855 results match your criteria test boronic

Boronic Acid-Functionalized Scholl-Coupling Mesoporous Polymers for Online Solid-Phase Extraction of Brassinosteroids from Plant-Derived Foodstuffs.

J Agric Food Chem 2021 Apr 13. Epub 2021 Apr 13.

School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.

Brassinosteroids (BRs) are natural, nontoxic, non-hazardous, biosafe, and eco-friendly plant hormones, possessing diverse pharmacological activities. However, little is known about the type and content of BRs in frequently consumed plant-derived foodstuffs because of their low abundance and high abundance of interference. In this study, a selective, accurate, and sensitive method based on the online solid-phase extraction using the boronic acid-functionalized Scholl-coupling microporous polymer was developed for the analysis of BRs in plant-derived foodstuffs. Read More

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Phenotypic Identification and Genotypic Characterization of Plasmid-Mediated AmpC β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates in Iran.

Curr Microbiol 2021 Apr 10. Epub 2021 Apr 10.

Medical Microbiology Research Center, Qazvin University of Medical Science, Qazvin, Iran.

One of the mechanisms of Klebsiella pneumoniae and Escherichia coli resistance to β-lactam antibiotics is the production of β-lactamase enzymes. Among these are the AmpC β-lactamases, which confer resistance to a class of antibiotics. However, little is known about the AmpC β-lactamases of K. Read More

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Structure-Based Design of Selective LONP1 Inhibitors for Probing Biology.

J Med Chem 2021 Apr 6. Epub 2021 Apr 6.

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, California 92121, United States.

LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the importance of LONP1 in human biology and disease, very few LONP1 inhibitors have been described in the literature. Read More

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Synthesis of Computationally Designed 2,5(6)-Benzimidazole Derivatives via Pd-Catalyzed Reactions for Potential DNA Gyrase B Inhibition.

Molecules 2021 Mar 2;26(5). Epub 2021 Mar 2.

Coimbra Chemistry Centre, Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.

A pharmacophore model for inhibitors of 's DNA Gyrase B was developed, using computer-aided drug design. Subsequently, docking studies showed that 2,5(6)-substituted benzimidazole derivatives are promising molecules, as they possess key hydrogen bond donor/acceptor groups for an efficient interaction with this bacterial target. Furthermore, 5(6)-bromo-2-(2-nitrophenyl)-1-benzimidazole, selected as a core molecule, was prepared on a multi-gram scale through condensation of 4-bromo-1,2-diaminobenzene with 2-nitrobenzaldehyde using a sustainable approach. Read More

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High Prevalence and Mechanism Associated With Extended Spectrum Beta-Lactamase-Positive Phenotype in .

Front Microbiol 2021 9;12:618894. Epub 2021 Feb 9.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

In this study, we reported the prevalence and mechanism associated with the extended-spectrum beta-lactamase (ESBL)-positive phenotype in isolated from patients and fish. Using the inhibition zone enhancement test, 20 (95.2%) of the 21 patient strains and 8 (57. Read More

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February 2021

Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery.

Nat Commun 2021 02 18;12(1):1138. Epub 2021 Feb 18.

Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China.

DNA nanostructures have been demonstrated as promising carriers for gene delivery. In the carrier design, spatiotemporally programmable assembly of DNA under nanoconfinement is important but has proven highly challenging due to the complexity-scalability-error of DNA. Herein, a DNA nanotechnology-based strategy via the cascade hybridization chain reaction (HCR) of DNA hairpins in polymeric nanoframework has been developed to achieve spatiotemporally programmable assembly of DNA under nanoconfinement for precise siRNA delivery. Read More

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February 2021

Cu-Catalyzed -selective ring-opening cross-coupling of an oxabicyclic olefin with an organoboron reagent.

Org Biomol Chem 2021 02;19(7):1493-1497

Department of Chemistry and Biology, Changchun University of Technology, Changchun, Jilin 130012, P. R. China.

The Cu(i)-catalyzed ring-opening cross-coupling of an oxabicyclic olefin with an organoboron reagent provides access to cis-2-aryl-1,2-dihydronaphthalen-1-ol derivatives, in contrast to the exclusive trans-selectivity in related Cu-catalyzed reactions with Grignard reagents. DFT calculations suggest that the reaction possibly proceeds via boronic ester by-product assisted ring-opening as an alternative pathway to the canonical β-oxygen elimination as the rate-determining step. Read More

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February 2021

Ceftazidime/avibactam and eravacycline susceptibility of carbapenem-resistant Klebsiella pneumoniae in two Greek tertiary teaching hospitals.

Acta Microbiol Immunol Hung 2021 Jan 29. Epub 2021 Jan 29.

3Medical School, Demokritus University of Thrace, Thessaloniki, Greece.

The present study evaluated the carbapenem resistance mechanisms of Klebsiella pneumoniae strains isolated in two Greek tertiary teaching hospitals and their susceptibility to currently used and novel antimicrobial agents.Forty-seven carbapenem resistant K. pneumoniae strains were collected in G. Read More

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January 2021

Glucose-Sensitive Polyphosphoester Diblock Copolymer for an Insulin Delivery System.

ACS Biomater Sci Eng 2020 03 14;6(3):1553-1564. Epub 2020 Feb 14.

College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, Soochow University, Suzhou 215123, P. R. China.

In this study, we report a diblock copolymer based on a polyphosphate backbone and pendant phenylboronic acid with glucose sensitivity. The copolymer, abbreviated as (PBYP--MPBA)--PEEP, was prepared via a combination of ring-opening copolymerization, "click" chemistry, and amide reaction, in which the PBYP and PEEP blocks, respectively, represent two kinds of polyphosphoester structures and MPBA represents 3-mercaptopropionic acid modified with 3-aminophenylboronic acid. The amphiphilic copolymer (PBYP--MPBA)--PEEP could self-assemble into core-shell nanoparticles (NPs) in aqueous solutions. Read More

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Molecular design of a high-performance polymeric carrier for delivery of a variety of boronic acid-containing drugs.

Acta Biomater 2021 02 13;121:554-565. Epub 2020 Dec 13.

Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan; Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan; Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan. Electronic address:

Because of their many useful and unique properties, boronic acids are well suited for biomedical applications such as antitumor chemotherapy and boron neutron capture therapy (BNCT). Bortezomib, a boronic acid derivative, has drawn a lot of attention as a potent proteasome inhibitor. Nevertheless, because of rapid excretion and off-target effects, the clinical translation of boronic acid-containing drugs is limited. Read More

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February 2021

96-Well Microtiter Plate Made of Paper: A Printed Chemosensor Array for Quantitative Detection of Saccharides.

Anal Chem 2021 01 15;93(2):1179-1184. Epub 2020 Dec 15.

Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Simple, rapid, and accurate detection methods for saccharides are potentially applicable to various fields such as clinical and food chemistry. However, the practical applications of on-site analytical methods are still limited. To this end, herein, we propose a 96-well microtiter plate made of paper as a paper-based chemosensor array device (PCSAD) for the simultaneous classification of 12 saccharides and the quantification of fructose and glucose among 12 saccharides. Read More

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January 2021

Intermolecular B-N coordination and multi-interaction synergism induced selective glycoprotein adsorption by phenylboronic acid-functionalized magnetic composites under acidic and neutral conditions.

J Mater Chem B 2021 01;9(2):453-463

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China.

Abnormal protein glycosylation is associated with many diseases including cardiovascular disease, diabetes, and cancer. Therefore, selective capturing of glycoproteins under physiological or weak acid conditions (tumor microenvironment) is vital for disease diagnosis and further comprehensive analysis. Here, we propose a strategy of intermolecular B-N bond-based phenylboronic acid affinity to capture glycoproteins under neutral and slightly acidic conditions. Read More

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January 2021

Plasmid-Mediated AmpC β-Lactamase and Genes Among Gram-Negative Clinical Isolates.

Infect Drug Resist 2020 24;13:4249-4261. Epub 2020 Nov 24.

Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

Background: Antibiotic resistance mediated by the production of extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases is posing a serious threat in the management of the infections caused by Gram-negative pathogens. The aim of this study was to determine the prevalence of two AmpC β-lactamases genes, and , in Gram-negative bacterial isolates.

Materials And Methods: A total of 1151 clinical samples were obtained and processed at the microbiology laboratory of Annapurna Neurological Institute and Allied Science, Kathmandu between June 2017 and January 2018. Read More

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November 2020

Supramolecular Caffeic Acid and Bortezomib Nanomedicine: Prodrug Inducing Reactive Oxygen Species and Inhibiting Cancer Cell Survival.

Pharmaceutics 2020 Nov 11;12(11). Epub 2020 Nov 11.

Department of Molecular Biology, College of Natural Science, Jeonbuk National University, Jeollabuk-do 54896, Korea.

Phenolics from plant materials have garnered attention in nanomedicine research, due to their various medicinal properties. Caffeic acid, a phenolic compound that is abundant in coffee beans, has been proven to have anticancer effects, due to its reactive oxygen species (ROS)-inducing properties. Here, a supramolecular nanomedicine was designed using caffeic acid molecule and the synthetic anticancer drug bortezomib, via catechol-boronic acid conjugation and Fe(III) ion crosslinking. Read More

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November 2020

Chemical Tuning of Fibers Drawn from Extensible Hyaluronic Acid Networks.

J Am Chem Soc 2020 11 3;142(46):19715-19721. Epub 2020 Nov 3.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Polymer fibers with specific chemical and mechanical properties are key components of many biomaterials used for regenerative medicine and drug delivery. Here, we develop a bioinspired, low-energy process to produce mechanically tunable biopolymer fibers drawn from aqueous solutions. Hyaluronic acid (HA) forms dynamic cross-links with branched polyethylene glycol polymers end-functionalized with boronic acids of varied structure to produce extensible polymer networks. Read More

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November 2020

Detection of CMY-type beta-lactamases in Escherichia coli isolates from paediatric patients in a tertiary care hospital in Mexico.

Antimicrob Resist Infect Control 2020 10 29;9(1):168. Epub 2020 Oct 29.

Molecular Microbiology Laboratory, Instituto Nacional de Pediatria, Insurgentes Sur 3700C, Insurgentes Cuicuilco, Coyoacan, 04530, Mexico City, Mexico.

Background: The aim of this study was to detect CMY-type beta-lactamases in E. coli isolates obtained from paediatric patients.

Methods: In total, 404 infection-causing E. Read More

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October 2020

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology.

Front Chem 2020 25;8:580899. Epub 2020 Sep 25.

Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI, United States.

Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examples of the practical use of those probes in selected chemical, enzymatic, and biological systems. The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. Read More

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September 2020

Flexible Synthetic Carbohydrate Receptors as Inhibitors of Viral Attachment.

Biochemistry 2021 04 23;60(13):999-1018. Epub 2020 Oct 23.

Advanced Science Research Center at the Graduate Center of the City University of New York, New York, New York 10031, United States.

Carbohydrate-receptor interactions are often involved in the docking of viruses to host cells, and this docking is a necessary step in the virus life cycle that precedes infection and, ultimately, replication. Despite the conserved structures of the glycans involved in docking, they are still considered "undruggable", meaning these glycans are beyond the scope of conventional pharmacological strategies. Recent advances in the development of synthetic carbohydrate receptors (SCRs), small molecules that bind carbohydrates, could bring carbohydrate-receptor interactions within the purview of druggable targets. Read More

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Characteristics of dual carbapenemase-producing strains from an outbreak in Venezuela: a retrospective study.

Rev Panam Salud Publica 2020 23;44:e50. Epub 2020 Sep 23.

Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias Querétaro Mexico Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Querétaro, Mexico.

Objective: To characterize carbapenemase-producing isolated from patients treated at a hospital in Cumaná, Sucre, Venezuela.

Methods: This was a retrospective study conducted at the general hospital in Cumaná where 58 strains were analyzed for resistance to antimicrobials, specifically carbapenems, in January - June 2015. Production of metallo-β-lactamases and serine carbapenemases was determined by the double-disc synergy test, using EDTA-sodium mercaptoacetic acid and 3-aminophenyl boronic acid discs, respectively. Read More

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September 2020

Advanced Functional Hydrogel Biomaterials Based on Dynamic B-O Bonds and Polysaccharide Building Blocks.

Biomacromolecules 2020 10 24;21(10):3984-3996. Epub 2020 Sep 24.

Departament d'Enginyeria Quı́mica, EEBE, Universitat Politécnica de Catalunya, C/Eduard Maristany, 10-14, Barcelona, Spain.

Dynamic covalent chemistry applied to polymers has attracted significant attention over the past decade. Within this area, this review highlights the recent research on polysaccharide-based hydrogels cross-linked by boronic acid moieties, illustrating its versatility and relevance in biomaterials science to design self-healing, multiple stimuli-responsive, and adaptive biointerfaces and advanced functional devices. Read More

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October 2020

New Design Strategy Toward NIR I Xanthene-Based Dyes.

J Org Chem 2020 10 11;85(19):12108-12116. Epub 2020 Sep 11.

Department of Chemistry, Mississippi State University, Hand Lab 1115, Mississippi State, Mississippi 39762, United States.

An effective design strategy with an efficient synthetic route to xanthene-based far-red to near-infrared dyes is reported. The dyes were prepared by the Suzuki cross-coupling of the electron-poor fluorescein ditriflate with the electron-rich boronic acid/ester-functionalized pyrrole () and indole () moieties. Upon treatment with trifluoroacetic acid, the closed nonfluorescent forms of the dyes ( and ) ring-opened to their fluorescent forms ( and ). Read More

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October 2020

Linking Molecular Behavior to Macroscopic Properties in Ideal Dynamic Covalent Networks.

J Am Chem Soc 2020 09 31;142(36):15371-15385. Epub 2020 Aug 31.

Macromolecular Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.

Dynamic covalent networks (DCvNs) are increasingly used in advanced materials design with applications ranging from recyclable thermosets to self-healing hydrogels. However, the relationship between the underlying chemistry at the junctions of DCvNs and their macroscopic properties is still not fully understood. In this work, we constructed a robust framework to predict how complex network behavior in DCvNs emerges from the chemical landscape of the dynamic chemistry at the junction. Read More

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September 2020

3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos.

Drug Chem Toxicol 2020 Jul 21:1-8. Epub 2020 Jul 21.

Faculty of Dentistry, Department of Basic Medical Sciences, Marmara University, Istanbul, Turkey.

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the molecular pathways in the pathogenesis of Parkinson's disease and also for potential therapeutic agent research. Boron has been shown to play an important role in the neural activity of the brain. Read More

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Engineering Boron Hot Spots for the Site-Selective Installation of Iminoboronates on Peptide Chains.

Chemistry 2020 Nov 19;26(66):15226-15231. Epub 2020 Oct 19.

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.

Boronic acids (BAs) are a promising bioconjugation function to design dynamic materials as they can establish reversible covalent bonds with oxygen/nitrogen nucleophiles that respond to different pH, ROS, carbohydrates and glutathione levels. However, the dynamic nature of these bonds also limits the control over the stability and site-selectivity of the bioconjugation, which ultimately leads to heterogeneous conjugates with poor stability under physiological conditions. Here we disclose a new strategy to install BAs on peptide chains. Read More

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November 2020

1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Cephalosporinase.

ACS Infect Dis 2020 07 24;6(7):1965-1975. Epub 2020 Jun 24.

Department of Life Sciences, University of Modena and Reggio Emilia, via Campi 103, Modena 41125, Italy.

Boronic acid transition state inhibitors (BATSIs) are known reversible covalent inhibitors of serine β-lactamases. The selectivity and high potency of specific BATSIs bearing an amide side chain mimicking the β-lactam's amide side chain are an established and recognized synthetic strategy. Herein, we describe a new class of BATSIs where the amide group is replaced by a bioisostere triazole; these compounds were designed as molecular probes. Read More

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Diastereoselective desymmetric 1,2-cis-glycosylation of meso-diols via chirality transfer from a glycosyl donor.

Nat Commun 2020 05 15;11(1):2431. Epub 2020 May 15.

Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

Chemical desymmetrization reactions of meso-diols are highly effective for the precise and efficient synthesis of chiral molecules. However, even though enzyme-catalyzed desymmetric glycosylations are frequently found in nature, there is no method for highly diastereoselective desymmetric chemical glycosylation of meso-diols. Herein, we report a highly diastereoselective desymmetric 1,2-cis-glycosylation of meso-diols found in myo-inositol 1,3,5-orthoesters using a boronic acid catalyst based on predictions of regioselectivity by density functional theory (DFT) calculations. Read More

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Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors.

Biomolecules 2020 04 27;10(5). Epub 2020 Apr 27.

Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Boronic acid transition-state analog inhibitors (BATSIs) are partners with β-lactam antibiotics for the treatment of complex bacterial infections. Herein, microbiological, biochemical, and structural findings on four BATSIs with the FOX-4 cephamycinase, a class C β-lactamase that rapidly hydrolyzes cefoxitin, are revealed. FOX-4 is an extended-spectrum class C cephalosporinase that demonstrates conformational flexibility when complexed with certain ligands. Read More

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Design and discovery of boronic acid drugs.

Eur J Med Chem 2020 Jun 30;195:112270. Epub 2020 Mar 30.

Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montréal, Québec, H3A0B8, Canada. Electronic address:

Research related to boronic acids, from synthetic development to materials to drug discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation of boronic acids into medicinal chemistry endeavours has seen a steady increase in recent years. In fact, the Food and Drug Administration (FDA) and Health Canada have thus far approved five boronic acid drugs, three of which were approved in the past four years, and several others are in clinical trials. Read More

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Copolymers containing carbohydrates and other biomolecules: design, synthesis and applications.

Zhiyuan Ma X X Zhu

J Mater Chem B 2019 03 6;7(9):1361-1378. Epub 2019 Feb 6.

Département de Chimie, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, QC H3C 3J7, Canada.

Glycopolymers are synthetic polymers containing pendant carbohydrate groups. Other biological compounds can be incorporated into glycopolymers to prepare both random and block copolymers aimed at bio-related applications: boronic acid can be introduced as a functional group to obtain crosslinked hydrogels; cholesterol and bile acids can be introduced to render the polymers more hydrophobic for the formation of micelles. Sugar-containing block copolymers with biocompatible blocks such as polypeptides, poly(ethylene glycol), poly(lactic acid) and poly(ε-caprolactone) were also prepared for potential application in drug carriers. Read More

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Different liposome patterns to detection of acute leukemia based on electrochemical cell sensor.

Anal Chim Acta 2020 May 27;1109:122-129. Epub 2020 Feb 27.

Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran; Radiation Sciences Department, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Leukemia is the worst type of malignancy in children which its proper diagnosis can be used in the treatment. We design the turn-off sensor by using the different electrochemical patterns of liposomes to the detection of acute lymphoblastic leukemia cells. Our design is first sandwiched by lectin liposome which increases the electrochemical exchange on the electrode. Read More

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