28,162 results match your criteria term preterm


Influence of intrauterine growth status on aortic intima-media thickness and aortic diameter in near-term fetuses: a comparative cross-sectional study.

J Dev Orig Health Dis 2021 Jun 15:1-8. Epub 2021 Jun 15.

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Aga Khan University, Pakistan.

Intrauterine undernutrition may lead to fetal vascular programming. We compared abdominal aortic intima-media thickness (aIMT) and aortic diameter (aD) between appropriate for gestational age (AGA) and growth-restricted fetuses (GRF). We recruited 136 singleton fetuses at 34-37 weeks of gestation from Fetal Medicine Unit of Aga Khan University Hospital, Karachi (January-November 2017). Read More

View Article and Full-Text PDF

Short-term effects of synchronized vs. non-synchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial.

Trials 2021 Jun 14;22(1):392. Epub 2021 Jun 14.

Neonatal Intensive Care Unit, Department of Public Health and Pediatrics, University of Turin, Turin, Italy.

Background: Non-invasive ventilation (NIV) has been recommended as the best respiratory support for preterm infants with respiratory distress syndrome (RDS). However, the best NIV technique to be used as first intention in RDS management has not yet been established. Nasal intermittent positive pressure ventilation (NIPPV) may be synchronized (SNIPPV) or non-synchronized to the infant's breathing efforts. Read More

View Article and Full-Text PDF

Clinical Profile and Long-Term Outcome in Neonatal Cerebral Sinus Venous Thrombosis.

Pediatr Neurol 2021 May 15;121:20-25. Epub 2021 May 15.

Department of Pediatrics, Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, Texas. Electronic address:

Background: Neonatal cerebral sinus venous thrombosis (CSVT) causes high morbidity and mortality. Factors associated with either favorable or unfavorable long-term outcomes have not been clearly established. This study aimed to determine the factors involved in long-term neurological outcomes in patients with neonatal CSVT. Read More

View Article and Full-Text PDF

Aberrant cortico-thalamic structural connectivity in premature-born adults.

Cortex 2021 May 8;141:347-362. Epub 2021 May 8.

Department of Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany; TUM Neuroimaging Center, School of Medicine, Technical University of Munich, Munich, Germany; Department of Psychiatry, School of Medicine, Technical University of Munich, Munich, Germany.

Premature birth is associated with alterations in brain structure, particularly in white matter. Among white matter, alterations in cortico-thalamic connections are present in premature-born infants, and they have been suggested both to last until adulthood and to contribute to impaired cognitive functions. To test these hypotheses, 70 very premature-born adults and 67 full-term controls underwent cognitive testing and diffusion-weighted imaging. Read More

View Article and Full-Text PDF

Longitudinal assessment of cardiac function in extremely low birth weight children at 7 and 11 years of age: implications for adult medicine.

Kardiol Pol 2021 ;79(5):539-545

Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland.

Background: The long-term impact of extreme prematurity on cardiac structure and function has not been fully evaluated.

Aims: The aim of the study was to assess cardiac condition at 11 years of age in a local cohort of extremely low birth weight (ELBW) children born between 2002 and 2004 and to compare it to a previous study in the same group at 7 years of age.

Methods: Sixty-four children with ELBW (median birth weight of 890 g) and 36 children born at full term underwent echocardiography and physical examination. Read More

View Article and Full-Text PDF

Historical Analysis of the Risk of Hepatitis E and Its Complications in Pregnant Women in Nepal, 1996-1998.

Am J Trop Med Hyg 2021 Jun 14. Epub 2021 Jun 14.

6Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland.

Hepatitis E (HE) during pregnancy can be fatal; there are no prospective risk estimates for HE and its complications during pregnancy. We followed 2,404 pregnant women for HE and pregnancy outcomes from 1996 to 1998. Subjects from Nepal were enrolled at an antenatal clinic with pregnancy of ≤ 24 weeks. Read More

View Article and Full-Text PDF

Levetiracetam as the first-line treatment for neonatal seizures: a systematic review and meta-analysis.

Dev Med Child Neurol 2021 Jun 13. Epub 2021 Jun 13.

University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Aim: To assess the effectiveness and safety of levetiracetam when used as first-line treatment of neonatal seizures.

Method: Four electronic databases, Medline, Embase, Web of Science, and ClinicalTrials.gov were systematically searched from inception until 20th November 2020. Read More

View Article and Full-Text PDF

Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner.

Front Nutr 2021 28;8:641227. Epub 2021 May 28.

The Liggins Institute, University of Auckland, Auckland, New Zealand.

Differing environmental conditions experienced by mother-infant dyads may influence composition of the milk received by the infant. As a consequence, diverse milk compositional profiles may contribute to different postnatal outcomes, especially in infants facing adverse perinatal environments. We investigated whether variability in milk concentrations of key metabolic hormones is associated with different growth outcomes in infants born preterm, a perinatal complication known to impact on infant growth. Read More

View Article and Full-Text PDF

Determination of risk factors and cumulative effects of the maternal and neonatal risk factors in relation to preterm labor.

J Family Med Prim Care 2021 Apr 29;10(4):1747-1753. Epub 2021 Apr 29.

Department of Obstetrics and Gynecology, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Preterm labor is the leading cause of neonatal morbidity and mortality this study aimed to determine single and combined effects of all risk factors in relation to preterm labor.

Methods: This was a case-control study that included patients from a teaching hospital affiliated to Tehran University of Medical Sciences. Women who came to this hospital for delivery were divided into two groups: 200 in preterm delivery (before 37 weeks) and 195 in term delivery (after 37 weeks). Read More

View Article and Full-Text PDF

Harmonized Segmentation of Neonatal Brain MRI.

Front Neurosci 2021 25;15:662005. Epub 2021 May 25.

Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Deep learning based medical image segmentation has shown great potential in becoming a key part of the clinical analysis pipeline. However, many of these models rely on the assumption that the train and test data come from the same distribution. This means that such methods cannot guarantee high quality predictions when the source and target domains are dissimilar due to different acquisition protocols, or biases in patient cohorts. Read More

View Article and Full-Text PDF

Interactions between preeclampsia and composition of the human milk: what do we know?

J Matern Fetal Neonatal Med 2021 Jun 13:1-7. Epub 2021 Jun 13.

Complex Structure Neonatology Unit, Department of Public Health and Paediatric, University of Turin, Torino, Italy.

Preeclampsia (PE) is a gestational hypertensive syndrome characterized by a complex disease with variable clinical manifestation. An aspect of increased interest is the possible effect of PE on the mammary gland (and therefore on breast milk composition) considering that a mother's own milk is always considered the first choice for the nutrition of all neonates. Human milk (HM) is a unique food believed to contain biological factors involved in both short and long-term benefits. Read More

View Article and Full-Text PDF

Care practices and outcomes of extremely preterm neonates born at 22-24 weeks -A single centre experience.

J Neonatal Perinatal Med 2021 Jun 5. Epub 2021 Jun 5.

Newborn Services, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Background: Wide variation in the care practices and survival rates of neonates born at peri-viable gestational ages of 22 +0 -24 +6 weeks exists. This study elucidates the postnatal risk factors for morbidity/mortality, contrasts the care practices and short-term outcomes of this vulnerable group of preterm neonates from a single center with others.

Methods: Retrospective study of neonates born at 22 +0 -24 +6 weeks in a level 3 neonatal intensive care unit in UK, over a period of 4 years (2016-2019). Read More

View Article and Full-Text PDF

Emotion regulation from infancy to toddlerhood: Individual and group trajectories of full-term and very-low-birthweight preterm infants.

Infancy 2021 Jun 13. Epub 2021 Jun 13.

Department of Psychology, Concordia University, Montreal, QC, Canada.

Adaptive emotion regulation begins with infants operating jointly with their parents to regulate their emotions, which fosters the development of independent regulation. Little is known about when or how this transition occurs, or the impact of factors such as parental availability or premature birth status. The current study examined the use of self-soothing, attentional distraction, and dyadic regulation in full-term and healthy very-low-birthweight (VLBW) preterm infant-mother dyads at 5 ½, 12, and 18 months of age. Read More

View Article and Full-Text PDF

Efficacy of transcutaneous bilirubinometry as compared to serum bilirubin in preterm newborn during phototherapy.

Eur J Pediatr 2021 Jun 12. Epub 2021 Jun 12.

NWRH, Burnie, TAS3, Australia.

Transcutaneous measurement of bilirubin is being used for neonatal jaundice. Its utility during phototherapy in preterm babies is not established. The objective of our study was to assess the efficacy of transcutaneous bilirubin (TcB) measurement in comparison to total serum bilirubin in preterm newborns at admission and during phototherapy at the covered skin area (glabella). Read More

View Article and Full-Text PDF

Music therapy enhances preterm infant's signs of engagement and sustains maternal singing in the NICU.

Infant Behav Dev 2021 Jun 9;64:101596. Epub 2021 Jun 9.

Psychology Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Hospitalized preterm infants are exposed to stressful stimuli and early parental separation, which can undermine their long-term development and mother-infant bonding. Family-centered music therapy can enable positive mother-infant interactions, mediated by maternal infant-directed singing. This study aimed to investigate the effects of music therapy on preterm infant's signs of engagement, namely Eye Opening (EO) and Smiling (SM), and maternal vocalizations. Read More

View Article and Full-Text PDF

Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):862-869. Epub 2021 Jun 11.

Division of Nephrology, University of Alabama at Birmingham, Children's of Alabama, Birmingham, Alabama.

Background And Objectives: AKI is associated with poor short- and long-term outcomes. Questions remain about the frequency and timing of AKI, and whether AKI is a cause of death in extremely low gestational age neonates.

Design, Setting, Participants, & Measurements: The Recombinant Erythropoietin for Protection of Infant Kidney Disease Study examines the kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo Neuroprotection study, a randomized, placebo-controlled trial of recombinant human erythropoietin. Read More

View Article and Full-Text PDF

Impairment of endothelium-dependent vasodilator function of retinal blood vessels in adult rats with a history of retinopathy of prematurity.

J Pharmacol Sci 2021 Aug 7;146(4):233-243. Epub 2021 May 7.

Department of Molecular Pharmacology, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease, initiated by delayed retinal vascular growth after premature birth. In the majority of cases, ROP resolves spontaneously; however, a history of ROP may increase the risk of long-term visual problems. In this study, we evaluated the endothelial function of retinal blood vessels in adult rats with a history of ROP. Read More

View Article and Full-Text PDF

Meta-analysis of ocular axial length in newborns and infants up to three years of age.

Surv Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Amsterdam UMC, University of Amsterdam, department of Ophthalmology, Meibergdreef 9, Amsterdam, Netherlands.

In pediatric ophthalmology it is often necessary to obtain axial length in young children. For children older than three years, non-contact biometry can be used. For younger children this is usually not an option, and the clinician needs to rely on other imaging modalities. Read More

View Article and Full-Text PDF

Influences of environmental exposures on preterm lung disease.

Expert Rev Respir Med 2021 Jun 17:1-9. Epub 2021 Jun 17.

Division of Pulmonary and Sleep, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

: Environmental factors play a critical role in the progression or resolution of chronic respiratory diseases. However, studies are limited on the impact of environmental risk factors on individuals born prematurely with lung disease after they leave the neonatal intensive care unit and are discharged into the home environment.: In this review, we cover current knowledge of environmental exposures that impact outcomes of preterm respiratory disease, including air pollution, infections, and disparities. Read More

View Article and Full-Text PDF

Pro-inflammatory signals induce 20α-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal.

J Cell Mol Med 2021 Jun 10. Epub 2021 Jun 10.

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α-HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic or infection-induced) and associated activation of transcription factors: NF-кB and AP-1, common to term and preterm labour. We found that 20α-HSD protein is significantly increased in human myometrium during term labour, and in mouse uterus during term and preterm labour. Treatment of human myometrial cells with the pro-inflammatory mediators, lipopolysaccharide (LPS, mimicking infection) and 12-O-tetradecanoylphorbol-13-acetate (TPA, mimicking inflammation), induced 20α-HSD gene expression and increased 20α-HSD protein abundance. Read More

View Article and Full-Text PDF

A systematic review of the impact of intensive care admissions on post discharge cognition in children.

Eur J Pediatr 2021 Jun 11. Epub 2021 Jun 11.

Faculty of Health, Medicine and Life Sciences, Educational Development Research Department, Maastricht University, Universiteitssingel 40, 6229ER, Maastricht, Netherlands.

Understanding how hospitalization affects cognitive development is crucial to safeguard children's cognition; however, there is little research evaluating the associations between NICU or PICU hospitalization and survivors' cognition. The objective of this study is to identify and characterize the associations between a neonatal or pediatric ICU hospitalization and the short- and long-term cognition of survivors. The databases Cochrane Library, Medline, EBSCO, Embase, and Google Scholar and the journals JAMA Pediatrics, Journal of Pediatrics, Pediatrics, Archives of Disease in Childhood, Academic Pediatrics, Pediatric Critical Care Medicine and Child Development were searched until April 2021. Read More

View Article and Full-Text PDF

Pulmonary Outcomes in Children Born Extremely and Very Preterm at 11 Years of Age.

Front Pediatr 2021 25;9:635503. Epub 2021 May 25.

Department of Pediatrics, University of Chieti, Chieti, Italy.

There is increasing evidence of prematurity being a risk factor for long-term respiratory outcomes regardless the presence of bronchopulmonary dysplasia (BPD). To assess the effect of prematurity on respiratory outcomes in children born ≤32 weeks of gestational age at 11 years of age. Fifty five ex-preterm children (≤ 32 weeks of gestational age), born in Chieti between January 1, 2006 and December 31, 2007, performed lung function and diffusing capacity test (DLCO) at 11 years of age. Read More

View Article and Full-Text PDF

Bilateral lower extremity ischemia due to a retained umbilical artery catheter in a preterm neonate.

J Pediatr Surg Case Rep 2020 May 7;56. Epub 2020 Mar 7.

Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

The use of umbilical artery catheters is common in Neonatal Intensive Care Units, especially in low and very low birth weight neonates. Rarely, these can break or fracture, leading to a retained fragment, which can embolize or cause thrombosis. We pre sent a case of a very low birth weight, premature neonate, 940 grams, with a retained umbilical artery catheter that led to bilateral lower extremity ischemia. Read More

View Article and Full-Text PDF

Adverse Pregnancy Outcomes in Endometriosis - Myths and Realities.

Curr Obstet Gynecol Rep 2020 Mar 30;9(1):27-35. Epub 2020 Jan 30.

Department of Epidemiology, Harvard T.H. Chan School of Public Health.

Purpose Of Review: There is increasing interest in the long-term health and comorbid conditions associated with endometriosis for both women and neonates. The purpose of this review was to synthesize and discuss the current state of the literature investigating endometriosis and risk of adverse pregnancy outcomes.

Recent Findings: Methodologic considerations for studying endometriosis and adverse pregnancy outcomes include complexities regarding the comparison population, endometriosis definition, sample size, residual confounding, and interactions. Read More

View Article and Full-Text PDF

COVID-19 during Pregnancy: Clinical and In Vitro Evidence against Placenta Infection at Term by SARS-CoV-2.

Am J Pathol 2021 Jun 7. Epub 2021 Jun 7.

Pole of Obstetrics, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium; Division of Obstetrics, Saint-Luc University Hospital, Brussels, Belgium.

Despite occasional reports of SARS-CoV-2 vertical transmission during pregnancy, the question of placental infection and its consequences for the newborn remain questionable. Here, we analyzed the placentas of 31 COVID-19-positive mothers by RT-PCR, immunohistochemistry and in situ hybridization. We only detected one case of placental infection, which was associated with intrauterine demise of the fetus. Read More

View Article and Full-Text PDF

Maternal and Fetal Vascular Lesions of Malperfusion in the Placentas Associated with Fetal and Neonatal Death: Results of a Prospective Observational Study.

Am J Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Columbia University, New York NY USA.

Background: Fetal death, one of the major adverse pregnancy outcomes, is especially common in low and middle-income countries. Placental lesions may play an important role in the etiology of fetal and possibly neonatal death. Prior research relating placental lesions to fetal death causation was often hindered by the lack of agreement on a placental classification scheme. Read More

View Article and Full-Text PDF

The difficulty to diagnose cervical cancer developing in the perinatal period with the first-trimester cytology: A retrospective study.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Hokkaido University Hospital, Sapporo, Japan.

Aim: Cytological cervical cancer screening for pregnant women is routinely performed and still plays an essential role in Japan because of the considerably low rate of human pappillomavirus (HPV) vaccination. Though almost all pregnant women undergo cytological screening at their first trimester, we experienced invasive cervical cancers (ICC) diagnosed during pregnancy or postpartum period. We investigated the characteristics of perinatally diagnosed ICCs to clarify the difficulty in diagnosis during the pregnancy. Read More

View Article and Full-Text PDF

The association of breastfeeding self-efficacy with breastfeeding duration and exclusivity: longitudinal assessment of the predictive validity of the Greek version of the BSES-SF tool.

BMC Pregnancy Childbirth 2021 Jun 9;21(1):421. Epub 2021 Jun 9.

Department of Nursing, School of Health Sciences, Cyprus University of Technology, Limassol, Cyprus.

Introduction: While breastfeeding self-efficacy (BSES) is an important modifiable determinant of breastfeeding, a structured assessment is not standard practice in Cyprus. We assessed the Greek version of the Breastfeeding Self-Efficacy Scale (BSES-SF), including its predictive validity in terms of Breastfeeding (BF) and Exclusive Breastfeeding (EBF) up to the sixth month.

Methods: A methodological study with longitudinal design among 586 mother-infant dyads, as part of the "BrEaST Start in Life" project. Read More

View Article and Full-Text PDF

Early combined rehabilitation intervention to improve the short-term prognosis of premature infants.

BMC Pediatr 2021 Jun 9;21(1):269. Epub 2021 Jun 9.

Department of Neonatology, Sichuan Provincial Maternity and Child Health Care Hospital, No. 290 West Second Street, Shayan Road, Chengdu, 610031, Sichuan, China.

Background: To explore the clinical effect of early combined rehabilitation intervention on premature infants in the neonatal intensive care unit (NICU).

Methods: Premature infants with gestational ages less than 32 weeks or birth weights less than 1500 g were included in the present study.The participants were divided into the intervention group and control group. Read More

View Article and Full-Text PDF

Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study.

BMC Pediatr 2021 Jun 9;21(1):270. Epub 2021 Jun 9.

Neonatal Unit, Cambridge University Foundation Trust, Cambridge, CB2 2QQ, UK.

Background: This study aimed to provide UK data describing the incidence of patent ductus arteriosus (PDA) surgery in the neonatal population, including: pre-ligation management, and outcomes until discharge. We used British Paediatric Surveillance Unit (BPSU) methodology; collecting data via questionnaires for preterm neonates undergoing PDA ligation (PDAL) between 1st Sept 2012 - 30th Sept 2013. Infants born less than 37 weeks gestation, who underwent PDAL prior to discharge home, with no other structural cardiac abnormality, were included. Read More

View Article and Full-Text PDF