1,073 results match your criteria templates solid

Selective Crystallization of d-Mannitol Polymorphs Using Surfactant Self-Assembly.

Cryst Growth Des 2021 Jul 28;21(7):3928-3935. Epub 2021 May 28.

Process & Energy Department, Delft University of Technology, Leeghwaterstraat 39, 2628 CB Delft, The Netherlands.

Selective crystallization of polymorphs is highly sought after in industrial practice. Yet, state-of-the-art techniques either use laboriously engineered solid surfaces or strenuously prepared heteronucleants. We propose an approach where surfactants in solution self-assemble effortlessly into mesoscopic structures dictating the polymorphic outcome of the target solute. Read More

View Article and Full-Text PDF

Cumulene-like bridged indeno[1,2-]fluorene π-conjugated polymers synthesized on metal surfaces.

Chem Commun (Camb) 2021 Jul 9. Epub 2021 Jul 9.

IMDEA Nanoscience, C/Faraday 9, Campus de Cantoblanco, 28049 Madrid, Spain.

Among the plethora of polycyclic structures that have emerged in recent years, indenofluorenes comprise a unique class of compounds due to their potential in organic electronic systems such as OLEDs, OFETs, and OPVCs. However, the synthesis of fully conjugated indenofluorenes without bulky groups on the apical carbons under standard chemistry conditions is not easily accessible. In this regard, on-surface synthesis has appeared as a newly developing field of research, which exploits the use of well-defined solid surfaces as confinement templates to initiate and develop chemical reactions. Read More

View Article and Full-Text PDF

Transcription, Reverse Transcription, and Amplification of Backbone-Modified Nucleic Acids with Laboratory-Evolved Thermophilic DNA Polymerases.

Curr Protoc 2021 Jul;1(7):e188

MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.

Backbone-modified nucleic acids are usually more stable enzymatically than their natural counterparts, enabling their broad application as potential diagnostic or therapeutic agents. Moreover, the development of nucleic acids with unnatural backbones has expanded the pool of genetic information carriers and paved the way toward synthetic xenobiology. However, synthesizing these molecules remains very challenging due to the requirement for harsh reaction conditions and the low coupling efficiency during their traditional solid-phase synthesis. Read More

View Article and Full-Text PDF

[Recent advances in applications of fragment/dummy molecularly imprinted polymers].

Se Pu 2021 Feb;39(2):134-141

Chinese Academy of Sciences Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Research Center for Coastal Environmental Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.

Molecularly imprinted polymers (MIPs) are designed to mimic the specific binding principle of enzymes to substrates or antigens to antibodies, while holding several advantages such as structure predictability, recognition specificity, easy preparation, low cost, high physical robustness, and thermal stability. Therefore, they have been widely applied in many fields including sample preparation (pretreatment), sensing analysis (chemo/biosensors), biomedicine, and environment/food analysis. To date, several strategies were developed for MIPs preparation, aiming to simplify the preparation process and/or improve the properties of the polymers, greatly broadening its usability. Read More

View Article and Full-Text PDF
February 2021

Nanocomposite synthesis strategies based on the transformation of well-tailored metal-organic frameworks.

Chem Commun (Camb) 2021 Jul;57(57):6960-6974

Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Ulsan 44919, Republic of Korea.

Increasing the complexity of nanomaterials in terms of their structure and chemical composition has attracted significant attention, because it can yield unique scientific outcomes and considerable improvements for practical applications. Various approaches are being developed for the synthesis of nanostructured composites. Coordination polymers (CPs) emerged as new precursors in solid-state reactions for nanomaterials nearly two decades ago; the repetitively arranged inorganic and organic units can facilitate the production of nanoscale particles and porous carbon upon thermal decomposition. Read More

View Article and Full-Text PDF

Macroscopic rods from assembled colloidal particles of hydrothermally carbonized glucose and their use as templates for silicon carbide and tricopper silicide.

J Colloid Interface Sci 2021 Jun 14;602:480-489. Epub 2021 Jun 14.

Department of Materials and Environmental Chemistry, Stockholm University Svante Arrhenius väg 16 C SE 10691 Stockholm, Sweden. Electronic address:

Self-aggregated colloids can be used for the preparation of materials, and we studied long rod-like aggregates formed on the evaporation of water from dispersed particles of colloidal hydrochar. The monodispersed hydrochar particles (100-200 nm) were synthesized by the hydrothermal carbonization of glucose and purified through dialysis. During the synthesis they formed colloidal dispersions which were electrostatically stable at intermediate to high pH and at low ion strengths. Read More

View Article and Full-Text PDF

MOF-Derived [email protected] Carbon Matrix Confined in Hollow Mesoporous Carbon Nanospheres as High-Performance Anodes for Potassium-Ion Batteries.

Nanomicro Lett 2020 Oct 27;13(1). Epub 2020 Oct 27.

Department of Materials Science and Engineering, Korea University, Anam-Dong, Seongbuk-Gu, Seoul, 136-713, Republic of Korea.

In this work, a novel vacuum-assisted strategy is proposed to homogenously form Metal-organic frameworks within hollow mesoporous carbon nanospheres (HMCSs) via a solid-state reaction. The method is applied to synthesize an ultrafine CoSe [email protected] carbon matrix confined within HMCSs (denoted as [email protected]/HMCS) for use as advanced anodes in high-performance potassium-ion batteries (KIBs). The approach involves a solvent-free thermal treatment to form a Co-based zeolitic imidazolate framework (ZIF-67) within the HMCS templates under vacuum conditions and the subsequent selenization. Read More

View Article and Full-Text PDF
October 2020

Informatics Methods and Infrastructure Needed to Study Factors Associated with High Incidence of Pediatric Brain and Central Nervous System Tumors in Kentucky.

J Registry Manag 2020 ;47(3):127-134

Pediatric brain and central nervous system tumors (PBCNSTs) are the most common solid tumors and are the leading cause of disease-related death in US children. PBCNST incidence rates in Kentucky are significantly higher than in the United States as a whole, and are even higher among Kentucky's Appalachian children. To understand and eventually eliminate such disparities, population-based research is needed to gain a thorough understanding of the epidemiology and etiology of the disease. Read More

View Article and Full-Text PDF

Multi-templates surface molecularly imprinted polymer for simultaneous and rapid determination of sulfonamides and quinolones in water: effect of carbon-carbon double bond.

Environ Sci Pollut Res Int 2021 Jun 13. Epub 2021 Jun 13.

School of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541000, China.

In this work, the effect of a carrier modified with a carbon-carbon double bond (C=C) on preparing multi-templates surface molecularly imprinted polymer MIP ([email protected]) for simultaneous detection of sulfonamides and quinolones was investigated. The results showed that the adsorption capacities of the [email protected] were obviously higher than those of MIP, which is the carrier without modified C=C, suggesting that C=C played a key role in preparing MIP with higher adsorption capacities. Then, [email protected] was used as adsorbents for solid-phase extraction (SPE) and coupled with high-performance liquid chromatography (HPLC) for the simultaneous determination of sulfonamides and quinolones in water. Read More

View Article and Full-Text PDF

Optical Signatures of Dirac Electrodynamics for hBN-Passivated Silicene on Au(111).

Nano Lett 2021 Jun 7;21(12):5301-5307. Epub 2021 Jun 7.

Institute of Solid State Electronics, Technische Universität Wien, Gußhausstraße 25-25a, 1040 Vienna, Austria.

The allotropic affinity for bulk silicon and unique electronic and optical properties make silicene a promising candidate for future high-performance devices compatible with mature complementary metal-oxide-semiconductor technology. However, silicene's outstanding properties are not preserved on its most prominent growth templates, due to strong substrate interactions and hybridization effects. In this letter, we report the optical properties of silicene epitaxially grown on Au(111). Read More

View Article and Full-Text PDF

Generalizing the Chiral Self-Assembly of Spheres and Tetrahedra to Non-Spherical and Polydisperse Molecules in (C)(C)(SnI).

Nano Lett 2021 Jun 20;21(11):4753-4756. Epub 2021 May 20.

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

We describe the spontaneous chiral self-assembly of C with SnI as well as a mixture of C and C with SnI. Macroscopic single crystals with the formula (C)(C)(SnI) ( = 0-1) are reported. C which is spherical, and C, which is ellipsoidal, form a solid solution in these crystals, and the cubic lattice parameter of the chiral phase linearly increases as grows from 0 to 1 in accordance with Vegard's law. Read More

View Article and Full-Text PDF

Fabrication of Pd/Mg P O via a Struvite-Template Way from Wastewater and Application as Chemoselective Catalyst in Hydrogenation of Nitroarenes.

Chemistry 2021 Jul 17;27(41):10666-10676. Epub 2021 Jun 17.

Key Laboratory of Automobile Materials of Ministry of Education, School of Materials Science and Engineering, Solid Waste Recycling Engineering Research Center of Jilin Province, Open Research Laboratory for Physicochemical Testing Methods of Functional Minerals, Ministry of Natural Resources, Jilin University, Changchun, 130022, P. R. China.

A highly efficient heterogeneous catalyst Pd/Mg P O was fabricated by combining palladium nanoparticles (PdNPs) and mesoporous Mg P O fibers/rods. Mg P O fibers with ultra-high specific surface area were prepared from struvite as templates, which were synthesized from waste water containing N- and P-containing pollutants. This strategy provided a novel pathway for developing advanced catalysts from eutrophication-polluted water. Read More

View Article and Full-Text PDF

Template-Free Construction of Tin Oxide Porous Hollow Microspheres for Room-Temperature Gas Sensors.

ACS Appl Mater Interfaces 2021 Jun 18;13(21):25111-25120. Epub 2021 May 18.

School of Optical and Electronic Information, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei 430074, China.

Porous hollow microsphere (PHM) materials represent ideal building blocks for realizing diverse functional applications such as catalysis, energy storage, drug delivery, and chemical sensing. This has stimulated intense efforts to construct metal oxide PHMs for achieving highly sensitive and low-power-consumption semiconductor gas sensors. Conventional methods for constructing PHMs rely on delicate reprogramming of templates and may suffer from the structural collapse issue during the removal of templates. Read More

View Article and Full-Text PDF

A Phase I Trial of the MET/ Inhibitor Crizotinib Combined with the VEGF Inhibitor Pazopanib in Patients with Advanced Solid Malignancies.

Onco Targets Ther 2021 7;14:3037-3049. Epub 2021 May 7.

Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Background: Crizotinib inhibits ALK, MET and ROS1 tyrosine kinases but the development of resistance to monotherapy is an issue. The anti-angiogenic properties of pazopanib could overcome crizotinib drug resistance. Additionally, the anti-angiogenic properties of crizotinib could augment the clinical efficacy of pazopanib. Read More

View Article and Full-Text PDF

L-Dopa release from mesoporous silica nanoparticles engineered through the concept of drug-structure-directing agents for Parkinson's disease.

J Mater Chem B 2021 05;9(20):4178-4189

Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/Tulipán s/n, 28933, Móstoles, Madrid, Spain.

Parkinson's disease (PD) is a progressive neurodegenerative disease, the 2nd most common after Alzheimer's disease, the main effect of which is the loss of dopaminergic neurons. Levodopa or l-Dopa is an amino acid used in the treatment of PD that acts as the immediate precursor to dopamine. However, over time the efficacy of the medication gradually decreases requiring modified delivery methods. Read More

View Article and Full-Text PDF

Heterostructures between a tin-based intermetallic compound and a layered semiconductor for gas sensing.

Chem Commun (Camb) 2021 Jun;57(45):5590-5593

Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, 211816, China. and Frontiers Science Center for Flexible Electronics (FSCFE) & Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an 710072, China.

SnS2 nanoplates are used as sacrificial templates to facilitate the in situ growth of intermetallic compound Pt3Sn nanoparticles. The Pt3Sn/SnS2 heterostructures show promise for selective NO2 sensing due to the favored gas adsorption and gas-solid charge transfer on Pt3Sn, combined with the optimized film conductance and formation of ohmic-type Pt3Sn/SnS2 heterointerfaces. Read More

View Article and Full-Text PDF

Liquid Wells as Self-Healing, Functional Analogues to Solid Vessels.

Adv Mater 2021 Jun 6;33(23):e2100117. Epub 2021 May 6.

Institute of Biological and Chemical Systems - Functional Materials Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Pl. 1, 76344, Eggenstein-Leopoldshafen, Germany.

Liquids are traditionally handled and stored in solid vessels. Solid walls are not functional, adaptive, or self-repairing, and are difficult to remove and re-form. Liquid walls can overcome these limitations, but cannot form free-standing 3D walls. Read More

View Article and Full-Text PDF

Co/CoO heterojunctions encapsulated N-doped carbon sheets via a dual-template-guided strategy as efficient electrocatalysts for rechargeable Zn-air battery.

J Colloid Interface Sci 2021 Oct 20;599:46-57. Epub 2021 Apr 20.

School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China. Electronic address:

Developing highly efficient oxygen electrocatalysts is of vital importance for rechargeable Zn-air batteries (ZABs). Herein, Co/CoO nano-heterojunctions encapsulated into nitrogen-doped carbon sheets ([email protected]/CoO) are fabricated via a dual-template-guided approach by using zeolitic imidazolate frameworks (ZIFs) as templates. The synergistic integration of structural and compositional advantages endows such catalyst with superior catalytic properties to benchmark noble-metal catalysts. Read More

View Article and Full-Text PDF
October 2021

Influence of Alumina Addition on the Optical Properties and the Thermal Stability of Titania Thin Films and Inverse Opals Produced by Atomic Layer Deposition.

Nanomaterials (Basel) 2021 Apr 20;11(4). Epub 2021 Apr 20.

Institute of Nanostructure and Solid State Physics & Center for Hybrid Nanostructures, Universität Hamburg, Luruper Chausse 149, 22761 Hamburg, Germany.

TiO thin films deposited by atomic layer deposition (ALD) at low temperatures (<100 °C) are, in general, amorphous and exhibit a smaller refractive index in comparison to their crystalline counterparts. Nonetheless, low-temperature ALD is needed when the substrates or templates are based on polymeric materials, as the deposition has to be performed below their glass transition or melting temperatures. This is the case for photonic crystals generated via ALD infiltration of self-assembled polystyrene templates. Read More

View Article and Full-Text PDF

Pressure induced topochemical polymerization of solid acrylamide facilitated by anisotropic response of the hydrogen bond network.

Phys Chem Chem Phys 2021 Apr 9;23(15):9448-9456. Epub 2021 Apr 9.

Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal 462 066, India.

The pressure induced polymerization of molecular solids is an appealing route to obtain pure, crystalline polymers without the need for radical initiators. Here, we report a detailed density functional theory (DFT) study of the structural and chemical changes that occur in defect free solid acrylamide, a hydrogen bonded crystal, when it is subjected to hydrostatic pressures. While our calculations are able to reproduce experimentally measured pressure dependent spectroscopic features in the 0-20 GPa range, our atomistic analysis predicts polymerization in acrylamide at a pressure of ∼23 GPa at 0 K albeit through large enthalpy barriers. Read More

View Article and Full-Text PDF

Constructing 3D Macroporous Microfibrous Scaffolds with a Featured Surface by Heat Welding and Embossing.

Biomacromolecules 2021 05 21;22(5):1867-1874. Epub 2021 Apr 21.

CSIRO Manufacturing, Geelong Technology Precinct, Geelong, Victoria 3216, Australia.

Three-dimensional (3D) microfibrous scaffolds hold great promise for biomedical applications due to their good mechanical properties and biomimetic structure similar to that of the fibrous natural extracellular matrix. However, the large diameter and smooth surface of microfibers provide limited cues for regulating cell activity and behaviors. In this work, we report a facile heat-welding-and-embossing strategy to develop 3D macroporous microfibrous scaffolds with a featured surface topography. Read More

View Article and Full-Text PDF

Hollow mesoporous polydopamine nanospheres: synthesis, biocompatibility and drug delivery.

Nanotechnology 2021 Apr 22;32(28). Epub 2021 Apr 22.

College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, People's Republic of China.

Various polydopamine (PDA) nanospheres were synthesized by utilizing triblock copolymer Pluronic F127 and 1,3,5-trimethylbenzene (TMB) as soft templates. Precise morphology control of polydopamine nanospheres was realized from solid polydopamine nanospheres to hollow polydopamine nanospheres, mesoporous polydopamine nanospheres and hollow mesoporous polydopamine nanospheres (H-MPDANSs) by adjusting the weight ratio of TMB to F127. The inner diameter of the prepared H-MPDANSs can be controlled in the range of 50-100 nm, and the outer diameter is about 180 nm. Read More

View Article and Full-Text PDF

A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies.

Clin Cancer Res 2021 Jun 26;27(11):3050-3060. Epub 2021 Mar 26.

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: As hypoxia can mediate resistance to immunotherapy, we investigated the safety, tolerability, and efficacy of combining evofosfamide, a prodrug that alleviates hypoxia, with ipilimumab, an immune checkpoint inhibitor, in immunologically "cold" cancers, which are intrinsically insensitive to immunotherapy, as well as in "hot/warm" metastatic cancers that are, atypical of such cancers, resistant to immunotherapy.

Patients And Methods: In a phase I, 3+3 dose-escalation trial (NCT03098160), evofosfamide (400-640 mg/m) and ipilimumab (3 mg/kg) were administered in four 3-week cycles. The former was administered on days 1 and 8 of cycles 1-2, while the latter was administered on day 8 of cycles 1-4. Read More

View Article and Full-Text PDF

Tunable Electrochemical Activity of P2-NaMnNiOF Microspheres as High-Rate Cathodes for High-Performance Sodium Ion Batteries.

ACS Appl Mater Interfaces 2021 Apr 26;13(13):15333-15343. Epub 2021 Mar 26.

School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao, Shandong 266580, P. R. China.

As an important cathode candidate for the high-performance sodium ion batteries (SIBs), P2-type oxides with layered structures are needed to balance the specific capacities and cycling stability. As a result, a cation and anion codoped strategy has been adopted to tune the electrochemical activity of the redox centers and modulate the structure properties. Herein, a series of P2-NaMnNiOF ( = 0, 0. Read More

View Article and Full-Text PDF

Surfactant-in-Polymer Templating for Fabrication of Carbon Nanofibers with Controlled Interior Substructures: Designing Versatile Materials for Energy Applications.

Small 2021 May 19;17(18):e2007775. Epub 2021 Mar 19.

Department of Polymer Engineering, Graduate School, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, South Korea.

A simple, scalable, surfactant-in-polymer templating approach is demonstrated to create controlled long-range secondary substructures in a primary structure. A metal bis(2-ethylhexyl) sulfosuccinate (MAOT) as the surfactant is shown to be capable of serving as a sacrificial template and metal precursor in carbon nanofibers. The low interfacial tension and controllable dimensions of the MAOT are maintained in the solid-phase polymer, even during electrospinning and heat-treatment processes, allowing for the long-range uniform formation of substructures in the nanofibers. Read More

View Article and Full-Text PDF

Safety and activity of vandetanib in combination with everolimus in patients with advanced solid tumors: a phase I study.

ESMO Open 2021 Apr 12;6(2):100079. Epub 2021 Mar 12.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:

Background: Preclinical studies suggest that combining vandetanib (VAN), a multi-tyrosine kinase inhibitor of rearranged during transfection (RET) proto-oncogene, vascular endothelial growth factor receptor (VEGFR), and epidermal growth factor receptor (EGFR), with everolimus (EV), a mammalian target of rapamycin (mTOR) inhibitor, may improve antitumor activity. We determined the safety, maximum tolerated dose (MTD), recommended phase II dose (RP2D), and dose-limiting toxicities (DLTs) of VAN + EV in patients with advanced solid cancers and the effect of combination therapy on cancer cell proliferation and intracellular pathways.

Patients And Methods: Patients with refractory solid tumors were enrolled in a phase I dose-escalation trial testing VAN (100-300 mg orally daily) + EV (2. Read More

View Article and Full-Text PDF

Ultrasound-Triggered Assembly of Covalent Triazine Framework for Synthesizing Heteroatom-Doped Carbon Nanoflowers Boosting Metal-Free Bifunctional Electrocatalysis.

ACS Appl Mater Interfaces 2021 Mar 11;13(11):13328-13337. Epub 2021 Mar 11.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai 201620, P. R. China.

The construction of multiple heteroatom-doped porous carbon with unique nanoarchitectures and abundant heteroatom active sites is promising for reversible oxygen-involving electrocatalysis. However, most of the synthetic methods required the use of templates to construct precisely designed nanostructured carbon. Herein, we introduced an ultrasound-triggered route for the synthesis of a piperazine-containing covalent triazine framework (P-CTF). Read More

View Article and Full-Text PDF

Dicyanamide-intertwined assembly of two new Zn complexes based on NO-type pro-ligand: Synthesis, crystal networks, spectroscopic insights, and selective nitroaromatic turn-off fluorescence sensing.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 23;254:119612. Epub 2021 Feb 23.

Department of Chemistry, Tamralipta Mahavidyalaya, Tamluk 721636, West Bengal, India. Electronic address:

Two new dicyanamide bridged multinuclear Zn complexes, [Zn(L)(µ-dca)(µ-dca)] (1) and [Zn(L)(µ-dca)(µ-dca)] (2) have been synthesized using NO-based pro-ligands (HL = N,N'-bis(5-bromo-3-methoxysalicylidenimino)-1,3-diaminopropane, HL = N,N'-bis(3-ethoxysalicylidene)-2,2-dimethyl-1,3-propanediamine) and characterized by microanalytical and spectroscopic techniques. Both complexes are stable in solution and solid-state. Thermogravimetric analysis (TGA) findings showed that complexes are stable at room temperature. Read More

View Article and Full-Text PDF

Fabrication of target specific solid-state optical sensors using chromoionophoric probe-integrated porous monolithic polymer and silica templates for cobalt ions.

Anal Bioanal Chem 2021 May 6;413(12):3177-3191. Epub 2021 Mar 6.

Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.

The article demonstrates the design of two solid-state sensors for the capturing of industrially relevant ultra-trace Co(II) ions using porous monolithic silica and polymer templates. The mesoporous silica reveals high surface area and voluminous pore dimensions that ensures homogeneous anchoring of 4-((5-(allylthio)-1,3,4-thiadiazol-2-yl)diazenyl)benzene-1,3-diol, as the chromoionophore. We report a first of its kind solid-state macro-/meso-porous polymer monolithic optical sensor from a monomeric chromoionophore, i. Read More

View Article and Full-Text PDF

Tetrasulfonate calix[4]arene modified large pore mesoporous silica microspheres: Synthesis, characterization, and application in protein separation.

Talanta 2021 May 2;226:122171. Epub 2021 Feb 2.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. Electronic address:

Effective protein adsorption by solid matrices from complex biological samples has attracted attention for broad application in biomedical field. Immobilization of calixarenes to solid supports is an essential process for their application in protein separation and purification. Silica is the most widely used support material in calixarene immobilization. Read More

View Article and Full-Text PDF