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Joint geophysical prospecting for groundwater exploration in weathered terrains of South Guangdong, China.

Environ Monit Assess 2021 Oct 19;193(11):734. Epub 2021 Oct 19.

Department of Earth Sciences, Quaid-I-Azam University, Islamabad, Pakistan.

Groundwater occurrence in a hard rock terrain is strongly controlled by the weathered/fractured zones. However, delineation of such zones is a challenging task given their structural heterogeneity. Traditionally, large numbers of well tests are conducted to assess the subsurface formation. Read More

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October 2021

Designed to Fail? Revisiting Uganda's Maternal Health Policies to Understand Policy Design Issues Underpinning Missed Targets for Reduction of Maternal Mortality Ratio (MMR): 2000-2015.

Int J Health Policy Manag 2021 Sep 7. Epub 2021 Sep 7.

Department of Health Policy, Planning and Management, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Despite Uganda and other sub-Saharan African countries missing their maternal mortality ratio (MMR) targets for Millennium Development Goal (MDG) 5, limited attention has been paid to policy design in the literature examining the persistence of preventable maternal mortality. This study examined the specific policy interventions designed to reduce maternal deaths in Uganda and identified particular policy design issues that underpinned MDG 5 performance. We suggest a novel prescriptive and analytical (re)conceptualization of policy in terms of its fidelity to '3Cs' (coherence of design, comprehensiveness of coverage and consistency in application) that could have implications for future healthcare programming. Read More

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September 2021

GproDIA enables data-independent acquisition glycoproteomics with comprehensive statistical control.

Nat Commun 2021 Oct 18;12(1):6073. Epub 2021 Oct 18.

Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200000, China.

Large-scale profiling of intact glycopeptides is critical but challenging in glycoproteomics. Data independent acquisition (DIA) is an emerging technology with deep proteome coverage and accurate quantitative capability in proteomics studies, but is still in the early stage of development in the field of glycoproteomics. We propose GproDIA, a framework for the proteome-wide characterization of intact glycopeptides from DIA data with comprehensive statistical control by a 2-dimentional false discovery rate approach and a glycoform inference algorithm, enabling accurate identification of intact glycopeptides using wide isolation windows. Read More

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October 2021

Residence Time, Water Contact, and Age-driven Schistosoma mansoni Infection in Hotspot Communities in Uganda.

Am J Trop Med Hyg 2021 Oct 18. Epub 2021 Oct 18.

Institute for Biodiversity, Animal Health and Comparative Medicine and Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom.

Schistosomiasis is the second most important parasitic infection after malaria in terms of its socioeconomic impact and is endemic in 78 countries. It affects more than 240 million people worldwide, with 90% of cases occurring in sub-Saharan Africa. In Uganda, Schistosoma mansoni is the most common species, with more than seven million people infected and 17 million living at risk despite mass drug administration (MDA) of praziquantel initiated more than 16 years ago. Read More

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October 2021

Resources and Geographical Access to Care for Severe Pediatric Pneumonia in Four Resource-Limited Settings.

Am J Respir Crit Care Med 2021 Oct 18. Epub 2021 Oct 18.

Johns Hopkins University, 1466, Division of Pulmonary and Critical Care, School of Medicine, Baltimore, Maryland, United States;

Rationale: Pneumonia is the leading cause of death in children worldwide. Identifying and appropriately managing severe pneumonia in a timely manner improves outcomes. Little is known about the readiness of healthcare facilities to manage severe pediatric pneumonia in low-resource settings. Read More

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October 2021

The impact of COVID-19-related media coverage on the return and volatility connectedness of cryptocurrencies and fiat currencies.

Technol Forecast Soc Change 2021 Nov 14;172:121025. Epub 2021 Jul 14.

Faculty of Economic and Business Sciences, University of Castilla-La Mancha, Albacete, Spain.

This research explores the impact of COVID-19-related media coverage on the dynamic return and volatility connectedness of the three dominant cryptocurrencies (Bitcoin (BTC), Ethereum (ETH) and Ripple (XRP)) and the fiat currencies of the euro, GBP and Chinese yuan. The sample period covers the first and second devasting waves of the COVID-19 pandemic crisis and ranges from January 1, 2020, to December 31, 2020. The dynamic return and volatility connectedness measures are estimated using the time varying parameter-VAR approach. Read More

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November 2021

Feasibility and preliminary patency of prophylactic hypogastric artery stenting for prevention of spinal cord ischemia in complex endovascular aortic repair.

Ann Vasc Surg 2021 Oct 13. Epub 2021 Oct 13.

Department of Vascular Medicine, University Heart & Vascular Center Hamburg, Hamburg, Germany.

Objective: To report early results of feasibility and patency of prophylactic hypogastric artery (HA) stenting during complex endovascular aortic repair.

Material And Methods: This is a single centre retrospective non comparative cohort study of all consecutive patients undergoing prophylactic HA stenting during fenestrated and/or branched EVAR (F/B EVAR) in order to prevent spinal cord ischemia (SCI). Endpoints included technical success and early outcomes in terms of morbidity, mortality and patency of the implanted stents. Read More

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October 2021

Random sequential adsorption of oriented rectangles with random aspect ratio.

Phys Rev E 2021 Sep;104(3-1):034903

Institute of Theoretical Physics, Jagiellonian University, 30-348 Kraków, Łojasiewicza 11, Poland.

We studied random sequential adsorption (RSA) of parallel rectangles with random aspect ratio but fixed area using a newly developed algorithm that allows to generate strictly saturated packing of this kind. We determined saturated packing fraction for several different distributions of a random variable used for selecting side length ratio of deposited rectangles. It was also shown that the anisotropy of deposited rectangles changes during packing generation. Read More

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September 2021

Unequal geographic distribution of water and sanitation at the household and school level in Sudan.

PLoS One 2021 15;16(10):e0258418. Epub 2021 Oct 15.

Communicable and Non-Communicable Diseases Control Directorate, Federal Ministry of Health, Khartoum, Sudan.

The Sudanese Government launched the National SDG-6 Plan and commences its implementation to achieve and sustain universal and equitable access to basic WASH services by 2030. It is critical to understand the geographical heterogeneity of Sudan and patterns in the inequality of access to safe drinking water and sanitation. Through such research, the disease control strategy can be optimized, and resource allocation can be prioritized. Read More

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October 2021

Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300).

Front Oncol 2021 28;11:740661. Epub 2021 Sep 28.

Radiotherapy Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.

Rectum and bladder volumes play an important role in the dose distribution reproducibility in prostate cancer adenocarcinoma (PCa) radiotherapy, especially for particle therapy, where density variation can strongly affect the dose distribution. We investigated the reliability and reproducibility of our image-guided radiotherapy (IGRT) and treatment planning protocol for carbon ion radiotherapy (CIRT) within the phase II mixed beam study (AIRC IG 14300) for the treatment of high-risk PCa. In order to calculate the daily dose distribution, a set of synthetic computed tomography (sCT) images was generated from the cone beam computed tomography (CBCT) images acquired in each treatment session. Read More

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September 2021

Treatment of a Diaphyseal Tibial Malunion with Use of the Clamshell Osteotomy.

JBJS Essent Surg Tech 2021 Jul-Sep;11(3). Epub 2021 Jul 14.

Serviço de Ortopedia e Traumatologia, Hospital Felicio Rocho, Belo Horizonte, Brazil.

Malunion, nonunion, congenital abnormalities, and osteometabolic diseases are the main causes of long bone deformities. Although the exact incidence is unclear, it is estimated that about 10% of all fractures have some complication in terms of fracture-healing. In addition to the aesthetic impact, malunions generally substantially impair function and quality of life. Read More

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Tissue Coverage and Functional Reconstruction Outcomes With Use of Serratus Osteomusculocutaneous Free Flap in Lateral Malleolar Reconstruction: A Case Report.

Authors:
Ayhan Okumus

J Foot Ankle Surg 2021 Sep 20. Epub 2021 Sep 20.

Private Aesthetic Plastic and Reconstructive Surgery Office, Bursa, Turkey. Electronic address:

Currently, there is no ideal method defined in the repair of complex lateral malleolar defects, and the existing methods (i.e., bone repair, soft tissue or free flap closure) are far from producing functional results in terms of the ultimate recovery of ankle movements. Read More

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September 2021

Gold-based nanostructured platforms for oxytetracycline detection from milk by a "signal-on" aptasensing approach.

Food Chem 2021 Sep 14;371:131127. Epub 2021 Sep 14.

"Iuliu Haţieganu" University of Medicine and Pharmacy, Faculty of Pharmacy, Analytical Chemistry Department, 4 Pasteur Street, 400349 Cluj-Napoca, Romania. Electronic address:

Several gold platforms of different morphologies were investigated in the elaboration of a new aptasensor for oxytetracycline. Au-nanostructures were electrochemically synthesized from solutions of different concentrations of HAuCl in different media by chronoamperometry, multipulse amperometry, and chronopotentiometry, respectively at carbon-based screen-printed electrodes (C-SPE). The nano-/micro-scale morphologies of the patterned surfaces and elemental composition were examined by scanning electron microscopy, atomic force microscopy, and X-ray photoelectron spectroscopy, respectively. Read More

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September 2021

High genetic and epigenetic variation of transposable elements: Potential drivers to rapid adaptive evolution for the noxious invasive weed .

Ecol Evol 2021 Oct 15;11(19):13501-13517. Epub 2021 Sep 15.

College of Life Sciences South China Agricultural University Guangzhou China.

Why invasive species can rapidly adapt to novel environments is a puzzling question known as the genetic paradox of invasive species. This paradox is explainable in terms of transposable elements (TEs) activity, which are theorized to be powerful mutational forces to create genetic variation. , a noxious invasive weed, in this sense provides an excellent opportunity to test the explanation. Read More

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October 2021

On-Orbit Geometric Calibration from the Relative Motion of Stars for Geostationary Cameras.

Sensors (Basel) 2021 Oct 7;21(19). Epub 2021 Oct 7.

Key Laboratory of Intelligent Infrared Perception, Chinese Academy of Sciences, Shanghai 200083, China.

Affected by the vibrations and thermal shocks during launch and the orbit penetration process, the geometric positioning model of the remote sensing cameras measured on the ground will generate a displacement, affecting the geometric accuracy of imagery and requiring recalibration. Conventional methods adopt the ground control points (GCPs) or stars as references for on-orbit geometric calibration. However, inescapable cloud coverage and discontented extraction algorithms make it extremely difficult to collect sufficient high-precision GCPs for modifying the misalignment of the camera, especially for geostationary satellites. Read More

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October 2021

Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature.

J Clin Med 2021 Sep 30;10(19). Epub 2021 Sep 30.

Maxilofacial Surgery Department, Hospital Universitario La Paz, 28046 Madrid, Spain.

Intraosseous venous malformations affecting the zygomatic bone are infrequent. Primary reconstruction is usually accomplished with calvarial grafts, although the use of virtual surgical planning, cutting guides and patient-specific implants (PSI) have had a major development in recent years. A retrospective study was designed and implemented in patients diagnosed with intraosseous venous malformation during 2006-2021, and a review of the scientific literature was also performed to clarify diagnostic terms. Read More

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September 2021

Ag/MgO Nanoparticles via Gas Aggregation Nanocluster Source for Perovskite Solar Cell Engineering.

Materials (Basel) 2021 Sep 23;14(19). Epub 2021 Sep 23.

Dipartimento di Scienze Fisiche, Matematiche e Informatiche, Università di Modena e Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy.

Nanocluster aggregation sources based on magnetron-sputtering represent precise and versatile means to deposit a controlled quantity of metal nanoparticles at selected interfaces. In this work, we exploit this methodology to produce Ag/MgO nanoparticles (NPs) and deposit them on a glass/FTO/TiO substrate, which constitutes the mesoscopic front electrode of a monolithic perovskite-based solar cell (PSC). Herein, the Ag NP growth through magnetron sputtering and gas aggregation, subsequently covered with MgO ultrathin layers, is fully characterized in terms of structural and morphological properties while thermal stability and endurance against air-induced oxidation are demonstrated in accordance with PSC manufacturing processes. Read More

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September 2021

O-JMeSH: creating a bilingual English-Japanese controlled vocabulary of MeSH UIDs through machine translation and mutual information.

Genomics Inform 2021 Sep 30;19(3):e26. Epub 2021 Sep 30.

Graduate School of Integrative Science and Engineering, Tokyo City University, Tokyo 158-8557, Japan.

Previous approaches to create a controlled vocabulary for Japanese have resorted to existing bilingual dictionary and transformation rules to allow such mappings. However, given the possible new terms introduced due to coronavirus disease 2019 (COVID-19) and the emphasis on respiratory and infection-related terms, coverage might not be guaranteed. We propose creating a Japanese bilingual controlled vocabulary based on MeSH terms assigned to COVID-19 related publications in this work. Read More

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September 2021

Supplementary private health insurance: The impact of physician financial incentives on medical practice.

Health Econ 2021 Oct 11. Epub 2021 Oct 11.

EA 7285, Versailles Saint Quentin University, Montigny-le-Bretonneux, France.

In the French diagnosis-related group (DRG)-based payment system, both private and public hospitals are financed by a public single payer. Public hospitals are overcrowded and have no direct financial incentives to choose one procedure over another. If a patient has a strong preference, they can switch to a private hospital. Read More

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October 2021

Data-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein.

Anal Bioanal Chem 2021 Oct 12. Epub 2021 Oct 12.

Department of Biochemistry, Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston University Medical Campus, 670 Albany St., Rm. 509, Boston, MA, 02118, USA.

The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now circulating worldwide that exhibit mutations in the spike protein. Protein sequence and glycosylation variations of the spike may affect viral fitness, antigenicity, and immune evasion. Read More

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October 2021

Immune Checkpoint Inhibitor-Associated Tumor Lysis Syndrome: A Real-World Pharmacovigilance Study.

Front Pharmacol 2021 23;12:679207. Epub 2021 Sep 23.

Department of Pharmacy, Peking University International Hospital, Beijing, China.

Immune checkpoint inhibitors (ICIs) have substantially improved the clinical outcomes of various malignancies. However, the adverse event of tumor lysis syndrome (TLS) has not been included in the National Comprehensive Cancer Network guidelines or drug inserts. In this study, we aimed to establish the relationship between ICI therapies and TLS events using data from a real-world pharmacovigilance database. Read More

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September 2021

On Neurorights.

Authors:
Marcello Ienca

Front Hum Neurosci 2021 24;15:701258. Epub 2021 Sep 24.

College of Humanities, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

In recent years, philosophical-legal studies on neuroscience (mainly in the fields of neuroethics and neurolaw) have given increasing prominence to a normative analysis of the ethical-legal challenges in the mind and brain sciences in terms of rights, freedoms, entitlements and associated obligations. This way of analyzing the ethical and legal implications of neuroscience has come to be known as "neurorights." Neurorights can be defined as the ethical, legal, social, or natural principles of freedom or entitlement related to a person's cerebral and mental domain; that is, the fundamental normative rules for the protection and preservation of the human brain and mind. Read More

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September 2021

Sex and gender specific health topics in medical student learners: pulse check eight years later.

Biol Sex Differ 2021 Oct 9;12(1):53. Epub 2021 Oct 9.

Division of Women's Health Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.

Background: An essential component of patient-centered, individualized medicine is considering how sex and gender affect mechanisms of health and disease.

Objectives: To assess medical students' current knowledge of sex and gender specific health (SGSH) concepts compared to results from the same survey in 2012 to better inform development of curricular materials for medical education.

Methods: A previously designed survey tool, which assessed current knowledge of sex and gender-based medicine of medical students, was emailed to all Mayo Clinic Alix School of Medicine (MCASOM) students on Minnesota, Arizona, and Florida campuses in 2020. Read More

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October 2021

Comparison of sequencing data processing pipelines and application to underrepresented African human populations.

BMC Bioinformatics 2021 Oct 9;22(1):488. Epub 2021 Oct 9.

Human Evolution, Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18C, 752 36, Uppsala, Sweden.

Background: Population genetic studies of humans make increasing use of high-throughput sequencing in order to capture diversity in an unbiased way. There is an abundance of sequencing technologies, bioinformatic tools and the available genomes are increasing in number. Studies have evaluated and compared some of these technologies and tools, such as the Genome Analysis Toolkit (GATK) and its "Best Practices" bioinformatic pipelines. Read More

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October 2021

Characteristics of secondary progressive multiple sclerosis: Disease activity and provision of care in Germany - A registry-based/multicentric cohort study.

Mult Scler Relat Disord 2021 Sep 26;56:103281. Epub 2021 Sep 26.

Neurological Rehabilitation Center Quellenhof, Bad Wildbad, Germany. Electronic address:

Background: The tailored immunomodulatory treatment strategy for secondary progressive multiple sclerosis (SPMS) depends on disease activity.

Objective: To assess the real-world situation in monitoring disease activity in SPMS patients and to identify associations of resulting subgroups with demographics, symptomatology, and therapy METHODS: This study included 4,263 SPMS patients from the German MS register (GMSR). For the classification into 'active' and 'inactive' according to relapse activity and MRI findings during the year prior to the latest clinical visit, we used the following definitions: active - gadolinium enhancing (Gd+)/new T2 lesions or ≥1 relapse, inactive - neither Gd+/new T2 lesions nor relapses. Read More

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September 2021

Content Analysis of E-cigarette News Articles Amidst the 2019 Vaping-Associated Lung Injury (EVALI) Outbreak in the U.S.

Nicotine Tob Res 2021 Oct 8. Epub 2021 Oct 8.

Rutgers Center for Tobacco Studies, Rutgers University, New Brunswick, NJ.

Introduction: News media can shape public perceptions about e-cigarettes, particularly in the context of ongoing uncertainty from the recent outbreak of e-cigarette or vaping product use-associated lung injury (EVALI). This study aimed to characterize news articles published about e-cigarettes in 2019, including before and during the EVALI outbreak.

Methods: Using 24 e-cigarette-related search terms, we gathered all articles published in leading print and online U. Read More

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October 2021

Measles outbreak, Montenegro January-July 2018: Lessons learned.

J Med Virol 2021 Oct 7. Epub 2021 Oct 7.

Institute of Public Health of Montenegro, Podgorica, Montenegro.

In 2017, the Regional Verification Commission for Measles and Rubella Elimination (RVC) of the World Health Organization confirmed that measles elimination was sustained in Montenegro, and the previous endemic transmission remained interrupted. However, the RVC was extremely concerned over the continuing low vaccination coverage reported for this country. In this study, we describe the most recent measles epidemic in Montenegro using the epidemiological data collected from January 1 to July 31, 2018. Read More

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October 2021

Influenza vaccination uptake and attitudes among adult cancer patients in Japan: a web-based questionnaire survey before the 2020/2021 season.

Hum Vaccin Immunother 2021 Oct 6:1-5. Epub 2021 Oct 6.

Medical Governance Research Institute, Minato-ku, Japan.

Influenza vaccination is necessary to reduce severe influenza complications, especially in immunocompromised people such as cancer patients. However, few studies have examined influenza vaccination uptake among adult Japanese patients with cancer; their attitudes toward vaccination, as well as factors related to vaccine hesitancy, are unclear. From September 1 to October 31, 2020, we disseminated a web-based questionnaire to patients with a history of cancer via snowball sampling through e-mails and social media of two Japanese cancer patients associations. Read More

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October 2021

A systematic review on the treatment of pediatric severe alopecia areata by topical immunotherapy or Anthralin (contact sensitization) or low-level light/laser therapy (LLLT): focus on efficacy, safety, treatment duration, recurrence, and follow-up based on clinical studies.

J Cosmet Dermatol 2021 Oct 4. Epub 2021 Oct 4.

Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Alopecia areata (AA) in its extensive and severe forms is treatment-challenging, especially in pediatrics.

Method: A PRISMA-compliant systematic review of seven electronic databases was searched by the terms "alopecia areata," "pediatric," "topical immunotherapy," "Anthralin," and "light therapy" from inception until March 2021. All the alternative names of the disease and therapies have been included in the search terms. Read More

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October 2021