4,581 results match your criteria tehran diabetes


The influence of mode of delivery, anthropometric indices, and infant's sex on the maternal and cord blood orexin-A levels: A cohort study.

J Obstet Gynaecol Res 2021 Apr 18. Epub 2021 Apr 18.

Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.

Background: Orexin as an adipokin hormone plays an important role in appetite regulation, energy metabolism, obesity, diabetes, and cardiovascular disease. The main source of orexin secretion in nonpregnant and pregnant women is adipose tissue and placenta, respectively. This research was conducted to evaluate the association between orexin-A level and the mode of delivery, anthropometric indices, and sex of the infant. Read More

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Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis.

Complement Med Res 2021 Apr 16:1-14. Epub 2021 Apr 16.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Background: Coenzyme Q10 (CoQ10) has been known as ubiquinone or ubidecarenone, which is a kind of lipid-soluble and vitamin-like antioxidant. It has a potent antioxidant effect against oxidation status via various mechanisms, including its ability to regenerate other antioxidants, such as vitamin E and vitamin C, and to increase antioxidant enzymes. Moreover, CoQ10 can quench free radicals and prevent lipid peroxidation. Read More

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Research gaps in Ramadan fasting studies in health and disease.

Diabetes Metab Syndr 2021 Apr 15;15(3):831-835. Epub 2021 Apr 15.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aim: Ramadan fasting is a religious fasting of Muslims and has many effects on health and disease. This study aim was to analyze Ramadan fasting research output during the past five years and identify research gaps in this field.

Materials And Methods: A systematic search was performed in Web of Science, pubmed, Scopus, EMBASE and Cochrane databases by appropriate keywords. Read More

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Higher dietary insulin load and index are not associated with risk of metabolic syndrome and obesity in Iranian adults.

Int J Clin Pract 2021 Apr 17:e14229. Epub 2021 Apr 17.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Background: Data about the relation between dietary insulin load (DIL) and dietary insulin index (DII) with metabolic syndrome (MetS) and obesity are scarce. Therefore, the present study aimed to examine the association of the insulinemic potential of the diet with MetS and obesity among Iranian adults.

Methods: This cross-sectional study was conducted among 850 adults aged 20-59 years. Read More

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Warning signals of elevated prediabetes prevalence in the modern Iranian urban population.

Prim Care Diabetes 2021 Apr 13. Epub 2021 Apr 13.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Research Center for the Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: We sought to estimate the prevalence of diabetes mellitus (DM) and pre-DM and their associated factors among a sample of the Iranian urban population between 2017 and 2019.

Methods: The present investigation is a sub-study on the HAMRAH cohort study, a longitudinal population-based cohort study to assess the 10-year risk of cardiovascular diseases and their related risk factors in the adult population of the Iranian capital, Tehran. Via a multistage cluster randomized sampling method, 2123 adults aged between 30 and 75 years who had no history of cardiovascular diseases were selected for the study. Read More

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Design, synthesis, and molecular docking of some novel tacrine based cyclopentapyranopyridin- and tetrahydropyranoquinolin-kojic acid derivatives as anti-acetylcholinesterase agents.

Chem Biodivers 2021 Apr 16. Epub 2021 Apr 16.

Hamadan University of Medical Sciences Medical Sciences, Medicinal Chemistry, Shahid fahmideh, 081, hamedan, IRAN (ISLAMIC REPUBLIC OF).

A novel series of tacrine based cyclopentapyranopyridin- and tetrahydropyranoquinolin-kojic acid derivatives were designed, synthesized, and evaluated as anti-cholinesterase agents. The chemical structures of all target compounds were characterized by 1H-NMR, 13C-NMR, and elemental analyses. The synthesized compounds mostly inhibited acetylcholinesterase enzyme (AChE) with IC50 values of 4. Read More

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Ethnomedicinal Uses, Phytochemistry and Pharmacology of Different Cichorium Species (Asteraceae): A Review.

Adv Exp Med Biol 2021 ;1308:501-546

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Cichorium species have been used widely in traditional medicine universally. It is reported as a treatment for various respiratory and gastrointestinal disorders, as well as diabetes and rheumatism. A range of constituents including phenolic and poly phenolic compounds, fatty and organic acids and essential oils comprise the chemical composition of Cichorium species. Read More

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Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica: A Comprehensive Review.

Adv Exp Med Biol 2021 ;1308:451-499

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Centella asiatica (CA) or Gotu cola is an herbal plant from the Apiaceae family with a long history of usage in different traditional medicines. It has long been used for the treatment of various ailments such as central nervous system (CNS), skin and gastrointestinal disorders especially in the Southeast Asia. This chapter focused on the phytochemical constituent and pharmacological activities of CA based on preclinical and clinical studies. Read More

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Ethnobotanical Uses, Phytochemistry and Pharmacology of Different Rheum Species (Polygonaceae): A Review.

Adv Exp Med Biol 2021 ;1308:309-352

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Today, there is an increased tendency to use herbal remedies. Rhubarb refers to several species of the genus Rheum L. in the Polygonaceae family. Read More

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Potato Consumption and Risk of Site-Specific Cancers in Adults: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies.

Adv Nutr 2021 Apr 16. Epub 2021 Apr 16.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

The etiology of cancer type may vary significantly due to anatomy, embryology, and physiology of the cancer site. Although the association between potato consumption and colorectal cancer (CRC) was summarized in a 2018 meta-analysis of 5 cohort studies, to the best of our knowledge, no meta-analysis has evaluated potato consumption in relation to multiple cancer sites in adults. Medline/PubMed, ISI Web of Knowledge, Scopus, and the Cochrane Database of Systematic Reviews were searched for relevant publications through August 2020. Read More

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Relationship between gestational diabetes and serum trace element levels in pregnant women from Eastern Iran: a multivariate approach.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.

The prevalence of gestational diabetes mellitus (GDM) has increased over the recent decades. Exposure to environmental contaminants may be a risk factor for the development of GDM, but this is heavily dependent on particular circumstances. Studies on various areas linking various factors are therefore needed. Read More

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Novel Treatment for Congenital Disorder of Glycosylation in a Patient with Novel Homozygote Mutation of PMM2: A Case Report and Review Literature.

Endocr Metab Immune Disord Drug Targets 2021 Apr 14. Epub 2021 Apr 14.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran. Iran.

Background: In Congenital Disorder of Glycosylation (CDG) type Ia, homozygous mutations of the PMM2 gene cause phosphomannomutase 2 dysfunction.

Case Presentation: Herein, a 10-month-old girl is presented with severe hypotonia along with inappropriately normal mental status and normal facies. High 2-ketoglutaric acid was detected in her urine; therefore the diagnosis of 2-Ketoglutarate dehydrogenase complex (KDHC) deficiency was made for this patient. Read More

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Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus: A randomized controlled trial.

Phytother Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Internal Medicine, Imam-Hossein General Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Inflammation and oxidative stress is a risk factor for the development of long-term consequences in patients with type 2 diabetes mellitus (T2DM). This study was designed to investigate the effects of crocin consumption on oxidative stress and inflammatory markers in patients with T2DM. In this clinical trial with a parallel-group design, 50 patients with T2DM were randomly assigned to either the crocin or the placebo group. Read More

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Association of common genetic variants of gene with the risk of type 2 diabetes mellitus.

Nucleosides Nucleotides Nucleic Acids 2021 Apr 14:1-11. Epub 2021 Apr 14.

Medical Genomics Research Center, Islamic Azad Tehran Medical Sciences University, Tehran, Iran.

Type 2 diabetes mellitus (T2DM) is a multifactorial polygenic disease. Potassium inwardly-rectifying channel, subfamily J, member 11 ( gene mutations can result in susceptibility of T2DM. The aim of this study is to investigate the relationship between risk of T2DM and its complications (retinopathy & renal) and polymorphisms rs5210 and rs5215 of the gene in a group of Iranian population. Read More

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Dalteparin as a Novel Therapeutic Agent to Prevent Diabetic Encephalopathy by Targeting Oxidative Stress and Inflammation.

Basic Clin Neurosci 2020 Nov-Dec;11(6):795-804. Epub 2020 Nov 1.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Hepcidin is the main modulator of systemic iron metabolism, and its role in the brain has been clarified recently. Studies have shown that hepcidin plays an important role in neuronal iron load and inflammation. This issue is of significance because neuronal iron load and inflammation are pathophysiological processes that are highly linked to neurodegeneration. Read More

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November 2020

Diabetic Encephalopathy Affecting Mitochondria and Axonal Transport Proteins.

Basic Clin Neurosci 2020 Nov-Dec;11(6):781-793. Epub 2020 Nov 1.

Departmentof Physiology, Neurophysiology Research Center, Shahed University, Tehran, Iran.

Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments associated with hippocampal degenerative changes, including the neurodegenerative process and decreased number of living cells. Mitochondrial diabetes (MD) appears following activation of mutant mitochondrial DNA and is a combination of diabetes and cognitive deficit. In this research, we showed the correlation of diabetic encephalopathy, dysfunctional mitochondria, and changes in the expression of axonal transport proteins (KIF5b, Dynein). Read More

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November 2020

High glucose promotes the aging of human dental pulp cells through Wnt/beta-catenin signaling.

Dent Med Probl 2021 Jan-Mar;58(1):39-46

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Iran.

Background: Diabetes is one of the most common metabolic diseases that disrupt the functioning of different body organs, including oral tissue. Some diabetic complications remain even after the control of the hyperglycemic condition. The adverse effect of hyperglycemia on the pulp structure and function has been shown previously. Read More

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Effect of Diabetes on Rotary Instrumentation of Dentin.

J Endod 2021 Apr 9. Epub 2021 Apr 9.

Associate Professor and Chairman, Department of Endodontics, Rutgers School of Dental Medicine, Newark, NJ.

Introduction: Diabetes Mellitus (DM) may affect the physical and mechanical properties of dentin, which could potentially have an impact on root canal procedures. This study aimed to compare the amount of dentin removed by an endodontic rotary file, comparing dentin from diabetic patients to dentin from control patients under laboratory conditions.

Methods: The amount of dentin removed was tested using new F2 ProTaper files applied against the surface of prepared dentin disks for three different groups; diabetic type I (D1), diabetic type II (D2), and non-diabetic (Normal). Read More

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Centrality Analysis of Protein-Protein Interaction Networks and Molecular Docking Prioritize Potential Drug-Targets in Type 1 Diabetes.

Iran J Pharm Res 2020 ;19(4):121-134

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Type 1 diabetes (T1D) occurs as a consequence of an autoimmune attack against pancreatic β- cells. Due to a lack of a clear understanding of the T1D pathogenesis, the identification of effective therapies for T1D is the active area in the research. The study purpose was to prioritize potential drugs and targets in T1D via systems biology approach. Read More

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January 2020

The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2021 26;12:640004. Epub 2021 Mar 26.

Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.

Objectives: It is uncertain whether the treatment of mild gestational diabetes mellitus (GDM) improves pregnancy outcomes. The aim of this systemic review and meta-analysis was to investigate the effect of mild GDM treatment on adverse pregnancy outcomes.

Methods: A comprehensive literature search was conducted on the databases of PubMed, Scopus, and Google Scholar to retrieve studies that compared interventions for the treatment of mild GDM with usual antenatal care. Read More

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Design and Development of a Mobile-Based Self-Care Application for Patients with Type 2 Diabetes.

J Diabetes Sci Technol 2021 Apr 10:19322968211007124. Epub 2021 Apr 10.

Department of Electrical and Computer Engineering, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Mobile-based applications play a leading role in changes in life-style, improve medication adherence, and provide a unique opportunity to aid patients with type 2 diabetes mellitus (T2DM) elevate their healthcare level. Therefore, we aim to design and develop a mobile-based self-care application for patients with T2DM.

Methods: The present study was an applied and developmental study to design and develop a mobile-based self-care application for people living with T2DM conducted in 2020. Read More

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Comparison of the one-year outcomes of bariatric surgery in adolescents and young adults: a matched case-control study, Tehran Obesity Treatment Study (TOTS).

Surg Today 2021 Apr 10. Epub 2021 Apr 10.

Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purposes: The increasing use of bariatric surgery in adolescents has raised some concerns regarding the postoperative outcomes and the optimal time of surgery at young ages. However, no study has yet compared the weight loss and comorbidity resolution following bariatric surgery between adolescents and young adults.

Methods: This study was conducted on a case group of adolescents (aged 11-18) and a control group of young adults (aged 19-29) undergoing bariatric surgery (sleeve gastrectomy or gastric bypass). Read More

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Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives as potential α-glucosidase inhibitors.

Bioorg Chem 2021 Mar 29;111:104869. Epub 2021 Mar 29.

Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

In this work, a novel series of hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives were designed, synthesized, and evaluated for their anti-α-glucosidase activity due to an urgent need to develop effective anti-diabetic agents. Among tested 15 compounds, 8 derivatives (9a, 9b, 9c, 9d, 9e, 9f, 9h, and 9o) demonstrated superior potency compared to that of positive control, acarbose. Particularly, compound 9d possessed the best anti-α-glucosidase activity with around a 46-fold improvement in the inhibitory activity. Read More

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Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial.

Nutr J 2021 Apr 10;20(1):35. Epub 2021 Apr 10.

Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Non-alcoholic fatty liver disease (NAFLD) is much more frequent and more severe, including cirrhosis, hepatocellular carcinoma in patients with type 2 diabetes. Coffee is a complex beverage with hundreds of compounds whereas caffeine and chlorogenic acid are the most abundant bioactive compounds. The published epidemiological data demonstrating beneficial associations between all categories of coffee exposure and ranges of liver outcomes are rapidly growing; however, the main contributors and cause-effect relationships have not yet been elucidated. Read More

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IgG4-related hypophysitis.

Endocrine 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurological Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Hypophysitis is a rare pituitary inflammatory disorder classified in different ways. Immunoglobulin G4-related disease (IgG4-RD), also a rare disease is a systemic fibro-inflammatory condition characterized by infiltration of tissue with IgG4-positive plasma cells; however prevalence of both of them probably is underestimated. In this paper, we present an Iranian patient with biopsy-proven IgG4-related hypophysitis and then review the clinical characteristics, laboratory, imaging, pathologic findings and therapeutic management as well as prognosis of 115 published cases of hypophysitis secondary to IgG4-related disease. Read More

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Potential Alteration of Statin-Related Pharmacological Features in Diabetes Mellitus.

Biomed Res Int 2021 26;2021:6698743. Epub 2021 Mar 26.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Type 2 diabetes mellitus is a chronic metabolic disease caused by insulin resistance or insulin deficiency resulting in elevated blood glucose levels. Poorly controlled diabetes is associated with the development of cardiovascular disease and dyslipidemia. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statin) are an important class of therapeutic agents used to control hyperlipidemia and prevent cardiovascular disease in diabetic and nondiabetic patients. Read More

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Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder.

Genet Med 2021 Apr 6. Epub 2021 Apr 6.

Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.

Purpose: To elucidate the novel molecular cause in families with a new autosomal recessive neurodevelopmental disorder.

Methods: A combination of exome sequencing and gene matching tools was used to identify pathogenic variants in 17 individuals. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) and subcellular localization studies were used to characterize gene expression profile and localization. Read More

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Designing a Logistic Regression Model for a Dataset to Predict Diabetic Foot Ulcer in Diabetic Patients: High-Density Lipoprotein (HDL) Cholesterol Was the Negative Predictor.

J Diabetes Res 2021 16;2021:5521493. Epub 2021 Mar 16.

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Objectives: Although the risk factors for diabetic neuropathy and diabetic foot ulcer have been detected, there was no practical modeling for their prediction. We aimed to design a logistic regression model on an Iranian dataset to predict the probability of experiencing diabetic foot ulcers up to a considered age in diabetic patients.

Methods: The present study was a statistical modeling on a previously published dataset. Read More

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A systematized review on diabetes gamification.

Med J Islam Repub Iran 2020 14;34:168. Epub 2020 Dec 14.

Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Gamification is an effective tool used to enhance the quality of education and training, to create motivation and enthusiasm, and to maintain competitiveness in the targeted population. Given that, the present study is an attempt to review gamification used in the field of diabetes systematically and its effects on the target group. Articles were retrieved from eight databases via an electronic advanced search. Read More

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December 2020

Dyslipidemia and Its Components Across Body Mass Index Levels Among Type II Diabetic Patients in the West of Iran.

Int J Prev Med 2020 11;11:188. Epub 2020 Dec 11.

Department of Epidemiology, Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The combination of dyslipidemia, obesity, and hyperglycemia can accelerate the progression to cardiovascular disease. Therefore, this study aimed to investigate dyslipidemia and its components across body mass index (BMI) levels among type II diabetic patients.

Methods: The data for this cross-sectional study were extracted from the records of diabetic patients during 2014 to 2015. Read More

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December 2020