346,686 results match your criteria temporal


Response to targeted cognitive training may be neuroprotective in patients with early schizophrenia.

Psychiatry Res Neuroimaging 2021 Apr 7;312:111285. Epub 2021 Apr 7.

University of California, San Francisco, Department of Psychiatry and Behavioral Science, USA; San Francisco Veterans Affairs Medical Center, USA.

Individuals with schizophrenia exhibit widespread cortical thinning associated with illness severity and deficits in cognition. However, intact cortical thickness (CTh) may serve as a protective factor. The current study sought to examine changes in CTh in response to auditory targeted cognitive training (TCT) in individuals with recent onset schizophrenia. Read More

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Agricultural nutrient loading under alternative climate, societal and manure recycling scenarios.

Sci Total Environ 2021 Mar 31;783:146871. Epub 2021 Mar 31.

Finnish Environment Institute, Latokartanonkaari 11, 00790 Helsinki, Finland. Electronic address:

This paper introduces a framework for extending global climate and socioeconomic scenarios in order to study agricultural nutrient pollution on an individual catchment scale. Our framework builds on and extends Representative Concentration Pathways (RCPs) and Shared Socioeconomic Pathways (SSPs) at the spatial and temporal scales that are relevant for the drivers of animal husbandry, manure recycling and the application of inorganic fertilisers in crop production. Our case study area is the Aura river catchment in South-West Finland, which discharges into the heavily eutrophic Baltic Sea. Read More

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Responses of phytoplankton community structure and association to variability in environmental drivers in a tropical coastal lagoon.

Sci Total Environ 2021 Apr 1;783:146873. Epub 2021 Apr 1.

Wetland Research and Training Centre, Chilika Development Authority, Balugaon 752030, Odisha, India. Electronic address:

Spatial and seasonal heterogeneity in phytoplankton communities are governed by many biotic and abiotic drivers. However, the identification of long-term spatial and temporal trends in abiotic drivers, and their interdependencies with the phytoplankton communities' structure is understudied in tropical brackish coastal lagoons. We examined phytoplankton communities' spatiotemporal dynamics from a 5-year dataset (n = 780) collected from 13 sampling stations in Chilika Lagoon, India, where the salinity gradient defined the spatial patterns in environmental variables. Read More

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An AIS-based emission inventory and the impact on air quality in Tianjin port based on localized emission factors.

Sci Total Environ 2021 Apr 6;783:146869. Epub 2021 Apr 6.

Tianjin Key Laboratory of Urban Transport Emission Research & State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China. Electronic address:

Ship pollution has become a hot global issue. This study established a basic information database of Tianjin Port ship emissions and used it to screen representative ship types and perform real-world ship measurements by a portable emission measurement system (PEMS), which generated localized emission factors. The results show that the localized emission factors are significantly higher than those recommended in recommended in Chinese guidelines, which will lead to lower calculation results of the previous inventory. Read More

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Hydrologic and nutrient-driven regime shifts of cyanobacterial and eukaryotic algal communities in a large shallow lake: Evidence from empirical state indicator and ecological network analyses.

Sci Total Environ 2021 Apr 12;783:147059. Epub 2021 Apr 12.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

The detection and prediction of lake ecosystem responses to environmental changes are pressing scientific challenge of major global relevance. Specifically, an understanding of lake ecosystem stability over long-term scales is urgently needed to identify impending ecosystem regime shifts induced by human activities and improve lake ecosystem protection. This study investigated regime shifts in cyanobacterial and eukaryotic algal communities in a large shallow lake over a century in response to nutrient enrichment and hydrologic regulation using evidence from empirical state indicators and ecological network analyses of sedimentary-inferred communities. Read More

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Psychotic symptoms in drug resistant epilepsy patients after cortical stimulation.

Epilepsy Res 2021 Apr 2;173:106630. Epub 2021 Apr 2.

Epilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, 08036, Spain; Clinical Institute of Neurosciences, Hospital Clinic of Barcelona, Barcelona, 08036, Spain; Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, Barcelona, 08036, Spain.

Purpose: The use of invasive EEG (iEEG) recordings before epilepsy surgery has increased as more complex focal epilepsies are evaluated. Psychotic symptoms (PS) during iEEG have been scarcely reviewed. We aim to report our series of patients with psychotic symptoms (PS) brought about by cortical stimulation (CS) and to identify triggers. Read More

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An examination of reciprocal effects between cardiovascular morbidity, depressive symptoms and loneliness over time in a longitudinal cohort of Dutch older adults.

J Affect Disord 2021 Mar 31;288:122-128. Epub 2021 Mar 31.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.

Background: Unidirectional studies suggest that the effects between cardiovascular disease, depressive symptoms and loneliness are reciprocal, but this has not been tested empirically. The aim was to study how cardiovascular morbidity, depressive symptoms and loneliness influence each other longitudinally.

Methods: Data from 2979 older adults from the Longitudinal Aging Study Amsterdam were analysed. Read More

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Determination of the size of lipid rafts studied through single-molecule FRET simulations.

Biophys J 2021 Apr 14. Epub 2021 Apr 14.

Biological Physics Laboratory, Physics Institute, Universidad Autónoma de San Luis Potosí, Álvaro Obregón 64, San Luis Potosí, S.L.P. 78290, Mexico. Electronic address:

Fluorescence Resonance Energy Transfer (FRET) is a high resolution technique that allows the characterization of spatial and temporal properties of biological structures and mechanisms. In the present work, we developed an in silico single-molecule FRET methodology to study the dynamics of fluorophores inside lipid rafts. We monitored the fluorescence of a single acceptor molecule in the presence of several donor molecules. Read More

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Temporal evolution of the biological response to laser-induced refractive index change (LIRIC) in rabbit corneas.

Exp Eye Res 2021 Apr 14:108579. Epub 2021 Apr 14.

The Institute of Optics, University of Rochester, Rochester, NY, 14627, USA; The Center for Visual Science, University of Rochester, Rochester, NY, 14627, USA; The Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA. Electronic address:

Laser induced refractive index change (LIRIC) is a new, non-incisional, non-ablative, femtosecond photo-modification technique being developed for vision correction in humans. Prior, ex-vivo studies showed intra-tissue refractive index change to induce minimal cell death, restricted to the laser focal zone in the corneal stroma, and with no observable damage to the epithelium or endothelium. Here, we used live rabbits to ascertain longer-term consequences of LIRIC in vivo. Read More

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Temporal trends and patient characteristics associated with 30-day hospital readmission rates after a first acute myocardial infarction.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Meyers Primary Care Institute, Worcester, MA 01655; Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, 01655.

Background: Limited data exists about relatively recent trends in the magnitude and characteristics of patients who are re-hospitalized after hospital admission for an acute myocardial infarction (AMI). This study examined trends in the frequency and socio-demographic and clinical characteristics of patients readmitted to the hospital within 30 days after an initial acute myocardial infarction.

Methods: We reviewed the medical records of 3,116 individuals who were hospitalized for a validated first acute myocardial infarction in six study periods between 2003 and 2015 at the three major medical centers in central Massachusetts. Read More

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Late adverse events in patients with pulmonary atresia intact ventricular septum after valvuloplasty.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Cardiovascular Surgery, Kyushu Hospital, Japan Community Healthcare Organization.

Background: We aimed to explore the relationship between temporal right heart growth and long-term outcomes in patients with pulmonary atresia with intact ventricular septum (PA/IVS) who underwent balloon pulmonary valvulopalsty (BPV).

Methods: Echocardiography was performed to measure the pulmonary valve diameter (PVD), the right atrial end-systolic area (RAA), and the right ventricular end-diastolic area (RVA) before BPV, 1 and 5 years after BPV. The primary and secondary endpoints were to explore temporal changes in the right heart structures and to determine echocardiographic parameters related to late adverse events (LAEs). Read More

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A Guide to time-resolved structural analysis of light-activated proteins.

FEBS J 2021 Apr 17. Epub 2021 Apr 17.

Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, 131 Princess Street, M1 7DN, Manchester, United Kingdom.

Dynamical changes in protein structures are essential for protein function and occur over femtoseconds to seconds timescales. X-ray free electron lasers have facilitated investigations of structural dynamics in proteins with unprecedented temporal and spatial resolution. Light-activated proteins are attractive targets for time-resolved structural studies, as the reaction chemistry and associated protein structural changes can be triggered by short laser pulses. Read More

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Autochthonous and imported tegumentary leishmaniasis in Catalonia (Spain): aetiological evolution in the last four decades and usefulness of different typing approaches based on biochemical, molecular and proteomic markers.

Transbound Emerg Dis 2021 Apr 17. Epub 2021 Apr 17.

Secció de Parasitologia, Departament de Biologia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Sanitat i Medi Ambient, Barcelona, Spain.

Leishmaniasis is a transmissible disease caused by Leishmania protozoa. Spain is endemic for both visceral and cutaneous leishmaniasis, the autochthonous aetiological agent being Leishmania infantum. Around the world, the L. Read More

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[Two-stage contralateral combined microvascular and wide-lumen anastomosis inTwo-stage contralateral combined microvascular and wide-lumen anastomosis in a patient with acute ischemic stroke patient with acute ischemic stroke].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):68-74

Regional Clinical Hospital No. 2, Tyumen, Russia.

Common carotid artery (CCA) thrombosis is a rare cause of ischemic stroke. In available literature, we found no studies devoted to cerebral revascularization for CCA occlusion in acute period of ischemic stroke. Successful treatment of concomitant occlusion of CCA, internal (ICA) and external carotid arteries (ECA) with microvascular anastomoses is very interesting for various specialists. Read More

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January 2021

Temporal dynamics of cells expressing NG2 and platelet-derived growth factor receptor-β in the fibrotic scar formation after 3-nitropropionic acid-induced acute brain injury.

Cell Tissue Res 2021 Apr 17. Epub 2021 Apr 17.

Department of Anatomy, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Neuron-glia antigen 2 (NG2) proteoglycan and platelet-derived growth factor receptor beta (PDGFR-β) are widely used markers of pericytes, which are considered cells that form fibrotic scars in response to central nervous system insults. However, the exact phenotypes of NG2- and PDGFR-β-expressing cells, as well as the origin of the fibrotic scar after central nervous system insults, are still elusive. In the present study, we directly examined the identities and distributions of NG2- and PDGFR-β-positive cells in the control and lesioned striatum injured by the mitochondrial toxin 3-nitropropionic acid. Read More

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Neural Correlates of Alcohol Use Disorder Severity among Non-Treatment Seeking Heavy Drinkers: An Examination of the Incentive Salience and Negative Emotionality Domains of the Alcohol and Addiction Research Domain Criteria.

Alcohol Clin Exp Res 2021 Apr 17. Epub 2021 Apr 17.

The Mind Research Network, Albuquerque, NM, USA.

Background: The Alcohol and Addiction Research Domain Criteria (AARDoC) proposes that alcohol use disorder is associated with neural dysfunction in three primary domains: incentive salience, negative emotionality, and executive function. Prior studies in heavy drinking samples have examined brain activation changes associated with alcohol and negative affect cues, representing the incentive salience and negative emotionality domains, respectively; yet studies examining such cue-induced changes in functional connectivity are relatively sparse.

Methods: Non-treatment seeking heavy drinking adults (N=149, 56. Read More

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Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder.

Mol Psychiatry 2021 Apr 16. Epub 2021 Apr 16.

Affilianted Mental Health Center & Hangzhou Seventh People's Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China.

Major depressive disorder (MDD) is a complex state-dependent psychiatric illness for which biomarkers linking psychophysical, biochemical, and psychopathological changes remain yet elusive, though. Earlier studies demonstrate reduced GABA in lower-order occipital cortex in acute MDD leaving open its validity and significance for higher-order visual perception, though. The goal of our study is to fill that gap by combining psychophysical investigation of visual perception with measurement of GABA concentration in middle temporal visual area (hMT+) in acute depressed MDD. Read More

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Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery.

Sci Rep 2021 Apr 16;11(1):8411. Epub 2021 Apr 16.

Department of Neurosurgery and Neurotechnology, Eberhard Karls University Hospital, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

Tinnitus is attributed to partial sensory deafferentation resulting in a central maladaptive neuroplasticity. Unfortunately, the agent of deafferentation is usually unknown or irreversible. In patients with unilateral vestibular schwannoma (VS), however, the auditory nerve is affected by a benign tumor. Read More

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The neurodevelopment of delay discounting for monetary rewards in pre-adolescent children.

Sci Rep 2021 Apr 16;11(1):8337. Epub 2021 Apr 16.

CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.

Children are found to exhibit high degrees of delay discounting compared with adults in many delay discounting studies, which might be due to the asynchronous development of "bottom-up" and "top-down" neural systems. However, the temporal dynamics associated with the two systems in the development of delay discounting processes are not well known. In this study, we chose two age groups of participants and adopted event-related potential (ERP) techniques to investigate the neural dynamic differences between children and adults during delay discounting processes. Read More

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High spatial resolution global ocean metagenomes from Bio-GO-SHIP repeat hydrography transects.

Sci Data 2021 Apr 16;8(1):107. Epub 2021 Apr 16.

Department of Earth System Science, University of California at Irvine, Irvine, CA, USA.

Detailed descriptions of microbial communities have lagged far behind physical and chemical measurements in the marine environment. Here, we present 971 globally distributed surface ocean metagenomes collected at high spatio-temporal resolution. Our low-cost metagenomic sequencing protocol produced 3. Read More

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Fluid activity detection in geothermal areas using a single seismic station by monitoring horizontal-to-vertical spectral ratios.

Sci Rep 2021 Apr 16;11(1):8372. Epub 2021 Apr 16.

Research Institute of Earthquake and Volcano Geology, National Institute of Advanced Industrial Science and Technology, 1-1-1, Higashi, Tsukuba, Ibaraki, 305-8567, Japan.

Subsurface structure survey based on horizontal-to-vertical (H/V) spectral ratios is widely conducted. The major merit of this survey is its convenience to obtain a stable result using a single station. Spatial variations of H/V spectral ratios are well-known phenomena, and it has been used to estimate the spatial fluctuation in subsurface structures. Read More

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Experimental parameters defining ultra-low biomass bioaerosol analysis.

NPJ Biofilms Microbiomes 2021 Apr 16;7(1):37. Epub 2021 Apr 16.

Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.

Investigation of the microbial ecology of terrestrial, aquatic and atmospheric ecosystems requires specific sampling and analytical technologies, owing to vastly different biomass densities typically encountered. In particular, the ultra-low biomass nature of air presents an inherent analytical challenge that is confounded by temporal fluctuations in community structure. Our ultra-low biomass pipeline advances the field of bioaerosol research by significantly reducing sampling times from days/weeks/months to minutes/hours, while maintaining the ability to perform species-level identification through direct metagenomic sequencing. Read More

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Dynamics of brain function in chronic pain patients assessed by microstate analysis of resting-state electroencephalography.

Pain 2021 Apr 8. Epub 2021 Apr 8.

Department of Neurology, School of Medicine, Technical University of Munich (TUM), Munich, Germany TUM-Neuroimaging Center, School of Medicine, TUM, Munich, Germany Center for Interdisciplinary Pain Medicine, School of Medicine, TUM, Munich, Germany.

Abstract: Chronic pain is a highly prevalent and severely disabling disease that is associated with substantial changes of brain function. Such changes have mostly been observed when analyzing static measures of resting-state brain activity. However, brain activity varies over time and it is increasingly recognized that the temporal dynamics of brain activity provide behaviorally relevant information in different neuropsychiatric disorders. Read More

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Direct comparison of the tau PET tracers [F]flortaucipir and [F]MK-6240 in human subjects.

J Nucl Med 2021 Apr 16. Epub 2021 Apr 16.

University of Pittsburgh, United States.

Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding patterns that are more diverse than amyloid PET tracers. This study compares two frequently used tau PET tracers, [F]flortaucipir (FTP) and [F]MK-6240, in the same subjects. [F]flortaucipir and [F]MK-6240 scans were collected within two months in 15 elderly subjects varying in terms of clinical diagnosis and cognition. Read More

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The contributions from the progenitor genomes of the mesopolyploid Brassiceae are evolutionarily distinct but functionally compatible.

Genome Res 2021 Apr 16. Epub 2021 Apr 16.

Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695, USA.

The members of the tribe Brassiceae share a whole-genome triplication (WGT), and one proposed model for its formation is a two-step pair of hybridizations producing hexaploid descendants. However, evidence for this model is incomplete, and the evolutionary and functional constraints that drove evolution after the hexaploidy are even less understood. Here, we report a new genome sequence of , a species sister to most sequenced Brassiceae. Read More

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Time-Aligned Plane Wave Compounding Methods for High-Frame-Rate Shear Wave Elastography: Experimental Validation and Performance Assessment on Tissue Phantoms.

Ultrasound Med Biol 2021 Apr 13. Epub 2021 Apr 13.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Shear wave elastography (SWE) is an ultrasonic technique able to quantitatively assess the mechanical properties of tissues by combining acoustic radiation force and ultrafast imaging. While utilizing coherent plane wave compounding enhances echo and shear wave motion signal-to-noise ratio (SNR), it also reduces the effective pulse repetition frequency (PRF), affecting the accuracy of the measurements of motion and, consequently, of material properties. It is important to maintain both high-motion SNR and PRF, particularly for the characterization of (material and/or geometrical) dispersive tissues such as arteries. Read More

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Reorganization of auditory-visual network interactions in long-term unilateral postlingual hearing loss.

J Clin Neurosci 2021 May 19;87:97-102. Epub 2021 Mar 19.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, China; Neurosurgical Institute of Fudan University, China; Shanghai Clinical Medical Center of Neurosurgery, China. Electronic address:

Long-term unilateral hearing loss could reorganize the functional network association between the bilateral auditory cortices, while alterations of other functional networks need to be further explored. We attempted to investigate the pattern of the reorganization of functional network associations between the auditory and visual cortex caused by long-term postlingual unilateral hearing loss (UHI) and its relationship with clinical characteristics. Therefore, 48 patients with hearing loss caused by unilateral acoustic tumors and 52 matched healthy controls were enrolled, and their high-resolution structural MRI and resting-state functional MRI data were also collected to depict the brain network. Read More

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Novel grading system of sigmoid sinus dehiscence for radiologic evaluation of pulsatile tinnitus.

J Clin Neurosci 2021 May 22;87:147-149. Epub 2021 Mar 22.

Department of Head & Neck Surgery, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States. Electronic address:

Background: Sigmoid sinus dehiscence (SSD) is an important etiology of pulsatile tinnitus (PT) though there is currently no consensus on the prevalence of SSD in non-PT populations. This study establishes a grading system of SSD and analyzes a non-PT cohort for prevalence of SSD.

Methods: In this retrospective study temporal bone CT scans of 91 patients without PT were analyzed for SSD. Read More

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A rare case of spontaneous otogenic pneumocephalus with pictorial illustration of temporal evolution.

J Clin Neurosci 2021 May 20;87:132-136. Epub 2021 Mar 20.

Department of Diagnostic Imaging, National University Hospital, National University Health System, Singapore. Electronic address:

Pneumocephalus is commonly seen on imaging in the setting of craniofacial trauma, skull base tumours, intracranial infection and after neurological intervention. Spontaneous pneumocephalus in the absence of these conditions is exceedingly rare, with only approximately 30 cases reported in the literature to date. Spontaneous otogenic pneumocephalus (SOP) is believed to occur as a result of anomalous communication between the intracranial space and a hyper-pneumatised temporal bone, with either positive extra-to-intracranial pressure or negative intracranial pressure gradient. Read More

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Short- and long-term dynamics of the physiological and behavioral response to heat stress and thymol supplementation in Japanese quail.

J Therm Biol 2021 Apr 18;97:102876. Epub 2021 Feb 18.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Investigaciones Biológicas y Tecnológicas (IIByT), Av. Vélez Sarsfield 1611, CP 5016, Córdoba, Argentina; Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Instituto de Ciencia y Tecnología de Los Alimentos (ICTA), Av. Vélez Sarsfield 1611, CP 5016, Córdoba, Argentina; Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Cátedra de Química Biológica, Av. Vélez Sarsfield 1611, CP 5016, Córdoba, Argentina. Electronic address:

Organisms have evolved endogenous timing systems that enable them to predict temporal changes and to coordinate complex internal processes. However, temporal dynamics of biological responses are most often ignored in fields such as dietary supplementation of farm animals exposed to artificial environmental challenges. Herein, we hypothesized that the potential for thymol (2-isopropyl-5-methylphenol) to alleviate physiological and behavioral consequences of heat stress is time-dependent on both long-term (i. Read More

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