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The correlation between neonatal parameters and late-onset inner ear disorders in congenital cytomegalovirus infection: an 10-year population-based cohort study.

Clin Otolaryngol 2021 Sep 21. Epub 2021 Sep 21.

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Objective: To evaluate the correlation of neonatal parameters with late-onset sensorineural hearing loss (SNHL) and vestibular dysfunction in individuals with congenital cytomegalovirus (cCMV) infection using the National Health Insurance Research Database (NHIRD) in Taiwan.

Design: Retrospective cohort study.

Setting: The whole Taiwanese population. Read More

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September 2021

Secondary stability achieved in dental implants with a calcium-coated SLA surface and a chemically modified SLA surface placed without mechanical engagement: a preclinical study.

Clin Oral Implants Res 2021 Sep 21. Epub 2021 Sep 21.

Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.

Objectives: To assess the osseointegration of calcium-coated (CS) and chemically modified, sandblasted, large-grit, acid-etched (MS) dental implants with a lack of primary mechanical stability.

Materials And Methods: Eighteen implants in CS and MS groups each were loosely placed in the mandible of 6 mongrel dogs and allowed to heal for 2, 4 and 8 weeks. Implant stability quotient (ISQ) and implant stability test (IST) values recorded periodically and bone-to-implant contact (BIC) and the number of Haversian canals per 1 mm measured histologically were statistically analyzed (p < 0. Read More

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September 2021

Development of a 3D Printed Lung Model Made of Synthetic Materials for Simulation.

Thorac Cardiovasc Surg 2021 Sep 21. Epub 2021 Sep 21.

Peking University People's Hospital, Beijing, China.

Background:  Considering the complexity of lung structures and the difficulty of thoracoscopic surgery, simulation-based training is of paramount importance for junior surgeons. Here, we aim to design a high-fidelity lung model through utilizing the three-dimensional (3D) printing technology combined with synthetic materials to mimic the real human lung.

Methods:  The 3D printed lung model was manufactured based on the computed tomography images of a randomly selected male patient. Read More

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September 2021

Comparison of the current abattoir surveillance system for detection of paratuberculosis in Australian sheep with quantitative PCR tissue strategies using simulation modelling.

Prev Vet Med 2021 Sep 15;196:105495. Epub 2021 Sep 15.

Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia. Electronic address:

Abattoir surveillance for Johne's disease monitoring in Australia has provided valuable feedback to producers about their flock's disease status since its commencement in 1999. The current surveillance system relies on the identification of gross lesions in sheep carcases at an abattoir, followed by sampling and histopathology testing. This manual inspection system has not been adapted to meet the changing disease situation, as infection prevalence levels have declined over time due to vaccination. Read More

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September 2021

Association between perioperative intravenous lidocaine and subjective quality of recovery: A meta-analysis of randomized controlled trials.

J Clin Anesth 2021 Sep 18;75:110521. Epub 2021 Sep 18.

Department of Emergency Medicine, E-Da Hospital, Kaohsiung city, Taiwan; College of Medicine, I-Shou University, Kaohsiun cityg, Taiwan. Electronic address:

Study Objective: To evaluate the impact of perioperative intravenous lidocaine on the quality of recovery (QoR) following surgery.

Design: Meta-analysis of randomized controlled trials (RCTs).

Setting: Postoperative care. Read More

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September 2021

Do all patients with locoregionally advanced nasopharyngeal carcinoma benefit from the maintenance chemotherapy using S-1/capecitabine?

Oral Oncol 2021 Sep 18;122:105539. Epub 2021 Sep 18.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou 510060, PR China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China. Electronic address:

Background: The goal of this study was to explore the benefits of S-1/capecitabine as maintenance therapy in locoregionally advanced nasopharyngeal carcinoma (NPC) patients with different risks of treatment failure.

Methods: A total of 2205 eligible, locoregionally advanced NPC patients were recruited for this retrospective study. Multivariate Cox regression analysis was performed to identify optimal predictors of overall survival (OS) and distant metastasis-free survival (DMFS) for constructing the nomograms. Read More

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September 2021

Pregnancy after stillbirth: Maternal and neonatal outcomes and health service utilisation.

Am J Obstet Gynecol MFM 2021 Sep 18:100486. Epub 2021 Sep 18.

Pregnancy Loss Research Group, the Irish Centre for Maternal and Child Health Research (INFANT), University College Cork; Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, Cork, Ireland.

Background: Stillbirth occurs in every 3.5 of 1,000 pregnancies in Ireland and is a devastating event for a family. Women who have a pregnancy after stillbirth require increased antenatal support. Read More

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September 2021

Healthy Lifestyle and Mortality Among Adults Receiving Hemodialysis: The DIET-HD Study.

Am J Kidney Dis 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Medicine and Health, Sydney School of Public Health, The University of Sydney, Edward Ford Building A27, NSW 2006, Australia; Department of Emergency and Organ Transplantation, University of Bari, Bari, Piazza Giulio Cesare, 70124 Bari, Italy. Electronic address:

Rationale & Objective: A healthy lifestyle promotes cardiovascular health and reduces cardiac-related mortality in the general population but its benefits for people receiving maintenance hemodialysis are uncertain.

Study Design: Prospective cohort study.

Setting & Participants: 5,483 of 9,757 consecutive adults receiving maintenance hemodialysis (January 2014 to June 2017, median dialysis vintage: 3. Read More

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September 2021

Development and prospective validation of a spatial dose pattern based model predicting acute pulmonary toxicity in patients treated with volumetric arc-therapy for locally advanced lung cancer.

Radiother Oncol 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiation Oncology, University Hospital, Brest, France; LaTIM UMR 1101 INSERM, University Brest, Brest, France.

Introduction: (Chemo)-radiotherapy is the standard treatment for patients with locally advanced lung cancer (LALC) not accessible to surgery. Despite strict application of dose constraints, acute toxicities such as acute pulmonary toxicity (APT) remain frequent, and may impact treatment's compliance and patients' quality of life. Previously, on a population treated with intensity-modulated photon therapy or passive scattering proton therapy, spatial dose patterns associated with APT were identified in the lower lungs, especially in the posterior right lung. Read More

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September 2021

Changes in Condylar Position Within 12 Months After Bilateral Sagittal Split Ramus Osteotomy With and Without Le Fort I Osteotomy by Using Cone-Beam Computed Tomography.

Ye Han

J Oral Maxillofac Surg 2021 Aug 17. Epub 2021 Aug 17.

Researcher, PhD Candidate; Department of Preventive Dentistry, School of Dentistry, Institute of Oral Bioscience and BK 21 Plus Program, Jeonbuk National University, Jeonju, Republic of Korea; Clinical Fellow; Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea. Electronic address:

Objective: This study aimed to evaluate the condylar position changes in 12 months after bilateral sagittal split ramus osteotomy (BSSO) with and without a Le Fort I osteotomy in patients with Class III malocclusion and the influence of the 2 surgical approaches on the condylar position.

Methods: In this prospective cohort study, patients with skeletal Class III malocclusion who underwent orthognathic surgery between 2017 and 2019 were included. The main predictive variable is the effect of increasing Le Fort I osteotomy on condyle position, which is divided into BSSO-only group and BSSO + Le Fort I osteotomy group. Read More

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Characteristics, prognosis, risk factors, and management of recently diagnosed ductal carcinoma in situ with microinvasion.

Cancer Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Ductal carcinoma in situ with microinvasion (DCISM) represents ~1% of all breast cancer cases and is arguably a more aggressive subtype of ductal carcinoma in situ (DCIS). Lacking studies with a large population, the survival outcomes of DCISM are still poorly understood and the treatment recommendations remain controversial. This study aims to investigate the long-term outcome of patients with DCISM, potential risk factors for their prognosis, and the difference of survival between patients treated with breast-conserving surgery plus radiotherapy (BCT + RT) and mastectomy only. Read More

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September 2021

Effects of a web-based alcohol drinking prevention program linking school-to-home in elementary students.

Public Health Nurs 2021 Sep 21. Epub 2021 Sep 21.

Department of Nursing, Gwangju Health University, Gwangju, Republic of Korea.

Objectives: We investigated the effects of a web-based alcohol drinking prevention program among early elementary school students in South Korea using the theory of planned behavior. This study utilized a combined family and school intervention approach.

Design: This was a quasi-experimental study with a non-equivalent control group. Read More

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September 2021

Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Trial.

JAMA 2021 Sep;326(9):839-850

Harvard University Medical School, Boston, Massachusetts.

Importance: School and classroom allergens and particles are associated with asthma morbidity, but the benefit of environmental remediation is not known.

Objective: To determine whether use of a school-wide integrated pest management (IPM) program or high-efficiency particulate air (HEPA) filter purifiers in the classrooms improve asthma symptoms in students with active asthma.

Design, Setting, And Participants: Factorial randomized clinical trial of a school-wide IPM program and HEPA filter purifiers in the classrooms was conducted from 2015 to 2020 (School Inner-City Asthma Intervention Study). Read More

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September 2021

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial.

JAMA 2021 Sep;326(9):830-838

HCor Research Institute, São Paulo, Brazil.

Importance: Slower intravenous fluid infusion rates could reduce the formation of tissue edema and organ dysfunction in critically ill patients; however, there are no data to support different infusion rates during fluid challenges for important outcomes such as mortality.

Objective: To determine the effect of a slower infusion rate vs control infusion rate on 90-day survival in patients in the intensive care unit (ICU).

Design, Setting, And Participants: Unblinded randomized factorial clinical trial in 75 ICUs in Brazil, involving 11 052 patients requiring at least 1 fluid challenge and with 1 risk factor for worse outcomes were randomized from May 29, 2017, to March 2, 2020. Read More

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September 2021

A Novel Physical Examination Test for Ischiofemoral Impingement: Validation With Magnetic Resonance Imaging Correlation.

J Comput Assist Tomogr 2021 Sep-Oct 01;45(5):722-727

Department of Radiology, Hacettepe University School of Medicine, Sıhhiye, Ankara, Turkey.

Objective: The purpose of this study was to propose and validate a novel physical examination test for ischiofemoral impingement with magnetic resonance imaging (MRI) correlation.

Methods: We prospectively studied 24 women with buttock (deep gluteal) pain and 27 asymptomatic women. Each group underwent a 2-stage physical examination test that featured hip adduction-external rotation-extension and knee flexion. Read More

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September 2021

Knowledge about risk factors for cancer and cancer risk behavior among patients with severe mental illness.

Psychooncology 2021 Sep 21. Epub 2021 Sep 21.

Department of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.

Objective: To examine knowledge about, perception of and current risk factors for cancer, among patients with severe mental illness (SMI) and to compare these variables with patients without SMI.

Methods: A series of patients affected by SMI (i.e. Read More

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September 2021

Preterm birth among women with and without severe acute respiratory syndrome coronavirus 2 infection.

Acta Obstet Gynecol Scand 2021 Sep 21. Epub 2021 Sep 21.

Department of Obstetrics and Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

Introduction: Studies directly comparing preterm birth rates in women with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. Our objective was to determine whether preterm birth was affected by SARS-CoV-2 infection within a large integrated health system in New York with a universal testing protocol.

Material And Methods: This retrospective cohort study evaluated data from seven hospitals in New York City and Long Island between March 2020 and June 2021, incorporating both the first and second waves of the coronavirus disease 2019 (COVID-19) pandemic in the USA. Read More

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September 2021

The use of functional placental magnetic resonance imaging for assessment of the placenta after prolonged preterm rupture of the membranes in vivo: A pilot study.

Acta Obstet Gynecol Scand 2021 Sep 21. Epub 2021 Sep 21.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.

Introduction: Preterm prelabor rupture of membranes (PPROM) complicates 3% of pregnancies in the UK. Where delivery does not occur spontaneously, expectant management until 37 weeks of gestation is advocated, unless signs of maternal infection develop. However, clinical presentation of maternal infection can be a late sign and injurious fetal inflammatory responses may already have been activated. Read More

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September 2021

Nano-Molybdenum and Macleaya cordata Extracts Improved Antioxidant Capacity of Grazing Nanjiang Brown Goats on Copper and Cadmium-Contaminated Prairies.

Biol Trace Elem Res 2021 Sep 21. Epub 2021 Sep 21.

College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China.

To investigate the effects of nano-ammonium octamolybdate (nano-Mo) and Macleaya cordata extracts (MCE) on antioxidant capacity of grazing Nanjiang brown goats on natural prairies under Cu and Cd stress, a 2 × 2 factorial design was adopted in this test, and two factors were nano-Mo (0, 10 mg/kg) and MCE (0, 3000 mg/kg). 24 hm polluted grassland was used in this 30-day trial and was equally divided into twelve fenced units. A total of 36 Nanjiang brown goats (1 year old) with an average body weight (BW) of 40. Read More

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September 2021

CT scan structured report for the study of abdominal wall defects: a fast, easy and practical tool at the service of both surgeons and radiologist.

Hernia 2021 Sep 21. Epub 2021 Sep 21.

Department of General Surgery, S. Chiara Hospital, Trento, Italy.

Purpose: The advantages offered by structured reporting have already been highlighted in the literature. However, there is still no evidence on the validity of this reporting method for the study of abdominal wall defects. This study aims to show the experience of the Trentino Hernia Team (THT) multidisciplinary group in the development and use of a structured CT scan report for the study of abdominal wall defects. Read More

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September 2021

Comparison of the effect of sodium bicarbonate, sodium sesquicarbonate, and zeolite as rumen buffers on apparent digestibility, growth performance, and rumen fermentation parameters of Arabi lambs.

Trop Anim Health Prod 2021 Sep 21;53(5):465. Epub 2021 Sep 21.

Department of Animal Science, University College of Agriculture & Natural Resources, University of Tehran, Karaj, Iran.

The current research was conducted to compare the effect of various buffers or alkalizers in Arabi lambs and find new and less expensive buffering resources. Forty-five Arabi lambs with an average weight of 29.37 ± 3. Read More

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September 2021

Exercise for improving age-related hyperkyphosis: a systematic review and meta-analysis with GRADE assessment.

Arch Osteoporos 2021 Sep 21;16(1):140. Epub 2021 Sep 21.

Department of Kinesiology, University of Waterloo, Waterloo, Canada.

We reviewed exercise trials in men and women ≥ 45 years with hyperkyphosis at the baseline and performed meta-analyses for kyphosis and health-related outcomes.

Purpose: To determine the effects of exercise interventions on kyphosis angle, back extensor muscle strength or endurance, physical functioning, quality of life, pain, falls, and adverse events in adults 45 years or older with hyperkyphosis.

Methods: Multiple databases were searched to May 2020. Read More

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September 2021

The Tavistock First-Time Parent Study: a pilot randomised controlled feasibility trial of a brief couple-focused perinatal intervention to reduce inter-parental discord.

Eur Child Adolesc Psychiatry 2021 Sep 21. Epub 2021 Sep 21.

Research and Development Unit, The Tavistock and Portman NHS Foundation Trust, 120 Belsize Lane, London, NW3 5BA, UK.

Numerous studies report that some first-time parents experience a decline in relationship quality and an increase in conflict after the birth of a first baby. Inter-parental discord that is frequent, intense, and poorly resolved increases the likelihood of relationship breakdown and adversely impacts child development. We investigated the feasibility of a brief preventative couple-focused psychotherapeutic intervention in the perinatal period in a general population sample. Read More

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September 2021

Correlation between the position of the glenoid fossa and condylar translational movement in skeletal Class III mandibular asymmetry patients.

Eur J Orthod 2021 Sep 21. Epub 2021 Sep 21.

Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.

Objectives: Understanding the mechanism of mandibular asymmetry (MA) is important to provide suggestions for occlusal treatment and to know the developmental process of masticatory dysfunction. To investigate the morphological and functional effects on MA, we evaluated the three-dimensional position of the glenoid fossa and its relationship to asymmetrical condylar translational movement.

Methods: In this retrospective study, 50 subjects who previously underwent computed tomography for surgical purposes were divided into MA and control groups according to a menton deviation of at least 4 mm from the mid-sagittal plane. Read More

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September 2021

Elevated von Willebrand Factor Antigen is an Early Predictor of Mortality and Prolonged Length of Stay for Coronavirus Disease 2019 (COVID-19) Inpatients.

Arch Pathol Lab Med 2021 Sep 21. Epub 2021 Sep 21.

Departments of Pathology (AH Cotter, Shafi, Palmer-Toy), Research & Evaluation (Yang), and Cardiology (TM Cotter), at Kaiser Permanente / Southern California Permanente Medical Group, Pasadena, CA.

Context: Coagulation factor and endothelial injury marker, von Willebrand factor antigen (vWF:Ag), is elevated in coronavirus disease 2019 (COVID-19).

Objective: To assess prognostic value of vWF:Ag for COVID-19 inpatients.

Design: Citrated plasma samples collected from COVID-19 inpatients for D-dimer measurement were tested for vWF:Ag. Read More

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September 2021

A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement.

JAMA 2021 Sep;326(11):1045-1056

School of Public Health, University of Sydney, Sydney, Australia.

Importance: Mediation analyses of randomized trials and observational studies can generate evidence about the mechanisms by which interventions and exposures may influence health outcomes. Publications of mediation analyses are increasing, but the quality of their reporting is suboptimal.

Objective: To develop international, consensus-based guidance for the reporting of mediation analyses of randomized trials and observational studies (A Guideline for Reporting Mediation Analyses; AGReMA). Read More

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September 2021

Psychoeducational Social Anxiety Mobile Apps: Systematic Search in App Stores, Content Analysis, and Evaluation.

JMIR Mhealth Uhealth 2021 Sep 21;9(9):e26603. Epub 2021 Sep 21.

School of Medicine, Western Sydney University, Blacktown, New South Wales, Australia.

Background: The wide use of mobile health apps has created new possibilities in social anxiety education and treatment. However, the content and quality of social anxiety apps have been quite unclear, which makes it difficult for people to choose appropriate apps to use on smartphones and tablets.

Objective: This study aims to identify the psychoeducational social anxiety apps in the two most popular Australian app stores, report the descriptive and technical information provided in apps exclusively for social anxiety, evaluate app quality, and identify whether any apps would be appropriate for people with social anxiety or others who know someone with social anxiety. Read More

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September 2021

Exploring Associations of Housing, Relocation, and Active and Healthy Aging in Sweden: Protocol for a Prospective Longitudinal Mixed Methods Study.

JMIR Res Protoc 2021 Sep 21;10(9):e31137. Epub 2021 Sep 21.

Department of Health Sciences, Lund University, Lund, Sweden.

Background: While housing and neighborhood features have the potential to impact opportunities for active aging, there is a lack of knowledge related to how older people reason regarding their housing situation and how housing and fulfillment of relocation are associated with active and healthy aging.

Objective: The objectives of Prospective RELOC-AGE are to study housing choices and relocation and explore effects on active and healthy aging among men and women aged 55 years and older in Sweden considering relocation.

Methods: The estimated sample (2800) will include people aged 55 years and older being listed for relocation at either of two housing companies: a local public housing company in Southern Sweden and a national condominium provider. Read More

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September 2021