Int J Pharm 2021 Jul 19:120897. Epub 2021 Jul 19.
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya, Campus Diagonal-Besòs, Av. Eduard Maristany 10-14, E-08019 Barcelona, Catalonia, Spain; Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, Escola Enginyeria de Barcelona Est-EEBE, c/Eduard Maristany 10-14, Barcelona 08019, SPAIN. Electronic address:
Melt electrospinning of polylactide (PLA) loaded with chloramphenicol (CAM) has been performed and characteristics of fibers, physical properties of scaffolds, CAM release behavior, antibacterial properties and biocompatibility have been evaluated. The interest of CAM loaded samples is nowadays enhanced for biomedical applications since this antibiotic has been demonstrated to be efficient for the treatment of cancer. Melt electrospinning has been selected as an ideal preparation process because it avoids the use of toxic solvents which are harmful to the environment and could be problematic for biomedical applications. Read More