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Sorptive and microbial riddance of micro-pollutant ibuprofen from contaminated water: A state of the art review.

Sci Total Environ 2021 May 1;786:147327. Epub 2021 May 1.

Department of Chemical Engineering, National Institute of Technology Durgapur, India. Electronic address:

Continuous discharge of ibuprofen, a pharmaceutical compound in local water systems is becoming a budding concern as seen from data procured from the past few decades. Increased concentrations of the compound in water reservoirs resulted in adverse effects on the environment. In order to prevent the deleterious impacts of increasing ibuprofen concentration in water bodies, application of cost effective and energy efficient elimination of ibuprofen (IBP) is needed. Read More

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Diarrheagenic Escherichia coli pathotypes isolated from a swine farm in a region of Morelos state, Mexico.

Salud Publica Mex 2020 Dec 22;63(1, ene-feb):34-41. Epub 2020 Dec 22.

Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, Mexico..

Objective: Determine the frequency of diarrheagenic Escherichia coli pathotypes colonizing swine.

Materials And Methods: E. coli strains isolated of fecal samples from 280 swine, produced for local consumption, in a semi-technical farm of Morelos state, (central Mexico) were tested to identify the diarrheagenic E. Read More

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December 2020

Does atorvastatin therapy change the anti-Xa activity in xabans-treated patients with atrial fibrillation?

Pharmacol Res Perspect 2021 May;9(3):e00730

Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic.

Atorvastatin and direct oral factor Xa inhibitors (xabans) are frequently co-administrated in patients with atrial fibrillation (AF). However, no studies investigating the possibility of the pharmacologic interaction between these agents have been conducted. The aim of this prospective observational study was to determine the impact of atorvastatin therapy on anti-Xa activity in xabans-treated patients with AF. Read More

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SARS-CoV-2 antibody immunoassays in serial samples reveal earlier seroconversion in acutely ill COVID-19 patients developing ARDS.

PLoS One 2021 13;16(5):e0251587. Epub 2021 May 13.

Institute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany.

Objectives: During the COVID-19 pandemic, SARS-CoV-2 antibody testing has been suggested for (1) screening populations for disease prevalence, (2) diagnostics, and (3) guiding therapeutic applications. Here, we conducted a detailed clinical evaluation of four Anti-SARS-CoV-2 immunoassays in samples from acutely ill COVID-19 patients and in two negative cohorts.

Methods: 443 serum specimens from serial sampling of 29 COVID-19 patients were used to determine clinical sensitivities. Read More

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Effectiveness of thermal screening in detection of COVID-19 among truck drivers at Mutukula Land Point of Entry, Uganda.

PLoS One 2021 13;16(5):e0251150. Epub 2021 May 13.

Department of National Health Laboratory and Diagnostic Services, Ministry of Health, Kampala, Uganda.

Introduction: Despite the limited evidence for its effectiveness, thermal screening at points of entry has increasingly become a standard protocol in numerous parts of the globe in response to the COVID-19 pandemic. We sought to determine the effectiveness of thermal screening as a key step in diagnosing COVID-19 in a resource-limited setting.

Materials And Methods: This was a retrospective cross-sectional study based on a review of body temperature and Xpert Xpress SARS CoV-2 test results records for truck drivers entering Uganda through Mutukula between 15th May and 30th July 2020. Read More

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Influence of pregabalin maintenance on cannabis effects and related behaviors in daily cannabis users.

Exp Clin Psychopharmacol 2021 May 13. Epub 2021 May 13.

Department of Biostatistics.

No medications are approved for cannabis use disorder (CUD), though a small clinical trial demonstrated that the voltage-dependent calcium channel (VDCC) ligand gabapentin reduced cannabis use in treatment seekers. VDCCs are modulated by cannabinoid (CB) ligands, and there are shared effects between CB agonists and VDCC ligands. This overlapping neuropharmacology and the initial clinical results supported the evaluation of pregabalin, a "next-generation" VDCC ligand, as a CUD medication. Read More

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Parechovirus Infection in Early Childhood and Association With Subsequent Celiac Disease.

Am J Gastroenterol 2021 Apr;116(4):788-795

1Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway; 2Department of Paediatric, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic; 3Department of Pediatrics, Østfold Hospital Trust, Grålum, Norway; 4Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg and Queen Silvia Children's Hospital, Gothenburg, Sweden; 5Division of Institute Resources, Department of IT and e-health, Norwegian Institute of Public Health, Oslo, Norway; 6Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.

Introduction: To test whether parechovirus and anellovirus, frequent enteric viruses, were associated with subsequent celiac disease (CD). We hypothesized that children who later developed CD would have increased frequency of parechovirus infections before transglutaminase 2 (TG2) antibody development. Anellovirus testing was exploratory, as a potential marker of immune status. Read More

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One-Pot Synthesis of Fluorescent Nitrogen and Sulfur-Carbon Quantum Dots as a Sensitive Nanosensor for Trimetazidine Determination.

Luminescence 2021 May 13. Epub 2021 May 13.

Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Egypt.

A water-soluble and highly stable N,S-doped CQDs (N,S-CQDs) have been synthesized by a low-cost strategy using citric acid (CA) and thiosemicarbazide (TSC) in one-step as a fluorescent nanosensor. The achieved N, S-CQDs have strong emission at 446 nm upon excitation at 370 nm and a high quantum yield of 58.5%. Read More

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An ex vivo biomechanical comparison of two suture materials and two pattern combinations for equine superficial digital flexor tendon tenorrhaphy.

Vet Surg 2021 May 13. Epub 2021 May 13.

Weipers Centre Equine Hospital, School of Veterinary Medicine, University of Glasgow, Glasgow, UK.

Objective: To compare biomechanical characteristics of three-loop pulley (3LP) pattern versus Bunnell technique (BT) using polydioxanone (PDS) suture; to determine the influence of polyester tape (PT) versus PDS on the BT for equine superficial digital flexor tendon (SDFT) tenorrhaphy; to compare BT with PT versus 3LP with PDS.

Study Design: Ex vivo biomechanical study.

Sample Population: Forty equine forelimb SDFT. Read More

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Dynamic evaluation of swallowing in pediatric patients with dysphagia: The Brazilian perspective.

Anat Rec (Hoboken) 2021 May 12. Epub 2021 May 12.

Department of Diagnostic Imaging, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil.

Dynamic Evaluation of Swallowing (DES) is an exam which provides invaluable information on the swallowing function. This review describes the requirements, protocols and processes for DES in regions of Brazil. Dysphagia is a swallowing abnormality, in one or more swallowing phases, with risk and/or occurrence of aspiration, damage regarding nutrition and/or hydration and possible need of nonoral feeding methods. Read More

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Maternal Dietary Intake of Total Fat, Saturated Fat, and Added Sugar Is Associated with Infant Adiposity and Weight Status at 6 mo of Age.

J Nutr 2021 May 12. Epub 2021 May 12.

School of Public Health, University of Minnesota-Twin Cities, Minneapolis, MN, USA.

Background: Whether current dietary guidelines are appropriate for pregnancy and lactation has not been well studied. Many women of reproductive age are not meeting recommendations for dietary components such as fat, added sugar, and fiber.

Objectives: To assess associations between maternal dietary components during pregnancy and lactation and infant growth and adiposity at 6 mo of age. Read More

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Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models.

Surg Open Sci 2019 Oct 3;1(2):56-63. Epub 2019 Jul 3.

Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612.

Background: Auranofin, a Food and Drug Administration-approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for pancreatic cancer. We hypothesize that auranofin may prevent pancreatic ductal adenocarcinoma progression by inhibition of Txnrd1 and HIF-1α.

Methods: sensitivity of human pancreatic ductal adenocarcinoma cell lines was determined based on IC50. Read More

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October 2019

The Prevalence of in Hard Ticks in Europe and Their Role in Q Fever Transmission Revisited-A Systematic Review.

Front Vet Sci 2021 26;8:655715. Epub 2021 Apr 26.

Institute of Bacterial Infections and Zoonoses (IBIZ), Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, Jena, Germany.

The zoonosis Q fever is caused by the obligate intracellular bacterium . Besides the main transmission route inhalation of contaminated aerosols, ticks are discussed as vectors since the first isolation of the pathogen from a tick. The rare detection of in ticks and the difficult differentiation of from -like endosymbionts (CLEs) are questioning the relevance of ticks in the epidemiology of Q fever. Read More

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Evaluation of 24-h screen deployments as a standardized platform to monitor Gambierdiscus populations in the Florida Keys and U.S. Virgin Islands.

Harmful Algae 2021 Mar 13;103:101998. Epub 2021 Feb 13.

Biology Department, MS #32, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.

Anchored mesh screens have been suggested as a standardized approach to monitor the cell abundances of epiphytic dinoflagellates in benthic habitats, including toxigenic members of the Gambierdiscus genus responsible for ciguatera poisoning (CP). Here we deployed screens for 24h at eight sites in the Florida Keys and St. Thomas (US Virgin Islands) to evaluate their performance relative to the traditional method of assessing Gambierdiscus abundance in which cell counts are normalized to wet weight of host algae. Read More

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Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.

BMC Cancer 2021 May 12;21(1):541. Epub 2021 May 12.

Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, Saint Louis, MO, 63110, USA.

Background: EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. It was recently demonstrated that EpCAM contains a thyroglobulin type-1 (TY-1) domain. Read More

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Influence of the Head Neck Position on Imaging Measurements Used to Assess the Craniovertebral Junction in Small Breed Dogs: A Cadaveric Study.

Vet Comp Orthop Traumatol 2021 May 12. Epub 2021 May 12.

Department of Clinical Veterinary Medicine, Clinical Radiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Objective:  The study aimed to determine the influence of head neck position on imaging measurements used to assess the craniovertebral junction (CVJ) and to recommend the most appropriate position for the evaluation of the CVJ.

Study Design:  A cross-sectional sample of adult dogs' cadavers was subjected to a computed tomography scan of the cranium and the cranial cervical region in three standardized head positions. Imaging measurements often used to assess the CVJ were measured. Read More

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Gender stigma awareness is associated with adolescent risky health behaviors.

PLoS One 2021 12;16(5):e0251332. Epub 2021 May 12.

Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.

Objectives: Although racial stigma in school is associated with adolescent risky health behaviors, there are no studies investigating how gender stigma relates to adolescent risky health behaviors among low-income, minority youth. We sought to determine whether gender stigma awareness is associated with adolescent risky health behaviors (delinquency, fighting, and substance use) and whether this association is mediated by school disengagement (low perceived teacher support, low school engagement, cutting classes, and breaking school rules) among low-income, minority students.

Methods: We analyzed cross-sectional survey data, collected from 2017 to 2019, from 412 high school students. Read More

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Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study.

PLoS One 2021 12;16(5):e0251376. Epub 2021 May 12.

Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut, United States of America.

Importance: False negative SARS-CoV-2 tests can lead to spread of infection in the inpatient setting to other patients and healthcare workers. However, the population of patients with COVID who are admitted with false negative testing is unstudied.

Objective: To characterize and develop a model to predict true SARS-CoV-2 infection among patients who initially test negative for COVID by PCR. Read More

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Detection of Extended-Spectrum Beta-Lactamase-Producing and Carbapenem-Resistant Bacteria from Mink Feces and Feed in the United States.

Foodborne Pathog Dis 2021 May 11:1-10. Epub 2021 May 11.

Utah Water Research Laboratory, Department of Civil and Environmental Engineering, Utah State University, Logan, Utah, USA.

Antibiotic-resistant infections caused by extended-spectrum β-lactamases (ESBLs) and carbapenemases are increasing worldwide. Bacteria resistant to extended-spectrum cephalosporins and last resort carbapenems have been reported from food animals and their environments. Other concentrated nonfood-producing animals such as mink farming can be a reservoir of bacteria resistant to these critically important antibiotics. Read More

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Antielastase Activity of Macassar Kernels ( Stem Extract and Skin Elasticity Evaluation of Its Topical Gel Formulation.

Adv Pharmacol Pharm Sci 2021 21;2021:6690029. Epub 2021 Apr 21.

Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.

Background: Macassar kernels ( L.) has potential as an antiaging agent as it has antielastase activity, especially its stem extract which has best percent inhibition compared to its leaves and fruit extract. Moreover, the antiaging agent can be commonly used in the form of gel for topical applications. Read More

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A novel Tick Carousel Assay for testing efficacy of repellents on

PeerJ 2021 21;9:e11138. Epub 2021 Apr 21.

Department of Biology, New Mexico State University, Las Cruces, NM, United States of America.

Ticks are important vectors of human and veterinary diseases. A primary way ticks gain access to human hosts is by engaging to clothing. Repellents or acaricides sprayed onto fabric are used to deter ticks' access to human hosts. Read More

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Mycelial compatibility, anastomosis, and nucleus numbers of eight Mexican strains isolated from .

PeerJ 2021 19;9:e11080. Epub 2021 Apr 19.

Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo Leon, Mexico.

Background: Among entomopathogenic fungi, has been recognized as potential biocontrol agent against the Asian citrus psyllid (Hemiptera: Liviidae). Nevertheless, this fungus is poorly characterized. Previous molecular studies have shown high sequence similarities among strains, but significant differences in virulence. Read More

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The living heart: Climate gradients predict desert mountain endemism.

Ecol Evol 2021 May 15;11(9):4366-4378. Epub 2021 Mar 15.

Environmental Futures Research Institute and School of Environment and Science Griffith University Nathan Qld Australia.

Mountain regions are centers of biodiversity endemism at a global scale but the role of arid-zone mountain ranges in shaping biodiversity patterns is poorly understood. Focusing on three guilds of taxa from a desert upland refugium in Australia, we sought to determine: (a) the relative extent to which climate, terrain or geological substrate predict endemism, and (b) whether patterns of endemism are complimentary across broad taxonomic guilds. We mapped regional endemism for plants, land snails, and vertebrates using combined Species Distribution Models (SDMs) for all endemic taxa ( = 82). Read More

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Does the built environment have independent obesogenic power? Urban form and trajectories of weight gain.

Int J Obes (Lond) 2021 May 11. Epub 2021 May 11.

Center for Public Health Nutrition, 305 Raitt Hall, #353410, University of Washington, Seattle, WA, USA.

Objective: To determine whether selected features of the built environment can predict weight gain in a large longitudinal cohort of adults.

Methods: Weight trajectories over a 5-year period were obtained from electronic health records for 115,260 insured patients aged 18-64 years in the Kaiser Permanente Washington health care system. Home addresses were geocoded using ArcGIS. Read More

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Unexpected acceleration of Ultrasonic-Assisted iodide dosimetry in the catalytic presence of ionic liquids.

Ultrason Sonochem 2021 Apr 25;74:105576. Epub 2021 Apr 25.

LRP UMR 5520, Université de Savoie Mont-Blanc, 73000 Chambéry, France.

This study investigates the potential of using small amounts of ionic liquids (IL) to enhance ultrasound-assisted extraction of lipids content from green microalgae. Three imidazolium-based ILs (butyl, octyl and dodecyl), each of them with two anions (bromide and acetate) were tested as additives. Viscosity and surface tension of the ILs aqueous mixtures were analyzed to determine the influence of ILs' anions and alkyl chain length, whereas KI dosimetry experiments were used as an indicator of radicals formation. Read More

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Adult and adolescent C57BL/6 J and DBA/2 J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment.

Behav Brain Res 2021 May 8:113351. Epub 2021 May 8.

Department of Biobehavioral Health, Penn State University, 219 Biobehavioral Health Building, University Park, PA, 16801, United States. Electronic address:

Ethanol and other drugs of abuse disrupt learning and memory processes, creating problems associated with drug use and addiction. Understanding individual factors that determine susceptibility to drug-induced cognitive deficits, such as genetic background, age, and sex, is important for prevention and treatment. Comparison of adolescent and adult mice of both sexes across inbred mouse strains can reveal age, sex, and genetic contributions to phenotypes. Read More

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A New Assessment of Bicycle Helmets: The Brain Injury Mitigation Effects of New Technologies in Oblique Impacts.

Ann Biomed Eng 2021 May 10. Epub 2021 May 10.

Dyson School of Design Engineering, Imperial College, London, UK.

New helmet technologies have been developed to improve the mitigation of traumatic brain injury (TBI) in bicycle accidents. However, their effectiveness under oblique impacts, which produce more strains in the brain in comparison with vertical impacts adopted by helmet standards, is still unclear. Here we used a new method to assess the brain injury prevention effects of 27 bicycle helmets in oblique impacts, including helmets fitted with a friction-reducing layer (MIPS), a shearing pad (SPIN), a wavy cellular liner (WaveCel), an airbag helmet (Hövding) and a number of conventional helmets. Read More

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Impact of Different Mixing Methods on the Performance of Suspension-Based Transdermal Delivery Systems.

AAPS PharmSciTech 2021 May 10;22(4):150. Epub 2021 May 10.

Center for Drug Delivery Research, Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Dr, Atlanta, Georgia, 30341, USA.

Suspension-based matrix transdermal delivery systems (TDSs) are specialized systems that maintain a continuous driving force for drug delivery over prolonged wear. The pressure-sensitive adhesive (PSA) is the most critical constituent of such systems. Our study aimed to determine the effect of different mixing methods on the performance of silicone PSA-based suspension TDSs. Read More

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Clinically Approximated Hypoperfused Tissue in Large Vessel Occlusion Stroke.

Stroke 2021 May 11:STROKEAHA120033294. Epub 2021 May 11.

Department of Neurology, University of Pittsburgh Medical Center, PA. (S.M.D., A.P.J.).

Background And Purpose: Patient selection for thrombectomy of acute ischemic stroke caused by large vessel occlusion in the delayed time window (>6 hours) is dependent on delineation of clinical-core mismatch or radiological target mismatch using perfusion imaging. Selection paradigms not involving advanced imaging and software processing may reduce time to treatment and broaden eligibility. We aim to develop a conversion factor to approximately determine the volume of hypoperfused tissue using the National Institutes of Health Stroke Scale (NIHSS) score (clinically approximated hypoperfused tissue [CAT] volume) and explore its ability to identify patients eligible for thrombectomy in the late-time window. Read More

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Pneumonia severity indices predict prognosis in coronavirus disease-2019.

Respir Med Res 2021 Apr 27;79:100826. Epub 2021 Apr 27.

Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.

Background: Early recognition of the severe illness is critical in coronavirus disease-19 (COVID-19) to provide best care and optimize the use of limited resources.

Objectives: We aimed to determine the predictive properties of common community-acquired pneumonia (CAP) severity scores and COVID-19 specific indices.

Methods: In this retrospective cohort, COVID-19 patients hospitalized in a teaching hospital between 18 March-20 May 2020 were included. Read More

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