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Sexual harassment and assault predict sleep disturbances and is partly mediated by nightmares: Findings from a national survey of all university students in Norway.

J Sleep Res 2021 Jun 15:e13338. Epub 2021 Jun 15.

Department of Health Promotion, Norwegian Institute of Public Health, Bergen, Norway.

Sexual harassment and assault is common in most domains of society, and has been linked to several adverse outcomes, including reduced sleep quality. However, less is known about the possible impact of sexual harassment and assault on various sleep problems among university students. In a sample of 49,051 students in Norway (69. Read More

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Compliance Assessment of the Epithelial or Absorbed Power Density Below 10 GHz Using SAR Measurement Systems.

Bioelectromagnetics 2021 Jun 15. Epub 2021 Jun 15.

Foundation for Research on Information Technologies in Society (IT'IS), Zurich, Switzerland.

The introduction of new dosimetric quantities, in particular, epithelial or absorbed power density for frequencies above 6 GHz, in exposure guidelines and safety standards requires the development of new experimental assessment procedures for compliance testing. In this study, we propose to approximate the peak spatial-average absorbed power density (psS ) using the same measured data and algorithms that are used for determining the peak spatial-average specific absorption rate psSAR, which is currently limited to frequencies up to 10 GHz. The uncertainty component for the transformation of psSAR to psS was evaluated as less than 0. Read More

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Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Bioelectromagnetics 2021 Jun 15. Epub 2021 Jun 15.

Rehabilitation Medicine Center, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Read More

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Toward a Liver Cell Atlas: Understanding Liver Biology in Health and Disease at Single-Cell Resolution.

Semin Liver Dis 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Single-cell technologies are revolutionizing our understanding of cellular heterogeneity and functional diversity in health and disease. Here, we review the current knowledge and advances in liver biology using single-cell approaches. We focus on the landscape of the composition and the function of cells in a healthy liver in the context of its spatial organization. Read More

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Methyltransferase-like 3 contributes to inflammatory pain by targeting TET1 in YTHDF2-dependent manner.

Pain 2021 Jul;162(7):1960-1976

Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, China.

Abstract: The methyltransferase-like 3 (Mettl3) is a key component of the large N6-adenosine-methyltransferase complex in mammalian responsible for RNA N6-methyladenosine (m6A) modification, which plays an important role in gene post-transcription modulation. Although RNA m6A is enriched in mammalian neurons, its regulatory function in nociceptive information processing remains elusive. Here, we reported that Complete Freund's Adjuvant (CFA)-induced inflammatory pain significantly decreased global m6A level and m6A writer Mettl3 in the spinal cord. Read More

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A bionic soft tongue driven by shape memory alloy and pneumatics.

Bioinspir Biomim 2021 Jun 15. Epub 2021 Jun 15.

Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, No.96, JinZhai Road Baohe District, Hefei, 230026, CHINA.

Soft grippers have exhibited considerable advantages owing to their flexible deformation, compliant operation, and safe interaction with the objects. The ability to grip solid and liquid objects can greatly expand the application range of the soft grippers. Dogs stick out their tongues and then curl backward to form a ladle shape for eating food and drinking water. Read More

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Combining "Grafting to" and "Grafting from" to synthesize comb-like NCC-g-PLA as a macromolecular modifying agent of PLA.

Nanotechnology 2021 Jun 15. Epub 2021 Jun 15.

Sichuan University, Chengdu, Chengdu, Sichuan, 610065, CHINA.

The surface modification of nano particles is very important in nanotechnology. Grafting from (GF) and grafting to (GT) are two main methods to prepare surface modified nanoparticles like nanocellulose crystalline (NCC) grafted with polylactic acid (PLA) chains. In the GF method, the NCC can get high grafting degree but short side chains to improve its compatibility with the polymer matrix. Read More

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Online detection of movement during natural and self-initiated reach-and-grasp actions from EEG signals.

J Neural Eng 2021 Jun 15. Epub 2021 Jun 15.

Institute of Neural Engineering, Graz University of Technology, Stremayrgasse 16/IV, Graz, Steiermark, 8010, AUSTRIA.

Movement intention detection using electroencephalography (EEG) is a challenging but important component of brain-computer interfaces (BCIs) for people with motor disabilities. Objective​: The goal of this study is to exploit low-frequency time-domain EEG signals, concretely movement-related cortical potentials (MRCPs), to perform asynchronous online detection of movement. The experimental paradigm must be easily transferable to people without any residual upper-limb movement function. Read More

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Multimaterial bioprinting towards the fabrication of biomimetic tissues and organs.

Biofabrication 2021 Jun 15. Epub 2021 Jun 15.

UCLA, 570 Westwood Plaza, Los Angeles, California, 90095, UNITED STATES.

Tissue reconstruction requires the utilization of multiple biomaterials and cell types to replicate the delicate and complex structure of native tissues. Various three-dimensional (3D) bioprinting techniques have been developed to fabricate customized tissue structures; however, there are still significant challenges, such as vascularization, mechanical stability of printed constructs, and fabrication of gradient structures to be addressed for the creation of biomimetic and complex tissue constructs. One approach to address these challenges is to develop multimaterial 3D bioprinting techniques that can integrate various types of biomaterials and bioprinting capabilities towards the fabrication of more complex structures. Read More

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Design study of a PET detector with 0.5 mm crystal pitch for high-resolution preclinical imaging.

Phys Med Biol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Biomedical Engineering , Shenzhen Bay Laboratory, Shenzhen, CHINA.

Preclinical positron emission tomography (PET) is a sensitive and quantitative molecule imaging modality widely used in characterizing the biological processes and diseases in small animals. The purpose of this study is to investigate the methods to optimize a PET detector for high-resolution preclinical imaging. The PET detector proposed in this study consists of a 28×28 array of LYSO crystals 0. Read More

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An improved ultrasonic coda wave method for concrete behavior monitoring under various loading conditions.

Ultrasonics 2021 Jun 8;116:106498. Epub 2021 Jun 8.

College of Automotive and Mechanical Engineering, Changsha University of Science and Technology, Changsha, Hunan 410114, China.

Monitoring of concrete behavior is an important task to evaluate the safety of concrete structures. This paper proposes a new stretching factor accumulation method based on the stepwise coda wave interference (CWI) to accurately calculate the relative velocity change Δv/v. The Δv/v and residual decorrelation coefficient K are used to study the concrete behavior in step loading experiment and short-time fixed loading experiment. Read More

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Promoting corn stover degradation via sequential processing of steam explosion and cellulase/lactic acid bacteria-assisted ensilage.

Bioresour Technol 2021 Jun 10;337:125392. Epub 2021 Jun 10.

Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China. Electronic address:

To improve the utilization efficiency of corn stover , steam explosion pretreatment and cellulase/lactic acid bacteria-assisted ensilage storage were conducted in sequence, mainly focusing on morphological structure, lignocellulose fraction, cellulose accessibility and degradation profile. The results showed that there was a synergistic effect of steam explosion and ensilage storage, where hemicellulose of corn stover was partly degraded during steam explosion processing (70%) or ensilage storage (20-40%). Meanwhile, its morphological structure was apparently broken, increasing cellulose accessibility (2. Read More

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Surrogate Endpoints in Oncology: Overview of Systematic Reviews and Their Use for Health Decision Making in Mexico.

Value Health Reg Issues 2021 Jun 12;26:75-88. Epub 2021 Jun 12.

CENETEC (National Center for Health Technology Excellence), Mexico City, Mexico.

Objectives: The use of surrogate endpoints (SEs) for cancer drug approval in health systems is common. The objectives of this study were to identify systematic reviews (SRs) that evaluated the correlation of SEs with overall survival (OS) in cancer drugs to analyze the applications of approved cancer drugs with SEs in Mexico and to apply the validation framework proposed by the Institute for Quality and Efficiency in Health Care (IQWiG).

Methods: An overview of SRs was conducted according to Cochrane Collaboration methodology. Read More

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Direct 3D ultrasound fusion for transesophageal echocardiography.

Comput Biol Med 2021 May 21;134:104502. Epub 2021 May 21.

Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital and Laboratory of Cardiac Imaging and 3D Printing, Li Ka Shing Institute of Health Science, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Real-time three-dimensional transesophageal echocardiography (3D TEE) has been increasingly used in clinic for fast 3D analysis of cardiac anatomy and function. However, 3D TEE still suffers from the limited field of view (FoV). It is challenging to adopt conventional multi-view fusion methods to 3D TEE images because feature-based registration methods tend to fail in the ultrasound scenario, and conventional intensity-based methods have poor convergence properties and require an iterative coarse-to-fine strategy. Read More

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Dismantling the bacterial glycocalyx: Chemical tools to probe, perturb, and image bacterial glycans.

Bioorg Med Chem 2021 Jun 7;42:116268. Epub 2021 Jun 7.

Department of Chemistry & Biochemistry, Bowdoin College, 6600 College Station, Brunswick, ME 04011, USA. Electronic address:

The bacterial glycocalyx is a quintessential drug target comprised of structurally distinct glycans. Bacterial glycans bear unusual monosaccharide building blocks whose proper construction is critical for bacterial fitness, survival, and colonization in the human host. Despite their appeal as therapeutic targets, bacterial glycans are difficult to study due to the presence of rare bacterial monosaccharides that are linked and modified in atypical manners. Read More

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Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy.

Colloids Surf B Biointerfaces 2021 Jun 8;205:111915. Epub 2021 Jun 8.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea. Electronic address:

Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorectal cancer by using exosomes isolated from the tumor cell line as a drug carrier. The proposed EHN can have high biocompatibility by using exosomes, a biologically derived material, and show improved targeting performance by adding a tumor-targeting ligand (folic acid). Read More

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Ultrafiltration strategy combined with nanoLC-MS/MS based proteomics for monitoring potential residual proteins in TCMIs.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 30;1178:122818. Epub 2021 May 30.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Traditional Chinese medicine injections (TCMIs) containing complex constituents frequently cause unpredictable adverse reactions. The residual heterologous proteins in TCMIs may be one kind of the sensitized constituents. However, few methods were developed to identify and monitor the residual proteins of TCMIs in industry. Read More

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Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomed Pharmacother 2021 Jun 12;140:111732. Epub 2021 Jun 12.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0. Read More

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Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis.

Neuroimage Clin 2021 Jun 6;31:102715. Epub 2021 Jun 6.

Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disease, Beijing, China. Electronic address:

Pinpointing the brain dysconnectivity in idiopathic rapid eye movement sleep behaviour disorder (iRBD) can facilitate preventing the conversion of Parkinson's disease (PD) from prodromal phase. Recent neuroimage investigations reported disruptive brain white matter connectivity in both iRBD and PD, respectively. However, the intrinsic process of the human brain structural network evolving from iRBD to PD still remains largely unknown. Read More

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Physical field simulation of the ultrasonic radiation method: An investigation of the vessel, probe position and power.

Ultrason Sonochem 2021 Jun 9;76:105626. Epub 2021 Jun 9.

School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China.

In this paper, the effects of ultrasonic probe position, vessel shape, and ultrasonic input power on the sound pressure distribution in the reactor were investigated by solving the Helmholtz equation using COMSOL Multiphysis software. Three different types of glass containers were used in the study, which are beaker, Erlenmeyer flask, and round bottom flask. The maximum value of sound pressure in the three containers will gradually increase when the distance between the probe and the bottom of the container decreases. Read More

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Study on the influence of advanced treatment processes on the surface properties of polylactic acid for a bio-based circular economy for plastics.

Ultrason Sonochem 2021 Jun 10;76:105627. Epub 2021 Jun 10.

Clausthal Centre for Materials Technology (CZM), Clausthal University of Technology, Leibnizstr. 9, 38678 Clausthal-Zellerfeld, Germany; School of Chemical Engineering, National Technical University of Athens, 9 Heroon Polytechneiou St., Zografou Campus, 15780 Athens, Greece. Electronic address:

New biotechnological processes using microorganisms and/or enzymes to convert carbonaceous resources, either biomass or depolymerized plastics into a broad range of different bioproducts are recognized for their high potential for reduced energy consumption and reduced GHG emissions. However, the hydrophobicity, high molecular weight, chemical and structural composition of most of them hinders their biodegradation. A solution to reduce the impact of non-biodegradable polymers spread in the environment would be to make them biodegradable. Read More

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Emission tuning of highly efficient quaternary Ag-Cu-Ga-Se/ZnSe quantum dots for white light-emitting diodes.

J Colloid Interface Sci 2021 May 23;602:307-315. Epub 2021 May 23.

Institute for Electric Light Sources, School of Information Science and Technology, Fudan University, Shanghai 200433, China; Institute of Future Lighting, Academy for Engineering and Technology, Fudan University, Shanghai 200433, China; Zhongshan - Fudan Joint Innovation Center, Zhongshan 528437, China. Electronic address:

With the blooming development of zero-dimensional nanomaterials, I-III-VI alloying quantum dots (QDs) with outstanding photoelectrical properties have emerged to attract much attention as promising environmentally-friendly substitutions for conventional binary Cd-based QDs. In this work, a facile one-pot method was introduced to synthesize unreported quaternary Ag-Cu-Ga-Se/ZnSe (ACGSe/ZnSe) QDs. A relatively high photoluminescence quantum yield (PL QY) of 71. Read More

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Nanonewton scale adhesion force measurements on biotinylated microbeads with a robotic micropipette.

J Colloid Interface Sci 2021 Jun 3;602:291-299. Epub 2021 Jun 3.

ELTE Eötvös Loránd University, Department of Biological Physics, Budapest, Hungary; CellSorter Company for Innovations, Erdőalja út 174, H-1037 Budapest, Hungary. Electronic address:

Binding force between biomolecules has a crucial role in most biological processes. Receptor-ligand interactions transmit physical forces and signals simultaneously. Previously, we employed a robotic micropipette both in live cell and microbead adhesion studies to explore the adhesion force of biomolecules such as cell surface receptors including specific integrins on immune cells. Read More

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Variations of antibiotic resistome in swine wastewater during full-scale anaerobic digestion treatment.

Environ Int 2021 Jun 12;155:106694. Epub 2021 Jun 12.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address:

Anaerobic digesters have been widely used to treat wastewaters in livestock farms. With the increasing risk of antibiotic resistance originated from livestock husbandry, removal of antibiotics and antibiotic resistance genes (ARGs) via anaerobic digesters deserved more attention. Here we investigated the removal of antibiotics and ARGs in swine wastewater by three on-farm full-scale anaerobic digesters, including buried biogas digester (BBD), up-flow anaerobic sludge blanket (UASB) and high density polyethylene covered biogas digester (HDPE-BD). Read More

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Microplastic degradation methods and corresponding degradation mechanism: Research status and future perspectives.

J Hazard Mater 2021 Jun 10;418:126377. Epub 2021 Jun 10.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China; Institute of Eco-Environmental Research, Guangxi Academy of Sciences, Nanning 530007, China. Electronic address:

Microplastics (MPs) pollution has become a global environmental concern because of their severe threat to biota. However, limited studies on the elimination of MPs pollution were reported. The conventional treatment methods were not suitable for MPs owing to their smaller size than plastic items. Read More

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Nitrogen fertilizer affects rhizosphere Cd re-mobilization by mediating gene AmALM2 and AmALMT7 expression in edible amaranth roots.

J Hazard Mater 2021 Jun 6;418:126310. Epub 2021 Jun 6.

Key Laboratory of Environmental Pollution and Health of Guangdong Province, School of Environment, Jinan University, Guangzhou 510632, China. Electronic address:

In-situ stabilization of Cd-contaminated farmland is a commonly used remediation technology. Yet, rhizosphere metabolites (e.g. Read More

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Highly efficient nano-Fe/Cu bimetal-loaded mesoporous silica Fe/Cu-MCM-41 for the removal of Cr(VI): Kinetics, mechanism and performance.

J Hazard Mater 2021 Jun 8;418:126344. Epub 2021 Jun 8.

Shaanxi provincial Center for Disease Control and Prevention, Xian 710054, China. Electronic address:

Zero valent iron (Fe) can reduce Cr(VI) in water, where Fe and Fe(Ⅱ) are possible electron donors, but passivation and aggregation easily occur to Fe. To improve the performance of Fe, a new hybridization strategy of Fe/Cu bimetal and silica-based mesoporous molecular sieve MCM-41 for the removal of Cr(VI) from water has been proposed. The results show that the two-dimensional mesoporous structure of MCM-41 can provide skeleton support for Fe, improve the mass transfer rate, and overcome the aggregation bottleneck of Fe. Read More

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Modification of ordered mesoporous carbon for removal of environmental contaminants from aqueous phase: A review.

J Hazard Mater 2021 May 30;418:126266. Epub 2021 May 30.

College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225127, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225127, Jiangsu, China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, China. Electronic address:

Contamination of water bodies by potentially toxic elements and organic pollutants has aroused extensive concerns worldwide. Thus it is significant to develop effective adsorbents for removing these contaminants. As a new member of carbonaceous material families (activated carbon, biochar, and graphene), ordered mesoporous carbon (OMC) with larger specific surface area, ordered pore structure, and higher pore volume are being evaluated for their use in contaminant removal. Read More

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Efficient heavy metal removal from water by alginate-based porous nanocomposite hydrogels: The enhanced removal mechanism and influencing factor insight.

J Hazard Mater 2021 Jun 8;418:126358. Epub 2021 Jun 8.

School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410114, China; Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China. Electronic address:

Novel porous alginate-based nanocomposite hydrogels were prepared by incorporating polyaniline-polypyrrole modified graphene oxide ([email protected]) as reinforcing fillers into the alginate matrix ([email protected]/SA) for Cr(VI) and Cu(II) removal from water. Different in-situ co-polymerization functionalized GO with Py-to-An mass ratios of monomers (from nil to 1:1) and contents of [email protected] (from nil to 2.0%(w/v)) were embedded into the alginate backbone to improve the sorption performance. Read More

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Foliar absorption and field herbicidal studies of atrazine-loaded polymeric nanoparticles.

J Hazard Mater 2021 Jun 7;418:126350. Epub 2021 Jun 7.

Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março 511, 18087-180 Sorocaba, SP, Brazil. Electronic address:

Nanoparticles loaded with atrazine show weed control efficacy even with lower application doses of the active ingredient. Changes in the mode of action of the herbicide through the nanoformulation are key to understanding the efficiency of post-emergence activity of nanoatrazine. Here, we report the leaf absorption and translocation of nanoatrazine and atrazine employing radiometric techniques and compare their herbicidal effects in greenhouse and field conditions. Read More

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