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No association of both serum pro-brain-derived neurotrophic factor (proBDNF) and BDNF concentrations with depressive state in community-dwelling elderly people.

Psychogeriatrics 2021 Apr 20. Epub 2021 Apr 20.

Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan.

Background: Brain-derived neurotrophic factor (BDNF) is involved in emotional and cognitive function. Low-BDNF levels occur in patients with depression, while proBDNF, a precursor of BDNF with the opposite physiological function, increases in major depression. However, it is unclear whether BDNF and proBDNF are associated with depression in the elderly. Read More

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A Randomized Controlled Trial on the Effect of Standardized Video Education on Prenatal Genetic Testing Choices: Uptake of Genetic Testing.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, California.

Objective:  This study aimed to assess the use of a standardized prenatal genetic testing educational video and its effects on patient uptake of prenatal testing, patient knowledge, decisional conflict, and decisional regret.

Study Design:  This was an IRB-approved randomized controlled trial. Patients were randomized to intervention (standardized video education) or control (no video education). Read More

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Improving Postpartum Attendance among Women with Gestational Diabetes Using the Medical Home Model of Care.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective:  Poor attendance at the 6-week postpartum (PP) visit has been well reported. Attendance at this visit is crucial to identify women who have persistent diabetes mellitus (DM) following pregnancies affected by gestational DM (GDM). The medical home model has eliminated barriers to care in various other settings. Read More

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Effects of Different Onset Times of Early Caffeine Treatment on Mesenteric Tissue Oxygenation and Necrotizing Enterocolitis: A Prospective, Randomized Study.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Neonatology, Department of Pediatrics, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective:  Caffeine treatment is routinely used in premature infants to prevent development of apnea and bronchopulmonary dysplasia. Although a limited number of studies have reported that early caffeine treatment may cause development of necrotizing enterocolitis (NEC) by reducing mesenteric blood flow, this issue is still under discussion. The aim of this study is to investigate the possible effect of different onset times of early caffeine treatment on mesenteric tissue oxygen saturation and NEC development in premature infants. Read More

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Does Fetal Growth Adequacy Affect the Nutritional Composition of Mothers' Milk?: A Historical Cohort Study.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Neonatal Intensive Care Unit, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Objective:  The study aimed to assess the association between intrauterine growth of preterm infants and energy and macronutrient contents in their mothers' milk.

Study Design:  A historical cohort of mothers of preterm infants was assessed according to offspring's intrauterine growth. Fetal growth restriction (FGR) was defined as small-for-gestational age or appropriate for gestational age with fetal growth deceleration. Read More

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Comparison of Maternal and Neonatal Subspecialty Care Provision by Hospital.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.

Objective:  The aim of the study is to determine the relationship between a hospital's provision of subspecialty neonatal and maternal care. Specifically, we sought to understand where women with high-risk maternal conditions received intrapartum care and estimate the potential transfer burden for those with maternal high-risk conditions delivering at hospitals without subspecialty maternal care.

Study Design:  This is a descriptive study using data from 2015 State Inpatient Databases and the American Hospital Association Annual Survey. Read More

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Validity of the 6-Minute Walk Test in Patients with End-Stage Lung Diseases Wearing an Oronasal Surgical Mask in Times of the COVID-19 Pandemic.

Respiration 2021 Apr 20:1-6. Epub 2021 Apr 20.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.

Background And Objectives: The 6-minute walk test (6MWT), as a clinical assessment tool for functional exercise capacity, is an integral component of lung allocation scores (LASs). In times of the coronavirus disease (COVID-19) pandemic, patients underwent 6MWTs wearing a surgical mask in ambulatory care. We investigated the impact of wearing a mask on 6-minute walk distances (6MWDs). Read More

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Crucial Music Components Needed for Speech Perception Enhancement of Pediatric Cochlear Implant Users: A Systematic Review and Meta-Analysis.

Audiol Neurootol 2021 Apr 20:1-25. Epub 2021 Apr 20.

Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Background: Although many clinicians have attempted music training for the hearing-impaired children, no specific effects have yet been reported for individual music components. This paper seeks to discover specific music components that help in improving speech perception of children with cochlear implants (CI) and to identify the effective training periods and methods needed for each component.

Method: While assessing 5 electronic databases, that is, ScienceDirect, Scopus, PubMed, CINAHL, and Web of Science, 1,638 articles were found initially. Read More

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Deep learning based photoplethysmography classification for peripheral arterial disease detection: a proof-of-concept study.

Physiol Meas 2021 Apr 20. Epub 2021 Apr 20.

Northern Vascular Centre, Freeman Hospital, Newcastle upon Tyne, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: A proof-of-concept study to assess the potential of a Deep Learning (DL) based photoplethysmography PPG ('DLPPG') classification method to detect peripheral arterial disease (PAD) using toe PPG signals.

Approach: PPG spectrogram images derived from our previously published multi-site PPG datasets (214 participants; 31.3% legs with PAD by Ankle Brachial Pressure Index (ABPI)) were input into a pretrained 8-layer (5 Convolutional Layers + 3 Fully Connected Layers) AlexNet as tailored to the 2-class problem with transfer learning to fine tune the Convolutional Neural Network (CNN). Read More

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A novel method to reduce false alarms in ECG diagnostic systems: capture and quantification of noisy signals.

Physiol Meas 2021 Apr 20. Epub 2021 Apr 20.

Soochow University, Suzhou, 215006, CHINA.

Objective: Muscle artifacts (MA) and electrode motion artifacts (EMA) in electrocardiogram (ECG) signals lead to a large number of false alarms from cardiac diagnostic systems. To reduce false alarms, it is necessary to improve the performance of the diagnostic algorithm in noisy environments by removing excessively noisy signals. However, existing methods focus on signal quality assessment and contain too many artificial features. Read More

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Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non-Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors.

J Natl Compr Canc Netw 2021 Apr 20:1-7. Epub 2021 Apr 20.

3Division of Medical Oncology, and.

Background: Bone metastases and skeletal-related events (SREs) are a frequent cause of morbidity in patients with metastatic non-small cell lung cancer (mNSCLC). Data are limited on bone metastases and SREs in patients with mNSCLC treated using immune checkpoint inhibitors (ICIs), and on the efficacy of bone-modifying agents (BMAs) in this setting. Here we report the incidence, impact on survival, risk factors for bone metastases and SREs, and impact of BMAs in patients with mNSCLC treated with ICIs in a multi-institutional cohort. Read More

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Comprehensive characterization of tire and road wear particles in highway tunnel road dust by use of size and density fractionation.

Chemosphere 2021 Apr 8;279:130530. Epub 2021 Apr 8.

Helmholtz-Centre for Environmental Research - UFZ, Department Analytical Chemistry, Permoserstrasse 15, 04318, Leipzig, Germany.

Tire and road wear particles (TRWPs) are a major component of non-exhaust traffic emissions, but knowledge about their physico-chemical properties is limited. Road dust of a highway tunnel was fractionated by size and density, and fractions were analyzed for TRWPs, metals, seven tire tread indicator chemicals (benzothiazoles, 6-PPD and DPG) and effects in in-vitro bioassays. TRWP content in tunnel dust was very high (11-12%). Read More

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A predictive processing framework of tool use.

Michiel van Elk

Cortex 2021 Mar 27;139:211-221. Epub 2021 Mar 27.

Institute of Psychology, Leiden University, Leiden, The Netherlands. Electronic address:

In this paper I introduce the theory of predictive processing as a unifying conceptual framework to account for the human ability to use and innovate tools. I explain the basic concepts of predictive processing and illustrate how this framework accounts for the development of tool use in young infants and for findings in the neuropsychological and neuroscientific literature. Then, I argue that the predictive processing model needs to be complemented with a functional-evolutionary perspective, according to which the developmental and neurocognitive mechanisms should be understood in relation to the adaptive function that tools subserve. Read More

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A procedure for method development and protein binding ratio as the indicator of sensitivity with anticancer agents on MALDI mass spectrometry imaging.

Drug Metab Pharmacokinet 2021 Jan 30;38:100385. Epub 2021 Jan 30.

Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Medical Oncology and Translational Research, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. Electronic address:

The concentration and distribution of a drug and its metabolites in tissues are key factors for elucidating both drug efficacy and toxicity in drug development. In this study we developed a pharamaco-imaging procedure for 12 agents and investigated the relationship between the properties of target compounds and the sensitivities of detection in matrix-assisted laser desorption/ionization-mass spectrometer imaging (MALDI-MSI). We prepared mock samples with mouse liver homogenates diluted with gelatin solution, limit of detection concentrations of each compound was confirmed. Read More

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January 2021

Exponential quasi-synchronization of coupled delayed memristive neural networks via intermittent event-triggered control.

Neural Netw 2021 Feb 16;141:98-106. Epub 2021 Feb 16.

School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China, Wuhan 430074, China. Electronic address:

Firstly, an intermittent event-triggered control (IETC), as a combination of intermittent control and event-triggered control, is proposed. Then, the quasi-synchronization problem of coupled memristive neural networks with time-varying delays (CDMNN) is discussed under this IETC. To include more of the existing work, aperiodic intermittent control and event-triggered control with combined measurement errors are adopted in the IETC. Read More

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February 2021

Pediatric Emergency Medical Care in Yerevan, Armenia: A Knowledge and Attitudes Survey of Out-of-hospital Emergency Nurses.

Int Emerg Nurs 2021 Apr 17;56:100998. Epub 2021 Apr 17.

Virginia Commonwealth University School of Medicine, Department of Emergency Medicine Richmond, VA. Electronic address:

Background: Emergency Medical Services (EMS) system in Armenia follows the Franco-German model in which physician - nurse dyads staff ambulances. This study aims to evaluate the knowledge and attitudes of EMS nurses regarding pediatric rapid assessment and resuscitation.

Methods: This is a cross-sectional, anonymous, self-administered survey study of a convenience sample of 200 out-of-hospital emergency nurses in June and July 2015. Read More

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Effects of different detergent-containing children's toothpastes on the viability, osteogenic and chondrogenic differentiation of human dental periodontal ligament stem cells and gingival stem cells in vitro.

Tissue Cell 2021 Mar 26;72:101538. Epub 2021 Mar 26.

Istanbul University, Faculty of Dentistry, Department of Pedodontics, Istanbul, Turkey. Electronic address:

Background: Detergents are the most commonly used compounds in toothpastes due to their foaming and cleaning peoperties. This study aimed to investigate the effects of children's toothpastes with different detergent content on the viability, the osteogenic and chondrogenic differentiation potentials of human mesenchymal stem cells.

Methods: The necessary tissues for human periodontal ligament mesenchymal stem cells (hPDLMSCs) and human gingival mesenchymal stem cells (hGMSCs) isolation were obtained during extraction of 10 impacted third molar teeth. Read More

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The cost of living with cancer during the second wave of COVID-19: A mixed methods study of Danish cancer patients' perspectives.

Eur J Oncol Nurs 2021 Apr 17;52:101958. Epub 2021 Apr 17.

Research Unit of Oncology, The Academy of Geriatric Cancer Research (www.agecare.org), Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, DK-5000 Odense C, Denmark.

Purpose: This study investigated experiences and levels of distress and resilience of Danish cancer patients during the second wave of the COVID-19 pandemic.

Methods: The mixed methods design included a subset of cancer patients who responded to a cross-sectional survey in May 2020. Data were collected through telephone interviews. Read More

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Prediction of repeated-dose intravenous ketamine response in major depressive disorder using the GWAS-based machine learning approach.

J Psychiatr Res 2021 Apr 12;138:284-290. Epub 2021 Apr 12.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Major depressive disorder (MDD) is one of the most common psychiatric disorders. Various clinical studies have shown that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has rapid, robust, and sustained antidepressant effects. However, given the concerns about the adverse effects of ketamine on patients, it would be important to identify a set of biomarkers that could be used to predict clinical outcomes for its treatment. Read More

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A pilot randomized controlled trial of robotic exoskeleton-assisted exercise rehabilitation in multiple sclerosis.

Mult Scler Relat Disord 2021 Apr 13;51:102936. Epub 2021 Apr 13.

Kessler Foundation, West Orange, New Jersey, USA; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, USA.

Background: Co-occurring mobility and cognitive impairments are common, debilitating, and poorly-managed with pharmacological therapies in persons with multiple sclerosis (MS). Exercise rehabilitation (ER), particularly walking ER, has been suggested as one of the best approaches for managing these manifestations of MS. However, there is a focal lack of efficacy of ER on mobility and cognitive outcomes in persons with MS who present with substantial neurological disability. Read More

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Effect of uterine ozone therapy and anticoagulant sampling on oxidative stress parameters in mares.

Res Vet Sci 2021 Apr 13;136:503-511. Epub 2021 Apr 13.

Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Espinardo, Murcia, Spain.

With the purpose of assessing the effects of uterine ozone therapy and anticoagulant sampling on oxidative stress (OS) parameters in mares, ten mares underwent three consecutive days of uterine ozone therapy by flushing the uterus with ozonated lactated Ringer's solution followed by insufflation with ozone‑oxygen gas. Serum samples were obtained at baseline and days 3, 6, 10 and 17 to determine the effect of ozone therapy on OS markers. Plasma obtained with anticoagulants citrate, ethylenediaminetetraacetic acid (EDTA) and heparin were at baseline and 6 days following therapy to determine the effect of anticoagulant on OS parameters. Read More

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Perinatal determinants of neonatal hair glucocorticoid concentrations.

Psychoneuroendocrinology 2021 Apr 10;128:105223. Epub 2021 Apr 10.

MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK; Centre for Cardiovascular Science, University of Edinburgh, UK. Electronic address:

Adult hair glucocorticoid concentrations reflect months of hypothalamic-pituitary-adrenal axis activity. However, little is known about the determinants of neonatal hair glucocorticoids. We tested associations between perinatal exposures and neonatal hair glucocorticoids. Read More

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Estimating perceived parental substance use disorder: Using register data to adjust for non-participation in survey research.

Addict Behav 2021 Mar 8;119:106897. Epub 2021 Mar 8.

Centre for Alcohol and Drug Research, Aarhus University, Denmark.

Aims: To estimate the prevalence of parental substance use disorder (PSUD) in the general population based on young adults' reports adjusted for non-participation using register-based indicators of PSUD.

Design: A national sample survey study combined with a retrospective register-based study. Setting Denmark. Read More

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Stranger rape; distinctions between the typical rape type and other types of rape. A study based on data from Center for Victims of Sexual Assault.

J Forensic Leg Med 2021 Apr 1;80:102159. Epub 2021 Apr 1.

Institute of Forensic Medicine, University of Southern Denmark, J.B. Winsløvs Vej 17, Odense C, Denmark. Electronic address:

Objective: The aim of this descriptive cohort study was to characterize stranger rape compared to other types of rape.

Method & Materials: All cases of women aged 12 years or older, who contacted a Center for Victims of Sexual Assault in the region of Southern Denmark and underwent a forensic examination in 2018, were collected and analyzed. Descriptive frequencies, Pearson's χ-test and Fisher's exact-test were performed. Read More

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Spectrofluorimetric analyzes of thiamine and riboflavin in monofloral honey varieties of africanized bees (Apis mellifera).

Food Chem 2021 Apr 9;357:129756. Epub 2021 Apr 9.

Department of Biological Chemistry, Regional University of Cariri, R. Cel. Antonio Luis 1161, 63105000 Crato, CE, Brazil.

This research aimed to study the validation of a viable and low-cost spectrofluorimetric method, capable of detecting and quantifying B vitamins in floral varieties of bee honey. The analyzes were performed using chemical and operational methods of pre-defined solutions and standards, performed in triplicate and the results expressed as mean ± standard deviation. The data were recorded in a Microsoft Office Excel spreadsheet (version 2013) and studied using the statistical program Bioestatic version 3. Read More

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Identification, quantitation and sensorial contribution of lactones in brandies between China and France.

Food Chem 2021 Apr 9;357:129761. Epub 2021 Apr 9.

Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, PR China; State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, PR China. Electronic address:

Lactones are important flavor compounds in lots of foodstuffs. They also play an important role in brandy, but have not been studied at large. In this study, solid-phase extraction (SPE) and stir bar sorptive extraction (SBSE) combined with comprehensive two-dimensional gas chromatography and time-of-flight mass spectrometry (GC × GC-TOFMS) were applied to identify and quantify lactones in brandies between China and France. Read More

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Intraoperative Mapping of Parathyroid Glands using Fluorescence Lifetime Imaging.

J Surg Res 2021 Apr 17;265:42-48. Epub 2021 Apr 17.

University of California, Davis Department of Surgery, Sacramento, California. Electronic address:

Background: Hypoparathyroidism is a common complication following thyroidectomy. There is a need for technology to aid surgeons in identifying the parathyroid glands. In contrast to near infrared technologies, fluorescence lifetime imaging (FLIm) is not affected by ambient light and may be valuable in identifying parathyroid tissue, but has never been evaluated in this capacity. Read More

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