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Theoretical and Experimental Evaluation of the Reduction Potential of Straight-Chain Alcohols for the Designed Synthesis of Bimetallic Nanostructures.

Inorg Chem 2021 Apr 13. Epub 2021 Apr 13.

Department of Materials Science, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan.

Recently, the development of bimetallic nanoparticles with functional properties has been attempted extensively but with limited control over their morphological and structural properties. The reason was the inability to control the kinetics of the reduction reaction in most liquid-phase syntheses. However, the alcohol reduction technique has demonstrated the possibility of controlling the reduction reaction and facilitating the incorporation of other phenomena such as diffusion, etching, and galvanic replacement during nanostructure synthesis. Read More

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High-throughput label-free detection of DNA-to-RNA transcription inhibition using brightfield microscopy and deep neural networks.

Comput Biol Med 2021 Apr 4;133:104371. Epub 2021 Apr 4.

Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Villejuif, France; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China; Po^le de Biologie, Ho^pital Européen Georges Pompidou, AP-HP, Paris, France; Karolinska Institutet, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

Drug discovery is in constant evolution and major advances have led to the development of in vitro high-throughput technologies, facilitating the rapid assessment of cellular phenotypes. One such phenotype is immunogenic cell death, which occurs partly as a consequence of inhibited RNA synthesis. Automated cell-imaging offers the possibility of combining high-throughput with high-content data acquisition through the simultaneous computation of a multitude of cellular features. Read More

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Closure of Challenging Pediatric Scalp Wounds by a Tension-Relief System.

J Craniofac Surg 2021 Apr 5. Epub 2021 Apr 5.

Plastic Surgery and Burns Unit, Schneider Children's Medical Center of Israel Department of Plastic Surgery and Burns, Rabin Medical Center, affiliated with the Sackler Faculty of Medicine, Petah Tikva, Israel.

Abstract: Pediatric scalp defects may be challenging, due to their variant tension level and specific etiologies. Tissue characteristics and pre- and post-management considerations may pose difficulties to reconstruction in the pediatric patient. Primary closure is the preferred surgical technique but is not always possible. Read More

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A chromosome-level genome assembly of the yellowfin seabream (Acanthopagrus latus; Hottuyn, 1782) provides insights into its osmoregulation and sex reversal.

Genomics 2021 Apr 8. Epub 2021 Apr 8.

Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, Guangdong Province, PR China; Tropical Aquaculture Research and Development Center, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Sanya 572018, China; Guangdong Provincial Engineer Technology Research Center of Marine Biological Seed Industry, Guangzhou, Guangdong Province, PR China; Sanya Tropical Fisheries Research Institute, Sanya, Hainan Province, China. Electronic address:

The yellowfin seabream Acanthopagrus latus is the economically most important Sparidae fish in the northern South China Sea. As euryhaline fish, they are perfect model for investigating osmoregulatory mechanisms in teleosts. Moreover, the reproductive biology of hermaphrodites has long been intriguing; however, little information is known about the molecular pathways underlying their sex change. Read More

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Modified team-based and blended learning perception: a cohort study among medical students at King Saud University.

BMC Med Educ 2021 Apr 8;21(1):199. Epub 2021 Apr 8.

College of Computer and Information Science, Prince Sultan University, Riyadh, Saudi Arabia.

Background & Objective: Medical schools have evolved toward competency-based education and active learner-centered strategies. Medical informatics course was introduced in 2011 in the 3rd year at the College of Medicine (CoM), King Saud University (KSU), to enhance future medical graduates with technological and information competencies. Modified team-based learning and blended learning were emphasized using face-to-face lectures, various e-learning technologies, workshop and seminars. Read More

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Newly developed SYBR Green-based quantitative real-time PCRs revealed coinfection evidence of and in existing in Bangkok Metropolitan, Thailand.

Food Waterborne Parasitol 2021 Jun 15;23:e00119. Epub 2021 Mar 15.

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Thailand Mahidol University, Thailand.

is a well-known pathogen causing eosinophilic meningitis associated with angiostrongyliasis. Humans, as accidental hosts, are infected by consuming undercooked snails containing third-stage larvae. is closely related to and has been described as a potential human pathogen. Read More

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The classification of movement intention through machine learning models: the identification of significant time-domain EMG features.

PeerJ Comput Sci 2021 25;7:e379. Epub 2021 Feb 25.

Department of Mechatronics, Kulliyyah of Engineering, Biomechatronics Research Laboratory, International Islamic University, Gombak, Selangor, Malaysia.

Electromyography (EMG) signal is one of the extensively utilised biological signals for predicting human motor intention, which is an essential element in human-robot collaboration platforms. Studies on motion intention prediction from EMG signals have often been concentrated on either classification and regression models of muscle activity. In this study, we leverage the information from the EMG signals, to detect the subject's intentions in generating motion commands for a robot-assisted upper limb rehabilitation platform. Read More

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February 2021

Dynamic External Pelvimetry Test in Third Trimester Pregnant Women: Shifting Positions Affect Pelvic Biomechanics and Create More Room in Obstetric Diameters.

Cureus 2021 Mar 1;13(3):e13631. Epub 2021 Mar 1.

Obstetrics and Gynecology, San Paolo Hospital, Savona, ITA.

Dystocia in labor is still a clinical challenge. The "contracted pelvis" is the absence of pelvic mobility, which leads to fetal-pelvic disproportion, obstructed labor, and operative delivery. Maternal pelvis biomechanics studies by high technological techniques have shown that maternal shifting positions during pregnancy and labor can create more room in the pelvis for safe delivery. Read More

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RECONSTRUCTIVE FUNCTIONAL RESERVOIRS IN TREATMENT OF CHILDREN WITH AGANGLIONOSIS AFTER TOTAL COLECTOMY.

Authors:
V Prytula O Kurtash

Georgian Med News 2021 Feb(311):115-120

2Ivano-Frankivsk National Medical University, Ukraine.

The object of the study is to develop optimal reconstructive functional reservoirs for the treatment of children with aganglionosis after total colectomy. Since 1980 till 2020 we have been treating 53 children up to 3 years with aganglionosis after total colectomy using optimal reconstructive surgery technique lying in the formation of a functional intestinal reservoir. Colostomy was performed as the first stage of surgical treatment of all children. Read More

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February 2021

Dual trocar laparoscopy improves reduced-port surgery of the distal pancreas.

Minim Invasive Ther Allied Technol 2021 Apr 2:1-7. Epub 2021 Apr 2.

Department of Surgery, Saint John of God Hospital, Teaching Hospital of the Paracelsus Medical University Salzburg, Salzburg, Austria.

Background: The technical feasibility of transumbilical single-incision surgery (SIL) for pancreatic resections has been demonstrated. However, this technique is hampered by the limited degrees of freedom for instrument handling. Dual-incision laparoscopy (DIL) with an additional trocar may simplify dissection and allow drainage. Read More

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Efficiency of Machine Learning Algorithms for the Determination of Macrovesicular Steatosis in Frozen Sections Stained with Sudan to Evaluate the Quality of the Graft in Liver Transplantation.

Sensors (Basel) 2021 Mar 12;21(6). Epub 2021 Mar 12.

Experimental Pathology Service, Institute for Biomedical Research of Murcia (IMIB), 30120 Murcia, Spain.

Liver transplantation is the only curative treatment option in patients diagnosed with end-stage liver disease. The low availability of organs demands an accurate selection procedure based on histological analysis, in order to evaluate the allograft. This assessment, traditionally carried out by a pathologist, is not exempt from subjectivity. Read More

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Firm Growth as a Driver of Sustainable Product Innovation: Mediation and Moderation Analysis. Evidence from Manufacturing Firms.

Int J Environ Res Public Health 2021 Mar 5;18(5). Epub 2021 Mar 5.

Department of Business and Economics, University of Almería, La Cañada de San Urbano, 04120 Almería, Spain.

Facing worldwide environmental and social concerns, manufacturing firms are trying to adopt effective environmentally friendly actions to mitigate their environmental impacts. Although the existent literature has provided many insights about the drivers of sustainable product innovation, little is known about the impact of firm growth. Thus, we intend to contribute to this gap in the literature by examining the impact that firm growth can have on sustainable product innovation. Read More

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Upper mini sternotomy approach for pulmonary artery banding: A single centre experience.

J Card Surg 2021 Apr 2. Epub 2021 Apr 2.

Department of Global Health, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Pulmonary artery banding (PAB) remains a crucial technique in modern cardiac surgery. Left lateral thoracotomy, median sternotomy, and left anterior thoracotomy are well-known approaches. With significant scarce reports addressing the application of the upper mini sternotomy approach for PAB, this study aims to share experience and report outcomes of patients operated upon using this approach and its impact on facilitating the redo surgery. Read More

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[Micrographic surgery and its variants].

Rev Med Suisse 2021 Mar;17(732):630-634

Unité de dermatochirurgie, Service de dermatologie et vénéréologie, Département des spécialités de médecine, HUG, 1211 Genève 14.

Cutaneous tumours can be ill-delineated and subclinical tumour can be missed when using the usual methods of pathology processing because only less than 1 % of the margin is examined. Micrographic surgery was developed to allow for examination of 100 % of the margin. It reduces the recurrence rate and spares healthy tissue thus reducing lesion size and facilitating reconstruction. Read More

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Aesthetic Rhinoplasty: Technique, 3-Dimensional Simulation, and Outcome Assessment.

Aesthet Surg J Open Forum 2021 Jan 4;3(1):ojaa054. Epub 2020 Dec 4.

Yale Plastic Surgery, New Haven, CT, USA.

Communication of goals and realistic expectations between the surgeon and patient is a crucial step of aesthetic rhinoplasty. Three-dimensional (3D) imaging technology allows for sharing of simulated outcomes in the office setting, thereby facilitating this process. This article highlights the use of 3D rhinoplasty simulation in preoperative assessment and the senior author's preferred surgical technique in open rhinoplasty. Read More

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January 2021

Image Inversion during Xi Robotic ventral hernia repair: making it even more effective.

Rev Col Bras Cir 2021 24;48:e20202879. Epub 2021 Mar 24.

- Instituto Morrell, Cirurgia do Aparelho Digestivo Minimamente Invasiva e Robótica - São Paulo -SP - Brasil.

Introduction: currently, there are several clinical applications for robot-assisted surgery and in the hernia scenario, robot-assisted surgery seems to have the ability to overcome laparoscopic ventral hernias repairs limitations, facilitating dissection, defect closure, and mesh positioning. Exponentially grown in numbers of robotic approaches have been seen and even more complex and initially not suitable cases have recently become eligible for it. An appropriate tension-free reestablishment of the linea alba is still a major concern in hernia surgery and even with the robotic platform, dissecting and suturing in anterior abdominal wall may be challenging. Read More

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Using Spatial Probability Maps to Highlight Potential Inaccuracies in Deep Learning-Based Contours: Facilitating Online Adaptive Radiation Therapy.

Adv Radiat Oncol 2021 Mar-Apr;6(2):100658. Epub 2021 Jan 29.

Department of Radiation Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Purpose: Contouring organs at risk remains a largely manual task, which is time consuming and prone to variation. Deep learning-based delineation (DLD) shows promise both in terms of quality and speed, but it does not yet perform perfectly. Because of that, manual checking of DLD is still recommended. Read More

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January 2021

Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach.

Neuroophthalmology 2021 26;45(1):1-16. Epub 2020 Oct 26.

Departments of Clinical Neurosciences and Surgery, University of Calgary, Calgary, Alberta, Canada.

Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the diagnosis. Read More

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October 2020

Facilitating recall and particularisation of repeated events in adults using a multi-method interviewing format.

Memory 2021 Mar 24:1-15. Epub 2021 Mar 24.

Department of Psychology, Goldsmiths University of London, London, UK.

Reports about repeated experiences tend to include more schematic information than information about specific instances. However, investigators in both forensic and intelligence settings typically seek specific over general information. We tested a multi-method interviewing format (MMIF) to facilitate recall and particularisation of repeated events through the use of the self-generated cues mnemonic, the timeline technique, and follow-up questions. Read More

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Safety and Efficacy of Manual Aspiration Via Small Bore Chest Tube in Facilitating the Outpatient Management of Transbronchial Biopsy-related Iatrogenic Pneumothorax.

J Bronchology Interv Pulmonol 2021 Mar 22. Epub 2021 Mar 22.

Thoracic Surgery and Interventional Pulmonology Service, Helen F. Graham Cancer Center and Research Institute, Christiana Care Health System Department of Medicine, Christiana Care Health System, Newark, DE Division of Pulmonary and Critical Care Medicine, Rutgers New Jersey Medical School, NJ.

Background: Iatrogenic pneumothorax complicates transbronchial biopsies with a prevalence of 1% to 6%. Conventional treatment consists of inpatient management with chest tube drainage. While aspiration techniques have been investigated in the management of both primary spontaneous and transthoracic lung biopsy-induced pneumothorax, its role in the management of transbronchial biopsy-iatrogenic pneumothorax (TBBX-IP) is undefined. Read More

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Identification of a localization wire tip in an occult breast lesion using a handheld magnetometer.

Adv Clin Exp Med 2021 Mar;30(3):273-278

Breast Unit, Division of Breast Surgery, Lower Silesian Oncology Center, Wrocław, Poland.

Background: The Sentimag hand-held probe detects the magnetic response from iron oxide particles trapped in a sentinel node.

Objectives: To investigate if an electromagnetic probe can be helpful in the identification of a hook wire tip located in an occult breast lesion.

Material And Methods: Forty-two patients undergoing lumpectomy without axillary procedure were enrolled. Read More

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Rust expression browser: an open source database for simultaneous analysis of host and pathogen gene expression profiles with expVIP.

BMC Genomics 2021 Mar 9;22(1):166. Epub 2021 Mar 9.

John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

Background: Transcriptomics is being increasingly applied to generate new insight into the interactions between plants and their pathogens. For the wheat yellow (stripe) rust pathogen (Puccinia striiformis f. sp. Read More

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Shockwave lithotripsy facilitates large-bore vascular access through calcified arteries.

J Vasc Surg Cases Innov Tech 2021 Mar 12;7(1):164-170. Epub 2020 Sep 12.

Division of Vascular Surgery, Department of Surgery, The Icahn School of Medicine at Mount Sinai, New York, NY.

Background: Our objective is to explore the Peripheral Intravascular Lithotripsy (IVL) System in the treatment of calcific access vessels during thoracic endovascular aortic repair (TEVAR), endovascular aortic repair (EVAR), and transcatheter aortic valve intervention.

Methods: This retrospective, single-center study evaluated the outcomes of patients undergoing TEVAR, EVAR, or transcatheter aortic valve intervention with severe calcific arterial disease between July 2018 and August 2019. Maximum circumferential calcification, length of calcification, and inner/outer diameter measurements were collected with curved planar reformation by medical imaging software (Aquarius APS, TeraRecon, Foster City, Calif). Read More

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Comparative Analysis of Outer Membrane Vesicle Isolation Methods With an Mutant Reveals a Hypervesiculating Phenotype With Outer-Inner Membrane Vesicle Content.

Front Microbiol 2021 5;12:628801. Epub 2021 Mar 5.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

Outer membrane vesicles (OMVs) produced by Gram-negative bacteria are mediators of cell survival and pathogenesis by facilitating virulence factor dissemination and resistance to antimicrobials. Studies of OMV properties often focus on hypervesiculating mutants that have increased OMV production when compared to their corresponding wild-type (WT) strains. Currently, two conventional techniques, ultracentrifugation (UC) and ultradiafiltration (UF), are used interchangeably to isolate OMVs, however, there is concern that each technique may inadvertently alter the properties of isolated OMVs during study. Read More

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Enhancing Interfacial Contact in Solid-State Batteries with a Gradient Composite Solid Electrolyte.

Small 2021 Mar 19:e2006578. Epub 2021 Mar 19.

School of Materials Science & Engineering, Beijing Key Laboratory of Environmental Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China.

Solid-state batteries promise to meet the challenges of high energy density and high safety for future energy storage. However, poor interfacial contact and complex manufacturing processes limit their practical applications. Herein, a simple strategy is proposed to enhance interfacial contact by introducing a gradient composite polymer solid electrolyte (GCPE), which is prepared by a facile UV-curing polymerization technique. Read More

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The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders.

Front Bioeng Biotechnol 2021 2;9:629832. Epub 2021 Mar 2.

Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, China.

Brain is by far the most complex organ in the body. It is involved in the regulation of cognitive, behavioral, and emotional activities. The organ is also a target for many diseases and disorders ranging from injuries to cancers and neurodegenerative diseases. Read More

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Patellar Tendon Revision Reconstruction With Hamstring Tendon Autografts.

Arthrosc Tech 2021 Mar 22;10(3):e873-e876. Epub 2021 Feb 22.

Twin Cities Orthopedics Edina-Crosstown, Edina, Minnesota, U.S.A.

Patellar tendon rupture is an infrequent cause of disability in patients younger than 40 years, with chronic injury and repeat procedures creating difficulty in facilitating healing. Use of hamstring autograft to reinforce the repair has been reported to strengthen the repair construct in patients with previous failure or chronic injury. This technique describes utilization of gracilis and semitendinosus tendon autografts to reconstruct the patellar tendon in a case of primary repair failure. Read More

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Devices for dosimetric measurements and quality assurance of the Xstrahl 300 orthovoltage unit.

J Appl Clin Med Phys 2021 Apr 18;22(4):151-157. Epub 2021 Mar 18.

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The Xstrahl 300 orthovoltage unit is designed to deliver kilovoltage radiation therapy using the appositional technique. However, it is not equipped with some typical linear accelerator features, such as mechanical distance indicator and crosshair projection, which are useful for facilitating equipment setup during various quality assurance (QA) and research activities. Therefore, we designed and constructed slip-in devices to facilitate QA for dosimetric measurements of our Xstrahl 300 unit. Read More

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Macroporous 3D Scaffold with Self-Fitting Capability for Effectively Repairing Massive Rotator Cuff Tear.

ACS Biomater Sci Eng 2021 03 23;7(3):904-915. Epub 2020 Apr 23.

Department of Sports Medicine, Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai 200233, PR China.

The postoperative retear rate of direct repair of massive rotator cuff tear has risen up to 40% because of the dissatisfied tendon-to-bone healing and poor regenerative potential of remnant rotator cuff tissue. A biological scaffold that connects the remnant rotator cuff tissue and bone might be a promising substitute. In the present study, we have developed a macroporous three-dimensional scaffold poly(ester-urethane)urea (PEUU), with self-fitting capability employing thermally induced phase separation (TIPS) technique. Read More

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Rearing system with nurse cows and risk factors for Cryptosporidium infection in organic dairy calves.

Prev Vet Med 2021 Mar 4;190:105321. Epub 2021 Mar 4.

INRAE, Oniris, BIOEPAR, 44300, Nantes, France.

Rearing dairy calves with nurse cows has been increasingly adopted by French farmers especially in organic farming and is characterized by a fostering of two to four calves during the first month of life by an unmilked lactating cow. This type of rearing remains poorly documented regarding its impact on calf health, such as cryptosporidiosis. The objectives of our study were to describe practices related to rearing dairy calves with nurse cows and to evaluate the prevalence, intensity and risk factors for Cryptosporidium infection in calf neonates. Read More

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