Anal Bioanal Chem 2021 Oct 12. Epub 2021 Oct 12.
Department of Biochemistry, Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston University Medical Campus, 670 Albany St., Rm. 509, Boston, MA, 02118, USA.
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now circulating worldwide that exhibit mutations in the spike protein. Protein sequence and glycosylation variations of the spike may affect viral fitness, antigenicity, and immune evasion. Read More