Chest 2021 Apr 17. Epub 2021 Apr 17.
Div. of Respirology, St. Michael's Hospital, Toronto, Canada; Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Background: Understanding how health outcomes differ for cystic fibrosis (CF) patients with advanced lung disease in the United States (US) compared to Canada has health policy implications.
Research Question: What are rates of lung transplant (LTx) and rates of death without LTx in the US and Canada among individuals with forced expiratory volume in 1 second (FEV) <40% predicted?
Study Design: and Methods: Retrospective population-based cohort study, 2005-2016, using the US CF Foundation, United Network for Organ Sharing, and Canadian CF registries. Individuals with CF and ≥2 FEV measurements <40% predicted within a 5-year period, age ≥6 years, without prior LTx were included. Read More