202,620 results match your criteria technology applied

Combining "Grafting to" and "Grafting from" to synthesize comb-like NCC-g-PLA as a macromolecular modifying agent of PLA.

Nanotechnology 2021 Jun 15. Epub 2021 Jun 15.

Sichuan University, Chengdu, Chengdu, Sichuan, 610065, CHINA.

The surface modification of nano particles is very important in nanotechnology. Grafting from (GF) and grafting to (GT) are two main methods to prepare surface modified nanoparticles like nanocellulose crystalline (NCC) grafted with polylactic acid (PLA) chains. In the GF method, the NCC can get high grafting degree but short side chains to improve its compatibility with the polymer matrix. Read More

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Design study of a PET detector with 0.5 mm crystal pitch for high-resolution preclinical imaging.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Biomedical Engineering , Shenzhen Bay Laboratory, Shenzhen, CHINA.

Preclinical positron emission tomography (PET) is a sensitive and quantitative molecule imaging modality widely used in characterizing the biological processes and diseases in small animals. The purpose of this study is to investigate the methods to optimize a PET detector for high-resolution preclinical imaging. The PET detector proposed in this study consists of a 28×28 array of LYSO crystals 0. Read More

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Surrogate Endpoints in Oncology: Overview of Systematic Reviews and Their Use for Health Decision Making in Mexico.

Value Health Reg Issues 2021 Jun 12;26:75-88. Epub 2021 Jun 12.

CENETEC (National Center for Health Technology Excellence), Mexico City, Mexico.

Objectives: The use of surrogate endpoints (SEs) for cancer drug approval in health systems is common. The objectives of this study were to identify systematic reviews (SRs) that evaluated the correlation of SEs with overall survival (OS) in cancer drugs to analyze the applications of approved cancer drugs with SEs in Mexico and to apply the validation framework proposed by the Institute for Quality and Efficiency in Health Care (IQWiG).

Methods: An overview of SRs was conducted according to Cochrane Collaboration methodology. Read More

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Study on the influence of advanced treatment processes on the surface properties of polylactic acid for a bio-based circular economy for plastics.

Ultrason Sonochem 2021 Jun 10;76:105627. Epub 2021 Jun 10.

Clausthal Centre for Materials Technology (CZM), Clausthal University of Technology, Leibnizstr. 9, 38678 Clausthal-Zellerfeld, Germany; School of Chemical Engineering, National Technical University of Athens, 9 Heroon Polytechneiou St., Zografou Campus, 15780 Athens, Greece. Electronic address:

New biotechnological processes using microorganisms and/or enzymes to convert carbonaceous resources, either biomass or depolymerized plastics into a broad range of different bioproducts are recognized for their high potential for reduced energy consumption and reduced GHG emissions. However, the hydrophobicity, high molecular weight, chemical and structural composition of most of them hinders their biodegradation. A solution to reduce the impact of non-biodegradable polymers spread in the environment would be to make them biodegradable. Read More

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Effect of hyperspectral image-based initial conditions on improving short-term algal simulation of hydrodynamic and water quality models.

J Environ Manage 2021 Jun 12;294:112988. Epub 2021 Jun 12.

School of Civil and Environmental Engineering, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Hydrodynamic and water quality modeling have provided valuable simulation results that have enhanced the understanding of the spatial and temporal distribution of algal blooms. Typical model simulations are performed with point-based observational data that are used to configure initial and boundary conditions, and for parameter calibration. However, the application of such conventional modeling approaches is limited due to cost, labor, and time constraints that preclude the retrieval of high-resolution spatial data. Read More

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Facilitating the use of personal safety alerting device with older adults: The views, experiences and roles of relatives and health care professionals.

Geriatr Nurs 2021 Jun 11;42(4):935-942. Epub 2021 Jun 11.

School CAPHRI, Department of Health Services Research, Maastricht University, Maastricht, The Netherlands; School CAPHRI, Department of Family Medicine, Maastricht University, Maastricht, The Netherlands. Electronic address:

To explore relatives', community nurses' and general practitioners' perspectives and experiences in promoting Personal Safety Alerting Device (PSAD) use among community-dwelling older adults, we applied a qualitative study design. Altogether 15 focus groups and 11 semi-structured interviews were conducted. Data-analysis followed the Qualitative Analysis Guide of Leuven. Read More

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Techno-economic study for a gasification plant processing residues of sewage sludge and solid recovered fuels.

Waste Manag 2021 Jun 12;131:148-162. Epub 2021 Jun 12.

VALORIZA - Research Centre for Endogenous Resource Valorization, Polytechnic Institute of Portalegre, 7300-555 Portalegre, Portugal. Electronic address:

The energetic valorisation of wastes through gasification is a promising solution with a better environmental impact in terms of pollutant emissions compared with incineration, landfilling, and heat and power generation from fossil fuels. However, techno-economic studies are imperative to define the viability of these technologies and to optimise heat and power consumptions and costs. This work intended to develop a techno-economic analysis for a small-scale gasification plant processing mixtures of solid recovered fuels and sewage sludge, assuming a capacity of 883 kg/h and two different sale scenarios: (A) production of electric energy, and (B) production of hydrogen. Read More

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Trimethylacetic anhydride-based derivatization facilitates quantification of histone marks at the MS1 level.

Mol Cell Proteomics 2021 Jun 12:100114. Epub 2021 Jun 12.

Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic; Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. Electronic address:

Histone post-translational modifications (hPTMs) are epigenetic marks that strongly affect numerous processes, including cell cycling and protein interactions. They have been studied by both antibody- and mass spectrometry-based methods for years, but the analyses are still challenging, mainly due to the diversity of histones and their modifications arising from high contents of reactive amine groups in their amino acid sequences. Here, we introduce use of trimethylacetic anhydride (TMA) as a new reagent for efficient histone derivatization, which is a requirement for bottom-up proteomic hPTM analysis. Read More

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Developing a simple box-behnken experimental design on the removal of doxorubicin anticancer drug using FeO/graphene nanoribbons adsorbent.

Environ Res 2021 Jun 12;200:111522. Epub 2021 Jun 12.

Department of Chemical Sciences (formerly Department of Applied Chemistry), University of Johannesburg, P.O. Box 17011, Doornfontein Campus, Johannesburg, 2028, South Africa.

This paper aims to develop a Box-Behnken experimental design system to optimize the removal process of doxorubicin anticancer drugs. For this goal, FeO/graphene nanoribbons was selected as adsorbent and removal of doxorubicin anticancer drug optimized using Box-Behnken experimental design with a selection of four effective factors. A three-level, four-factor Box-Behnken experimental design was used to assess the relationship between removal percentage as a dependent variable with adsorption weight (0. Read More

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Highly Sensitive, Flexible, Stable, and Hydrophobic Biofoam Based on Wheat Flour for Multifunctional Sensor and Adjustable EMI Shielding Applications.

ACS Appl Mater Interfaces 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510641, China.

Biofoam materials are attractive alternatives for petroleum-based foams to be used to solve environmental problems. Inspired by steamed bread, we report herein a novel utilization of wheat flour (WF) with the introduction of carbon nanotubes (CNTs) to form an environmentally friendly WF/CNT composite foam. This foam displayed a high elasticity (nearly 100% shape recovery), recyclable (5000 cycles), fast (100 ms), and superstability pressure-sensing response. Read More

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Ether-functionalized Pyrrolidinium-based Room Temperature Ionic Liquids: Physicochemical Properties, Molecular Dynamics, and the Li ion Coordination Environment.

Chemphyschem 2021 Jun 15. Epub 2021 Jun 15.

Keio University: Keio Gijuku Daigaku, Applied Chemistry, JAPAN.

The physicochemical properties of room temperature ionic liquids (RTILs) consisting of bis(trifluoromethanesulfonyl)amide (TFSA - ) combined with 1-hexyl-1-methylpyrrolidinium (Pyr 1,6 + ), 1-(butoxymethyl)-1-methylpyrrolidinium (Pyr 1,1O4 + ), 1-(4-methoxybutyl)-1-methyl pyrrolidinium (Pyr 1,4O1 + ), and 1-((2-methoxyethoxy)methyl)-1-methylpyrrolidinium (Pyr 1,1O2O1 + ) were investigated using both experimental and computational approaches. Pyr 1,1O2O1 TFSA, which contains two ether oxygen atoms, showed the lowest viscosity, and the relationship between its physicochemical properties and the position and number of the ether oxygen atoms was discussed by a careful comparison with Pyr 1,1O4 TFSA and Pyr 1,4O1 TFSA. Ab initio calculations revealed the conformational flexibility of the side chain containing the ether oxygen atoms. Read More

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Long-term ABA promotes GLK1 degradation through COP1 in a light intensity-dependent manner to suppress chloroplast development.

Plant Cell Environ 2021 Jun 15. Epub 2021 Jun 15.

Division of Integrative Biosciences and Biotechnology and 2Department of Life Science, Pohang University of Science and Technology, Pohang, Korea.

Abiotic stress, a serious threat to plants, occurs for extended periods in nature. Abscisic acid (ABA), plays a critical role in abiotic stress responses in plants. Therefore, stress responses mediated by ABA have been studied extensively, especially in short-term responses. Read More

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Rapid and selective detection of macrocyclic trichothecene producing Stachybotrys chartarum strains by loop-mediated isothermal amplification (LAMP).

Anal Bioanal Chem 2021 Jun 15. Epub 2021 Jun 15.

TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354, Freising, Germany.

Cytotoxic macrocyclic trichothecenes such as satratoxins are produced by chemotype S strains of Stachybotrys chartarum. Diseases such as stachybotryotoxicosis in animals and the sick building syndrome as a multifactorial disease complex in humans have been associated with this mold and its toxins. Less toxic non-chemotype S strains of S. Read More

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Effect of Mobile Phone Text Message Reminders on the Completion and Timely Receipt of Routine Childhood Vaccinations: Superiority Randomized Controlled Trial in Northwest Ethiopia.

JMIR Mhealth Uhealth 2021 Jun 15;9(6):e27603. Epub 2021 Jun 15.

Department of Health Informatics, Institute of Public Health, University of Gondar, Gondar, Ethiopia.

Background: Nonattendance at vaccination appointments is a big challenge for health workers as it is difficult to track routine vaccination schedules. In Ethiopia, 3 out of 10 children have incomplete vaccination and the timely receipt of the recommended vaccines is low. Thus, innovative strategies are required to reach the last mile where mobile technology can be effectively utilized to achieve better compliance. Read More

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MyPal: Designing and Evaluating Digital Patient-Reported Outcome Systems for Cancer Palliative Care in Europe.

J Palliat Med 2021 Jul;24(7):962-964

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.

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DNA Extraction and Host Depletion Methods Significantly Impact and Potentially Bias Bacterial Detection in a Biological Fluid.

mSystems 2021 Jun 15:e0061921. Epub 2021 Jun 15.

Department of Food Science, Cornell University, Ithaca, New York, USA.

Untargeted sequencing of nucleic acids present in food can inform the detection of food safety and origin, as well as product tampering and mislabeling issues. The application of such technologies to food analysis may reveal valuable insights that are simply unobtainable by targeted testing, leading to the efforts of applying such technologies in the food industry. However, before these approaches can be applied, it is imperative to verify that the most appropriate methods are used at every step of the process: gathering of primary material, laboratory methods, data analysis, and interpretation. Read More

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Electrochemical Nozaki-Hiyama-Kishi Coupling: Scope, Applications, and Mechanism.

J Am Chem Soc 2021 Jun 15. Epub 2021 Jun 15.

Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

One of the most oft-employed methods for C-C bond formation involving the coupling of vinyl-halides with aldehydes catalyzed by Ni and Cr (Nozaki-Hiyama-Kishi, NHK) has been rendered more practical using an electroreductive manifold. Although early studies pointed to the feasibility of such a process, those precedents were never applied by others due to cumbersome setups and limited scope. Here we show that a carefully optimized electroreductive procedure can enable a more sustainable approach to NHK, even in an asymmetric fashion on highly complex medicinally relevant systems. Read More

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Dopamine-Substituted Multidomain Peptide Hydrogel with Inherent Antimicrobial Activity and Antioxidant Capability for Infected Wound Healing.

ACS Appl Mater Interfaces 2021 Jun 15. Epub 2021 Jun 15.

Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China.

Wound infection can cause a delay in wound healing or even wound deterioration, threatening patients' lives. The excessive accumulation of reactive oxygen species (ROS) in infected wounds activates a strong inflammatory response to delay wound healing. Therefore, it is highly desired to develop hydrogels with inherent antimicrobial activity and antioxidant capability for infected wound healing. Read More

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High-Entropy 2D Carbide MXenes: TiVNbMoC and TiVCrMoC.

ACS Nano 2021 Jun 15. Epub 2021 Jun 15.

Department of Mechanical and Energy Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202, United States.

Two-dimensional (2D) transition metal carbides and nitrides, known as MXenes, are a fast-growing family of 2D materials. MXenes 2D flakes have + 1 ( = 1-4) atomic layers of transition metals interleaved by carbon/nitrogen layers, but to-date remain limited in composition to one or two transition metals. In this study, by implementing four transition metals, we report the synthesis of multi-principal-element high-entropy MCT MXenes. Read More

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Characterization of Compound-Specific Chlorine Isotopologue Distributions of Polychlorinated Organic Compounds by GC-HRMS for Source Identification.

Anal Chem 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Distributions of chlorine isotopologues are potentially a fingerprint feature of organochlorines. However, the exact distributions remain little known. This study measured compound-specific chlorine isotopologue distributions of six polychlorinated organic compounds (POCs) for source identification. Read More

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Negative Magnetoresistance in the GeSn Strip.

ACS Appl Mater Interfaces 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, P. R. China.

Discovery of topological materials associated with an exotic phenomenon has attracted increasing attention in modern condensed matter physics. A typical example is the chiral anomaly proposed in the Dirac or Weyl semimetals. In addition to the well-known topological semimetals, such as TaAs and NaBi, recently, group IV GeSn alloys were also proposed to be Dirac semimetals in theory, demonstrating potential applications compatible with current Si-based technology. Read More

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Graphene-coated nanoporous nickel towards a metal-catalyzed oxygen evolution reaction.

Nanoscale 2021 Jun 15. Epub 2021 Jun 15.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. and WPI Advanced Institute for Materials Research, Tohoku University, Sendai 980-8577, Japan.

Developing highly active electrocatalysts with low costs and long durability for oxygen evolution reactions (OERs) is crucial towards the practical implementations of electrocatalytic water-splitting and rechargeable metal-air batteries. Anodized nanostructured 3d transition metals and alloys with the formation of OER-active oxides/hydroxides are known to have high catalytic activity towards OERs but suffer from poor electrical conductivity and electrochemical stability in harsh oxidation environments. Here we report that high OER activity can be achieved from the metallic state of Ni which is passivated by atomically thick graphene in a three-dimensional nanoporous architecture. Read More

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Unique phage-bacterium interplay in sponge holobionts from the southern Okinawa Trough hydrothermal vent.

Environ Microbiol Rep 2021 Jun 14. Epub 2021 Jun 14.

State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University (Xiang'an), Xiamen, 361102, China.

Deep-sea hydrothermal vents harbour diverse and abundant animals and their symbiotic microorganisms, which together comprise holobionts. The interplay between bacterial members of holobionts and their viruses (phages) is important for maintaining these symbiotic systems; however, phage-bacterium interactions in deep-sea vent holobionts are not well understood. Marine sponges serve as good models for such studies and are used to unveil phage-bacterium interplay via metagenomic analysis. Read More

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Effect of Compounds from Moringa oleifera Lam. on in Vitro Non-Alcoholic Fatty Liver Disease (NAFLD) Model System.

Chem Biodivers 2021 Jun 14. Epub 2021 Jun 14.

Department of Applied Chemistry, College of Science and Technology, Nihon University, 1-5-1 Kandasurugadai, Chiyoda, Tokyo, 101-0062, Japan.

Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in the world, with a prevalence of 25 % in many countries. To date, no drug has been approved to treat NAFLD, therefore, the use of phytochemicals to prevent this disease is meaningful. In this study, we focused on the effects of Moringa oleifera Lam. Read More

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Silver-N-heterocyclic carbene complexes-catalyzed multicomponent reactions: Synthesis, spectroscopic characterization, density functional theory calculations, and antibacterial study.

Arch Pharm (Weinheim) 2021 Jun 15:e2100111. Epub 2021 Jun 15.

Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Tunis, Tunisia.

Nowadays, silver-N-heterocyclic carbene (silver-NHCs) complexes are widely used in medicinal chemistry due to their low toxic nature toward humans. Due to the success of silver-NHCs in medicinal applications, interest in these compounds is rapidly increasing. Therefore, the interaction of N,N-disubstituted benzimidazolium salts with Ag O in dichloromethane to prepare novel Ag(I)-NHCs complexes was carried out at room temperature for 120 h in the absence of light. Read More

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Pharmacokinetics, bioavailability and metabolism of neferine in rat by LC-MS/MS and LC-HRMS.

Biomed Chromatogr 2021 Jun 14:e5193. Epub 2021 Jun 14.

Department of Gerontology & Department of Surgery, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China.

In this study, a simple and sensitive analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of neferine in rat plasma. After acetonitrile-mediated protein precipitation, the samples were separated on an ACQUITY BEH C column (2.1 × 50 mm, 1. Read More

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Quantitation of six steroid hormones in rat plasma and PFC by UPLC-MS/MS: Application to CUMS induced depression rats.

Biomed Chromatogr 2021 Jun 14:e5200. Epub 2021 Jun 14.

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Steroid hormones such as glucocorticoids and its metabolites are closely related to mental diseases and neuroendocrine diseases. Quantitative analysis of these substances will help understanding their roles in related research fields. In this study, an UPLC-MS/MS method was developed to detect the concentration of corticosterone (CORT) and its metabolites, progesterone, and testosterone in rat plasma and prefrontal cortex (PFC), and was applied to investigate the changes in hormones in depression rats induced by chronic unpredictable mild stress (CUMS). Read More

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Are photocatalytic processes effective for removal of airborne viruses from indoor air? A narrative review.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Nutrition Health Research Center, Health Sciences & Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.

A wide variety of methods have been applied in indoor air to reduce the microbial load and reduce the transmission rate of acute respiratory diseases to personnel in healthcare sittings. In recent months, with the occurrence of COVID-19 pandemic, the role of portable ventilation systems in reducing the load of virus in indoor air has received much attention. The present study delineates a comprehensive up-to-date overview of the available photocatalysis technologies that have been applied for inactivating and removing airborne viruses. Read More

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BAFF signaling drives interstitial transformation of mouse renal tubular epithelial cells in a Pin1-dependent manner.

In Vitro Cell Dev Biol Anim 2021 Jun 14. Epub 2021 Jun 14.

Urology Department, Third Affiliated Hospital of Soochow University, 185# Juqian Street, Changzhou, 213003, China.

Aberrant expression of B cell-activating factor belonging to TNF superfamily (BAFF) and its receptors results in abnormal biological activities in hematopoietic and non-hematopoietic cells and is closely associated with the occurrence and development of various diseases. However, the biological significance and potential mechanisms underlying BAFF signaling in renal tubular epithelial cells (RTECs) remain unknown. This study aimed to investigate the biological role of BAFF signaling in RTECs. Read More

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