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Supracondylar rotation osteotomy of the femur influences the coronal alignment of the ankle.

J Exp Orthop 2021 Apr 20;8(1):32. Epub 2021 Apr 20.

Department for Trauma and Reconstructive Surgery, BG Klinik, University of Tübingen, Tübingen, Germany.

Purpose: Osteotomies represent well-established treatment-options for the redistribution of loads and forces within and around the knee-joint. Effects of these osteotomies on the remaining planes and adjacent joints are not fully understood. The aim of this study was to determine the influence of a distal-femoral-rotation-osteotomy on the coronal alignment of the ankle. Read More

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[Evaluation of fracture strength of two kinds of zirconia all-ceramic crowns with different edge compensation angles].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Mar;53(2):402-405

Center for Digital Dentistry, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the effects of different edge compensation angles on the fracture strength of multilayer zirconia all-ceramic crowns and traditional uniform zirconia all-ceramic crowns.

Methods: The resin tooth preparation specimen of the mandibular first molar with a knife-edge was fabricated. A 3D digital model of the specimen was obtained by scanning it with a 3D dental model scanner. Read More

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Comparative analysis of antigen and molecular tests for the detection of Sars-CoV-2 and related variants: a study on 4266 samples.

Int J Infect Dis 2021 Apr 17. Epub 2021 Apr 17.

Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy; Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, 00179 Rome, Italy. Electronic address:

Objectives: The present study compared the performance of Lumipulse G Sars-CoV-2 Ag kit with TaqPath COVID-19 RT-PCR CE IVD kit.

Methods: The study was conducted on 4266 naso-oropharyngeal swabs. Samples were subjected to antigen RT-PCR tests for detection of Sars-CoV-2 and related variants. Read More

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Real-time mechanical responses to overload and fatigue using a flywheel training device.

J Biomech 2021 Apr 8;121:110429. Epub 2021 Apr 8.

Physical Performance & Sports Research, Universidad Pablo de Olavide, Seville, Spain.

Purpose: This study aimed to analyze mechanical performance and mechanical losses across different sets and repetitions of unilateral leg extensions under flywheel loading conditions.

Methods: In a cross-over design, 23 physically active participants executed 3 sets of 30 repetitions using two different loads. Angular speed, angular acceleration and power were monitored, and mean and peak values of these variables were calculated for each set of repetitions. Read More

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Relationship between vertical jumping ability and endurance capacity with internal training loads in professional volleyball players during preseason.

J Sports Med Phys Fitness 2021 Apr 19. Epub 2021 Apr 19.

The College of Healthcare Sciences, James Cook University, Queensland, Australia.

Background: This study aimed to quantify internal training load and changes in vertical jumping ability and endurance capacity of professional volleyball players during the preseason, and to explore relationships between players` physical qualities at the beginning of the preseason with internal training load accumulated during the first two weeks of training.

Methods: Sixteen male professional volleyball players from a team participating in the Brazilian National Super League took part in the study. Before and after a 10-week preseason, their vertical jumping ability and endurance capacity were assessed by squat jump, countermovement jump without and with arm swing, and YoYo endurance test, level 1. Read More

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SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study.

Lancet Respir Med 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Whether young adults who are infected with SARS-CoV-2 are at risk of subsequent infection is uncertain. We investigated the risk of subsequent SARS-CoV-2 infection among young adults seropositive for a previous infection.

Methods: This analysis was performed as part of the prospective COVID-19 Health Action Response for Marines study (CHARM). Read More

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The SARS-CoV-2 Spike variant D614G favors an open conformational state.

Sci Adv 2021 04 16;7(16). Epub 2021 Apr 16.

Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

The COVID-19 (coronavirus disease 2019) pandemic underwent a rapid transition with the emergence of a dominant viral variant (from the "D-form" to the "G-form") that carried an amino acid substitution D614G in its "Spike" protein. The G-form is more infectious in vitro and is associated with increased viral loads in the upper airways. To gain insight into the molecular-level underpinnings of these characteristics, we used microsecond all-atom simulations. Read More

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Chemical compounds released by combustion of polymer composites flat belts.

Sci Rep 2021 Apr 15;11(1):8269. Epub 2021 Apr 15.

Scientific and Research Centre for Fire Protection, National Research Institute, 05-420, Józefów, Poland.

Machines and devices for the production, transport and segregation of products are placed in production and storage rooms. Flat conveyor and drive belts are very often used for their construction. Due to heavy loads and difficult operating conditions, these belts can catch fire and, as a result, become the main source of air contaminants harmful to human health and life. Read More

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Relationship Between Anterior Knee Laxity and General Joint Laxity During the Menstrual Cycle.

Orthop J Sports Med 2021 Mar 29;9(3):2325967121993045. Epub 2021 Mar 29.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.

Background: Anterior cruciate ligament (ACL) injury has been reported to have a higher incidence in women than in men.

Purpose/hypothesis: The purpose was to examine the relationship of anterior knee laxity (AKL), stiffness, and generalized joint laxity (GJL) with respect to the menstrual cycle. It was hypothesized that AKL and GJL would increase during the ovulation phase, when estrogen levels are high. Read More

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genotypes and clinical outcome in children.

J Clin Microbiol 2021 Apr 14. Epub 2021 Apr 14.

TU Dresden, Medical Faculty Carl Gustav Carus, Institute of Medical Microbiology and Hygiene, Dresden, Germany.

Factors leading to the wide range of manifestations associated with () infection are unclear. We investigated whether genotypes are associated with specific clinical outcomes. We compared loads and genotypes of children with mucocutaneous disease to those with pneumonia, family members with upper respiratory tract infection (URTI), and carriers from a prospective cohort study (=47; 2016-2017), and to other children with mucocutaneous disease from a case series (=7; 2017-2020). Read More

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Laboratory simulation of longitudinally-cracked teeth using the step-stress cyclic loading method.

Int Endod J 2021 Apr 14. Epub 2021 Apr 14.

Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, Minneapolis, USA.

Aim: To simulate in a laboratory setting longitudinal cracking in root filled premolar teeth, using cyclic mechanical fatigue.

Methodology: Mesial-occlusal-distal (MOD) cavities were prepared in twenty root filled, single-rooted, mandibular premolars restored with fibre posts and resin composites. The samples were randomly divided into two groups based on the loading approaches: static loading with a crosshead speed of 0. Read More

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SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests.

medRxiv 2021 Apr 7. Epub 2021 Apr 7.

Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and pre-symptomatic spread of COVID-19, curb the spread of viral variants by travelers, and maximize efficacy of therapeutic treatments. We designed a study to evaluate the preferred test sensitivity and sample type (saliva and nasal swab) for detecting early infections of COVID-19. We performed a case-ascertained study to monitor household contacts of individuals recently diagnosed with a SARS-CoV-2 infection. Read More

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Unified model of short- and long-term HIV viral rebound for clinical trial planning.

J R Soc Interface 2021 Apr 14;18(177):20201015. Epub 2021 Apr 14.

Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.

Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. Typically suspension of therapy is rapidly followed by rebound of viral loads to high, pre-therapy levels. Indeed, a recent study showed that approximately 90% of treatment interruption study participants show viral rebound within at most a few months of therapy suspension, but the remaining 10%, showed viral rebound some months, or years, after ART suspension. Read More

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Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study.

Lancet Microbe 2021 Apr 7. Epub 2021 Apr 7.

Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Antigen point-of-care tests (AgPOCTs) can accelerate SARS-CoV-2 testing. As some AgPOCTs have become available, interest is growing in their utility and performance. Here we aimed to compare the analytical sensitivity and specificity of seven commercially available AgPOCT devices. Read More

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Design and finite element simulation of metal-core piezoelectric fiber/epoxy matrix composites for virus detection.

Sens Actuators A Phys 2021 Aug 7;327:112742. Epub 2021 Apr 7.

Department of Frontier Sciences for Advanced Environment, Graduate School of Environmental Studies, Tohoku University, Aoba-yama 6-6-02, Sendai, Japan.

Undoubtedly, the coronavirus disease 2019 (COVID-19) has received the greatest concern with a global impact, and this situation will continue for a long period of time. Looking back in history, airborne transimission diseases have caused huge casualties several times. COVID-19 as a typical airborne disease caught our attention and reminded us of the importance of preventing such diseases. Read More

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Invasive pulmonary aspergillosis is associated with cytomegalovirus viremia in critically ill patients - A retrospective cohort study.

J Microbiol Immunol Infect 2021 Mar 31. Epub 2021 Mar 31.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Background/purpose: Cytomegalovirus (CMV) viremia is associated with a higher mortality rate and prolonged intensive care unit (ICU) stay for critically ill patients. CMV infection causes transient but substantial immunosuppression for transplant recipients, increasing risk of fungal infection. The association between CMV viremia and invasive pulmonary aspergillosis (IPA) for critically ill patients is still unknown. Read More

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To etch or not to etch, Part I: On the fatigue strength and dentin bonding performance of universal adhesives.

Dent Mater 2021 Apr 7. Epub 2021 Apr 7.

Department of Restorative Dentistry and Cariology, Adhesive Dentistry Research Group, Institute of Dentistry, University of Turku, Turku, Finland; Turku University Hospital, TYKS, University of Turku, Turku, Finland. Electronic address:

Objective: To characterize whether the bonding performance and fatigue strength of resin-dentin interfaces created by a universal adhesive would be affected by different HPO-application times to more accurately assess long-term durability.

Methods: Mid-coronal flat dentin surfaces with standardized smear-layers were produced on sound third molars, etched with 32% HPO for 0, 3 and 15 s, bonded with a mild universal adhesive (3M-ESPE) and restored with a nanofilled composite. Bonded specimens (0. Read More

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Performance of the RT-LAMP-based eazyplex® SARS-CoV-2 as a novel rapid diagnostic test.

J Clin Virol 2021 Apr 1;138:104817. Epub 2021 Apr 1.

Institute of Medical Microbiology, Jena University Hospital, Jena, Germany. Electronic address:

Background: Diagnostic assays for severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) that are easy to perform and produce fast results are essential for timely decision making regarding the isolation of contagious individuals.

Objective: We evaluated the CE-approved eazyplex® SARS-CoV-2, a ready-to-use real time RT-LAMP assay for identification of the SARS-CoV-2 N and ORF8 genes from swabs in less than 30 min without RNA extraction.

Study Design: Oropharyngeal and nasal swabs from 100 positive and 50 negative patients were inoculated into 0. Read More

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[The efficacy of the anti-acidemic agent dimephosphone at the first rehabilitation stage in patients in the acute period of carotid-related ischemic stroke].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):44-51

Kazan State Medical University, Kazan, Russia.

Objective: To evaluate the efficacy of the intravenous form of dimephosphon at the first stage of rehabilitation in patients with ischemic stroke in the carotid system.

Material And Methods: The article presents the results of examination of 60 patients in the acute period of ischemic stroke in the carotid system (30 patients were treated with dimephosphon and 30 patients were in the comparison group). The dynamics of the clinical picture (according to the NIHSS), functional dependence in self-service (according to the modified Rankin scale), state of autonomic response using spectral analysis of heart rate variability, cerebrovascular reactivity using functional tests were assessed during the treatment. Read More

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Evaluation of rapid SARS-CoV-2 antigen tests, AFIAS COVID-19 Ag and ichroma COVID-19 Ag, with serial nasopharyngeal specimens from COVID-19 patients.

PLoS One 2021 8;16(4):e0249972. Epub 2021 Apr 8.

Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

We evaluated the diagnostic accuracy of two newly developed, point-of-care, rapid antigen tests (RATs) for detecting SARS-CoV-2, the AFIAS COVID-19 Ag and the ichromaTM COVID-19 Ag, and investigated antigen kinetics. A total of 200 serially collected nasopharyngeal (NP) specimens from 38 COVID-19 patients and 122 specimens from negative controls were analyzed. Diagnostic sensitivity and specificity were assessed in comparison to molecular test results and subdivided according to targeted genes (E, RdRP, and N) and days post-symptom onset (PSO). Read More

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Efficacy of a nanoparticle vaccine administered in-ovo against Salmonella in broilers.

PLoS One 2021 6;16(4):e0247938. Epub 2021 Apr 6.

Department of Poultry Science, The University of Georgia, Athens, GA, United States of America.

Salmonella is a zoonotic pathogen that persists in poultry. Salmonella vaccines that can be delivered in-ovo can be cost-effective and can decrease Salmonella load in poultry. This study evaluates the efficacy of a Salmonella chitosan-nanoparticle (CNP) vaccine, administered in-ovo, in broilers. Read More

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Multiparameter one-sided tests for nonlinear mixed effects models with censored responses.

Authors:
Guohai Zhou Lang Wu

Stat Med 2021 Apr 5. Epub 2021 Apr 5.

Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.

Nonlinear mixed-effects (NLME) models are commonly used in longitudinal studies such as pharmacokinetics and HIV viral dynamics studies. NLME models are often derived based on underlying data-generating mechanisms, therefore the parameters in these models often have natural physical interpretations that may suggest reasonable constraints on certain parameters. For example, the HIV viral decay rates for populations receiving anti-HIV treatments may be reasonably expected to be nonnegative. Read More

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Omega-3 long-chain polyunsaturated fatty acids promote antibacterial and inflammation-resolving effects in -infected C3HeB/FeJ mice, dependent on fatty acid status.

Br J Nutr 2021 Apr 5:1-35. Epub 2021 Apr 5.

Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.

Non-resolving inflammation is characteristic of tuberculosis (TB). Given their inflammation-resolving properties, omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) may support TB treatment. This research aimed to investigate the effects of n-3 LCPUFA on clinical and inflammatory outcomes of Mycobacterium tuberculosis (Mtb)-infected C3HeB/FeJ mice with either normal or low n-3 PUFA status before infection. Read More

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Prevalence and association with birth outcomes of low Vitamin D levels among pregnant women living with HIV.

AIDS 2021 Mar 31. Epub 2021 Mar 31.

Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet Research Unit for infectious Diseases, Odense University Hospital, University of Southern Denmark Department of Infectious Diseases, Aarhus University Hospital, Skejby Department of Infectious Diseases, Aalborg University Hospital, Aalborg Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen.

Objectives: To evaluate the prevalence of low vitamin D levels among well-treated pregnant women living with HIV (WLWH) on combination antiretroviral therapy in Denmark, to identify risk factors of low vitamin D levels, and to assess the association between vitamin D status and birth outcomes.

Design: Nationwide cohort study.

Methods: All WLWH in Denmark giving birth from 2000-2018 with a vitamin D measurement during pregnancy were identified. Read More

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ART administration reduces neuroinflammation without restoring BDNF signaling in alcohol-administered SIV-infected macaques.

AIDS 2021 Mar 31. Epub 2021 Mar 31.

Department of Physiology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, New Orleans, LA Department of Microbiology, Immunology, and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA Biostatistics, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA.

Objective: This study examined interactions between simian immunodeficiency virus (SIV), chronic binge alcohol (CBA), and antiretroviral therapy (ART) on growth factor signaling, neuroinflammatory markers, viral loads (VL), and CD4 counts.

Design: Adult male rhesus macaques were administered CBA (13-14 g EtOH/kg/week) or sucrose (SUC) three months prior to SIVmac251 infection until study endpoint. At viral setpoint, a subset of CBA/SIV+ and SUC/SIV+ macaques were randomized to receive daily ART (PMPA 20 mg/kg, FTC, 30 mg/kg). Read More

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Fabrication of Oil-in-Water Emulsions with Whey Protein Isolate-Puerarin Composites: Environmental Stability and Interfacial Behavior.

Foods 2021 Mar 26;10(4). Epub 2021 Mar 26.

State Key Laboratory of Food Science and Technology, Nanchang University, 235 East Nanjing Road, Nanchang 330047, China.

Protein-polyphenol interactions influence emulsifying properties in both directions. Puerarin (PUE) is an isoflavone that can promote the formation of heat-set gels with whey protein isolate (WPI) through hydrogen bonding. We examined whether PUE improves the emulsifying properties of WPI and the stabilities of the emulsions. Read More

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Prevention of Covid-19 Infection and Related Complications by Ozonized Oils.

J Pers Med 2021 Mar 22;11(3). Epub 2021 Mar 22.

Department of Health Sciences, University of Genoa, 16132 Genoa, Italy.

Background: The COVID-19 pandemic continues to ravage the human population; therefore, multiple prevention and intervention protocols are being rapidly developed. The aim of our study was to develop a new chemo-prophylactic/-therapeutic strategy that effectively prevents COVID-19 and related complications.

Methods: In in vitro studies, COVID-19 infection-sensitive cells were incubated with human oropharyngeal fluids containing high SARS-CoV-2 loads. Read More

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The Micro Topology and Statistical Analysis of the Forces of Walking and Failure of an ITAP in a Femur.

Micromachines (Basel) 2021 Mar 12;12(3). Epub 2021 Mar 12.

Department of Mechanical Engineering, University of Bath, Bath BA2 7AY, UK.

This paper studies the forces acting upon the Intraosseous Transcutaneous Amputation Prosthesis, ITAP, that has been designed for use in a quarter amputated femur. To design in a failure feature, utilising a safety notch, which would stop excessive stress, σ, permeating the bone causing damage to the user. To achieve this, the topology of the ITAP was studied using MATLAB and ANSYS models with a wide range of component volumes. Read More

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High Efficacy of Saliva in Detecting SARS-CoV-2 by RT-PCR in Adults and Children.

Microorganisms 2021 Mar 19;9(3). Epub 2021 Mar 19.

Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.

Rising demands for repetitive SARS-CoV-2 screens and mass testing necessitate additional test strategies. Saliva may serve as an alternative to nasopharyngeal swab (NPS) as its collection is simple, non-invasive and amenable for mass- and home testing, but its rigorous validation, particularly in children, is missing. We conducted a large-scale head-to-head comparison of SARS-CoV-2 detection by RT-PCR in saliva and NPS of 1270 adults and children reporting to outpatient test centers and an emergency unit. Read More

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Mechanical and Morphological Assessment of an Innovative Textile for Patient Positioning Applications: Comparison to Two Standard Bandage Systems.

Materials (Basel) 2021 Mar 19;14(6). Epub 2021 Mar 19.

Experimental Orthopedics, Department of Orthopedic and Trauma Surgery, Medical University Innsbruck, 6020 Innsbruck, Austria.

In the healthcare environment, bandage systems are versatile medical devices to position and fix patients' torsos or extremities. In this study, the mechanical and morphological properties of an innovative patient position system, iFix, were assessed and compared to two commercially available bandages. Morphological properties were investigated using a scanning electron microscope (SEM). Read More

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