65,634 results match your criteria termination

Management of acute hemorrhage due to cerebral AVM during pregnancy ---- case series and literature review.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Objective: Acute hemorrhage due to cerebral arteriovenous malformation (cAVM) during pregnancy is uncommon but life-threatening for both the mother and the fetus, and presents a great challenge to clinical management. However, there is still no consensus on the treatment strategy and the treatment timing of acute hemorrhage from cAVM during pregnancy. The aim of this study was to amalgamate published case series and our cases regarding the clinical management of pregnant patients under this special condition. Read More

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Preliminary Outcomes of an Ecological Momentary Intervention for Social Functioning in Schizophrenia: Pre-Post Study of the Motivation and Skills Support App.

JMIR Ment Health 2021 Jun 15;8(6):e27475. Epub 2021 Jun 15.

Department of Psychological & Brain Sciences, Boston University, Boston, MA, United States.

Background: People with schizophrenia and other serious mental illnesses often lack access to evidence-based interventions, particularly interventions that target meaningful recovery outcomes such as social functioning and quality of life. Mobile technologies, including smartphone apps, have the potential to provide scalable support that places elements of evidence-based interventions at the palm of patients' hands.

Objective: We aim to develop a smartphone app-called Motivation and Skills Support-to provide targeted social goal support (eg, making new friends and improving existing relationships) for people with schizophrenia enrolled in a stand-alone open trial. Read More

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Structure of Tau filaments in Prion protein amyloidoses.

Acta Neuropathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein cerebral amyloid angiopathy (PrP-CAA) with a nonsense mutation in the PRNP gene that leads to early termination of translation of PrP (Q160Ter or Q160X), and Gerstmann-Sträussler-Scheinker (GSS) disease, with a missense mutation in the PRNP gene that leads to an amino acid substitution at residue 198 (F198S) of PrP. The clinical and neuropathologic phenotypes associated with these two mutations in PRNP are different; however, the neuropathologic analyses of these two genetic variants have consistently shown the presence of numerous neurofibrillary tangles (NFTs) made of filamentous Tau aggregates in neurons. Read More

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Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance.

Nat Commun 2021 06 14;12(1):3607. Epub 2021 Jun 14.

Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, USA.

Ribosomes are recycled for a new round of translation initiation by dissociation of ribosomal subunits, messenger RNA and transfer RNA from their translational post-termination complex. Here we present cryo-EM structures of the human 55S mitochondrial ribosome (mitoribosome) and the mitoribosomal large 39S subunit in complex with mitoribosome recycling factor (RRF) and a recycling-specific homolog of elongation factor G (EF-G2). These structures clarify an unusual role of a mitochondria-specific segment of RRF, identify the structural distinctions that confer functional specificity to EF-G2, and show that the deacylated tRNA remains with the dissociated 39S subunit, suggesting a distinct sequence of events in mitoribosome recycling. Read More

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Lack of Reperfusion Rather Than Number of Passes Defines Futility in Stroke Thrombectomy: A Matched Case-Control Study.

Stroke 2021 Jun 15:STROKEAHA120033539. Epub 2021 Jun 15.

Department of Neurology, Marcus Stroke & Neuroscience Center, Emory University School of Medicine, Atlanta, GA (M.H.M., D.C.H., L.P., A.R.A., N.B., B.L., N.B., D.J., M.R.F., R.G.N.).

Background And Purpose: There is a robust relationship between the duration of ischemia and functional outcomes after mechanical thrombectomy. Higher number of mechanical thrombectomy passes strongly correlate with lower chances of favorable outcomes. Indeed, previous studies have suggested that after multiple passes the procedure may be futile. Read More

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Synthesis of side-chain regioregular and main-chain alternating poly(bichalcogenophene)s and an ABC-type periodic poly(terchalcogenophene).

Chem Sci 2020 Mar 10;11(15):3836-3844. Epub 2020 Mar 10.

Department of Applied Chemistry, National Chiao Tung University 1001 University Road Hsin-Chu Taiwan

Three unsymmetrical diiodobichalcogenophenes , , and and a diiodoterchalcogenophene were prepared. Grignard metathesis of , , , and occurred regioselectively at the lighter chalcogenophene site because of its relatively lower electron density and less steric bulk. Nickel-catalyzed Kumada catalyst-transfer polycondensation of these Mg species provided a new class of side-chain regioregular and main-chain AB-type alternating poly(bichalcogenophene)s-, , and -through a chain-growth mechanism. Read More

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Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus.

J Invest Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Duke University Medical Center, Durham, NC USA.

Pemphigus is a debilitating immunoglobulin G (IgG)-mediated autoimmune disease in need of better tolerated, more targeted and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor (FcRn) interactions with IgG. A multicenter, open-label safety and tolerability phase 1b/2 trial (NCT03075904) was conducted in North America from July 2017 to January 2019 and included patients aged ≥ 18 years with a confirmed diagnosis of pemphigus (vulgaris or foliaceus) and active disease. Read More

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sRNA-mediated RNA processing regulates bacterial cell division.

Nucleic Acids Res 2021 Jun 14. Epub 2021 Jun 14.

Institute of Microbiology and Molecular Biology, University of Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany.

Tight control of cell division is essential for survival of most organisms. For prokaryotes, the regulatory mechanisms involved in the control of cell division are mostly unknown. We show that the small non-coding sRNA StsR has an important role in controlling cell division and growth in the alpha-proteobacterium Rhodobacter sphaeroides. Read More

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Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin.

Nucleic Acids Res 2021 Jun 14. Epub 2021 Jun 14.

Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, SE-75124 Uppsala, Sweden.

How aminoglycoside antibiotics limit bacterial growth and viability is not clearly understood. Here we employ fast kinetics to reveal the molecular mechanism of action of a clinically used, new-generation, semisynthetic aminoglycoside Arbekacin (ABK), which is designed to avoid enzyme-mediated deactivation common to other aminoglycosides. Our results portray complete picture of ABK inhibition of bacterial translation with precise quantitative characterizations. Read More

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Two-Dimensional Functionalized Germananes as Photoelectrocatalysts.

ACS Nano 2021 Jun 14. Epub 2021 Jun 14.

Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 61200 Brno, Czech Republic.

Succeeding graphene, monoelemental two-dimensional (2D) materials such as germanene and silicene, coined as "Xenes", have attracted vast scientific and technological interests. Adding covalently bonded hydrogen on both sides of germanene leads to germanane (.. Read More

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Psychotherapy and depressive symptom trajectories among VA patients: Comparing dose-effect and good-enough level models.

J Consult Clin Psychol 2021 May;89(5):379-392

Veterans Affairs Center for Clinical Management Research, Veterans Affairs Ann Arbor Health Care System.

Psychotherapy for depression is effective for many veterans, but the relationship between number of treatment sessions and symptom outcomes is not well established. The Dose-Effect model predicts that greater psychotherapeutic dose (total sessions) yields greater symptom improvement with each additional session resulting in smaller session-to-session improvement. In contrast, the Good-Enough Level (GEL) model predicts that rate of symptom improvement varies by total psychotherapeutic dose with faster improvement associated with earlier termination. Read More

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Short-term stress responses and recovery of giant kelp (Macrocystis pyrifera, Laminariales, Phaeophyceae) juvenile sporophytes to a simulated marine heatwave and nitrate scarcity.

J Phycol 2021 Jun 14. Epub 2021 Jun 14.

Universidad Autónoma de Baja California, Instituto de Investigaciones Oceanológicas, Km 106 Carretera Tijuana-Ensenada, Ensenada, Baja California, México, CP, 22860.

The frequency of marine heatwaves (MHWs) is increasing due to climate change. Although seaweeds are resilient to environmental changes, an increasing body of evidence shows that rising sea surface temperatures have deleterious effects on temperate kelp species. However, information on the vulnerability of juvenile kelp to these stressors and their population stability is limited. Read More

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A case report reappraising the usefulness of Valsalva manoeuvre in drug-refractory ventricular tachycardia.

Eur Heart J Case Rep 2021 May 5;5(5):ytab171. Epub 2021 May 5.

Department of Cardiology, Glenfield Hospital, University of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, UK.

Background: Ventricular tachycardia (VT) is often misdiagnosed as supraventricular tachycardia with aberrancy. Twelve-lead electrocardiogram remains a key diagnostic tool to differentiate them while providing insights to aid localization of VT. The use of Valsalva manoeuvre (VM) in terminating VT is not conventionally recommended due to lack of robust evidence of its effectiveness and poor understanding of its mechanism in terminating VT. Read More

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Perspectives and Emotional Experiences of Patients With Chronic Myeloid Leukemia During ENESTPath Clinical Trial and Treatment-Free Remission: Rationale and Protocol of the Italian Substudy.

Front Oncol 2021 26;11:638689. Epub 2021 May 26.

Department of Health Sciences, University of Milan, Milan, Italy.

Achievement of deep molecular response following treatment with a tyrosine kinase inhibitor (TKI) allows for treatment-free remission (TFR) in many patients with chronic myeloid leukemia (CML). Successful TFR is defined as the achievement of a sustained molecular response after cessation of ongoing TKI therapy. The phase 3 ENESTPath study was designed to determine the required optimal duration of consolidation treatment with the second-generation TKI, nilotinib 300 mg twice-daily, to remain in successful TFR without relapse after entering TFR for 12 months. Read More

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The role of sodium in stabilizing tin-lead (Sn-Pb) alloyed perovskite quantum dots.

J Mater Chem A Mater 2021 Mar 19;9(20):12087-12098. Epub 2021 Mar 19.

Materials Simulation and Modelling, Department of Applied Physics, Eindhoven University of Technology 5600 MB Eindhoven The Netherlands

Narrow-bandgap CsSn Pb I perovskite quantum dots (QDs) show great promise for optoelectronic applications owing to their reduced use of toxic Pb, improved phase stability, and tunable band gaps in the visible and near-infrared range. The use of small ions has been proven beneficial in enhancing the stability and photoluminescence quantum yield (PLQY) of perovskite QDs. The introduction of sodium (Na) has succeeded in boosting the PLQY of CsSnPbI QDs. Read More

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Rapidly self-deoxygenating controlled radical polymerization in water disproportionation of Cu(i).

Chem Sci 2020 May 5;11(20):5257-5266. Epub 2020 May 5.

University of Warwick, Department of Chemistry Library Road Coventry CV4 7AL UK

Rapidly Cu-RDRP in aqueous media is investigated. The disproportionation of Cu(i)/MeTren in water towards Cu(ii) and highly reactive Cu(0) leads to O-free reaction environments within the first seconds of the reaction, even when the reaction takes place in the open-air. By leveraging this significantly fast O-reducing activity of the disproportionation reaction, a range of well-defined water-soluble polymers with narrow dispersity are attained in a few minutes or less. Read More

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Effector Avr4 in Escapes Host Immunity Mainly Through Early Termination.

Front Microbiol 2021 28;12:646062. Epub 2021 May 28.

Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Effector genes play critical roles in the antagonistic interactions between plants and pathogens. However, knowledge of mutation mechanisms and evolutionary processes in effector genes and the contribution of climatic factors to the evolution of effector genes are fragmented but important in sustainable management of plant diseases and securing food supply under changing climates. Here, we used a population genetic approach to explore the evolution of the Avr4 gene in , the causal agent of potato blight. Read More

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Restoration Strategies Following Short-Term Vocal Exertion in Healthy Young Adults.

J Speech Lang Hear Res 2021 Jun 12:1-18. Epub 2021 Jun 12.

Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN.

Purpose This study aims to investigate the effects of a 10-min vocal exertion task on voice and respiratory measures, to determine whether restorative strategies can mitigate these effects after cessation of exertion, and to assess whether these strategies continue to reduce these detrimental effects when vocal exertion is resumed. Method A prospective, repeated-measures design was used. On consecutive days, 20 participants (equal men and women) completed two vocal exertion tasks separated by 10 min of restoration strategies: vocal rest or controlled phonation (low-level tissue mobilization using straw phonation). Read More

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Fetal double outlet right ventricle without heterotaxy syndrome: diagnostic spectrum, associated extracardiac pathology and clinical outcomes.

Prenat Diagn 2021 Jun 12. Epub 2021 Jun 12.

Fetal & Neonatal Cardiology Program, Division of Pediatric Cardiology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To document the clinical spectrum and outcomes of fetal DORV without heterotaxy in a recent diagnostic era.

Methods: Prenatal cases of DORV consecutively diagnosed from 2007-2018 were retrospectively identified. Clinical records, including details regarding genetic testing and pre and postnatal imaging were reviewed. Read More

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Hirschsprung disease with Edward syndrome: A rare association: A case report.

Int J Surg Case Rep 2021 Jun 9;84:106084. Epub 2021 Jun 9.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal. Electronic address:

Introduction And Importance: Edward's syndrome (ES) occurs as a result of trisomy of chromosome 18 and is associated with multisystem congenital anomalies. The association of ES with various gastrointestinal malformations but Hirschsprung disease (HD) is well documented.

Case Presentation: A female infant on her 5th day of life presented with episodes of bilious vomiting along with abdominal distension and no passage of stool. Read More

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Termination of Pregnancy Services in Irish General Practice from January 2019 to June 2019.

Contraception 2021 Jun 9. Epub 2021 Jun 9.

Broadlane Family Practice, 72 Great William O'Brien St, Blackpool, Cork, T23 EDX9.

Objective: To describe how a general-practitioner-delivered community medical abortion service is provided in Ireland, including a description of the unique model of care delivered within the framework of new legislation. To investigate the characteristics and contraceptive choices of women attending in the first six months of the service.

Study Design: Twenty-seven general practitioners conducted a retrospective chart review. Read More

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Myofibroblast fate plasticity in tissue repair and fibrosis: de-activation, apoptosis, senescence and reprogramming.

Wound Repair Regen 2021 Jun 11. Epub 2021 Jun 11.

Fibrosis Research Center, Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

In response to tissue injury, fibroblasts differentiate into professional repair cells called myofibroblasts, which orchestrate many aspects of the normal tissue repair program including synthesis, deposition and contraction of extracellular matrix proteins, leading to wound closure. Successful tissue repair responses involve termination of myofibroblast activities in order to prevent pathologic fibrotic scarring. Here, we discuss the cellular and molecular mechanisms limiting myofibroblast activities during physiological tissue repair, including myofibroblast de-activation, apoptosis, reprogramming and immune clearance of senescent myofibroblasts. Read More

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Endocannabinoids, Cannabinoids and the Regulation of Anxiety.

Neuropharmacology 2021 Jun 8:108626. Epub 2021 Jun 8.

Hotchkiss Brain Institute and the Mathison Centre for Mental Health Education and Research, Departments of Cell Biology and Anatomy & Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 1N4. Electronic address:

Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety often reported as a primary reason for use. Only recently has the specific role cannabinoids play in anxiety been thoroughly investigated. Here we discuss the body of evidence describing how endocannabinoids and exogenous cannabinoids are capable of regulating the generation and termination of anxiety states. Read More

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Chronic levetiracetam (Keppra®) treatment increases the reinforcing strength of cocaine in rhesus monkeys.

Pharmacol Biochem Behav 2021 Jun 8;207:173217. Epub 2021 Jun 8.

Department of Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157-1083, United States of America.

Background: Drugs that increase inhibitory neuronal activity in the brain have been proposed as potential medications for stimulant use disorders.

Objective: The present study assessed the ability of chronically administered levetiracetam (Keppra®), a clinically available anticonvulsant drug that increases GABA by binding to synaptic vesicle glycoprotein 2A, to modulate the reinforcing strength of cocaine in monkeys.

Methods: Three adult male rhesus monkeys (Macaca mulatta) self-administered cocaine intravenously each day under a progressive-ratio (PR) schedule of reinforcement. Read More

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Rho-dependent transcription termination regulates the toxin-antitoxin modules of cryptic prophages to silence their expression in Escherichia coli.

FEBS Lett 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Transcription, Centre for DNA Fingerprinting and Diagnostics, Inner Ring Road, Uppal, Hyderabad, 39, India.

Bacterial Rho-dependent transcription termination regulates many physiological processes. Here, we report that it controls the expression of toxin-antitoxin (TA) modules of cryptic prophages in E. coli. Read More

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Ayurveda botanicals in COVID-19 management: An in silico multi-target approach.

PLoS One 2021 11;16(6):e0248479. Epub 2021 Jun 11.

AYUSH-Center of Excellence, Center for Complementary and Integrative Health, Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune, India.

The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagious disease. There is an urgent need to find a specific cure for the disease and global efforts are directed at developing SARS-CoV-2 specific antivirals and immunomodulators. Read More

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Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions.

J Am Chem Soc 2021 Jun 11. Epub 2021 Jun 11.

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, we report an "ene"-reductase catalyzed asymmetric hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Read More

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The Pharmacokinetics of Crushed Levetiracetam Tablets Administered to Neonates.

J Trop Pediatr 2021 05;67(2)

Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa.

Background: Intravenous phenobarbital remains the first-line therapy in the management of neonatal seizures. Shortages of intravenous phenobarbital in South Africa necessitated the addition of oral levetiracetam as part of management of neonatal seizures.

Objective: We evaluated the pharmacokinetics of crushed immediate-release levetiracetam tablets administered to neonates to terminate seizures. Read More

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Engineering of Exciton Spatial Distribution in CdS Nanoplatelets.

Nano Lett 2021 Jun 11. Epub 2021 Jun 11.

Key Laboratory of Excited-State Materials of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou 310027, China.

Zinc-blende CdS nanoplatelets with atomically flat and very large {100} basal planes terminated solely by one type of element (either Cd or S atoms) are synthesized. Optical spectroscopy, X-ray diffraction, X-ray absorption, and transmission electron microscopy confirm that the surface structures of newly developed S-terminated CdS nanoplatelets are at least as well-defined as the original Cd-terminated nanoplatelets. Band gaps of the nanoplatelets are found to depend on not only the quantum-confined dimension (thickness) but also the nature of the surface termination. Read More

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Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC Peripartum Cardiomyopathy Registry.

Eur J Heart Fail 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands.

Aims: Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. Read More

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