Am J Surg Pathol 2021 Mar 22. Epub 2021 Mar 22.
*Department of Pathology and Laboratory Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto †Department of Pathology, Stanford Medical Center, Stanford, CA ‡Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH §Department of Pathology, Indiana University School of Medicine, Indianapolis, IN.
Sex cord-stromal tumors (SCSTs) account for the second most common category of testicular neoplasms and include several entities that may show overlapping morphologies and present diagnostic challenges. We analyzed a cohort of 120 testicular SCSTs and investigated the diagnostic utility of SRY-box transcription factor 9 (SOX9), forkhead box protein L2 (FOXL2), and steroidogenic factor 1 (SF-1) immunohistochemical stains. The results were compared with the more commonly used SCST markers, inhibin α, calretinin, and Wilms' tumor 1 (WT1). Read More