598,387 results match your criteria terms


[The use of immuno-oncologic therapy in hepatocellular carcinoma in the context of liver transplantation. An interdisciplinary benefit/risk assessment].

Z Gastroenterol 2021 Oct 20. Epub 2021 Oct 20.

I. Medizinische Klinik und Poliklinik, UKE Hamburg, Hamburg, Deutschland.

Background: Multiple systemic therapy options have been recently approved for the treatment of hepatocellular carcinoma (HCC). In particular, immuno-oncology combination therapies can now achieve impressive response rates and significantly prolonged survival with good tolerability. These immuno-oncology (IO)-based combinations are currently not only evaluated for the therapy of advanced HCC, but increasingly also in earlier stages in terms of peri-interventional therapy concepts and also for down-sizing to local therapies. Read More

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October 2021

Versatility of the subscapular system of flaps in head and neck oncologic reconstruction.

Curr Opin Otolaryngol Head Neck Surg 2021 Oct 19. Epub 2021 Oct 19.

Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, School of Medicine, Brescia, Italy.

Purpose Of Review: This review analyzes the different ways of applying the subscapular system of flaps (SSSF) as a convenient and versatile solution for a large variety of head and neck oncologic defects.

Recent Findings: The ventral approach permits safe and efficient harvest of various chimeric SSSF in a supine position, thus allowing simultaneous flap preparation and tumor ablation. Conformational studies have revealed how similar the tip of the scapula is to the hard palate in terms of dimensions, shape, and conformation. Read More

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October 2021

Abuse detection in healthcare insurance with disease-treatment network embedding.

J Biomed Inform 2021 Oct 17:103936. Epub 2021 Oct 17.

Department of Industrial Engineering & Institute for Industrial Systems Innovation, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:

Abuse in healthcare insurance refers to a medical service or practice inconsistent with the generally accepted sound fiscal practices, such as overtreatment or overcharging. These types of abuses may lead to prescriptions that do not meet the criteria for medical stability. On the other hand, abuse may incur unnecessary costs by deliberately executing gratuitous treatments. Read More

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October 2021

Fully automated lumen and vessel contour segmentation in intravascular ultrasound datasets.

Med Image Anal 2021 Oct 7;75:102262. Epub 2021 Oct 7.

Interventional Cardiology Department, MedStar Washington Hospital Center, Washington, DC, USA; Georgetown University School of Medicine, Washington, DC, USA. Electronic address:

Segmentation of lumen and vessel contours in intravascular ultrasound (IVUS) pullbacks is an arduous and time-consuming task, which demands adequately trained human resources. In the present study, we propose a machine learning approach to automatically extract lumen and vessel boundaries from IVUS datasets. The proposed approach relies on the concatenation of a deep neural network to deliver a preliminary segmentation, followed by a Gaussian process (GP) regressor to construct the final lumen and vessel contours. Read More

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October 2021

npSCOPE: A New Multimodal Instrument for In Situ Correlative Analysis of Nanoparticles.

Anal Chem 2021 Oct 20. Epub 2021 Oct 20.

Advanced Instrumentation for Nano-Analytics (AINA), MRT Department, Luxembourg Institute of Science and Technology, 41 rue du Brill, L-4422 Belvaux, Luxembourg.

Over the last few decades, nanoparticles have become a key element in a number of scientific and technological fields, spanning from materials science to life sciences. The characterization of nanoparticles or samples containing nanoparticles, in terms of morphology, chemical composition, and other parameters, typically involves investigations with various analytical tools, requiring complex workflows and extending the duration of such studies to several days or even weeks. Here, we report on the development of a new unique in situ correlative instrument, allowing us to answer questions about the shape, size, size distribution, and chemical composition of the nanoparticles using a single probe. Read More

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October 2021

Multiple-Rod Constructs Do Not Reduce Pseudarthrosis and Rod Fracture After Pedicle Subtraction Osteotomy for Adult Spinal Deformity Correction but Improve Quality of Life.

Neurospine 2021 Oct 21. Epub 2021 Oct 21.

Clinique du Dos, Elsan Jean Villar Private hospital, Bordeaux, France.

Objective: To compare the radiological and functional outcomes and complications of adult spinal deformity patients who underwent a pedicle subtraction osteotomy (PSO) but categorized according to their construct where either 2-rod or multiple-rod construct is applied.

Methods: 67 patients met the inclusion criteria, and were categorized into 3 groups: 2 rods (2R), multiple rods around the PSO (MRP), multiple rods around the PSO and lumbosacral junction (MRL). Demographic data, operative parameters, spinopelvic parameters, functional outcomes and complications were collected. Read More

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October 2021

Surgical outcomes of tension-free vaginal tape (TVT)-abbrevo® and TVT-obturator® for the treatment of stress urinary incontinence: a retrospective study.

Obstet Gynecol Sci 2021 Oct 20. Epub 2021 Oct 20.

Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: We compared the efficacy and postoperative complications of tension-free vaginal tape (TVT)-abbrevo® (TVT-A) and TVT-obturator® (TVT-O) surgeries for the treatment of stress urinary incontinence (SUI).

Methods: We retrospectively analyzed the medical records of 143 female patients with SUI who underwent TVT-A or TVT-O surgery between January 2010 and December 2019 at the Asan Medical Center in Seoul. We evaluated intra- and postoperative complications such as bladder injury, groin pain, urinary retention, and mesh exposure. Read More

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October 2021

Metallurgical characterisation and torsional resistance of blue thermomechanically treated nickel titanium instruments after simulated ex vivo retreatment procedure.

Aust Endod J 2021 Oct 20. Epub 2021 Oct 20.

Department of Endodontics, Faculty of Dentistry, Ondokuz Mayıs University, Samsun, Turkey.

To compare used and unused Reciproc Blue and Reciproc after retreatment, the instruments were used in the mesiobuccal canals of maxillary molars with curvature. The torsional resistances were tested and then unused instruments were subjected to XRD, DSC and microhardness tests. Student's t, ANOVA and Tukey's tests were performed (α-level 0. Read More

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October 2021

Validation of a deterministic linear Boltzmann transport equation solver for rapid CT dose computation using physical dose measurements in pediatric phantoms.

Med Phys 2021 Oct 20. Epub 2021 Oct 20.

Department of Biomedical Engineering, Medical College of Wisconsin and Marquette University, Milwaukee, WI, 53201, USA.

Purpose: The risk of inducing cancer to patients undergoing CT examinations has motivated efforts for CT dose estimation, monitoring and reduction, especially among pediatric population. The method investigated in this study is Acuros CTD (Varian Medical Systems, Palo Alto, CA), a deterministic linear Boltzmann transport equation (LBTE) solver aimed at generating rapid and reliable dose maps of CT exams. By applying organ contours, organ doses can also be obtained, thus patient-specific organ dose estimates can be provided. Read More

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October 2021

Causes and Consequences of Polycystic Ovary Syndrome: Insights from Mendelian Randomization.

J Clin Endocrinol Metab 2021 Oct 20. Epub 2021 Oct 20.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Context: Though polycystic ovarian syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age, risk factors that may cause the syndrome are poorly understood. Based on epidemiologic studies, PCOS is thought to cause several adverse outcomes such as cardiovascular disease; however, the common presence of co-morbidities such as obesity may be responsible for such associations, rather than PCOS in and of itself. To overcome the limitations of observational studies, investigators have employed Mendelian randomization (MR), which uses genetic variants to interrogate causality between exposures and outcomes. Read More

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October 2021

Communicating Certainty in Pathology Reports: Interpretation Differences Among Staff Pathologists, Clinicians, and Residents in a Multicenter Study.

Arch Pathol Lab Med 2021 Oct 20. Epub 2021 Oct 20.

Department of Pathology (Geisler, DeFrances), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Context.—: Pathology reports are the main modality in which results are communicated to other physicians. For various reasons, the diagnosis may be qualified on a spectrum of uncertainty. Read More

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October 2021

IS BODY MASS INDEX AND OBESITY SURGERY MORTALITY SCORE IMPORTANT IN PERIOPERATIVE COMPLICATIONS OF LAPAROSCOPIC SLEEVE GASTRECTOMY BEFORE DISCHARGE?

Arq Bras Cir Dig 2021 15;34(2):e1602. Epub 2021 Oct 15.

Department of Surgery, Elazig Training and Research Hospital, Professor, Elazig, Turkey.

Background: Morbid obesity surgery and related complications have increased with time.

Aim: To evaluate the relationship between perioperative complications before discharge and preoperative body mass index and obesity surgery mortality score in laparoscopic sleeve gastrectomy.

Method: 1617 patients who met the inclusion criteria were evaluated retrospectively. Read More

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October 2021

Is combined rather than single antibiotic therapy actually reasonable in patients with acute calculous cholecystitis?

Rev Assoc Med Bras (1992) 2021 Aug;67(8):1155-1160

University of Health Sciences, Gulhane Education and Research Hospital, Department of General Surgery - Ankara, Turkey.

Objective: Acute calculous cholecystitis (AC) is a frequently encountered emergency surgery disease and its standard treatment is cholecystectomy. In patients with high risk in surgery, antibiotic treatment (AT) is important. In routine clinical practices, antibiotics are frequently used either as single or in combination in the treatment of AC. Read More

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Association between SYNTAX II Score and late saphenous vein graft failure in patients undergoing isolated coronary artery bypass graft surgery.

Rev Assoc Med Bras (1992) 2021 Aug;67(8):1093-1101

Necmettin Erbakan University Meram Faculty of Medicine, Department of Cardiology - Konya, Türkiye.

Objective: Coronary artery bypass graft (CABG) surgery is a well-established treatment modality for patients with multivessel coronary artery disease (CAD). Syntax II Score has been established as novel scoring system with better prediction of postprocedural outcomes. This study aimed to investigate the prognostic value of SYNTAX II Score for predicting late saphenous vein graft (SVG) failure in patients undergoing isolated CABG. Read More

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Use of hydroxychloroquine to prevent SARS-CoV-2 infection and treat mild COVID-19: a systematic review and meta-analysis.

J Bras Pneumol 2021 15;47(5):e20210236. Epub 2021 Oct 15.

. Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.

Objective: Chloroquine or hydroxychloroquine has demonstrated no effect on the treatment of hospitalized COVID-19 patients. This study aimed to answer questions related to the use of hydroxychloroquine for pre-exposure or post-exposure prophylaxis of SARS-CoV-2 infection and in the treatment of patients with mild COVID-19 in terms of hospitalization, adverse events, and mortality.

Methods: This was a systematic review and meta-analysis of phase 3 randomized clinical trials, selected from various databases, which compared patients who received hydroxychloroquine for SARS-CoV-2 prophylaxis or treatment of mild COVID-19 cases with controls. Read More

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October 2021

Impact of exposure to smoke from biomass burning in the Amazon rain forest on human health.

J Bras Pneumol 2021 15;47(5):e20210219. Epub 2021 Oct 15.

. Departamento Científico de Polución, Sociedad Latinoamericana de Alergia, Asma e Inmunología, Asunción, Paraguay.

This review study aimed to determine the relationship between exposure to smoke from biomass burning in the Amazon rain forest and its implications on human health in that region in Brazil. A nonsystematic review was carried out by searching PubMed, Google Scholar, SciELO, and EMBASE databases for articles published between 2005 and 2021, either in Portuguese or in English, using the search terms "biomass burning" OR "Amazon" OR "burned" AND "human health." The review showed that the negative health effects of exposure to smoke from biomass burning in the Amazon have been poorly studied in that region. Read More

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October 2021

Consensus statement on thoracic radiology terminology in Portuguese used in Brazil and in Portugal.

J Bras Pneumol 2021 15;47(5):e20200595. Epub 2021 Oct 15.

. Universidade da Beira Interior, Covilhã, Portugal.

Effective communication among members of medical teams is an important factor for early and appropriate diagnosis. The terminology used in radiology reports appears in this context as an important link between radiologists and other members of the medical team. Therefore, heterogeneity in the use of terms in reports is an important but little discussed issue. Read More

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October 2021

Environmental characteristics, nutritional and executive functions in children of 6 to 7 years.

Braz J Biol 2021 11;83:e248778. Epub 2021 Oct 11.

Centro Universitário CESMAC, Maceió, AL, Brasil.

This study aimed to analyze the socio-environmental characteristics, executive and nutritional functions in children aged 6 to 7 years, from public schools in Alagoas, Brazil. A quantitative, cross-sectional and descriptive study was performed involving 64 children of the mentioned age group, from public schools located in Alagoas: Maceió, on the coast; Major Isidoro, in the hinterland and Palmeira dos Índios, in the country. Such analyzes were made through the application of neuropsychological tests and anthropometric assessment with children and food and socio-environmental surveys with their parents. Read More

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October 2021

The impact of combined age-related vision loss and dementia on the participation of older adults: A scoping review.

PLoS One 2021 20;16(10):e0258854. Epub 2021 Oct 20.

CBI Health Centre, Ottawa, Ontario, Canada.

Introduction: There are a growing number of older adults with combined age-related vision loss (ARVL) and dementia. Existing literature shows the pervasive impact that both diagnoses have separately on the participation of older adults, however, little is known about the societal participation of older adults with both conditions. As such, the aim of this scoping review was to explore the combined impact of ARVL and dementia on the participation of older adults, with a specific focus on highlighting strategies that help mitigate the impact of ARVL and dementia on participation. Read More

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October 2021

Factors influencing inappropriate use of antibiotics: Findings from a nationwide survey of the general public in Malaysia.

PLoS One 2021 20;16(10):e0258698. Epub 2021 Oct 20.

Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Antibiotic resistance is one of the biggest threats to global public health. Misuse of antibiotics has never been investigated on a nationwide scale among the general public in Malaysia. This study aimed to identify sociodemographic and knowledge factors associated with inappropriate use of antibiotics in the Malaysian context to inform the development of interventions to mitigate inappropriate antibiotic use. Read More

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October 2021

Land use and land cover change and its impacts on dengue dynamics in China: A systematic review.

PLoS Negl Trop Dis 2021 Oct 20;15(10):e0009879. Epub 2021 Oct 20.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Dengue is a prioritized public health concern in China. Because of the larger scale, more frequent and wider spatial distribution, the challenge for dengue prevention and control has increased in recent years. While land use and land cover (LULC) change was suggested to be associated with dengue, relevant research has been quite limited. Read More

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October 2021

Understanding degraded speech leads to perceptual gating of a brain stem reflex in human listeners.

PLoS Biol 2021 Oct 20;19(10):e3001439. Epub 2021 Oct 20.

Department of Linguistics, The Australian Hearing Hub, Macquarie University, Sydney, Australia.

The ability to navigate "cocktail party" situations by focusing on sounds of interest over irrelevant, background sounds is often considered in terms of cortical mechanisms. However, subcortical circuits such as the pathway underlying the medial olivocochlear (MOC) reflex modulate the activity of the inner ear itself, supporting the extraction of salient features from auditory scene prior to any cortical processing. To understand the contribution of auditory subcortical nuclei and the cochlea in complex listening tasks, we made physiological recordings along the auditory pathway while listeners engaged in detecting non(sense) words in lists of words. Read More

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October 2021

Postoperative Opioid Prescribing After Female Pelvic Medicine and Reconstructive Surgery.

Female Pelvic Med Reconstr Surg 2021 Oct 19. Epub 2021 Oct 19.

From the Urogynecology and Pelvic Reconstructive Surgery, MultiCare Health Systems, Tacoma, WA Division of Urognecology, The Oregon Clinic, Portland, OR Female Pelvic Medicine and Reconstructive Surgery, University of California, Irvine, Orange, CA Department of Obstetrics and Gynecology and Department of Urology, Mayo Clinic, Rochester, MN Urogynecology and Reconstructive Pelvic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Obstetrics and Gynecology, Female Pelvic Medicine and Reconstructive Surgery, Oregon Health & Science University, Portland, OR Department of Obstetrics and Gynecology, Female Pelvic Medicine and Reconstructive Surgery, Penn State College of Medicine, Hershey, PA.

Objective: This study aimed to provide female pelvic medicine and reconstructive surgery (FPMRS) providers with evidence-based guidance on opioid prescribing following surgery.

Methods: A literature search of English language publications between January 1, 2000, and March 31, 2021, was conducted. Search terms identified reports on opioid prescribing, perioperative opioid use, and postoperative pain after FPMRS procedures. Read More

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October 2021

Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019-2021.

Curr Opin Oncol 2021 Oct 19. Epub 2021 Oct 19.

Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Purpose Of Review: comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC.

Recent Findings: 423 studies were published between 2019 and 2021. Read More

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October 2021

A Review of Wearable Multi-wavelength Photoplethysmography.

IEEE Rev Biomed Eng 2021 Oct 20;PP. Epub 2021 Oct 20.

Optical pulse detection photoplethysmography (PPG) provides a means of low cost and unobtrusive physiological monitoring that is popular in many wearable devices. However, the accuracy, robustness and generalizability of single-wavelength PPG sensing are sensitive to biological characteristics as well as sensor configuration and placement; this is significant given the increasing adoption of single-wavelength wrist-worn PPG devices in clinical studies and healthcare. Since different wavelengths interact with the skin to varying degrees, researchers have explored the use of multi-wavelength PPG to improve sensing accuracy, robustness and generalizability. Read More

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October 2021

Asthma Phenotypes and COVID-19 Risk: A Population-based Observational Study.

Am J Respir Crit Care Med 2021 Oct 20. Epub 2021 Oct 20.

Imperial College London, National Heart and Lung Institute, London, United Kingdom of Great Britain and Northern Ireland.

Rationale: Studies have suggested some asthma patients are at risk of severe COVID-19, but they have had limited data on asthma phenotype and have not considered if risks are specific to COVID-19.

Objectives: Determine the effect of asthma phenotype on three levels of COVID-19 outcomes. Compare hospitalisation rates to influenza and pneumonia. Read More

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October 2021

From Hell to Heaven? Lived experiences of LGBTQ migrants in relation to health and their reflections on the future.

Cult Health Sex 2021 Oct 20:1-13. Epub 2021 Oct 20.

School of Health and Welfare, Halmstad University, Halmstad, Sweden.

This paper explores the lived experiences of LGBTQ migrants participating in a civil society group in Sweden during the migration process and their reflections on the future. Eleven migrants who self-identified as LGBTQ (seven male/gay, one female/lesbian, one female/bi-sexual, and two transgender/gay persons) from three local support groups for LGBTQ migrants agreed to be interviewed. Participants came from Guinea, Iraq, Kurdistan, North Macedonia, Nigeria, Nicaragua, Pakistan, the Russian Federation, Syria, Uganda and Ukraine. Read More

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October 2021

New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).

Expert Opin Ther Targets 2021 Oct 20. Epub 2021 Oct 20.

Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY 10029, USA.

Introduction: Acute Graft-versus-Host Disease (GVHD) is the major toxicity of allogeneic hematopoietic cell transplantation (HCT). Systemic steroids are the standard primary treatment but only half of patients will respond completely and the survival of steroid-refractory patients is poor. The gastrointestinal (GI) tract is a key target organ that usually determines a patient's response to therapy. Read More

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October 2021

Intrinsic brainstem circuits comprised of Chx10-expressing neurons contribute to reticulospinal output in mice.

J Neurophysiol 2021 Oct 20. Epub 2021 Oct 20.

Department of Neuromuscular Diseases, UCL Queen Square, Institute of Neurology, University College London, London, United Kingdom.

Glutamatergic reticulospinal neurons in the gigantocellular reticular nucleus (GRN) of the medullary reticular formation can function as command neurons, transmitting motor commands to spinal cord circuits to instruct movement. Recent advances in our understanding of this neuron-dense region have been facilitated by the discovery of expression of the transcriptional regulator, Chx10, in excitatory reticulospinal neurons. Here, we address the capacity of local circuitry in the GRN to contribute to reticulospinal output. Read More

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October 2021