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Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

University of Yamanashi, School of Medicine, Yamanashi, Japan.

Asparaginase therapy is a key component of chemotherapy for T-cell acute lymphoblastic leukemia (T-ALL) patients. Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine synthetase (ASNS) activity, while leukemia cells are supposed to undergo apoptosis due to silencing of the ASNS gene. Read More

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September 2021

Racial disparities in the SOFA score among patients hospitalized with COVID-19.

PLoS One 2021 17;16(9):e0257608. Epub 2021 Sep 17.

Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.

Background: Sequential Organ Failure Assessment (SOFA) score predicts probability of in-hospital mortality. Many crisis standards of care suggest the use of SOFA scores to allocate medical resources during the COVID-19 pandemic.

Research Question: Are SOFA scores elevated among Non-Hispanic Black and Hispanic patients hospitalized with COVID-19, compared to Non-Hispanic White patients?

Study Design And Methods: Retrospective cohort study conducted in Yale New Haven Health System, including 5 hospitals with total of 2681 beds. Read More

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September 2021

Recognition of general anesthesia-induced loss of consciousness based on the spatial pattern of the brain networks.

J Neural Eng 2021 Sep 17. Epub 2021 Sep 17.

University of Electronic Science and Technology of China, No.2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu, 610054, CHINA.

Objective: Unconsciousness is a key feature related to general anesthesia (GA) but is difficult to be evaluated accurately by anesthesiologists clinically.

Approach: To tracking the loss of consciousness (LOC) and recovery of consciousness (ROC) under GA, in this study, by investigating functional connectivity of the scalp electroencephalogram (EEG), we explore any potential difference in brain networks among anesthesia induction, anesthesia recovery, and the resting state.

Main Results: The results of this study demonstrated significant differences among the three periods, concerning the corresponding brain networks. Read More

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September 2021

Electron Spin Resonance of the itinerant ferromagnets LaCrGe, CeCrGeand PrCrGe.

J Phys Condens Matter 2021 Sep 17. Epub 2021 Sep 17.

Department of Physics, Indian Institute of Technology Kanpur, Kalyanpur, Kanpur, Uttar Pradesh, 208016, INDIA.

We report Electron Spin Resonance of the itinerant ferromagnets LaCrGe3, CeCrGe3, and PrCrGe3. These compounds show well defined and very similar spectra of itinerant Cr 3d spins in the paramagnetic temperature region. Upon cooling and crossing the Cr-ferromagnetic ordering (below around 90 K) strong spectral structures start to dominate the resonance spectra in a quite different manner in the three compounds. Read More

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September 2021

EEG-based emotion classification using LSTM under new paradigm.

Biomed Phys Eng Express 2021 Sep 17. Epub 2021 Sep 17.

Electrical Engineering, National Institute of Technology Silchar, NIT Silchar, Silchar, Assam, 788010, INDIA.

Deep learning has gained much popularity in solving challenging machine learning problems related to image, speech classification, etc. Research has been conducted to apply deep learning models in emotion classification based on physiological signals such as EEG. Most of the research works have based their model on the spatial aspects of the EEG. Read More

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September 2021

Regular magnetic orders in triangular and kagome lattices.

J Phys Condens Matter 2021 Sep 17. Epub 2021 Sep 17.

Indian Institute of Technology Guwahati, Dept. of physics , Indian Institute of Technology Guwahati, Guwahati, Assam, India 781039, Guwahati, Assam, 781039, INDIA.

We investigate the possible regular magnetic order (RMO) for the spin models with global O(3) spin rotation, based on a group theoretical approach for triangular and kagome lattices. The main reason to study these RMOs is that they are good variational candidates for the ground states of many specific models. In this work, we followed the prescription introduced by Messio et al. Read More

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September 2021

Can a ToF-PET photon attenuation reconstruction test stopping power estimations in proton therapy? a phantom study.

Phys Med Biol 2021 Sep 17. Epub 2021 Sep 17.

WPE, University Hospital Essen, Essen, GERMANY.

Objective: The aim of the phantom study was to validate and to improve the computed tomography (CT) images used for the dose computation in proton therapy. It was tested, if the joint reconstruction of activity and attenuation images of time-of-flight PET (ToF-PET) scans could improve the estimation of the proton stopping power.

Approach: The attenuation images, i. Read More

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September 2021

Aptamer functionalized DNA hydrogels: Design, applications and kinetics.

Biosens Bioelectron 2021 Sep 3;194:113597. Epub 2021 Sep 3.

Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, China. Electronic address:

DNA hydrogels have received considerable attention in various promising applications due to their excellent biocompatibility, controlled biodegradability, adjustable mechanical properties, stability against proteases, self-healing ability, and stimuli responsiveness. To obtain the specific molecular recognition capability, aptamers and many other functional motifs are utilized. Aptamers are short single-stranded DNA or RNA selected through SELEX to bind with specific target with high affinity and specificity. Read More

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September 2021

Accessible detection of SARS-CoV-2 through molecular nanostructures and automated microfluidics.

Biosens Bioelectron 2021 Sep 12;194:113629. Epub 2021 Sep 12.

Institute for Health Innovation & Technology, National University of Singapore, Singapore; Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Accurate and accessible nucleic acid diagnostics is critical to reducing the spread of COVID-19 and resuming socioeconomic activities. Here, we present an integrated platform for the direct detection of SARS-CoV-2 RNA targets near patients. Termed electrochemical system integrating reconfigurable enzyme-DNA nanostructures (eSIREN), the technology leverages responsive molecular nanostructures and automated microfluidics to seamlessly transduce target-induced molecular activation into an enhanced electrochemical signal. Read More

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September 2021

Characteristics of a novel heterotrophic nitrification and aerobic denitrification bacterium and its bioaugmentation performance in a membrane bioreactor.

Bioresour Technol 2021 Sep 8;342:125908. Epub 2021 Sep 8.

Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang 222005, PR China; Key Laboratory of Environment Controlled Aquaculture, Ministry of Education, Dalian 116023, PR China; The Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China. Electronic address:

A novel bacteria with heterotrophic nitrification and aerobic denitrification ability was obtained from a membrane bioreactor (MBR) and identified as Acinetobacter sp. TSH1. The nitrogen removal characteristics, nitrogen balance analysis, kinetic characteristics, and enhanced biological treatment in MBR of the novel isolated strain TSH1 were determined. Read More

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September 2021

Enhanced nitrogen removal by partial nitrification-anammox process with a novel high-frequency micro-aeration (HFMA) mode: Metabolic interactions among functional bacteria.

Bioresour Technol 2021 Sep 8;342:125917. Epub 2021 Sep 8.

School of Human Settlements and Civil Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi Province 710049, China; School of Environmental and Municipal Engineering, Xi'an University of Architecture and Technology, Xi'an, Shaanxi Province 710055, China.

A novel high-frequency micro-aeration (HFMA) mode with aeration frequency of 15 times/h and DO concentration lower than 0.5 mg/L was proposed. Advanced partial nitrification-anammox (PN-A) performance was achieved in a two-stage sequencing batch reactor-integrated fixed-film activated sludge reactor with the HFMA mode. Read More

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September 2021

Insights into the beneficial effects of woody peat for reducing abundances of antibiotic resistance genes during composting.

Bioresour Technol 2021 Sep 8;342:125903. Epub 2021 Sep 8.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.

Antibiotic resistance genes (ARGs) in manure endangered human health, while heavy metals in manure will pose selective pressure on ARGs. This study explored the effects on ARGs of adding woody peat during composting at different ratios (0 (CK), 5% (T1), and 15% (T2)). After composting, the relative abundances of 8/11 ARGs were 6. Read More

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September 2021

pH and charge reversal-driven nanoplatform for efficient delivery of therapeutics.

Colloids Surf B Biointerfaces 2021 Sep 14;208:112106. Epub 2021 Sep 14.

Henan Engineering Technology Research Center of Ultrasonic Molecular Imaging and Nanotechnology, Zhengzhou City, China; Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou City, China. Electronic address:

Nanomedicine which delivers therapeutics to tumours holds great potential for cancer treatment. However, endosomal trapping and uncontrollable release usually limit the efficiency of nanomedicine. Herein, a smart mesoporous silica based nanoplatform was constructed, in which mesoporous silica nanoparticles (MSNs) serve as the core, capped with pH-induced charge-reversal polymer -PAH-cit- and cationic polyelectrolyte polyethyleneimine (PEI). Read More

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September 2021

An ensemble learning framework for potential miRNA-disease association prediction with positive-unlabeled data.

Comput Biol Chem 2021 Aug 24;95:107566. Epub 2021 Aug 24.

School of Management and Economics, Beijing Institute of Technology, Beijing 100081, China.

To explore the pathogenic mechanisms of MicroRNA (miRNA) on diverse diseases, many researchers have concentrated on discovering the potential associations between miRNA and disease using machine learning methods. However, the prediction accuracy of supervised machine learning methods is limited by lacking of experimentally-validated uncorrelated miRNA-disease pairs. Without these negative samples, training a highly accurate model is much more difficult. Read More

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Use of transcriptomic analysis to identify microRNAs related to the effect of stress on thymus immune function in a chicken stress model.

Res Vet Sci 2021 Sep 10;140:233-241. Epub 2021 Sep 10.

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China. Electronic address:

In modern poultry production, stress-induced immunosuppression leads to serious economic losses and harm to animals, but the molecular mechanisms governing the effects of stress on the chicken thymus have not been elucidated. In this study, we successfully constructed a stress model of 7-day-old Gushi chickens by adding exogenous corticosterone (CORT) to their diet and determined the microRNA (miRNA) expression profile of thymus tissues using RNA-seq technology. The results identified 51 differentially expressed miRNAs (DEMs), including 30 upregulated miRNAs and 21 downregulated miRNAs. Read More

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September 2021

The role of Escherichia coli type III secretion system 2 chaperone protein ygeG in pathogenesis of avian pathogenic Escherichia coli.

Res Vet Sci 2021 Sep 10;140:203-211. Epub 2021 Sep 10.

Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, PR China. Electronic address:

The Escherichia coli type III secretion system 2 (ETT2) is present in most E. coli strains, carries a 29.9-kb ETT2 pathogenicity island (PAI) and is involved in the virulence of avian pathogenic Escherichia coli (APEC). Read More

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September 2021

Does weight change modify the association between the consumption of sugar-sweetened beverages and 100% fruit juice and the risk of metabolic syndrome?

Clin Nutr 2021 Aug 28;40(10):5261-5268. Epub 2021 Aug 28.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background & Aims: This study aimed to determine the prospective relationship between the consumption of sugar-sweetened beverages (SSBs) and 100% fruit juice and metabolic syndrome (MetS) and to investigate whether weight change can modify this association in a representative sample of the population of Tehran, Iran.

Methods: In this 8.9-year follow-up study, the consumption of SSBs and 100% fruit juice by 1915 individuals, who participated in Tehran Lipid and Glucose Study (TLGS), was examined using a validated food frequency questionnaire. Read More

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Reinterpreting the human ABR binaural interaction component: isolating attention from stimulus effects.

Hear Res 2021 Sep 4;410:108350. Epub 2021 Sep 4.

Faculty of Information Technology and Communication Sciences, Tampere University, 33720 Tampere, Finland.

Subtracting the sum of left and right monaural auditory brainstem responses (ABRs) from the corresponding binaural ABR isolates the binaural interaction component (ABR-BIC). In a previous investigation (Ikeda, 2015), during auditory yet not visual tasks, tone-pips elicited a significant difference in amplitude between summed monaural and binaural ABRs. With click stimulation, this amplitude difference was task-independent. Read More

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September 2021

Molecular dynamics study of conformation transition from helix to sheet of Aβ42 peptide.

J Mol Graph Model 2021 Sep 8;109:108027. Epub 2021 Sep 8.

School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China. Electronic address:

Aβ42 peptides can form helix and sheet structure under different conditions. The conformational conversion is closely associated with Aβ peptides aggregation and their neurotoxicity. But the transition from helix to sheet is not be clearly understood. Read More

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September 2021

A DFT study of the double (3 + 2) cycloaddition of nitrile oxides and allenoates for the formation of spirobiisoxazolines.

J Mol Graph Model 2021 Sep 12;109:108033. Epub 2021 Sep 12.

Theoretical and Computational Chemistry Laboratory, Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Electronic address:

The molecular mechanism of the double (3 + 2) cycloaddition (32CA) reaction between nitrile oxides and allenoates has been studied using density functional theory at the M06-2X/6-311G (d,p) level of theory. In the first 32CA, the nitrile oxide adds chemo- and regio-selectively to the C-C double bond of the allenoate closest to the carboxylate group followed by a subsequent regioselective addition to the olefinic bond of the isoxazoline intermediate. The rate constant for the preferred pathway (formation of 4-methylene-2-isoxazoline intermediate) in the reaction of ethyl substituted allenoate and mesitonitrile oxide is 5. Read More

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September 2021

Human-like performance umami electrochemical biosensor by utilizing co-electrodeposition of ligand binding domain T1R1-VFT and Prussian blue.

Biosens Bioelectron 2021 Sep 13;193:113627. Epub 2021 Sep 13.

School of Agricultural Engineering and Food Science, Shandong University of Technology, No. 266 Xincun Xilu, Zibo, 255049, Shandong Province, China; Department of Food Science&Technology, School of Agriculture&Biology, Shanghai Jiaotong University, Shanghai, 200240, China.

Over the past decades, due to the desire for artificial umami flavors, apparatuses for detecting the umami taste have constantly been developed. Nevertheless, most information on umami is still acquired through human sensory assessment, which makes it difficult to establish an umami standard or quantify the umami flavor. In this study, the ligand binding domain called venus flytrap (VFT) domain of the umami taste receptor protein T1R1 was used as a recognition element, and an electrochemical biosensor based on a double-signal amplification strategy was constructed using single-walled carbon nanotubes (SWCNTs) and Prussian blue (PB). Read More

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September 2021

SARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases.

Sci Total Environ 2021 Sep 4;805:150121. Epub 2021 Sep 4.

Department of Biological Engineering, Massachusetts Institute of Technology, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, USA; Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group, Singapore; Campus for Research Excellence and Technological Enterprise (CREATE), Singapore; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

Current estimates of COVID-19 prevalence are largely based on symptomatic, clinically diagnosed cases. The existence of a large number of undiagnosed infections hampers population-wide investigation of viral circulation. Here, we quantify the SARS-CoV-2 concentration and track its dynamics in wastewater at a major urban wastewater treatment facility in Massachusetts, between early January and May 2020. Read More

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September 2021

Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems.

J Mech Behav Biomed Mater 2021 Sep 8;124:104814. Epub 2021 Sep 8.

Department of Mechanical and Industrial Engineering, University of Brescia, Via Branze 38, 25133, Brescia, Italy; Italian Interuniversity Consortium on Materials Science and Technology (INSTM), Research Unit of Brescia, Via Branze 38, 25133, Brescia, Italy. Electronic address:

The present paper aims at developing an integrated experimental/computational approach towards the design of shape memory devices fabricated by hot-processing with potential for use as gastroretentive drug delivery systems (DDSs) and for personalized therapy if 4D printing is involved. The approach was tested on a plasticized poly(vinyl alcohol) (PVA) of pharmaceutical grade, with a glass transition temperature close to that of the human body (i.e. Read More

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September 2021

Indomethacin-based PROTACs as pan-coronavirus antiviral agents.

Eur J Med Chem 2021 Sep 4;226:113814. Epub 2021 Sep 4.

Department of Chemistry, Biology, and Biotechnology, University of Perugia, Italy. Electronic address:

Indomethacin (INM), a well-known non-steroidal anti-inflammatory drug, has recently gained attention for its antiviral activity demonstrated in drug repurposing studies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Although the mechanism of action of INM is not yet fully understood, recent studies have indicated that it acts at an early stage of the coronaviruses (CoVs) replication cycle. In addition, a proteomic study reported that the anti-SARS-CoV-2 activity of INM could be also ascribed to its ability to inhibit human prostaglandin E synthase type 2 (PGES-2), a host protein which interacts with the SARS-CoV-2 NSP7 protein. Read More

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September 2021

Deciphering the chromatin organization and dynamics for muscle stem cell function.

Curr Opin Cell Biol 2021 Sep 14;73:124-132. Epub 2021 Sep 14.

Division of Life Science, Center for Stem Cell Research, HKUST-Nan Fung Life Sciences Joint Laboratory, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong, China; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, China. Electronic address:

The chromatin landscape represents a critical regulatory layer for precise transcriptional control. Chromosome architecture restrains the physical access to the DNA elements and is one of the determinants that specifies cell identity. Adult stem cells possess the unique ability to differentiate into a specific lineage. Read More

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September 2021

A pilot nationwide baseline survey on the concentrations of Neonicotinoid insecticides in tap water from China: Implication for human exposure.

Environ Pollut 2021 Sep 8;291:118117. Epub 2021 Sep 8.

School of Environmental Science and Engineering, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology (Sun Yat-Sen University), Guangzhou, 510275, China. Electronic address:

Neonicotinoids (NEOs) have become the most widely used insecticides in the world. However, information on the NEO concentrations in tap water based on nationwide surveys is limited in China. In this study, the levels of six NEOs were measured in tap water samples collected from 38 cities in China. Read More

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September 2021

Emerging materials and technologies for landfill leachate treatment: A critical review.

Environ Pollut 2021 Sep 9;291:118133. Epub 2021 Sep 9.

School of Civil and Environmental Engineering, Queensland University of Technology, Australia.

Sanitary landfill is the most popular way to dispose solid wastes with one major drawback: the generation of landfill leachate resulting from percolation of rainfall through exposed landfill areas or infiltration of groundwater into the landfill. The landfill leachate impacts on the environment has forced authorities to stipulate more stringent requirements for pollution control, generating the need for innovative technologies to eliminate waste degradation by-products incorporated in the leachate. Natural attenuation has no effect while conventional treatment processes are not capable of removing some the pollutants contained in the leachate which are reported to reach the natural environment, the aquatic food web, and the anthroposphere. Read More

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September 2021

Two novelty learning models developed based on deep cascade forest to address the environmental imbalanced issues: A case study of drinking water quality prediction.

Environ Pollut 2021 Sep 11;291:118153. Epub 2021 Sep 11.

School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, And Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, 510632, China.

Environmental quality data sets are typically imbalanced, because environmental pollution events are rarely observed in daily life. Prediction of imbalanced data sets is a major challenge in machine learning. Our recent work has shown deep cascade forest (DCF), as a base learning model, is promising to be recommended for environmental quality prediction. Read More

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September 2021

Human norovirus contamination in water sources: A systematic review and meta-analysis.

Environ Pollut 2021 Sep 13;291:118164. Epub 2021 Sep 13.

Department of Microbiology, Federal University of Technology Akure, Nigeria.

The human norovirus (HNoV), on a global scale, is the prevailing cause of contagious viral gastroenteritis outbreaks, with more than 200 000 deaths annually. This study aimed at assessing specific prevalence of HNoV pollution in different water sources and their roles in the dissemination of HNoV, with a view to refocus water sources and sewage management options for policy making towards public health safety. In this regard, we conducted a systematic review and meta-analysis (SR/MA) of the prevalence of HNoV in water sources. Read More

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September 2021