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Exercise Testing in Idiopathic Pulmonary Fibrosis: Expanding Our Options.

Respiration 2021 Apr 13:1-3. Epub 2021 Apr 13.

First Academic Department of Pneumonology, Medical School, National and Kapodistrian University of Athens, and Athens Medical Center, Athens, Greece.

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Hollow Fiber and Nanofiber Membranes in Bioartificial Liver and Neuronal Tissue Engineering.

Cells Tissues Organs 2021 Apr 13:1-30. Epub 2021 Apr 13.

Institute on Membrane Technology, National Research Council of Italy, CNR-ITM, Rende, Italy.

To date, the creation of biomimetic devices for the regeneration and repair of injured or diseased tissues and organs remains a crucial challenge in tissue engineering. Membrane technology offers advanced approaches to realize multifunctional tools with permissive environments well-controlled at molecular level for the development of functional tissues and organs. Membranes in fiber configuration with precisely controlled, tunable topography, and physical, biochemical, and mechanical cues, can direct and control the function of different kinds of cells toward the recovery from disorders and injuries. Read More

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Development of a Checklist Tool to Assess the Quality of Skin Lesion Images Acquired by Consumers Using Sequential Mobile Teledermoscopy.

Dermatology 2021 Apr 13:1-8. Epub 2021 Apr 13.

Centre of Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Background: Mobile teledermoscopy is an emerging technology that involves imaging and digitally sending dermoscopic images of skin lesions to a clinician for assessment. High-quality, consistent images are required for accurate telediagnoses when monitoring lesions over time. To date there are no tools to assess the quality of sequential images taken by consumers using mobile teledermoscopy. Read More

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Auditory stimulus-response modeling with a Match-Mismatch task.

J Neural Eng 2021 Apr 13. Epub 2021 Apr 13.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Kettegard Allé 30, Hvidovre, DK-2650, DENMARK.

An auditory stimulus can be related to the brain response that it evokes by a stimulus-response model fit to the data. This offers insight into perceptual processes within the brain and is also of potential use for devices such as Brain Computer Interfaces (BCI). The quality of the model can be quantified by measuring the fit with a regression problem, or by applying it to a classification task and measuring its performance. Read More

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MoS2/WSe2 Nanohybrids for flexible paper-based photodetectors.

Nanotechnology 2021 Apr 13. Epub 2021 Apr 13.

Department of Physics, Charotar University of Science and Technology, Changa, Anand, 388 421, changa, INDIA.

Flexible photodetectors functionalised by transition metal dichalcogenides have captivated intensive attention due their excellent photo-harvesting efficiency. However, field of opto-electronics still needs advancement in production of large area, broad band and flexible photodetectors. Herein, we reported the flexible, stable, broad band and fast photodetector based on MoS2/WSe2 heterostructure on ordinary photocopy paper with pencil drawn graphite electrodes. Read More

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Examining the acceptance of an integrated Electronic Health Records system: Insights from a repeated cross-sectional design.

Int J Med Inform 2021 Mar 31;150:104450. Epub 2021 Mar 31.

Faculty of Business Economics, Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium. Electronic address:

Background And Purpose: Hospital staff's acceptance of an integrated Electronic Health Records system (EHR) is a critical success factor to exploit the benefits EHRs can offer. This study employs a repeated cross-sectional design to differentiate between the enablers and barriers of EHR acceptance prior to EHR implementation and those that arise over time by testing a theoretical model specifically tailored to the EHR context.

Methods: A repeated cross-sectional design, consisting of one measurement of staff's acceptance before and two after EHR implementation, was employed in a Belgian hospital. Read More

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Effect of movement speed on lower and upper body biomechanics during sit-to-stand-to-sit transfers: Self-selected speed vs. fast imposed speed.

Hum Mov Sci 2021 Apr 10;77:102797. Epub 2021 Apr 10.

Department of Orthopaedic Surgery, University of Arkansas for Medical Science, Little Rock, AR, USA; Mechanical and Biomedical Engineering Department, Boise State University, Boise, ID, USA.

Preferred and fast speed sit-to-stand and stand-to-sit (STS) tests are prevalent in literature, but biomechanical changes between the different speeds of STS have never been studied. Understanding differences between these STS techniques will better inform experimental design for research assessing functional ability in clinical populations. The purpose of this study was to investigate the effect of different speeds of STS transfers on lower body and trunk kinematics and kinetics in healthy adults. Read More

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Early prediction keys for COVID-19 cases progression: A meta-analysis.

J Infect Public Health 2021 Mar 5;14(5):561-569. Epub 2021 Mar 5.

Department of Pathology, College of Medicine, Qassim University, Buraidah, Qassim, Saudi Arabia.

BACKGROUNDː: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), within few months of being declared as a global pandemic by WHO, the number of confirmed cases has been over 75 million and over 1.6 million deaths since the start of the Pandemic and still counting, there is no consensus on factors that predict COVID-19 case progression despite the diversity of studies that reported sporadic laboratory predictive values predicting severe progression. We review different biomarkers to systematically analyzed these values to evaluate whether are they are correlated with the severity of COVID-19 disease and so their ability to be a predictor for progression. Read More

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Effectiveness of patient-targeted interventions to inform decision making and improve uptake of colorectal cancer genetic evaluation for at-risk individuals: A systematic review.

Int J Nurs Stud 2021 Mar 20;118:103928. Epub 2021 Mar 20.

Basic Nursing Department, School of Nursing, Jilin University, 965 Xinjiang Street, Changchun, Jilin 130021, China. Electronic address:

Background: Inherited colorectal cancer syndromes increase the risk of contracting colorectal and other cancers. International guidelines recommend the identification of individuals with hereditary colorectal cancer and the supervision of asymptomatic individuals with a family history. However, detection of hereditary colorectal cancer is suboptimal. Read More

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Doping control analysis of small peptides: A decade of progress.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jan 15;1173:122551. Epub 2021 Jan 15.

Department of Diagnostic Sciences, Doping Control Laboratory, Ghent University, Zwijnaarde, Belgium.

Small peptides are handled in the field of sports drug testing analysis as a separate group doping substances. It is a diverse group, which includes but is not limited to growth hormone releasing-factors and gonadotropin-releasing hormone analogues. Significant progress has been achieved during the past decade in the doping control analysis of these peptides. Read More

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January 2021

Microbiome and colorectal cancer: A review of the past, present, and future.

Surg Oncol 2021 Apr 3;37:101560. Epub 2021 Apr 3.

Department of Surgical Oncology, Helen F. Graham Cancer Center, ChristianaCare, Newark, DE, USA.

The gastrointestinal tract is home to diverse and abundant microorganisms, collectively referred to as the microbiome. This ecosystem typically contains trillions of microbial cells that play an important role in regulation of human health. The microbiome has been implicated in host immunity, nutrient absorption, digestion, and metabolism. Read More

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Immediate effects of myofascial release on neuromechanical characteristics in female and male patients with low back pain and healthy controls as assessed by tensiomyography. A controlled matched-pair study.

Clin Biomech (Bristol, Avon) 2021 Apr 5;84:105351. Epub 2021 Apr 5.

Department of Physical Therapy, Faculty of Health Sciences, University of Malaga, Malaga, Spain. Electronic address:

Background: Low back pain (LBP) is a major health issue in most industrialised countries. Lumbodorsal fascia has been advocated as a potential source of pain in the lumbopelvic region. Myofascial release constitutes a manual therapeutic approach focussing on the restoration of altered soft tissue function. Read More

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Olfaction and anosmia: From ancient times to COVID-19.

J Neurol Sci 2021 Apr 3;425:117433. Epub 2021 Apr 3.

Department of Neurology (Nerve-Muscle Unit), University Hospital of Bordeaux (CHU Bordeaux), Pellegrin Hospital, 1 place Amélie Raba-Léon, 33076 Bordeaux, France; Grand Sud-Ouest' National Reference Center for neuromuscular disorders, University Hospital of Bordeaux (CHU Bordeaux), Pellegrin Hospital, 1 place Amélie Raba-Léon, 33076 Bordeaux, France.

Olfaction, one of our five main qualitative sensory abilities, is the action of smelling or the capacity to smell. Olfactory impairment can be a sign of a medical problem, from a benign nasal/sinus problem up to a potentially serious brain injury. However, although clinicians (neurologists or not) usually test the olfactory nerves in specific clinical situations (for example, when a neurodegenerative disorder is suspected), they may omit such tests in many other situations. Read More

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Variability and Power to Detect Progression of Different Visual Field Patterns.

Ophthalmol Glaucoma 2021 Apr 10. Epub 2021 Apr 10.

Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY. Electronic address:

Purpose: To compare the variability and ability to detect visual field progression of 24-2, central 12 locations of the 24-2 and 10-2 visual field (VF) tests in eyes with abnormal VFs.

Design: Retrospective, multisite cohort.

Participants: A total of 52,806 24-2 and 11,966 10-2 VF tests from 7,307 eyes from the Glaucoma Research Network database were analyzed. Read More

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A sequence-based prediction of Kruppel-like factors proteins using XGBoost and optimized features.

Gene 2021 Apr 10:145643. Epub 2021 Apr 10.

Faculty of Applied Sciences, Ton Duc Thang University, No.19 Nguyen Huu Tho Street, Tan Hung Ward, District 7, Ho Chi Minh City, Vietnam.

Krüppel-like factors (KLF) refer to a group of conserved zinc finger-containing transcription factors that are involved in various physiological and biological processes, including cell proliferation, differentiation, development, and apoptosis. Some bioinformatics methods such as sequence similarity searches, multiple sequence alignment, phylogenetic reconstruction, and gene synteny analysis have also been proposed to broaden our knowledge of KLF proteins. In this study, we proposed a novel computational approach by using machine learning on features calculated from primary sequences. Read More

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Parkinson's disease.

Lancet 2021 Apr 9. Epub 2021 Apr 9.

Institute of Neurogenetics and Department of Neurology, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany.

Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause. In most populations, 3-5% of Parkinson's disease is explained by genetic causes linked to known Parkinson's disease genes, thus representing monogenic Parkinson's disease, whereas 90 genetic risk variants collectively explain 16-36% of the heritable risk of non-monogenic Parkinson's disease. Read More

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The Emergence and Global Spread of Noninvasive Prenatal Testing.

Annu Rev Genomics Hum Genet 2021 Apr 13. Epub 2021 Apr 13.

Department of Sociology and Anthropology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; email:

Since its introduction in 2011, noninvasive prenatal testing (NIPT) has spread rapidly around the world. It carries numerous benefits but also raises challenges, often related to sociocultural, legal, and economic contexts. This article describes the implementation of NIPT in nine countries, each with its own unique characteristics: Australia, Canada, China and Hong Kong, India, Israel, Lebanon, the Netherlands, the United Kingdom, and the United States. Read More

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Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties.

Int J Cosmet Sci 2021 Apr 13. Epub 2021 Apr 13.

Pierre Fabre Dermo-cosmétique, Centre R&D Pierre Fabre, Innovation et Développement Pharmacologie, Avenue Hubert Curien, Cedex 01, 31025, Toulouse, France.

Objective: We investigated the dermal bioavailability and antioxidative properties of a sunscreen formulation containing two antioxidants, oxothiazolidine (OTZ) and δ-tocopheryl glucoside (DTG). OTZ reacts directly with reactive oxygen species to form taurine, while DTG is metabolized in δ-tocopherol to achieve antioxidative activities.

Methods: After topical application to a hair follicle-derived reconstructed human epidermis (RHE) model, followed by solar-simulated radiation, kinetics of bioavailability and antioxidative responses were measured over 24 h. Read More

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Prenatal chromosome microarray: 'The UK experience'. A survey of reporting practices in UK genetic services (2012-2019).

Prenat Diagn 2021 Apr 2. Epub 2021 Apr 2.

West of Scotland Centre for Genomic Medicine, Laboratory Medicine Building, QEUH, Glasgow, UK.

Background: The value of chromosome microarray (CMA) in the prenatal detection of significant chromosome anomalies is well-established. To guide the introduction of this technique in routine clinical practice, the Joint Committee on Genomics in Medicine developed national UK guidelines for reporting prenatal CMA in 2015.

Objective: To evaluate the UK experience of utilising prenatal CMA. Read More

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Atelectasis in Primary Graft Dysfunction Survivors after Lung Transplantation.

Clin Transplant 2021 Apr 13:e14315. Epub 2021 Apr 13.

Department of Medicine, University of Alberta, Edmonton, Canada.

Background: Primary graft dysfunction (PGD) is an important contributor to early mortality in lung transplant recipients and is associated with impaired lung function. The radiographic sequelae of PGD on computed tomography (CT) have not been characterized.

Methods: We studied adult double lung transplant recipients from 2010-2016 for whom protocol 3-month post-transplant CT scans were available. Read More

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Validation of the VIRSeek SARS-CoV-2 Mplex assay for Detection of SARS-CoV-2 on Stainless Steel surfaces: AOAC Performance Tested MethodSM 122006.

J AOAC Int 2021 Apr 12. Epub 2021 Apr 12.

Viracor Eurofins, 1001 NW Technology Drive, Lee's Summit, MO 64086, USA.

Background: The Eurofins GeneScan Technologies' VIRSeek SARS-CoV-2 Mplex kit is a RT-qPCR assay for the detection of two targets on the N-gene (nucleocapsid) of SARS-CoV-2. An extraction control, that allows monitoring of the extraction procedure and PCR inhibition, is included.

Objective: In-silico analysis and wet testing showed inclusivity and exclusivity of the assay. Read More

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The relationship between trauma exposure and adult tobacco use: Analysis of the National Epidemiologic Survey on Alcohol and Related Conditions (III).

Nicotine Tob Res 2021 Apr 13. Epub 2021 Apr 13.

Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD.

Introduction: Previous research has examined cigarette smoking in trauma exposed populations. However, the relationships between trauma exposure and use of other tobacco products (e.g. Read More

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Multiplexing Mutation Rate Assessment: Determining Pathogenicity of Msh2 Variants in S. cerevisiae.

Genetics 2021 Apr 12. Epub 2021 Apr 12.

Genome Sciences Department, University of Washington, Seattle, WA 98195, USA.

Despite the fundamental importance of mutation rate as a driving force in evolution and disease risk, common methods to assay mutation rate are time consuming and tedious. Established methods such as fluctuation tests and mutation accumulation experiments are low-throughput and often require significant optimization to ensure accuracy. We established a new method to determine the mutation rate of many strains simultaneously by tracking mutation events in a chemostat continuous culture device and applying deep sequencing to link mutations to alleles of a DNA-repair gene. Read More

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Comparison of the disinfecting effect of sodium hypochlorite aqueous solution and surfactant on hospital kitchen hygiene using adenosine triphosphate swab testing.

PLoS One 2021 13;16(4):e0249796. Epub 2021 Apr 13.

Dietary Department, Shizuoka Cancer Centre, Shizuoka, Japan.

The Japanese Ministry of Health requires large-scale cooking facilities to use sodium hypochlorite aqueous solution (HYP) on food preparation tools, equipment, and facilities to prevent secondary contamination. This study aimed to compare the disinfecting effect of HYP and surfactant using adenosine triphosphate (ATP) swab testing on large-scale equipment and facilities that could not be disassembled and disinfected in hospital kitchen. From May 2018 to July 2018, ATP swab tests were performed on the following six locations in the Shizuoka Cancer Centre Dietary Department Kitchen: cooking counter, mobile cooking counter, refrigerator handle, conveyor belt, tap handle, and sink. Read More

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Serological test performance for bovine tuberculosis in cattle from herds with evidence of on-going infection in Northern Ireland.

PLoS One 2021 13;16(4):e0245655. Epub 2021 Apr 13.

Veterinary Sciences Division, Agri-Food and Biosciences Institute, Stormont, Belfast, Northern Ireland.

The ability to accurately identify infected hosts is the cornerstone of effective disease control and eradication programs. In the case of bovine tuberculosis, accurately identifying infected individual animals has been challenging as all available tests exhibit limited discriminatory ability. Here we assess the utility of two serological tests (IDEXX Mycobacterium bovis Ab test and Enfer multiplex antibody assay) and assess their performance relative to skin test (Single Intradermal Comparative Cervical Tuberculin; SICCT), gamma-interferon (IFNγ) and post-mortem results in a Northern Ireland setting. Read More

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Low risk of SARS-CoV-2 in blood transfusion.

PLoS One 2021 13;16(4):e0249069. Epub 2021 Apr 13.

Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), continues to remain a global challenge. There is emerging evidence of SARS-CoV-2 virus found in the blood of patients from China and some developed countries. However, there is inadequate data reported in Ghana and other parts of Africa, where blood transfusion service heavily relies on voluntary and replacement blood donors. Read More

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United States Chronic Thromboembolic Pulmonary Hypertension Registry: Protocol Design.

JMIR Res Protoc 2021 Apr 13. Epub 2021 Apr 13.

Temple University Hospital, Philadelphia, US.

Background: Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare sequela of acute pulmonary embolism that is treatable when recognized. Awareness of this disease has increased with recent advancements in therapeutic options, but delays in diagnosis remain common and diagnostic and treatment guidelines are often not followed. Data gathered from international registries has improved our understanding of CTEPH, but this data may not be applicable to the U. Read More

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Attention-based LSTM for Non-Contact Sleep Stage Classification using IR-UWB radar.

IEEE J Biomed Health Inform 2021 Apr 13;PP. Epub 2021 Apr 13.

Manual scoring of sleep stages from polysomnography (PSG) records is essential to understand the sleep quality and architecture. Since the PSG requires specialized personnel, a lab environment, and uncomfortable sensors, non-contact sleep staging methods based on machine learning techniques have been investigated over the past years. In this study, we propose an attention-based bidirectional long short-term memory (Attention Bi-LSTM) model for automatic sleep stage scoring using an impulse-radio ultra-wideband (IR-UWB) radar which can remotely detect vital signs. Read More

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Investigating the effects of Citrullus colocynthis on cognitive performance and anxiety-like behaviors in STZ-induced diabetic rats.

Int J Neurosci 2021 Apr 13:1-18. Epub 2021 Apr 13.

Student Research Committee, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Diabetes can impair cognitive performance and lead to dementia. Patients with type 1 diabetes mellitus (T1DM) are reported with different levels of cognitive dysfunctions in various cognitive domains ranging from general intellectual testing to specific deficits with visuospatial abilities, motor speed, writing, attention, reading, and psychomotor efficiency. The present study aimed to investigate the effect of cognitive functions. Read More

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Bleeding and Thrombotic Adverse Events in Hospitalized Patients Under Empiric Treatment for Suspected Heparin-Induced Thrombocytopenia While Awaiting Confirmatory Testing.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621996473

Hematology, 23217Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Empiric management in suspected heparin-induced thrombocytopenia (HIT) is challenging due to imperfect prediction models, latency while awaiting test results and risks of empiric therapies. When there is high clinical suspicion for HIT, cessation of heparin and empiric non-heparin anticoagulation with FDA-approved argatroban is recommended. Alternatively off-label fondaparinux or watchful waiting have been utilized in clinical practice. Read More

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