47,587 results match your criteria technology variety

Enriching activities during childhood are associated with variations in functional connectivity patterns later in life.

Neurobiol Aging 2021 Apr 20;104:92-101. Epub 2021 Apr 20.

Department of Psychology, Northeastern University, Boston, MA, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Champaign, IL, USA.

Enriching early life experiences (e.g., sport, art, music, volunteering, language learning) during a critical period of brain development may promote structural and functional brain changes that are still present decades later (>60 years). Read More

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Neuronal circuits on a chip for biological network monitoring.

Biotechnol J 2021 May 13:e2000355. Epub 2021 May 13.

Group of Optics, Photonics and Biophotonics (GOFB), Center for Biomedical Technology, Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcón, Madrid, Spain.

Cultured neuronal networks (CNNs) are a robust model to closely investigate neuronal circuits' formation and monitor their structural properties evolution. Typically, neurons are cultured in plastic plates or, more recently, in microfluidic platforms with potentially a wide variety of neuroscience applications. As a biological protocol, cell culture integration with a microfluidic system provides benefits such as accurate control of cell seeding area, culture medium renewal, or lower exposure to contamination. Read More

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Golden Vaterite as a Mesoscopic Metamaterial for Biophotonic Applications.

Adv Mater 2021 May 13:e2008484. Epub 2021 May 13.

Department of Electrical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.

Mesoscopic photonic systems with tailored optical responses have great potential to open new frontiers in implantable biomedical devices. However, biocompatibility is typically a problem, as engineering of optical properties often calls for using toxic compounds and chemicals, unsuitable for in vivo applications. Here, a unique approach to biofriendly delivery of optical resonances is demonstrated. Read More

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Presenteeism Among Nurses in Switzerland and Portugal and Its Impact on Patient Safety and Quality of Care: Protocol for a Qualitative Study.

JMIR Res Protoc 2021 May 13;10(5):e27963. Epub 2021 May 13.

School of Health Sciences, Polytechnic of Leiria, Leiria, Portugal.

Background: Nurses dispense direct care in a wide variety of settings and are considered the backbone of the health care system. They often work long hours, face emotional stress, and are at a high risk of psychosocial and somatic illnesses. Nurses sometimes fall sick but work regardless, leading to presenteeism and subsequent risks to quality of care and patient safety due to the increased likelihood of patients falling, medication errors, and staff-to-patient disease transmission. Read More

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Polymer-Laminated TiCT MXene Electrodes for Transparent and Flexible Field-Driven Electronics.

ACS Nano 2021 May 13. Epub 2021 May 13.

Department of Materials Science and Engineering, Yonsei University, Yonsei-ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.

MXenes (TiCT) are two-dimensional transition-metal carbides and carbonitrides with high conductivity and optical transparency. However, transparent MXene electrodes with high environmental stability suitable for various flexible organic electronic devices have rarely been demonstrated. By laminating a thin polymer film onto a solution-processed MXene layer to protect the MXene film from harsh environmental conditions, we present transparent and flexible MXene electronic devices. Read More

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[Criticalquality attribute assessment of big brand traditional Chinese medicine: visualization method for quality control of Ginkgo Leaves Tablets based on spatial distribution uniformity].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1616-1621

School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Engineering Research Center of Chinese Medicine Production and New Drug Development, Ministry of Education Beijing 102488, China.

Spatial distribution uniformity is the critical quality attribute(CQA) of Ginkgo Leaves Tablets, a variety of big brand traditional Chinese medicine. The evaluation of the spatial distribution uniformity of active pharmaceutical ingredients(APIs) in Ginkgo Leaves Tablets is important in ensuring their stable and controllable quality. In this study, hyperspectral imaging technology was used to construct the spatial distribution map of API concentration based on three prediction models, further to realize the visualization research on the spatial distribution uniformity of Ginkgo Leaves Tablets. Read More

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Hemifacial Spasm as the Presenting Manifestation of Type 3c Diabetes Mellitus.

Tremor Other Hyperkinet Mov (N Y) 2021 Apr 26;11:14. Epub 2021 Apr 26.

Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.

Background: Type 3c diabetes mellitus (T3cDM) usually occurs because of a variety of exocrine pancreatic diseases with varying mechanisms, which eventually lead to secondary pancreatic endocrine insufficiency i.e. hyperglycemia. Read More

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Optimum chalcone synthase for flavonoid biosynthesis in microorganisms.

Crit Rev Biotechnol 2021 May 12:1-15. Epub 2021 May 12.

National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, China.

Chalcones and the subsequently generated flavonoids, as well as flavonoid derivatives, have been proven to have a variety of physiological activities and are widely used in: the pharmaceutical, food, feed, and cosmetic industries. As the content of chalcones and downstream products in native plants is low, the production of these compounds by microorganisms has gained the attention of many researchers and has a history of more than 20 years. The mining and engineering of chalcone synthase (CHS) could be one of the most important ways to achieve more efficient production of chalcones and downstream products in microorganisms. Read More

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[Risk assessment and management of hepatocellular carcinoma occurrence in patients with chronic hepatitis B in the era of antiviral therapy].

H G Xin Q Xie

Zhonghua Gan Zang Bing Za Zhi 2021 Apr;29(4):297-300

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Chronic hepatitis B (CHB) virus infection remains the leading cause of hepatocellular carcinoma (HCC) in China. Oral antiviral drugs have been shown to significantly reduce the HCC risk in CHB patients, but it cannot completely eliminate the HCC occurrence. Therefore, accurate HCC risk assessment and standardized screening in CHB patients are essential for early diagnosis and improved prognosis. Read More

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Ultrasound deep beamforming using a multiconstrained hybrid generative adversarial network.

Med Image Anal 2021 Apr 28;71:102086. Epub 2021 Apr 28.

Fudan University, Department of Electronic Engineering, Shanghai 200433, China; Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai 200032, China. Electronic address:

Ultrasound beamforming is a principal factor in high-quality ultrasound imaging. The conventional delay-and-sum (DAS) beamformer generates images with high computational speed but low spatial resolution; thus, many adaptive beamforming methods have been introduced to improve image qualities. However, these adaptive beamforming methods suffer from high computational complexity, which limits their practical applications. Read More

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Chicken C/EBPζ gene: Expression profiles, association analysis, and identification of functional variants for abdominal fat.

Domest Anim Endocrinol 2021 Apr 15;76:106631. Epub 2021 Apr 15.

Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address:

CCAAT enhancer binding protein ζ (C/EBPζ) plays an important role in adipose proliferation and differentiation in humans. However, very little is known about the effect of C/EBPζ on the growth and development of adipose tissues in domesticated animals. The present study attempted to investigate the mRNA expression profiles of chicken C/EBPζ in a variety of tissues; analyze the association of its variants with abdominal fat; and identify the functional variants for abdominal fat. Read More

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Reactivity of mono- and divalent aluminium compounds towards group 15 nanoparticles.

Chem Commun (Camb) 2021 May 12. Epub 2021 May 12.

Institute of Inorganic Chemistry, Karlsruhe Institute of Technology (KIT), Engesserstraße 15, Karlsruhe D-76131, Germany.

Herein, we present a novel approach towards organometallic group 13/15-compounds, i.e. the reaction of nanoparticular arsenic and antimony with low-valent aluminium species. Read More

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Neural network hyperparameter optimization for prediction of real estate prices in Helsinki.

PeerJ Comput Sci 2021 19;7:e444. Epub 2021 Apr 19.

Department of Applied Informatics, Vytautas Magnus University, Kaunas, Lithuania.

Accurate price evaluation of real estate is beneficial for many parties involved in real estate business such as real estate companies, property owners, investors, banks, and financial institutes. Artificial Neural Networks (ANNs) have shown promising results in real estate price evaluation. However, the performance of ANNs greatly depends upon the settings of their hyperparameters. Read More

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Molecular evolution and SSRs analysis based on the chloroplast genome of .

Ecol Evol 2021 May 20;11(9):4786-4802. Epub 2021 Mar 20.

College of Life Sciences South China Agricultural University Guangzhou China.

Chloroplast genome sequences have been used to understand evolutionary events and to infer efficiently phylogenetic relationships. (Cupressaceae) is an endemic species in China. Its phylogenetic position is controversial due to morphological characters similar to those of , and . Read More

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Comparison of sample types from white-tailed deer (Odocoileus virginianus) for DNA extraction and analyses.

Sci Rep 2021 May 11;11(1):10003. Epub 2021 May 11.

U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, The Pennsylvania State University, 403 Forest Resources Building, University Park, PA, 16802, USA.

Collection of biological samples for DNA is necessary in a variety of disciplines including disease epidemiology, landscape genetics, and forensics. Quantity and quality of DNA varies depending on the method of collection or media available for collection (e.g. Read More

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First comprehensive quantification of annual land use/cover from 1990 to 2020 across mainland Vietnam.

Sci Rep 2021 May 11;11(1):9979. Epub 2021 May 11.

Faculty of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, 305-8572, Japan.

Extensive studies have highlighted a need for frequently consistent land cover information for interdisciplinary studies. This paper proposes a comprehensive framework for the automatic production of the first Vietnam-wide annual land use/land cover (LULC) data sets (VLUCDs) from 1990 to 2020, using available remotely sensed and inventory data. Classification accuracies ranged from 85. Read More

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Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase.

Sci Rep 2021 May 11;11(1):9944. Epub 2021 May 11.

National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo, Japan.

Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the development of improved drugs in the future. In previous work, we established methodology designated 'module editing' to precisely manipulate polyketide synthase genes cloned in a bacterial artificial chromosome. Read More

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Neural network aided approximation and parameter inference of non-Markovian models of gene expression.

Nat Commun 2021 May 11;12(1):2618. Epub 2021 May 11.

School of Biological Sciences, The University of Edinburgh, Edinburgh, Scotland, UK.

Non-Markovian models of stochastic biochemical kinetics often incorporate explicit time delays to effectively model large numbers of intermediate biochemical processes. Analysis and simulation of these models, as well as the inference of their parameters from data, are fraught with difficulties because the dynamics depends on the system's history. Here we use an artificial neural network to approximate the time-dependent distributions of non-Markovian models by the solutions of much simpler time-inhomogeneous Markovian models; the approximation does not increase the dimensionality of the model and simultaneously leads to inference of the kinetic parameters. Read More

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Can J Cardiol 2021 May 8. Epub 2021 May 8.

Division of Cardiology, Department of Internal Medicine, Città della Salute e della Scienza, Torino.

Background: The placebo effect is a well described phenomenon in blinded studies evaluating anti-anginal therapeutics, although its impact on clinical research metrics remains unknown. We conducted a systematic review and meta-analysis to quantify the impact of placebo on endpoints of symptoms, life-quality and functional outcomes in randomized placebo-controlled trials (RCTs) of symptomatic stable coronary artery disease.

Methods: We systematically reviewed MEDLINE, EMBASE, and the Cochrane database for double-blind RCTs of anti-angina therapeutics. Read More

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Analytical Technologies for Liquid Biopsy of Subcellular Materials.

Annu Rev Anal Chem (Palo Alto Calif) 2021 May 11. Epub 2021 May 11.

Bioengineering Program, University of Kansas, Lawrence, Kansas 66045, USA; email:

Liquid biopsy markers, which can be secured from a simple blood draw or other biological samples, are used to manage a variety of diseases and even monitor for bacterial or viral infections. Although there are several different types of liquid biopsy markers, the subcellular ones, including cell-free DNA, microRNA, extracellular vesicles, and viral particles, are evolving in terms of their utility. A challenge with liquid biopsy markers is that they must be enriched from the biological sample prior to analysis because they are a vast minority in a mixed population, and potential interferences may be present in the sample matrix that can inhibit profiling the molecular cargo from the subcellular marker. Read More

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Color-complexity enabled exhaustive color-dots identification and spatial patterns testing in images.

PLoS One 2021 11;16(5):e0251258. Epub 2021 May 11.

Department of Statistics, University of California at Davis, Davis, CA, United States of America.

Our computational developments and analyses on experimental images are designed to evaluate the effectiveness of chemical spraying via unmanned aerial vehicle (UAV). Our evaluations are in accord with the two perspectives of color-complexity: color variety within a color system and color distributional geometry on an image. First, by working within RGB and HSV color systems, we develop a new color-identification algorithm relying on highly associative relations among three color-coordinates to lead us to exhaustively identify all targeted color-pixels. Read More

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Incorporating Medical Students into Primary Care Telehealth Visits: A Tutorial.

JMIR Med Educ 2021 Apr 17. Epub 2021 Apr 17.

Johns Hopkins University School of Medicine, 1600 McElderry, Baltimore, US.

Background: The COVID-19 pandemic has brought about sweeping change in healthcare delivery, shifting from in-person consultation to a virtual format. Few medical schools provide virtual medicine or telemedicine training to their learners, though this is likely to be important for future medical practice.

Objective: This report communicates a framework to incorporate medical students into primary care telemedicine clinics. Read More

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Three-Dimensional Micropatterning Deters Early Bacterial Adherence and Can Eliminate Colonization.

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria 3800, Australia.

Developing strategies to prevent bacterial infections that do not rely on the use of drugs is regarded globally as an important means to stem the tide of antimicrobial resistance, as argued by the World Health Organization (WHO) (Mendelson, M.; Matsoso, M. P. Read More

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Microparticles enhance the formation of seven major classes of natural products in native and metabolically engineered actinobacteria through accelerated morphological development.

Biotechnol Bioeng 2021 May 11. Epub 2021 May 11.

Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.

Actinobacteria provide a rich spectrum of bioactive natural products and therefore display an invaluable source towards commercially valuable pharmaceuticals and agrochemicals. Here, we studied the use of inorganic talc microparticles (hydrous magnesium silicate, 3MgO·4SiO2·H2O, 10 µm) as a general supplement to enhance natural product formation in this important class of bacteria. Added to cultures of recombinant Streptomyces lividans, talc enhanced production of the macrocyclic peptide antibiotic bottromycin A2 and its methylated derivative Met-bottromycin A2 up to 109 mg L , the highest titer reported so far. Read More

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Resurrection of Ancestral Malate Dehydrogenases Reveals the Evolutionary History of Halobacterial Proteins : Deciphering Gene Trajectories and Changes in Biochemical Properties.

Mol Biol Evol 2021 May 11. Epub 2021 May 11.

Univ Grenoble Alpes, CNRS, CEA, IBS, Grenoble, F-38000, France.

Extreme halophilic Archaea thrive in high salt, where, through proteomic adaptation, they cope with the strong osmolarity and extreme ionic conditions of their environment. In spite of wide fundamental interest, however, studies providing insights into this adaptation are scarce, because of practical difficulties inherent to the purification and characterization of halophilic enzymes. In this work, we describe the evolutionary history of malate dehydrogenases (MalDH) within Halobacteria (a class of the Euryarchaeota phylum). Read More

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Lateral flow device for water fecal pollution assessment: from troubleshooting of its microfluidics using bioluminescence to colorimetric monitoring of generic .

Lab Chip 2021 May 11. Epub 2021 May 11.

Nanobioelectronics & Biosensors Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Spain. and ICREA, Institució Catalana de Recerca i Estudis Avançats, Pg. Lluís Companys, 23, 08010, Barcelona, Spain.

Water is the most important ingredient of life. Water fecal pollution threatens water quality worldwide and has direct detrimental effects on human health and the global economy. Nowadays, assessment of water fecal pollution relies on time-consuming techniques that often require well-trained personnel and highly-equipped laboratories. Read More

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Aortic Dissection with Rare Anatomical Aortic Arch Variation Depicted by Computed Tomography Angiography.

Heart Surg Forum 2021 Apr 27;24(2):E407-E408. Epub 2021 Apr 27.

Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.

Aortic dissection (AD) is a life-threatening disease, and endovascular repair by stent graft is an effective treatment. Surgery often fails for a variety of reasons, such as aortic arch variation. We present the case of a 27-year-old female with aortic dissection with a rare anatomical aortic arch variation caused by chest trauma. Read More

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Translating Data Analytics Into Improved Spine Surgery Outcomes: A Roadmap for Biomedical Informatics Research in 2021.

Global Spine J 2021 May 11:21925682211008424. Epub 2021 May 11.

Department of Neurological Surgery, 12275Washington University School of Medicine, St. Louis, MO, USA.

Study Design: Narrative review.

Objectives: There is growing interest in the use of biomedical informatics and data analytics tools in spine surgery. Yet despite the rapid growth in research on these topics, few analytic tools have been implemented in routine spine practice. Read More

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The Accumulation of Lutein and β-Carotene and Transcript Profiling of Genes Related to Carotenoids Biosynthesis in Yellow Celery.

Mol Biotechnol 2021 May 10. Epub 2021 May 10.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Ministry of Agriculture and Rural Affairs Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East China, College of Horticulture, Nanjing Agricultural University, 1 Weigang, Nanjing, 210095, China.

Carotenoids are the general term of natural pigments. The formation of plant color is probably related to the components of carotenoids. As the yellow variety of celery, it is rich in the composition and content of carotenoids. Read More

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MdBZR1 regulates ABA response by modulating the expression of MdABI5 in apple.

Plant Cell Rep 2021 May 10. Epub 2021 May 10.

State Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An, 271018, Shandong, China.

Key Message: MdBZR1 directly binds to the promoter of MdABI5 and suppresses its expression to mediate ABA response. The plant hormones brassinosteroids (BRs) and abscisic acid (ABA) antagonistically regulate various aspects of plant growth and development. However, the association between BR and ABA signaling is less clear. Read More

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