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Impact of new operational dosimetric quantities on individual monitoring services.

J Radiol Prot 2021 Jun 22. Epub 2021 Jun 22.

Fisica Sanitaria, Azienda Ospedaliero Universitaria Careggi, Firenze, ITALY.

The new operational dosimetric quantities framework, proposed in the report ICRU95, has stimulated the scientific community to start investigations aiming at assessing its impact on radiation protection practices. As part of this effort, the present study describes an inter-comparison exercise among Individual Monitoring Services (IMS) on passive whole body dosimetry. The intercomparison is performed in terms of both the existing Hp(10) and Hp(0. Read More

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Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study.

Thorax 2021 Jun 19;76(6):618-620. Epub 2021 Apr 19.

IRCCS NeuroMed, Pozzilli, Italy.

Tobacco habit still represents the leading preventable cause of morbidity and mortality worldwide. Heat-not-burn cigarettes (HNBCs) are considered as an alternative to traditional combustion cigarettes (TCCs) due to the lack of combustion and the absence of combustion-related specific toxicants. The aim of this observational study was to assess the effect of HNBC on endothelial function, oxidative stress and platelet activation in chronic adult TCC smokers and HNBC users. Read More

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Recursive Deep Prior Video: A super resolution algorithm for time-lapse microscopy of organ-on-chip experiments.

Med Image Anal 2021 Jun 4;72:102124. Epub 2021 Jun 4.

Department of Electronic Engineering, University of Tor Vergata, Via del Politecnico 1, Rome 00133, Italy; Interdisciplinary Center for Advanced Studies on Lab-on-Chip and Organ-on-Chip Applications (ICLOC), University of Tor Vergata, Via del Politecnico 1, Rome 00133, Italy.

Biological experiments based on organ-on-chips (OOCs) exploit light Time-Lapse Microscopy (TLM) for a direct observation of cell movement that is an observable signature of underlying biological processes. A high spatial resolution is essential to capture cell dynamics and interactions from recorded experiments by TLM. Unfortunately, due to physical and cost limitations, acquiring high resolution videos is not always possible. Read More

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Methotrexate treatment in hand osteoarthritis refractory to usual treatments: A randomised, double-blind, placebo-controlled trial.

Semin Arthritis Rheum 2021 May 6;51(4):831-838. Epub 2021 May 6.

Department of Rheumatology, Pasteur Hospital, Nice University Hospital, Cote d'Azur University, Nice F-06000, France; Department of Rheumatology, University of Cote d'Azur, Nice Hospital, Laboratory LAMHESS, EA6312, IBV CNRS IMR 7277 INSERM U1091 UNS, France.

Objective: To examine the effect of methotrexate (MTX) on pain and structural progression in symptomatic erosive hand osteoarthritis (HOA).

Methods: This 1-year prospective, single-centre, randomised, double-blind, placebo-controlled study (www.ClinicalTrial. Read More

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Effect of housing system and feed restriction on meat quality of medium-growing chickens.

Poult Sci 2021 Apr 27;100(8):101223. Epub 2021 Apr 27.

Department of Nutrition Physiology and Animal Product Quality, Institute of Animal Science, Czech Republic.

The aim of the study was to evaluate the differences in meat quality of 420 Hubbard JA757 cockerels in relation to the housing system (litter and mobile box) and level of mixed feed (ad libitum [AL], reducing the level by 20% [R20] and 30% [R30]). Three groups of chickens were housed in litter boxes for the entire fattening period (stocking density: 0.094 m/bird). Read More

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Network topology analysis of essential genes interactome of Helicobacter pylori to explore novel therapeutic targets.

Microb Pathog 2021 Jun 19:105059. Epub 2021 Jun 19.

Central Research Lab, K. S. Hegde Medical Academy, Nitte (Deemed to Be University), Mangalore-575018, Karnataka, India.

The Helicobacter pylori chronic colonization produces a wide range of gastric diseases in the gastric mucosa by abetting inflammation. Amidst coevolution and reorganization of its metabolism with humans, it has become difficult still imperative to understand and prevent its growth. This study focus to explore functional insights into identification of hub proteins/genes by aggregating the behavior of genes connected in a protein-protein interaction (PPI) network. Read More

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Mathematical modeling of cerebral capillary blood flow heterogeneity and its effect on brain tissue oxygen levels.

J Theor Biol 2021 Jun 19:110817. Epub 2021 Jun 19.

Division of Cerebrovascular Diseases and Neurocritical Care, Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210 USA.

Maintaining cerebral blood flow is critical for adequate neuronal function. Previous computational models of brain capillary networks have predicted that heterogeneous cerebral capillary flow patterns result in lower brain tissue partial oxygen pressures PO2). However, these previous models have often considered simple capillary networks in terms of their geometric properties. Read More

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Forecasting the COVID-19 epidemic integrating symptom search behavior: an infoveillance study.

J Med Internet Res 2021 May 1. Epub 2021 May 1.

Department of Ophthalmology, Vita-Salute University, IRCCS Ospedale San Raffaele Scientific Institute, Milan, IT.

Background: Previous studies have suggested associations between trends of web searches and COVID-19 traditional metrics. It remains unclear whether models incorporating trends of digital searches lead to better predictions.

Objective: To investigate the relationship between Google Trends searches of symptoms associated with COVID-19 and confirmed COVID-19 cases and deaths. Read More

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Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

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Spondylolisthesis in young patients: postoperative functional outcomes at 22-year mean follow-up.

Arch Orthop Trauma Surg 2021 Jun 22. Epub 2021 Jun 22.

Spine Surgery Division 1, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 6, 20161, Milan, Italy.

Introduction: Previous short- and intermediate-term clinical and radiographic studies demonstrated good results in patients who underwent spine surgery for spondylolisthesis, long-term outcomes are lacking instead. Young patients are often involved in high-demanding and sport activities, therefore good/excellent functional outcomes are very important for their future quality of life. The aim of this study is to assess the long-term functional results in young patients surgically treated for developmental spondylolisthesis. Read More

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Thymol in fattening rabbit diet, its bioavailability and effects on intestinal morphology, microbiota from caecal content and immunity.

J Anim Physiol Anim Nutr (Berl) 2021 Jun 22. Epub 2021 Jun 22.

Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic.

To our knowledge, no study has been carried out to evaluate the effects of thymol sustained administration on gut health and immune response in terms of its bioavailability in the rabbit organism. A total of 48 rabbits were randomly divided at 35 days of age into two dietary treatment groups (C/control or T/thymol at 0.025% addition). Read More

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An investigation on the association between sodium glucose co-transporter 2 inhibitors use and acute pancreatitis: A VigiBase study.

Pharmacoepidemiol Drug Saf 2021 Jun 22. Epub 2021 Jun 22.

Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Purpose: To characterize acute pancreatitis (AP) related to sodium glucose co-transporter 2 inhibitors and to investigate this relationship through disproportionality analysis in an international pharmacovigilance database.

Methods: We analysed all AP reports for canagliflozin, dapagliflozin and/or empagliflozin from the WHOs Global adverse drug reactions database VigiBase® up to July 2019. We characterized the patients, reporters, and reactions, and we present the proportional reporting ratio (PRR) and information component (IC) for each of the gliflozins. Read More

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Nutritional quality and carbon footprint of university students' diets: Results from the EHU12/24 study.

Public Health Nutr 2021 Jun 21:1-31. Epub 2021 Jun 21.

Department of Pharmacy and Food Sciences, Faculty of Pharmacy, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.

Objective: To evaluate diets in terms of nutritional characteristics and quality from the perspectives of health, greenhouse gas emissions (GHGEs) and possible associations with each other in a representative sample of students at a public university.

Design: Cross-sectional. Dietary intake was evaluated with a validated food frequency questionnaire, and diet quality was assessed through the Healthy Eating Index (HEI-2010) and MedDietScore (MDS). Read More

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L-carnitine supplementation for muscle weakness and fatigue in children with neurofibromatosis type 1: A Phase 2a clinical trial.

Am J Med Genet A 2021 Jun 21. Epub 2021 Jun 21.

Orthopaedic Research & Biotechnology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Reduced muscle tone, muscle weakness, and physical fatigue can impact considerably on quality of life for children with neurofibromatosis type 1 (NF1). Human muscle biopsies and mouse models of NF1 deficiency in muscle show intramyocellular lipid accumulation, and preclinical data have indicated that L-carnitine supplementation can ameliorate this phenotype. The aim of this study is to examine whether daily L-carnitine supplementation is safe and feasible, and will improve muscle strength and reduce fatigue in children with NF1. Read More

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Nonlinear mixed-effects modeling of longitudinal count data: Bayesian inference about median counts based on the marginal zero-inflated discrete Weibull distribution.

Stat Med 2021 Jun 21. Epub 2021 Jun 21.

I-BioStat, KU Leuven, Leuven, Belgium.

This article proposes a Bayesian regression model for nonlinear zero-inflated longitudinal count data that models the median count as an alternative to the mean count. The nonlinear model generalizes a recently introduced linear mixed-effects model based on the zero-inflated discrete Weibull (ZIDW) distribution. The ZIDW distribution is more robust to severe skewness in the data than conventional zero-inflated count distributions such as the zero-inflated negative binomial (ZINB) distribution. Read More

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Photovoltaic-driven microbial protein production can use land and sunlight more efficiently than conventional crops.

Proc Natl Acad Sci U S A 2021 Jun;118(26)

Systems and Synthetic Metabolism, Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam, Germany.

Population growth and changes in dietary patterns place an ever-growing pressure on the environment. Feeding the world within sustainable boundaries therefore requires revolutionizing the way we harness natural resources. Microbial biomass can be cultivated to yield protein-rich feed and food supplements, collectively termed single-cell protein (SCP). Read More

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Lateral entry pins and Slongo's external fixation: which method is more ideal for older children with supracondylar humeral fractures?

J Orthop Surg Res 2021 Jun 21;16(1):396. Epub 2021 Jun 21.

Department of Orthopedics, Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Shuangqiao District, Chengde, Hebei, 067000, People's Republic of China.

Objective: The standard surgical treatment for supracondylar humeral fractures in children is closed reduction and percutaneous pinning. Given the need for greater fixation strength and higher risk of joint stiffness for children older than 8 years, external fixation is often performed for treating supracondylar humeral fractures in older children. The aim of this study was to compare the efficacy of lateral entry pins and Slongo's external fixation for treating supracondylar humeral fractures in older children. Read More

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The use of computational models in the management and prognosis of refractory epilepsy: A critical evaluation.

Seizure 2021 Jun 10;91:132-140. Epub 2021 Jun 10.

Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, United Kingdom. Electronic address:

Purpose: Drug resistant epilepsy (DRE) affects approximately 30 percent of individuals with epilepsy worldwide. Surgery remains the most effective treatment for individuals with DRE, but referral to surgery is low and only about 60 percent of individuals who undergo surgery experience seizure control postoperatively. The present paper evaluates the evidence for using computational models in the prediction of surgical resection sites and surgical outcomes for patients with DRE. Read More

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Impact of dimethylpyrazole-based nitrification inhibitors on soil-borne bacteria.

Sci Total Environ 2021 Jun 15;792:148374. Epub 2021 Jun 15.

Department of Genetics, Physical Anthropology & Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.

Nitrogen (N) input from fertilizers modifies the properties of agricultural soils as well as bacterial community diversity, composition and relationships. This can lead to negative impacts such as the deterioration of system multifunctionality, whose maintenance is critical to normal nutrient cycling. Synthetic nitrification inhibitors (NIs) can be combined with fertilizers to improve the efficiency of N use by reducing N losses. Read More

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Spatiotemporally flexible subnetworks reveal the quasi-cyclic nature of integration and segregation in the human brain.

Neuroimage 2021 Jun 18:118287. Epub 2021 Jun 18.

Department of Women's and Children's health, Karolinska Institutet, Sweden.

Though the organization of functional brain networks is modular at its core, modularity does not capture the full range of dynamic interactions between individual brain areas nor at the level of subnetworks. In this paper we present a hierarchical model that represents both flexible and modular aspects of intrinsic brain organization across time by constructing spatiotemporally flexible subnetworks. We also demonstrate that segregation and integration are complementary and simultaneous events. Read More

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Increased procedural safety of cryoballoon pulmonary vein isolation with a double 120 seconds freeze protocol.

Pacing Clin Electrophysiol 2021 Jun 21. Epub 2021 Jun 21.

Cardioangiologisches Centrum Bethanien (CCB) / Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.

Background: recently a double 120 seconds freeze cryoballoon (CB) pulmonary vein isolation (PVI) protocol proved to be non inferior to a double 240 seconds freeze protocol in terms of atrial fibrillation recurrences. We hypothesized that this approach could also result in an increased procedure safety.

Methods: 80 consecutive patients treated with a double 120 seconds freeze protocol (Group CB120) were compared with 80 previous consecutive patients treated with a single 240 seconds freeze protocol (Group CB240). Read More

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Measurement-Based Variational Quantum Eigensolver.

Phys Rev Lett 2021 Jun;126(22):220501

Institute for Quantum Computing and Department of Physics and Astronomy, University of Waterloo, Waterloo N2L 3G1, Canada.

Variational quantum eigensolvers (VQEs) combine classical optimization with efficient cost function evaluations on quantum computers. We propose a new approach to VQEs using the principles of measurement-based quantum computation. This strategy uses entangled resource states and local measurements. Read More

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Adsorption and Desorption of Polymers on Bioinspired Chemically Structured Substrates.

ACS Appl Mater Interfaces 2021 Jun 21. Epub 2021 Jun 21.

L'Oréal Research and Innovation, Aulnay-Sous Bois 93600, France.

Natural biological surfaces exhibit interesting properties due to their inhomogeneous chemical and physical structure at the micro- and nanoscale. In the case of hair or skin, this also influences how waterborne macromolecules ingredients will adsorb and form cosmetically performing deposits (i.e. Read More

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A Simple Model Setup Using Spray-Drying Principles and Fluorescent Silica Nanoparticles to Evaluate the Efficiency of Facemask Materials in Terms of Virus Particle Retention.

Adv Mater Technol 2021 Jun 4;6(6):2100235. Epub 2021 May 4.

Fraunhofer-Institute for Silicate Research ISC Neunerplatz 2 D97082 Würzburg Germany.

Herein, a simple model setup is presented to spray fine liquid droplets containing nanoparticles in an air stream transporting this toward a filter material. The nanoparticles are made of silica and tagged with a fluorescent dye in order to render the trace of the particles easily visible. The silica nanoparticles, in a first approximation, mimic virus (severe acute respiratory syndrome coronavirus 2) particles. Read More

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Modified application of distal medial tibial locking plate as an alternative for fixation of an extraarticular distal-third diaphyseal humerus fracture.

Trauma Case Rep 2021 Aug 10;34:100420. Epub 2021 Feb 10.

Department of Orthopaedic Surgery, Amandeep Hospital, Amritsar, India.

Introduction: Surgical management of Extraarticular Distal-third diaphyseal Humerus Fracture (EADHF) poses a dilemma in terms of surgical approach, implant selection and position of the implant due to the availability of various pre-contoured implants and plate configurations. Various studies have described a modified application of anatomic locking plates as a satisfactory method of fixation in the surgical management of EADHF.

Case Presentation: This report discusses the modified application of anatomic Distal Medial Tibial locking Plate (DMTP) as an alternative strategy in fixation of an acute extraarticular distal-third diaphyseal fracture of the humerus in a 45-years-old female patient. Read More

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Biological Mechanisms Induced by Soybean Agglutinin Using an Intestinal Cell Model of Monogastric Animals.

Front Vet Sci 2021 2;8:639792. Epub 2021 Jun 2.

Animal Production Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.

Soybean agglutinin (SBA) has a toxic effect on most animals. The anti-nutritional mechanisms of SBA are not fully understood, in terms of cell survival activity and metabolism of intestinal cells. This study aims to investigate the effects of SBA on the cell cycle, apoptosis, and to verify the mechanism of SBA anti-nutritional characters based on proteomic-based analysis. Read More

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Randomised, Double-Blind, Placebo-Controlled Study of Iguratimod in the Treatment of Active Spondyloarthritis.

Front Med (Lausanne) 2021 2;8:678864. Epub 2021 Jun 2.

Department of Rheumatology and Immunology, First Medical Center, General Hospital of Chinese People's Liberation Army, Beijing, China.

The effect of Iguratimod in the treatment of rheumatoid arthritis was confirmed in past studies. In terms of the mechanism of the effect and clinical application experience, Iguratimod has a potential value in the treatment of spondyloarthritis (SpA). This study evaluated the efficacy and safety of Iguratimod on active SpA. Read More

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Identification of Methylation-Regulated Differentially Expressed Genes and Related Pathways in Hepatocellular Carcinoma: A Study Based on TCGA Database and Bioinformatics Analysis.

Front Oncol 2021 3;11:636093. Epub 2021 Jun 3.

Department of Internal Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Background: In recent years, DNA methylation modification has been shown to be a critical mechanism in the field of epigenetics.

Methods: Hepatocellular carcinoma (HCC) data were obtained from The Cancer Genome Atlas project, including RNA expression profiles, Illumina Human Methylation 450K BeadChip data, clinical information, and pathological features. Then, differentially expressed genes (DEGs) and differentially methylated genes were identified using R software. Read More

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Thumb CMCJ prosthetic total joint replacement: a systematic review.

EFORT Open Rev 2021 May 4;6(5):316-330. Epub 2021 May 4.

Epsom & St Helier University Hospitals NHS Trust, Trauma & Orthopaedics, Carshalton, UK.

Thumb carpometacarpal joint (CMCJ) arthritis is a common and painful condition. Thumb CMCJ prosthetic replacement aims to restore thumb biomechanics and improve pain and function. Early reviews demonstrated a lack of high-quality studies, but more recently a significant number of higher-quality studies have been published. Read More

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Effect of comprehensive nursing on the appearance and recovery effect of oral squamous cell carcinoma patients.

Am J Transl Res 2021 15;13(5):5519-5525. Epub 2021 May 15.

Administration, Qingdao Chengyang District People's Hospital Qingdao, China.

Objective: To investigate the effect of comprehensive nursing on the appearance and recovery of oral squamous cell carcinoma.

Methods: 52 patients with oral squamous cell carcinoma admitted to our hospital from February 2019 to February 2020 were selected and divided into a control group (n = 26, conventional nursing care) and an observation group (n = 26, comprehensive nursing). The postoperative hospital stay and postoperative intravenous infusion time, quality of life score, postoperative complications, nursing satisfaction, shape recovery, SAS score, etc. Read More

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