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Outcomes in Hirschsprung's disease with coexisting learning disability.

Eur J Pediatr 2021 Jun 11. Epub 2021 Jun 11.

Department of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital for Children, London, UK.

This study describes functional and health-related quality of life (HRQoL) outcomes in patients with Hirschsprung's disease (HSCR) with associated learning disability or neurodevelopmental delay (LD), completing a core outcome set for HSCR. This was a cross-sectional study from a tertiary pediatric surgery center. Patients treated between 1977 and 2013 were prospectively contacted to complete an outcomes survey. Read More

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A variant in IL6ST with a selective IL-11 signaling defect in human and mouse.

Bone Res 2020 Jun 11;8(1):24. Epub 2020 Jun 11.

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.

The GP130 cytokine receptor subunit encoded by IL6ST is the shared receptor for ten cytokines of the IL-6 family. We describe a homozygous non-synonymous variant in IL6ST (p.R281Q) in a patient with craniosynostosis and retained deciduous teeth. Read More

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Al-Anon Intensive Referral (AIR): A qualitative formative evaluation for implementation.

J Subst Abuse Treat 2021 Jun 2;132:108520. Epub 2021 Jun 2.

University of Arkansas for Medical Sciences, Little Rock, AR, USA; Central Arkansas Veterans Healthcare System, North Little Rock, AR, USA.

Introduction: The Al-Anon mutual-help program helps concerned others (COs; e.g., families, friends) of persons with excessive alcohol use. Read More

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La réponse aux besoins affectifs et cognitifs de l’enfant : Application du modèle cumulatif à la population générale: Responding to children’s emotional and cognitive needs: Applying the cumulative model to the general population.

Can J Psychiatry 2021 Jun 10:7067437211020597. Epub 2021 Jun 10.

Professeure au Département de psychoéducation et de psychologie Université du Québec en Outaouais.

Objectives: Several risk factors are associated with neglectful behaviors. Yet their cumulative effect, which refers to the accumulation of risk regardless of the presence or absence of specific factors, remains unknown. This study aims to determine whether risk accumulation predicts caregivers' responses to children's emotional and cognitive needs in the general population and to examine the presence of clinical thresholds. Read More

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Exposure to phthalates and cardiovascular diseases in Chinese with type 2 diabetes.

Environ Sci Pollut Res Int 2021 Jun 9. Epub 2021 Jun 9.

Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, China.

Cardiovascular disease (CVD) results in more than half of the mortality and the majority of morbidity in patients with type 2 diabetes. We aim to evaluate the associations of urinary concentrations of phthalate metabolites with CVD in diabetic patients and explore whether CVD risk factors mediate or interact with these associations. A total of 675 type 2 diabetic participants were enrolled from Shanghai, China, in 2018. Read More

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Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement.

Aging (Albany NY) 2021 Jun 9;13. Epub 2021 Jun 9.

Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.

Amyloid β (Aβ) plays a major role in the neurodegeneration of Alzheimer's disease (AD). The accumulation of misfolded Aβ causes oxidative stress and inflammatory damage leading to apoptotic cell death. Traditional Chinese herbal medicine (CHM) has been widely used in treating neurodegenerative diseases by reducing oxidative stress and neuroinflammation. Read More

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It Takes Two to Tango: Patients' and Providers' Perspectives in Tobacco Cessation and Head/Neck Cancer.

Oncologist 2021 Jun 8. Epub 2021 Jun 8.

University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

Background: Tobacco cessation among head/neck cancer patients continues to be challenging despite evidence that cessation improves treatment outcomes. The purpose of this study was to understand barriers/facilitators to tobacco cessation among head/neck cancer patients and healthcare providers and to obtain perspectives toward the development of a patient-centered tobacco cessation intervention.

Materials And Methods: In-depth qualitative interviews with ten healthcare providers and 21 head/neck cancer patients (12 inpatients and 9 outpatients) who were current or former smokers. Read More

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Impairment of left atrial function in pediatric patients with repaired tetralogy of Fallot: a cardiovascular magnetic resonance imaging study.

Int J Cardiovasc Imaging 2021 Jun 8. Epub 2021 Jun 8.

Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China.

We aimed to assess left atrial (LA) strain before LA dilatation in patients with repaired tetralogy of Fallot (rTOF) compared with healthy controls. We also determined the effects of right atrial (RA) dilatation on LA performance using cardiovascular magnetic resonance-feature tracking (CMR-FT). Forty-nine pediatric patients with rTOF and 36 age- and sex-matched healthy controls were prospectively recruited between June 2017 and August 2019. Read More

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Complete mitogenome of the entomopathogenic fungus and phylogenetic analysis of Hypocreales.

Mitochondrial DNA B Resour 2021 May 19;6(6):1689-1690. Epub 2021 May 19.

Institute of Applied Chemistry, Shanxi University, Taiyuan, China.

, with a narrow host range, is an entomopathogenic fungus in the family Clavicipitaceae. Its nuclear genome has been sequenced, whereas its mitogenome is still unknown. In this study, the complete mitogenome of was assembled and annotated. Read More

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Is There a Benefit of Vitamin D Supplementation in Deficient Children and Adolescents Suffering from Obesity? A Meta-Analysis.

Glob Pediatr Health 2021 27;8:2333794X211018352. Epub 2021 May 27.

Department of Family Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

This systematic review/meta-analysis aims to highlight the effect of vitamin D supplementation in deficient children suffering from obesity. Published clinical studies on vitamin D supplementation in obese children and adolescents with vitamin D deficiency were identified through a comprehensive MEDLINE/PubMed search (from July 1966 to November 2017). Outcomes intended after vitamin D supplementation were improvements in vitamin D status, BMI alterations and appetite changes. Read More

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Improving the efficacy of exome sequencing at a quaternary care referral centre: novel mutations, clinical presentations and diagnostic challenges in rare neurogenetic diseases.

J Neurol Neurosurg Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Background: We used a multimodal approach including detailed phenotyping, whole exome sequencing (WES) and candidate gene filters to diagnose rare neurological diseases in individuals referred by tertiary neurology centres.

Methods: WES was performed on 66 individuals with neurogenetic diseases using candidate gene filters and stringent algorithms for assessing sequence variants. Pathogenic or likely pathogenic missense variants were interpreted using in silico prediction tools, family segregation analysis, previous publications of disease association and relevant biological assays. Read More

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Clinical Efficacy of Bone Marrow Aspirate Concentrate Versus Stromal Vascular Fraction Injection in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Am J Sports Med 2021 Jun 8:3635465211014500. Epub 2021 Jun 8.

USC Epstein Family Center for Sports Medicine at Keck Medicine of USC, Los Angeles, California, USA.

Background: Knee injection using either bone marrow aspirate concentrate (BMAC) or stromal vascular fraction (SVF) from adipose tissue has been shown to result in symptomatic improvement in patients with knee osteoarthritis (OA). It is still unclear whether one of these therapies is superior over the other.

Purpose: To systematically report the clinical studies evaluating BMAC and SVF in the treatment of knee OA and to compare the clinical efficacy of these 2 injection therapies. Read More

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The determinant factors for macroinvertebrate assemblages in a recreational river in Negeri Sembilan, Malaysia.

Environ Monit Assess 2021 Jun 8;193(7):394. Epub 2021 Jun 8.

Centre for Research and Development, Social and Environment (SEEDS), Faculty of Social Sciences and Humanities, Universiti Kebangsaan Malaysia, Bangi, Malaysia.

The determinant factors for macroinvertebrate assemblages in river ecosystems are varied and are unique and specific to the type of macroinvertebrate family. This study aims to assess the determinant factors for macroinvertebrate assemblages in a recreational river. The study was conducted on the Ulu Bendul River, Negeri Sembilan, Malaysia. Read More

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TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.

Nat Commun 2021 06 7;12(1):3359. Epub 2021 Jun 7.

Neuroscience Initiative Advanced Science Research Center, New York, NY, USA.

The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and defective in old mice. Constitutive and inducible oligodendrocyte lineage-specific ablation of Tet1 (but not of Tet2), recapitulate this age-related decline in repair of demyelinated lesions. Read More

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Status and challenges for tuberculosis control in India - Stakeholders' perspective.

Indian J Tuberc 2021 Jul 12;68(3):334-339. Epub 2020 Oct 12.

School of Health Systems Studies, Tata Institute of Social Sciences, Mumbai, India; National Institute of Health and Family Welfare, New Delhi, India. Electronic address:

Background: Tuberculosis is one of the ten major causes of mortality worldwide. The trend of increasing TB cases and drug resistance in India is very disturbing. The objectives of the study were to study the perspectives and opinions of different stakeholders on the status, challenges and the ways to tackle the issues of TB in India. Read More

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Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 4:109095. Epub 2021 Jun 4.

Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, United Kingdom.

The pyrethroid deltamethrin and the macrocyclic lactone emamectin benzoate (EMB) are used to treat infestations of farmed salmon by parasitic salmon lice, Lepeophtheirus salmonis. While the efficacy of both compounds against Atlantic populations of the parasite has decreased as a result of the evolution of resistance, the molecular mechanisms of drug resistance in L. salmonis are currently not fully understood. Read More

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First report of Nigrospora oryzae causing wilt in summer cypress (Bassia scoparia) in Pakistan.

Plant Dis 2021 Jun 7. Epub 2021 Jun 7.

University of Agriculture Faisalabad, 66724, Plant Pathology, Mehndi muhala dhobi ghat, st#2, p-126, Gojra, T. T. Singh, Faisalabad, Punjab, Pakistan, 38000.

Summer Cypress (Bassia scoparia) is a large annual herb belonging to the family Amaranthaceae native to Eurasia. It has been introduced in many other countries of the world. In Pakistan, summer cypress is also known as kochia and grown as an ornamental plant for its red fall foliage for landscapes. Read More

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Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers.

Acta Neuropathol 2021 Jun 6. Epub 2021 Jun 6.

Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Genetics and CNR-MAJ, F-76000, Rouen, France.

Microduplications of the 17q21.31 chromosomal region encompassing the MAPT gene, which encodes the Tau protein, were identified in patients with a progressive disorder initially characterized by severe memory impairment with or without behavioral changes that can clinically mimic Alzheimer disease. The unique neuropathological report showed a primary tauopathy, which could not be unanimously classified in a given known subtype, showing both 4R- and 3R-tau inclusions, mainly within temporal cortical subregions and basal ganglia, without amyloid deposits. Read More

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Neighborhood Poverty and Amygdala Response to Negative Face.

Shervin Assari

J Econ Public Financ 2020 25;6(4):67-85. Epub 2020 Nov 25.

Department of Family Medicine, College of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Introduction: Considerable research has established a link between socioeconomic status (SES) and brain function. While studies have shown a link between poverty status and amygdala response to negative stimuli, a paucity of knowledge exists on whether neighborhood poverty is also independently associated with amygdala hyperactive response to negative stimuli.

Purpose: Using functional brain imaging data, this study tested the association between neighborhood SES and the amygdala's response to negative stimuli. Read More

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November 2020

Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy.

Front Pharmacol 2021 21;12:666971. Epub 2021 May 21.

Department of Rheumatology and Hiller Research Center for Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany.

Patients with systemic lupus erythematosus (SLE) show increased serum levels of tumor necrosis factor (TNF)/TNF receptor (R) superfamily member, e.g. BAFF (B lymphocyte stimulator). Read More

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Antibiotic resistance and plasmid analysis of Enterobacteriaceae isolated from retail meat in Lagos Nigeria.

One Health Outlook 2021 Jun 7;3(1):10. Epub 2021 Jun 7.

Department of Microbiology, Faculty of Science, University of Lagos, Akoka-Yaba, Lagos, Nigeria.

Background: The presence of antibiotic resistant microorganisms in food is of great concern globally. This research was carried out to detect and characterize plasmid carriage and profiles among members of Enterobacteriaceae from different meat types in Nigeria.

Method: From a total of 80 meat samples comprising of mutton,pork, beef and chicken, organisms belonging to the family Enterobacteriaceae wereisolated by standard procedures and identified by API 20E system. Read More

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The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area.

J Headache Pain 2021 Jun 6;22(1):52. Epub 2021 Jun 6.

Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK.

Background: Cluster headache (CH) is a trigeminal autonomic cephalalgia (TAC) characterized by a highly disabling headache that negatively impacts quality of life and causes limitations in daily functioning as well as social functioning and family life. Since specific measures to assess the quality of life (QoL) in TACs are lacking, we recently developed and validated the cluster headache quality of life scale (CH-QoL). The sensitivity of CH-QoL to change after a medical intervention has not been evaluated yet. Read More

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Understanding the impact of systemic lupus erythematosus on work amongst South Asian people in the UK: An explorative qualitative study.

Lupus 2021 Jun 6:9612033211022816. Epub 2021 Jun 6.

Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

SLE has a range of fluctuating symptoms affecting individuals and their ability to work. Although South Asian (SA) patients are at increased risk of developing SLE there is limited knowledge of the impact on employment for these patients in the UK. Understanding ethnicity and disease-specific issues are important to ensure patients are adequately supported at work. Read More

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Measuring workplace violence for clinical dental hygienists.

Int J Dent Hyg 2021 Jun 6. Epub 2021 Jun 6.

Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju, Korea.

Objective: This study aimed to develop and assess a tool for measuring violence experienced by clinical dental hygienists in the workplace.

Methods: The basic questionnaire used in this study was created by referring to previous studies, the Negative Actions Questionnaire-Revised (NAQ-R) and the Workplace Bullying in Nursing-Type Inventory (WPBN-TI). The content feasibility was verified by ten experts in the field, and irrelevant questions were deleted, based on a content validity index value of 0. Read More

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Multiple machine learning models combined with virtual screening and molecular docking to identify selective human ALDH1A1 inhibitors.

J Mol Graph Model 2021 May 28;107:107950. Epub 2021 May 28.

Molecular Modeling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, 147002, India. Electronic address:

Aldehyde dehydrogenases (ALDHs) are the enzymes of oxidoreductase family that are responsible for the aldehyde metabolism. The unbalanced expression of these enzymes may be associated with a variety of disease conditions including cancers. ALDH1A1 is one of the isoform of ALDHs majorly overexpressed in a variety of tumors and responsible for the anti-cancer drug resistance. Read More

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Sleep disorders reveal distress among children and adolescents during the Covid-19 first wave: results of a large web-based Italian survey.

Ital J Pediatr 2021 Jun 4;47(1):130. Epub 2021 Jun 4.

Pediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy.

Background: Measures to contain the Covid-19 pandemic led to significant lifestyle changes for children and adolescents mainly related to the closure of schools and recreational activities, reduced social interaction, and increased family concerns.

Methods: A cross-sectional online survey of 78 questions investigating social determinants of health, mood changes, symptoms of anxiety, increase in sleep disorders and unusual repetitive movements was offered to parents living in Italy with children ≤18 years; including families of children with disabilities, autism spectrum disorders, chronic diseases, and specific learning disabilities. The survey was conducted on the Qualtrics platform 6 months after the beginning of the pandemic and distributed in hospitals and paediatricians' waiting rooms as well as through social networks. Read More

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Determinants of change in timely first antenatal booking among pregnant women in Ethiopia: A decomposition analysis.

PLoS One 2021 4;16(6):e0251847. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: Even though maternal health was highly targeted in different global strategies, maternal mortality could not be decreased as was expected. Besides this, prior decomposition analysis to the possible cause of changes to timely first antenatal booking has not been conducted. Therefore, this study aimed to assess determinants of change in timely first antenatal booking among pregnant women in Ethiopia. Read More

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Developing a collaborative and sustainable return to work program for employees with common mental disorders: a participatory research with public and private organizations.

Disabil Rehabil 2021 Jun 4:1-13. Epub 2021 Jun 4.

John Molson School of Business, Concordia University, Montreal, QC, Canada.

Purpose: To disentangle the key steps of the return to work (RTW) process and offer clearer recovery-focused and sustainable RTW for people on sick leave due to common mental disorders (CMDs).

Methods: This participatory research involves two large Canadian organizations. In each organization, we established an advisory committee composed of RTW stakeholders. Read More

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Flavobacterium agrisoli sp. nov., a novel bacterium isolated from soil.

Arch Microbiol 2021 Jun 3. Epub 2021 Jun 3.

School of Applied Biosciences, Kyungpook National University, Daegu, 41566, Republic of Korea.

A Gram-stain negative, rod shaped, motile by gliding, yellow-pigmented, aerobic bacterium, designated SE-1-e, was isolated from a soil sample collected on Dokdo Island, South Korea. The isolate was characterized taxonomically using a polyphasic approach based on the phenotypic and genomic analyses. The phylogenetic analysis based on 16S rRNA gene sequence revealed that strain SE-1-e belonged to the genus Flavobacterium in the family Flavobacteriaceae and had the highest sequence similarity with Flavobacterium cheongpyeongense IMCC34759 (97. Read More

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