9,769 results match your criteria terms responsible

Dependence of laser-induced optical breakdown on skin type during 1064 nm picosecond laser treatment.

J Biophotonics 2021 Jun 10:e202100129. Epub 2021 Jun 10.

Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan, Republic of Korea.

The current study aims to evaluate the dependence of laser-induced optical breakdown (LIOB) on skin types by using 1064-nm picosecond laser with micro-lens arrays (MLA) and diffractive optical elements (DOE). Both black and white skin tissues were examined to comparatively assess the LIOB effects in the skin in terms of laser-induced vacuolization. The black skin irradiated at 3. Read More

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In vivo and in vitro models show unexpected degrees of virulence among Toxoplasma gondii type II and III isolates from sheep.

Vet Res 2021 Jun 10;52(1):82. Epub 2021 Jun 10.

SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain.

Toxoplasma gondii is an important zoonotic agent with high genetic diversity, complex epidemiology, and variable clinical outcomes in animals and humans. In veterinary medicine, this apicomplexan parasite is considered one of the main infectious agents responsible for reproductive failure in small ruminants worldwide. The aim of this study was to phenotypically characterize 10 Spanish T. Read More

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From contact-electrification to triboelectric nanogenerators.

Zhong Lin Wang

Rep Prog Phys 2021 Jun 10. Epub 2021 Jun 10.

Georgia Institute of Technology, 500 10th Street NW, Atlanta, Georgia, 30332, UNITED STATES.

Although the contact electrification(CE) (or usually called "triboelectrification(TE)") effect has been known for over 2600 years, its scientific mechanism still remains debated after decades. Interest in studying CE has been recently revisited due to the invention of the triboelectric nanogenerators(TENGs), which are the most effective approach for converting random, low-frequency mechanical energy into electric power for distributed energy applications. This review is composed of three parts that are coherently linked ranging from basic physics, through classical electrodynamics, and to technological advances and engineering applications. Read More

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Effect of cavity design and material type on fracture resistance and failure pattern of molars restored by computer-aided design/computer-aided manufacturing inlays/onlays.

Dent Res J (Isfahan) 2021 17;18:14. Epub 2021 Mar 17.

Department of Dental Materials, Faculty of Dental Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt.

Background: The maximum conservation of tooth structure and the use of restorative materials with elastic modulus close to the dental structure may promote greater longevity of the tooth/restoration complex. This study was conducted to evaluate the effect of cavity design and material type on fracture resistance and failure pattern of molars restored by computer-aided design/computer-aided manufacturing (CAD/CAM) inlays/onlays.

Materials And Methods: In this study, 55 human maxillary molars were embedded in resin blocks and divided into control group (CG) and five main groups: Group 1: Inlay, Group 2: Conventional onlay/mesiobuccal (MB), Group 3: Conservative onlay/MB, Group 4: Conventional onlay/MB and distobuccal (DB), and Group 5: Conservative onlay/MB and DB. Read More

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Study of the relationship between applied transmembrane pressure and antimicrobial activity of lysozyme.

Sci Rep 2021 Jun 8;11(1):12086. Epub 2021 Jun 8.

Institut de Science Des Matériaux de Mulhouse, Université de Haute-Alsace, CNRS IS2M UMR 7361, 3 bis rue A. Werner, 68098, Mulhouse Cedex, France.

During the processing of biomolecules by ultrafiltration, the lysozyme enzyme undergoes conformational changes, which can affect its antibacterial activity. Operational conditions are considered to be one of the main parameters responsible for such changes, especially when using the same membrane and molecule. The present study demonstrates that, the same cut-off membrane (commercial data) can result in different properties of the protein after filtration, due to their different pore network. Read More

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Strong effect of Penicillium roqueforti populations on volatile and metabolic compounds responsible for aromas, flavor and texture in blue cheeses.

Int J Food Microbiol 2021 Mar 27:109174. Epub 2021 Mar 27.

Université Clermont Auvergne, INRAE, Vetagro Sup, UMRF, 20 Côte de Reyne, 15000 Aurillac, France.

Studies of food microorganism domestication can provide important insight into adaptation mechanisms and lead to commercial applications. Penicillium roqueforti is a fungus with four genetically differentiated populations, two of which were independently domesticated for blue cheese-making, with the other two populations thriving in other environments. Most blue cheeses are made with strains from a single P. Read More

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The Preparedness of Primary Health Care Network in terms of Emergency Risk Communication: A Study in Iran.

Disaster Med Public Health Prep 2021 Jun 9:1-10. Epub 2021 Jun 9.

Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Objective: Emergency Risk Communication (ERC) is known as 1 of the important components of an effective response to public health emergencies. In this study, we aimed to investigate the preparedness of the Primary Health Care Network (PHCN) of Iran in terms of the ERC.

Methods: This study was conducted in 136 Primary Health Care Facilities (PHCFs) affilated to Shahrekord University of Medical Sciences, Chaharmahal and Bakhtiari Province, Iran. Read More

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Comparative analysis of hypothalamus transcriptome between laying hens with different egg-laying rates.

Poult Sci 2021 Mar 11;100(7):101110. Epub 2021 Mar 11.

College of Animal Science, Henan Agricultural University, Zhengzhou 450046, China; Henan Innovative Engineering Research Center of Poultry Germplasm Resource, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Laboratory for Poultry Breeding of Henan, Henan Agricultural University, Zhengzhou 450046, China. Electronic address:

Egg-laying performance is one of the most important economic traits in the poultry industry. Commercial layers can lay one egg almost every day during their peak-laying period. However, many Chinese indigenous chicken breeds show a relatively low egg-laying rate, even during their peak-laying period. Read More

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The traditional uses, phytochemistry, and pharmacological properties of Paris L. (Liliaceae): A review.

J Ethnopharmacol 2021 Jun 5:114293. Epub 2021 Jun 5.

Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China. Electronic address:

Ethnopharmacological Relevance: Paris L. (Liliaceae) consisted of 33 species, of which the study focused on Paris polyphylla Smith, P. polyphylla var. Read More

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Understanding context: A qualitative analysis of the roles of family caregivers of people living with cancer in Vietnam and the implications for service development in low-income settings.

Psychooncology 2021 Jun 8. Epub 2021 Jun 8.

School of Nursing and Midwifery, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road Belfast.

Objectives: Research on the needs of family caregivers of people living with cancer remains disproportionately focused in high income contexts. This research gap adds to the critical challenge on global equitable delivery of cancer care. This study describes the roles of family caregivers of people living with cancer in Vietnam and possible implications for intervention development. Read More

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The Rotavirus Surveillance System in Yemen: Evaluation Study.

JMIR Public Health Surveill 2021 Jun 8;7(6):e27625. Epub 2021 Jun 8.

Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan.

Background: Rotavirus (RV) kills over 185,000 children <5 years every year and is responsible for over one-third of all child diarrheal deaths worldwide. The Rotavirus Surveillance System (RVSS) in Yemen was launched in 2007 at five sentinel sites to monitor the impact of the vaccine on RV morbidity and mortality.

Objective: This study aimed to determine the usefulness of the RVSS, assess its performance, and identify the strengths and weaknesses of its implementation. Read More

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Comprehensive transcriptome mining identified the gene expression signature and differentially regulated pathways of the late-onset preeclampsia.

Pregnancy Hypertens 2021 May 28;25:91-102. Epub 2021 May 28.

Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Preeclampsia (PE) is categorized as a pregnancy-related hypertensive disorder and is a serious concern in pregnancies. Several factors, including genetic factors (placenta gene expression, and imprinting), oxidative stress, the inaccurate immune response of the mother, and the environmental factors are responsible for PE development, but still, the exact mechanism of the pathogenesis has remained unknown. The main aim of the present study is to identify the gene expression signature in placenta tissue, to unveil disease etiology mechanisms. Read More

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Evaluation of the Hypoglycemic Activity of by Targeting Protein Tyrosine Phosphatase 1B.

Front Pharmacol 2021 14;12:661803. Epub 2021 May 14.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.

() Pers. is one of six wild edible mushrooms that are widely used by Asian and European countries for their nutritional value. The present study assessed the anti-diabetic potential of methanolic extract (100 mg/kg body weight) on streptozotocin (STZ)-induced diabetic mice. Read More

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A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease.

Front Neurosci 2021 20;15:626636. Epub 2021 May 20.

Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom.

Alzheimer's disease (AD) is characterized by cerebral glucose hypometabolism. Hypometabolism may be partly due to reduced glucose transport at the blood-brain barrier (BBB) and across astrocytic and neuronal cell membranes. Glucose transporters (GLUTs) are integral membrane proteins responsible for moving glucose from the bloodstream to parenchymal cells where it is metabolized, and evidence indicates vascular and non-vascular GLUTs are altered in AD brains, a process which could starve the brain of glucose and accelerate cognitive decline. Read More

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Motor and higher-order functions topography of the human dentate nuclei identified with tractography and clustering methods.

Hum Brain Mapp 2021 Jun 4. Epub 2021 Jun 4.

Department of Brain and Behavioral Sciences, University of Pavia, Pavia.

Deep gray matter nuclei are the synaptic relays, responsible to route signals between specific brain areas. Dentate nuclei (DNs) represent the main output channel of the cerebellum and yet are often unexplored especially in humans. We developed a multimodal MRI approach to identify DNs topography on the basis of their connectivity as well as their microstructural features. Read More

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A Systematic Review and Meta-analysis of the Medical Error Rate in Iran: 2005-2019.

Qual Manag Health Care 2021 Jun 3. Epub 2021 Jun 3.

Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran (Drs Khammarnia, Ansari-Moghaddam, and Setoodehzadeh and Mss Rezaei and Peyvand); and Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, England, United Kingdom (Dr Clark).

Background And Objectives: Medical errors (MEs) are one of the main factors affecting the quality of hospital services and reducing patient safety in health care systems, especially in developing countries. The aim of this study was to determine the rate of ME in Iran.

Methods: This is a systematic literature review and meta-analysis of extracted data. Read More

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Biomedical applications of natural rubber latex from the rubber tree Hevea brasiliensis.

Mater Sci Eng C Mater Biol Appl 2021 Jul 22;126:112126. Epub 2021 Apr 22.

Department of Biotechnology and Bioprocess Engineering, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Km01 Araraquara-Jaú Road, Araraquara, São Paulo, Brazil.

The past decades have witnessed tremendous progress in biomaterials in terms of functionalities and applications. To realize various functions such as tissue engineering, tissue repair, and controlled release of therapeutics, a biocompatible and biologically active material is often needed. However, it is a difficult task to find either synthetic or natural materials suitable for in vivo applications. Read More

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plays critical roles in disease progression and response to cytarabine in AML.

Oncol Rep 2021 Jul 3;46(1). Epub 2021 Jun 3.

Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, R.O.C.

Lysine methyltransferase 2A (, also known as ) translocations (‑t) are frequently associated with mutations in pathway genes in acute myeloid leukemia (AML). Previous findings with a mouse model showed that cooperation of with tyrosine‑protein phosphatase non‑receptor type 11  accelerated leukemia development, but increased cytarabine (Ara‑C) sensitivity of leukemia cells. To identify the genes responsible for reduced survival and Ara‑C resistance, transcriptomic profiling between six pairs of mouse leukemia cells harboring activating and wild‑type or was compared. Read More

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Interannual variability of the frequency of MJO phases and its association with two types of ENSO.

Sci Rep 2021 Jun 2;11(1):11541. Epub 2021 Jun 2.

Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, 411008, India.

In this study, we reexamine the effect of two types of El Niño Southern Oscillation (ENSO) modes on Madden Julian Oscillation (MJO) activity in terms of the frequency of MJO phases. Evaluating all-season data, we identify two dominant zonal patterns of MJO frequency exhibiting prominent interannual variability. These patterns are structurally similar to the Wheeler and Hendon (Mon. Read More

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Promoting recovery in daily life: study protocol for a randomized controlled trial.

BMC Psychol 2021 Jun 2;9(1):91. Epub 2021 Jun 2.

Saarland University, Campus A2 4, 66123, Saarbrücken, Germany.

Background: Work-related stress shows steadily increasing prevalence rates and has tangible consequences for individual workers, their organizations, and society as a whole. One mechanism that may help offset the negative outcomes of work-related stress on employees' well-being is recovery. Recovery refers to the experience of unwinding from one's job when not at work. Read More

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Comparative Study of the Genetic and Biochemical Variability of (Araliaceae) Regenerants Obtained by Indirect and Direct Somatic Embryogenesis as a Source of Triterpenes.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.

(Araliaceae) is broadly used in traditional medicine in Southeast Asia due to its antimicrobial, immunomodulating and cytotoxic activities. The main groups of compounds responsible for pharmacological effects are believed to be oleanolic triterpene saponins. However, plants demonstrate relatively slow growth in natural conditions, which led to applying a developing sustainable source of plant material via primary (PSE), secondary (DSE) and direct somatic embryogenesis from DSE (TSE). Read More

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Evaluation of Human Ear Anatomy and Functionality by Axiomatic Design.

Biomimetics (Basel) 2021 May 19;6(2). Epub 2021 May 19.

Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA.

The design of the human ear is one of nature's engineering marvels. This paper examines the merit of ear design using axiomatic design principles. The ear is the organ of both hearing and balance. Read More

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Microbial Contamination in Hospital Environment Has the Potential to Colonize Preterm Newborns' Nasal Cavities.

Pathogens 2021 May 17;10(5). Epub 2021 May 17.

Department of Chemical and Pharmaceutical Sciences, Section of Microbiology and LTTA, University of Ferrara, 44121 Ferrara, Italy.

Infants born before 28 weeks are at risk of contracting healthcare-associated infections (HAIs), which could be caused by pathogens residing on contaminated hospital surfaces. In this longitudinal study, we characterized by NGS the bacterial composition of nasal swabs of preterm newborns, at the time of birth and after admission to the Neonatal Intensive Care Unit (NICU), comparing it with that of the environmental wards at the time of delivery and during the hospitalization. We characterized the resistome on the samples too. Read More

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Rapid Detection of (Blackman) (Coleoptera, Curculionidae) with the Loop-Mediated Isothermal Amplification (LAMP) Method.

Plants (Basel) 2021 May 22;10(6). Epub 2021 May 22.

Department of Agricultural, Food, Environmental and Forestry Science and Technology (DAGRI), Plant Pathology and Entomology Section, University of Florence, Piazzale delle Cascine 28, 50144 Florence, Italy.

The walnut twig beetle is a phloem-boring bark beetle responsible, in association with the ascomycete , for the Thousand Cankers Disease (TCD) of walnut trees. The recent finding of TCD in Europe prompted the development of effective diagnostic protocols for the early detection of members of this insect/fungus complex. Here we report the development of a highly efficient, low-cost, and rapid method for detecting the beetle, or even just its biological traces, from environmental samples: the loop-mediated isothermal amplification (LAMP) assay. Read More

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Comparison of Latest and Innovative Silica-Based Consolidants for Volcanic Stones.

Materials (Basel) 2021 May 12;14(10). Epub 2021 May 12.

ACLabs-Applied Chemistry Labs, Department of Chemical, Materials and Industrial Production Engineering, University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy.

This research explores the new perspectives in conservation and protection of two macroporous tuff stones, widely employed in the architectural heritage of Campania region, characterized by highly heterogeneous rock fabric and texture and a variable mineralogical composition that represent crucial factors responsible for their weak durability. The consolidation treatments were performed with a recently and widely used suspension of nano-silica crystals in water and with a lithium silicate solution that has received up to now scarce attention as a consolidant agent. Physical investigations (open porosity, Hg porosimetry, water absorption), morphological observations (SEM analyses) and visual appearance test (colorimetric measurements), along with assessments of performance indicators such as ultrasonic pulse velocity, surface cohesion test (peeling test) and durability test (salt crystallization), were carried out to investigate the consolidation effectiveness. Read More

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Genetic and Epigenetic Alterations of Regulatory Regions in Hereditary and Sporadic Gastric Cancer.

Pharmaceuticals (Basel) 2021 May 12;14(5). Epub 2021 May 12.

Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.

E-cadherin is a key player in gastric cancer (GC) and germline alterations of , its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role of genetic variants and DNA methylation of promoter and enhancers in the regulation of gene expression. For this purpose, we analyzed genetic variants of the gene through Next-Generation Sequencing (NGS) in a series of GC cell lines (NCI-N87, KATO-III, SNU-1, SNU-5, GK2, AKG, KKP) and the corresponding expression levels. Read More

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Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel.

Int J Mol Sci 2021 May 20;22(10). Epub 2021 May 20.

Department of Cranial Maxillofacial Plastic Surgery, University Clinic Leipzig, 04103 Leipzig, Germany.

Bone transplantation is regarded as the preferred therapy to treat a variety of bone defects. Autologous bone tissue is often lacking at the source, and the mesenchymal stem cells (MSCs) responsible for bone repair mechanisms are extracted by invasive procedures. This study explores the potential of autologous mesenchymal stem cells derived from the hair follicle outer root sheath (MSCORS). Read More

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A New Regression Model for the Analysis of Overdispersed and Zero-Modified Count Data.

Entropy (Basel) 2021 May 21;23(6). Epub 2021 May 21.

Department of Applied Mathematics and Statistics, Institute of Mathematical and Computer Sciences, University of São Paulo, Av. Trab. São Carlense, 400 Parque Arnold Schimidt, São Carlos 13566-590, SP, Brazil.

Count datasets are traditionally analyzed using the ordinary Poisson distribution. However, said model has its applicability limited, as it can be somewhat restrictive to handling specific data structures. In this case, the need arises for obtaining alternative models that accommodate, for example, overdispersion and zero modification (inflation/deflation at the frequency of zeros). Read More

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TANVEER: Tri-Angular Nearest Vector-Based Energy Efficient Routing for IoT-Enabled Acoustic Sensor and Actor Networks (I-ASANs).

Sensors (Basel) 2021 May 21;21(11). Epub 2021 May 21.

Department of Automatic Control and Robotics, Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, AGH University of Science and Technology, 30-059 Kraków, Poland.

The Internet of Things (IoT) is an emerging technology in underwater communication because of its potential to monitor underwater activities. IoT devices enable a variety of applications such as submarine and navy defense systems, pre-disaster prevention, and gas/oil exploration in deep and shallow water. The IoT devices have limited power due to their size. Read More

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Targeting BRAF and RAS in Colorectal Cancer.

Cancers (Basel) 2021 May 3;13(9). Epub 2021 May 3.

University of Burgundy-Franche Comté, Maison de l'université Esplanade Erasme, 21000 Dijon, France.

Colorectal cancer (CRC) is still one of the most frequent forms of cancer in the world in terms of incidence. Around 40% of CRC patients carry a mutation of the Kirsten rat sarcoma (KRAS) gene, while 10% have a mutation in the B-Raf proto-oncogene serine/threonine kinase (BRAF) gene. These mutations are responsible for dysregulation of the mitogen-associated protein kinase (MAPK) pathway, leading to the proliferation, differentiation, angiogenesis, and resistance to apoptosis of cells. Read More

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