autophagy and Improved Acute Kidney Injury Induced by Ischemia-Reperfusion via the lncRNA TUG1/miR-29a/PTEN Axis.

Drug Des Devel Ther 2021 25;15:2229-2242. Epub 2021 May 25.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

Objective: Total glucosides of paeony (TGP) has been proven to affect anti-inflammatory, immunomodulatory and hypoxia tolerance. This study investigates the effect of TGP on autophagy in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R).

Methods: Rat model of AKI induced by I/R was established. Read More

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Integrated Analysis of Whole Genome and Epigenome Data Using Machine Learning Technology: Toward the Establishment of Precision Oncology.

Front Oncol 2021 12;11:666937. Epub 2021 May 12.

Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.

With the completion of the International Human Genome Project, we have entered what is known as the post-genome era, and efforts to apply genomic information to medicine have become more active. In particular, with the announcement of the Precision Medicine Initiative by U.S. Read More

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Total glucosides of Paeony restores intestinal barrier function through inhibiting Lyn/Snail signaling pathway in colitis mice.

Phytomedicine 2021 Jul 23;87:153590. Epub 2021 May 23.

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China. Electronic address:

Background: Inflammatory bowel disease (IBD) is an autoimmune disease. The pathogenesis of IBD is complicated and intestinal mucosal barrier damage is considered as the trigger factor for the initiation and recurrence of IBD. Total Glucosides of Paeony (TGP) has shown good inhibitory effects on immune-inflammation in clinic studies. Read More

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Transgenerational plasticity and the capacity to adapt to low salinity in the eastern oyster, .

Proc Biol Sci 2021 05 19;288(1951):20203118. Epub 2021 May 19.

Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.

Salinity conditions in oyster breeding grounds in the Gulf of Mexico are expected to drastically change due to increased precipitation from climate change and anthropogenic changes to local hydrology. We determined the capacity of the eastern oyster, , to adapt via standing genetic variation or acclimate through transgenerational plasticity (TGP). We outplanted oysters to either a low- or medium-salinity site in Louisiana for 2 years. Read More

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A latitudinal gradient in thermal transgenerational plasticity and a test of theory.

Proc Biol Sci 2021 05 12;288(1950):20210797. Epub 2021 May 12.

Department of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.

Transgenerational plasticity (TGP) occurs when phenotypes are shaped by the environment in both the current and preceding generations. Transgenerational responses to rainfall, CO and temperature suggest that TGP may play an important role in how species cope with climate change. However, little is known about how TGP will evolve as climate change continues. Read More

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Limited transgenerational effects of environmental temperatures on thermal performance of a cold-adapted salmonid.

Conserv Physiol 2021 24;9(1):coab021. Epub 2021 Apr 24.

Ontario Ministry of Natural Resources and Forestry, Trent University, Peterborough, Ontario K9L 0G2, Canada.

The capacity of ectotherms to cope with rising temperatures associated with climate change is a significant conservation concern as the rate of warming is likely too rapid to allow for adaptative responses in many populations. Transgenerational plasticity (TGP), if present, could potentially buffer some of the negative impacts of warming on future generations. We examined TGP in lake trout to assess their inter-generational potential to cope with anticipated warming. Read More

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Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes.

Skin Pharmacol Physiol 2021 6;34(4):183-193. Epub 2021 May 6.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Background: To understand the cumulative effect of topical formulations after medication, evaluate the therapeutic effect of microneedle-assisted (MN-assisted) paeoniflorin-loaded ethosomes (TGP-E), and explore the potential for deep penetration of drugs, this paper uses microdialysis to systematically study the percutaneous pharmacokinetics of TGP-E.

Methods: First, optical coherence tomography (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialysate were established. Read More

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Enhanced miRNA-140 expression of osteoarthritis-affected human chondrocytes cultured in a polymer based three-dimensional (3D) matrix.

Life Sci 2021 Aug 29;278:119553. Epub 2021 Apr 29.

The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Chennai 600034, Tamil Nadu, India; JBM Inc., 3-1-14, Higashi Koiwa, Edogawa, Tokyo 133-0052, Japan; University of Yamanashi -Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi 409-3898, Japan; GN Corporation Co. Ltd., 3-8, Wakamatsu, Kofu, Yamanashi 400-0866, Japan. Electronic address:

Aims: We have evaluated the potential of a three-dimensional (3D) thermoreversible gelation polymer (TGP) matrix in enhancing miRNA 140 expression (a biomarker correlating with homeostasis and cartilage regeneration) during the in vitro expansion of osteoarthritis (OA)-affected human chondrocytes.

Materials And Methods: OA-chondrocytes were cultured in two-dimensional (2D) monolayer followed by culture in 3D-TGP. miRNA 140 expression levels in cell culture supernatant followed by expression in the cell lysate of both 2D and 3D-TGP cultures were analyzed. Read More

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Landscape change patterns at three stages of the construction and operation of the TGP.

Sci Rep 2021 04 29;11(1):9288. Epub 2021 Apr 29.

The Research Center of Jinsha River Culture, School of Geographic Science and Tourism, Zhaotong University, Yunnan, 657000, China.

Analyses of landscape change patterns that are based on elevation and slope can not only provide reasonable interpretations of landscape patterns but can also help to reveal evolutionary laws. However, landscape change patterns and their model in different landforms of the typical watershed in the Three Gorges Reservoir Area (TGRA) has not been quantified and assessed effectively. As a complex geographical unit, the ecological environment in the middle reach of the Yangtze River has experienced great changes due to the construction of the Three Gorges Project (TGP) and its associated human activities. Read More

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Physicochemical Properties and Effects of Fruit Pulps from the Amazon Biome on Physiological Parameters in Rats.

Nutrients 2021 Apr 28;13(5). Epub 2021 Apr 28.

Department of Engineering and Food Technology, São Paulo State University, R. Cristóvão Colombo, 2265-Jardim Nazareth, 15054-000 São José do Rio Preto, Brazil.

This study aimed to analyze the physicochemical characteristics and the effects of Amazonian pulp fruits consumption, such as araçá-boi (), abiu grande (), araticum (), biri-biri ( L.), and yellow mangosteen (), on hematologic, metabolic, renal, and hepatic function parameters in Wistar rats ( = 10 rats/group). The pulp of abiu had the highest levels of soluble solids, sugars, and pH. Read More

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Ultrasound Echogenicity of Papillary Thyroid Cancer Is Affected by Tumor Growth Patterns and Tumor Fibrosis.

In Vivo 2021 May-Jun;35(3):1633-1640

Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine and Biomedical Research Institute, Busan, Republic of Korea

Background/aim: The association between preoperative ultrasound (US) echogenicity and histopathological characteristics of papillary thyroid cancer (PTC) has been rarely investigated is not well characterized. This study evaluated a relationship between the clinical characteristics of PTC, histopathological phenomena including tumor growth patterns (TGPs) and tumor fibrosis (TF), and US echogenicity.

Patients And Methods: In total, 170 patients with PTC (<2 cm) underwent total thyroidectomy with central neck dissection. Read More

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Cross-generational response of a tropical sea urchin to global change and a selection event in a 43-month mesocosm study.

Glob Chang Biol 2021 08 28;27(15):3448-3462. Epub 2021 May 28.

Department of Marine Science, University of Otago, Dunedin, New Zealand.

Long-term experimental investigations of transgenerational plasticity (TGP) and transgenerational acclimatization to global change are sparse in marine invertebrates. Here, we test the effect of ocean warming and acidification over a 25-month period of Echinometra sp. A sea urchins whose parents were acclimatized at ambient or one of two near-future (projected mid and end of the 21st century) climate scenarios for 18 months. Read More

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HIV and STI positivity rates among transgender people attending two large STI clinics in the Netherlands.

Sex Transm Infect 2021 Apr 19. Epub 2021 Apr 19.

Department of informatics, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Background: Global data show that transgender people (TGP) are disproportionally affected by HIV and sexually transmitted infections (STIs); however, data are scarce for Western European countries. We assessed gender identities, sexual behaviour, HIV prevalence and STI positivity rates, and compared these outcomes between TGP who reported sex work and those who did not.

Methods: We retrospectively retrieved data from all TGP who were tested at the STI clinics of Amsterdam and The Hague, the Netherlands in 2017-2018. Read More

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